Alzheimer’s disease(AD)is the most common cause of dementia,afecting approximately 40 million people worldwide.The inefectiveness of the available pharmacological treatments against AD has fostered researchers to foc...Alzheimer’s disease(AD)is the most common cause of dementia,afecting approximately 40 million people worldwide.The inefectiveness of the available pharmacological treatments against AD has fostered researchers to focus on alternative strategies to overcome this challenge.Mechanical vibrations delivered in diferent stimulation modes have been associated with marked improvements in cognitive and physical performance in both demented and nondemented elderly.Some of the mechanical-based stimulation modalities in eforts are earlier whole-body vibration,transcranial ultrasound stimulation with microbubble injection,and more recently,auditory stimulation.However,there is a huge variety of treatment specifcations,and in many cases,conficting results are reported.In this review,a search on Scopus,PubMed,and Web of Science databases was performed,resulting in 37 papers.These studies suggest that mechanical vibrations delivered through diferent stimulation modes are efective in attenuating many parameters of AD pathology including functional connectivity and neuronal circuit integrity defcits in the brains of AD patients,as well as in subjects with cognitive decline and non-demented older adults.Despite the evolving preclinical and clinical evidence on these therapeutic modalities,their translation into clinical practice is not consolidated yet.Thus,this comprehensive and critical systematic review aims to address the most important gaps in the reviewed protocols and propose optimal regimens for future clinical application.展开更多
基金This systematic review was supported by FCT(Fundação para a Ciência e Tecnologia)through the grant with reference SFRH/BD/09375/2020,and in the scope of the projects UIDB/04436/2020,UIDP/04436/2020,and NORTE-01-0145-FEDER-000023funded by the European Fund for Regional Development(FEDER)of the Operational Programme for Competitiveness and Internationalization(POCI),by Portugal 2020。
文摘Alzheimer’s disease(AD)is the most common cause of dementia,afecting approximately 40 million people worldwide.The inefectiveness of the available pharmacological treatments against AD has fostered researchers to focus on alternative strategies to overcome this challenge.Mechanical vibrations delivered in diferent stimulation modes have been associated with marked improvements in cognitive and physical performance in both demented and nondemented elderly.Some of the mechanical-based stimulation modalities in eforts are earlier whole-body vibration,transcranial ultrasound stimulation with microbubble injection,and more recently,auditory stimulation.However,there is a huge variety of treatment specifcations,and in many cases,conficting results are reported.In this review,a search on Scopus,PubMed,and Web of Science databases was performed,resulting in 37 papers.These studies suggest that mechanical vibrations delivered through diferent stimulation modes are efective in attenuating many parameters of AD pathology including functional connectivity and neuronal circuit integrity defcits in the brains of AD patients,as well as in subjects with cognitive decline and non-demented older adults.Despite the evolving preclinical and clinical evidence on these therapeutic modalities,their translation into clinical practice is not consolidated yet.Thus,this comprehensive and critical systematic review aims to address the most important gaps in the reviewed protocols and propose optimal regimens for future clinical application.
