MicroRNA (miRNA) is a type of endogenous non-coding RNA that can regulate cell proliferation,differentiation,invasion,apoptosis and several other biological activities by specially inducing gene silencing,and thereby ...MicroRNA (miRNA) is a type of endogenous non-coding RNA that can regulate cell proliferation,differentiation,invasion,apoptosis and several other biological activities by specially inducing gene silencing,and thereby is related to development and disease in life course.In recent years,researchers have found that miRNAs are closely related with refractory epilepsy.MiRNAs can intervene in the modification of mRNAs,the synthesis of proteins and some the connectivity of signal pathways in pathogenesis of epilepsy.Furthermore,some miRNAs in neurons are of great importance in neuronal differentiation.Therefore,miRNA may play a very important role in the occurrence,development and episodes of refractory epilepsy.These discoveries can provide a new direction for the research of pathogenesis,diagnostic methods and therapeutic approach of refractory epilepsy.Although research about miRNA and intractable epilepsy has progressed,more remains to be done before miRNA can be used in clinical diagnosis and treatment strategies.This paper focuses on the research progress of molecular diagnosis about miRNA in intractable epilepsy.展开更多
Background:Supratentorial primitive neuroectodermal tumors(sPNET)are rarely occurred in adults.Only 39 cases have been reported in the past decade.The transformation from low grade to aggressive astrocytoma is well kn...Background:Supratentorial primitive neuroectodermal tumors(sPNET)are rarely occurred in adults.Only 39 cases have been reported in the past decade.The transformation from low grade to aggressive astrocytoma is well known.However,such convert from a low-grade astrocytoma(LGA)into a sPNET between two completely different tumors is rarer.Case Presentation:This report discussed a 36-year-old male,who presented with the chief complaint of partial seizures and left limbs dysfunction and Magnetic resonance imaging(MRI)of whom revealed right frontal lesions which was operated to resect accompanied by the histological diagnosis of sPNET.The patient underwent operation 2.5 years ago because of seizures and was diagnosed with right frontal astrocytoma confirmed by pathology.However,radiotherapy was not preformed on him after the primary surgery.Histology now revealed high grade PNET.Conclusion:It is exactly uncertain that reports revelant to transformation from low-grade astrocytoma to a new kind of tumor or neoplasm induced by radiotation have been published.This case report is accompanied by a review of 39 cases of adult sPNET in the past decade,especially discussing about the transformation of low grade glioma into sPNET.展开更多
文摘MicroRNA (miRNA) is a type of endogenous non-coding RNA that can regulate cell proliferation,differentiation,invasion,apoptosis and several other biological activities by specially inducing gene silencing,and thereby is related to development and disease in life course.In recent years,researchers have found that miRNAs are closely related with refractory epilepsy.MiRNAs can intervene in the modification of mRNAs,the synthesis of proteins and some the connectivity of signal pathways in pathogenesis of epilepsy.Furthermore,some miRNAs in neurons are of great importance in neuronal differentiation.Therefore,miRNA may play a very important role in the occurrence,development and episodes of refractory epilepsy.These discoveries can provide a new direction for the research of pathogenesis,diagnostic methods and therapeutic approach of refractory epilepsy.Although research about miRNA and intractable epilepsy has progressed,more remains to be done before miRNA can be used in clinical diagnosis and treatment strategies.This paper focuses on the research progress of molecular diagnosis about miRNA in intractable epilepsy.
文摘Background:Supratentorial primitive neuroectodermal tumors(sPNET)are rarely occurred in adults.Only 39 cases have been reported in the past decade.The transformation from low grade to aggressive astrocytoma is well known.However,such convert from a low-grade astrocytoma(LGA)into a sPNET between two completely different tumors is rarer.Case Presentation:This report discussed a 36-year-old male,who presented with the chief complaint of partial seizures and left limbs dysfunction and Magnetic resonance imaging(MRI)of whom revealed right frontal lesions which was operated to resect accompanied by the histological diagnosis of sPNET.The patient underwent operation 2.5 years ago because of seizures and was diagnosed with right frontal astrocytoma confirmed by pathology.However,radiotherapy was not preformed on him after the primary surgery.Histology now revealed high grade PNET.Conclusion:It is exactly uncertain that reports revelant to transformation from low-grade astrocytoma to a new kind of tumor or neoplasm induced by radiotation have been published.This case report is accompanied by a review of 39 cases of adult sPNET in the past decade,especially discussing about the transformation of low grade glioma into sPNET.
