AIM： To study the variabilities of serum proteomic spectra in patients with gastric cancer before and after operation in order to detect the specific protein markers that can be used for quick diagnosis of gastric ca...AIM： To study the variabilities of serum proteomic spectra in patients with gastric cancer before and after operation in order to detect the specific protein markers that can be used for quick diagnosis of gastric cancer. METHODS： Proteomic spectra of 46 serum samples from patients with gastric cancer before and after operation and 40 from normal individuals were generated by IMAC-Cu protein chip and surface-enhanced laser desorption/ionization time of flight mass spectrometry. RESULTS： Fourteen differentially expressed proteins in serum were screened by analysis of proteomic spectra of preoperative patients and normal individuals. We obtained 4 proteins （heat shock protein 27, glucoseregulated protein, prohibitin, protein disulfide isomerase A3） making up marker pattern which was able to class the patient-team and normal-team. These marker patterns yielded 95.7% sensitivity and 92.5% specificity, respectively. The proteins over-expressed in serum of preoperative patients were obviously down-regulated. CONCLUSION： Specific protein markers of gastric cancer can be used for the quick diagnosis of gastric cancer and judgment of prognosis. SELDI-TOF-MS is a useful tool for the detection and identification of new protein markers in serum.展开更多
In order to characterize sleep and the cognitive patterns in patients with acute minor thalamic infarction （AMTI）, we enrolled 27 patients with AMTI and 12 mat- ched healthy individuals. Questionnaires about sleep a...In order to characterize sleep and the cognitive patterns in patients with acute minor thalamic infarction （AMTI）, we enrolled 27 patients with AMTI and 12 mat- ched healthy individuals. Questionnaires about sleep and cognition as well as polysomnography （PSG） were performed on days 14 and 90 post-stroke. Compared to heal- thy controls, in patients with AMTI, hyposomnia was more prevalent; sleep architecture was disrupted as indicated by decreased sleep efficiency, increased sleep latency, and decreased non-rapid eye movement sleep stages 2 and 3; more sleep-related breathing disorders occurred; and cog- nitive functions were worse, especially memory. While sleep apnea and long-delay memory recovered to a large extent in the patients, other sleep and cognitive function deficit often persisted. Patients with AMTI are at an increased risk for hyposomnia, sleep structure disturbance, sleep apnea, and memory deficits. Although these abnormalities improved over time, the slow and incomplete improvement suggest that early management should be considered in these patients.展开更多
Reactive Materials(RMs),a new material with structural and energy release characteristics under shockinduced chemical reactions,are promising in extensive applications in national defense and military fields.They can ...Reactive Materials(RMs),a new material with structural and energy release characteristics under shockinduced chemical reactions,are promising in extensive applications in national defense and military fields.They can increase the lethality of warheads due to their dual functionality.This paper focuses on the energy release characteristics of RM casings prepared by alloy melting and casting process under explosive loading.Explosion experiments of RM and conventional 2A12 aluminum alloy casings were conducted in free field to capture the explosive fireballs,temperature distribution,peak overpressure of the air shock wave and the fracture morphology of fragments of reactive material(RM)warhead casings by using high-speed camera,infrared thermal imager temperature and peak overpressure testing and scanning electron microscope.Results showed that an increase of both the fireball temperature and air shock wave were observed in all RM casings compared to conventional 2A12 aluminum ally casings.The RM casings can improve the peak overpressure of the air shock wave under explosion loading,though the results are different with different charge ratios.According to the energy release characteristics of the RM,increasing the thickness of RM casings will increase the peak overpressure of the near-field air shock wave,while reducing the thickness will increase the peak overpressure of the far-field air shock wave.展开更多
Enterovirus A71(EV-A71)is one of the main causative agents of hand,foot and mouth disease(HFMD)and it also causes severe neurologic complications in infected children.The interactions between some viruses and the host...Enterovirus A71(EV-A71)is one of the main causative agents of hand,foot and mouth disease(HFMD)and it also causes severe neurologic complications in infected children.The interactions between some viruses and the host mitochondria are crucial for virus replication and pathogenicity.In this study,it was observed that EV-A71 infection resulted in a perinuclear redistribution of the mitochondria.The mitochondria rearrangement was found to require the microtubule network,the dynein complex and a low cytosolic calcium concentration.Subsequently,the EV-A71 non-structural protein 2BC was identified as the viral protein capable of inducing mitochondria clustering.The protein was found localized on mitochondria and interacted with the mitochondrial Rho GTPase 1(RHOT1)that is a key protein required for attachment between the mitochondria and the motor proteins,which are responsible for the control of mitochondria movement.Additionally,suppressing mitochondria clustering by treating cells with nocodazole,EHNA,thapsigargin or A23187 consistently inhibited EV?A71 replication,indicating that mitochondria recruitment played a crucial role in the EV-A71 life cycle.This study identified a novel function of the EV-A71 2BC protein and provided a potential model for the regulation of mitochondrial motility in EV-A71 infection.展开更多
We report the secondary X(γ)radiation from the accelerator in a normal operating state and activated X(γ)radiation from the accelerator devices when the accelerator stops operating in the cancer treatment facility o...We report the secondary X(γ)radiation from the accelerator in a normal operating state and activated X(γ)radiation from the accelerator devices when the accelerator stops operating in the cancer treatment facility of the Shanghai Proton and Heavy Ion Center(SPHIC).These radiation measurements show us the structural radiation distribution along the beam lines and devices inside the accelerator room when the beam is on and off and can support the radiation protection design of the accelerator facility used for cancer treatment and help evaluate the accumulated radiation dose in the case of an emergency,such as a personal safety system failure or a radiation accident.The radiation dose rate measured in this facility shows that the facility is safe from the radiation protection point.After shooting the quality assurance(QA)beam,the radiation dose rate in the treatment room was also measured to investigate the radiation dose space distribution and decay time dependence.In addition,the time period before safely entering the treatment room after determining the shooting of the QA beam is recommended to be approximately 5 min.展开更多
A novel and simple chemical reaction method was developed to synthesize dendrite-like La（OH）3 nanostructures which was composed of centripetal arranged La（OH）3 nanorods with diameters of 50-100 nm and lengths of s...A novel and simple chemical reaction method was developed to synthesize dendrite-like La（OH）3 nanostructures which was composed of centripetal arranged La（OH）3 nanorods with diameters of 50-100 nm and lengths of several micrometers. The effect of different alkaline sources on the morphology of La（OH）3 nanostructures was investigated. It is indicated that diethyl- enetriamine acts not only as an alkaline source, but also as a surfactant which induces the centripetal growth of La（OH）3 nanostructures. Moreover, dendrite-like La203 nanostructures were prepared by the calcination of La（OH）3 nanostructures at 750 ℃. The morphology, structure, and composition of the as-synthesized products were characterized by transmission electron microscopy （SEM）, high-resolution transmission electron microscopy, field emission scanning electron microscopy （FESEM）, and X-ray powder diffraction （XRD）.展开更多
[Objectives] A simple and reliable HPLC fingerprint method was developed for the identification of dried barks of Ilex rotunda and I. godajam. [Methods] Nine batches of dried barks of I. rotunda,and seven batches of d...[Objectives] A simple and reliable HPLC fingerprint method was developed for the identification of dried barks of Ilex rotunda and I. godajam. [Methods] Nine batches of dried barks of I. rotunda,and seven batches of dried barks of I. godajam collected from different pharmacies and arboretums in different regions of China were used to establish fingerprints. The software Similarity Evaluation System of Chromatographic Fingerprints of Traditional Chinese Medicine( 2004 A Edition) was used to evaluate the fingerprints. [Results]The fingerprints of dried barks of I. rotunda and I. godajam were established. Methodological study met the technical requirements of fingerprints. The similarities of the fingerprints of dried barks of I. rotunda and I. godajam were all more than 0. 8 and 0. 9 respectively. There were 31 and 28 common peaks in I. rotunda and I. godajam,which could be classified into two clusters by principal component analysis( PCA) and hierarchical cluster analysis. [Conclusions] The feasibility and advantages of used HPLC fingerprints were verified,and the results indicated that the HPLC fingerprint as a characteristic distinguishing method combining similarity evaluation,principal component analysis and hierarchical cluster analysis can be successfully used to identify the authenticity of dried barks of I. rotunda and I. godajam.展开更多
A class of upwind finite volume element method based on tetrahedron partition is put forward for a nonlinear convection diffusion problem. Some techniques, such as calculus of variations, commutating operators and the...A class of upwind finite volume element method based on tetrahedron partition is put forward for a nonlinear convection diffusion problem. Some techniques, such as calculus of variations, commutating operators and the a priori estimate, are adopted. The a priori error estimate in L2-norm and H1-norm is derived to determine the error between the approximate solution and the true solution.展开更多
False smut is a destructive grain disease of rice worldwide,characterized by false smut balls formed in rice flowers.Here we identified a small secreted protein UV_1261 contributing to virulence of Ustilaginoidea vire...False smut is a destructive grain disease of rice worldwide,characterized by false smut balls formed in rice flowers.Here we identified a small secreted protein UV_1261 contributing to virulence of Ustilaginoidea virens,the causal agent of this disease.The sequence of UV_1261 was highly conserved among isolates of U.virens and absent in other fungi.UV_1261 encodes a protein targeted to plant chloroplasts.Its expression exhibited a bimodal pattern during pathogenesis.Ectopic expression of UV_1261 in Nicotiana benthamiana and Arabidopsis led to suppression of flg22-induced ROS burst,callose deposition,and expression of defense-related genes,as well as enhanced susceptibility to powdery mildew in Arabidopsis.Down-regulation of UV_1261 via exogenous siRNA treatment resulted in reduced number of false smut balls.Consistently,stably knocking-down UV_1261 caused less number of false smut balls associated with higher expression of defense-related genes in rice flower.Taken together,our data demonstrate that UV_1261 is a core effector of U.virens essential for virulence and suppressing defense in rice flower,and thus may serve as a potential molecular target for controlling rice false smut disease.展开更多
Aim:To identify serum biomarkers for non-small cell lung cancer(NSCLC)and assess their potential for early diagnosis.Methods:MB-WCX coupled with MALDI-TOF MS was utilized to profile serum samples from 64 NSCLC patient...Aim:To identify serum biomarkers for non-small cell lung cancer(NSCLC)and assess their potential for early diagnosis.Methods:MB-WCX coupled with MALDI-TOF MS was utilized to profile serum samples from 64 NSCLC patients and 64 healthy subjects,followed by ClinProTools software and Liquid chromatography-electrospray ionization-tandem mass spectrometry(LC-ESI-MS/MS)for recognition and characterization of differentially expressed peaks.Enzyme-linked immunosorbent assay(ELISA)confirmed protein concentrations,while The Cancer Genome Atlas(TCGA)database was leveraged for validation of candidate biomarkers in a larger cohort.Results:39 distinct proteomic m/z peaks were identified for NSCLC subjects,with five of these peaks significantly distinguishing NSCLC from healthy controls(HC).A model developed using the GA(Genetic Algorithm)with ClinProt data demonstrated a sensitivity of 84.72%and a specificity of 88.68%in identifying NSCLC patients.Peaks 2 through 5 were observed to be downregulated in the NSCLC group.Notably,a peptide peak,Peak 1,with an m/z value of 1,866,identified as a fragment of TUBB,was upregulated in NSCLC.ELISA validated the increased serum TUBB levels in NSCLC patients(P<0.001).Furthermore,analysis of TUBB expression in lung cancer tissues through TCGA data revealed elevated TUBB expression in lung cancer tissues.Conclusions:Serum TUBB is identified as a potential diagnostic biomarker for NSCLC,which may benefit early diagnosis and enhance the survival rate of NSCLC patients.展开更多
Two new compounds, named lyciumlignan D(1) and lyciumphenyl propanoid A(2), along with seven known compounds, were isolated from the root bark of Lycium chinense. Their structures were elucidated using spectroscopic d...Two new compounds, named lyciumlignan D(1) and lyciumphenyl propanoid A(2), along with seven known compounds, were isolated from the root bark of Lycium chinense. Their structures were elucidated using spectroscopic data(UV, IR, HR-ESI-MS, 1D and 2D NMR, CD), as well as by comparison with those of the literature. Compounds 3–9 were isolated from this genus for the first time. In the in vitro assay, compounds 3, 6, and 7 exhibited stronger anti-inflammatory effects than the positive control curcumin at a concentration of 10 μmol/L.展开更多
In cellular networks, users communicate with each other through their respective base stations(BSs).Conventionally, users are assumed to be in different cells. BSs serve as decode-and-forward(DF) relay nodes to users....In cellular networks, users communicate with each other through their respective base stations(BSs).Conventionally, users are assumed to be in different cells. BSs serve as decode-and-forward(DF) relay nodes to users.In addition to this type of conventional user, we recognize that there are scenarios users who want to communicate with each other are located in the same cell. This gives rise to the scenario of intra-cell communication. In this case, a BS can behave as a two-way relay to achieve information exchange instead of using conventional DF relay.We consider a multi-cell orthogonal frequency division multiple access(OFDMA) network that comprises these two types of users. We are interested in resource allocation between them. Specifically, we jointly optimize subcarrier assignment, subcarrier pairing, and power allocation to maximize the weighted sum rate. We consider the resource allocation problem at BSs when the end users' power is fixed. We solve the problem approximately through Lagrange dual decomposition. Simulation results show that the proposed schemes outperform other existing schemes.展开更多
We develop a fast stochastic Galerkin method for an optimal control problem governed by a random space-fractional diffusion equation with deterministic constrained control. Optimal control problems governed by a fract...We develop a fast stochastic Galerkin method for an optimal control problem governed by a random space-fractional diffusion equation with deterministic constrained control. Optimal control problems governed by a fractional diffusion equation tends to provide a better description for transport or conduction processes in heterogeneous media. Howev- er, the fractional control problem introduces significant computation complexity due to the nonlocal nature of fractional differential operators, and this is further worsen by the large number of random space dimensions to discretize the probability space. We ap- proximate the optimality system by a gradient algorithm combined with the stochastic Galerkin method through the discretization with respect to both the spatial space and the probability space. The resulting linear system can be decoupled for the random and spatial variable, and thus solved separately. A fast preconditioned Bi-Conjugate Gradient Stabilized method is developed to efficiently solve the decoupled systems derived from the fractional diffusion operators in the spatial space. Numerical experiments show the utility of the method.展开更多
文摘AIM： To study the variabilities of serum proteomic spectra in patients with gastric cancer before and after operation in order to detect the specific protein markers that can be used for quick diagnosis of gastric cancer. METHODS： Proteomic spectra of 46 serum samples from patients with gastric cancer before and after operation and 40 from normal individuals were generated by IMAC-Cu protein chip and surface-enhanced laser desorption/ionization time of flight mass spectrometry. RESULTS： Fourteen differentially expressed proteins in serum were screened by analysis of proteomic spectra of preoperative patients and normal individuals. We obtained 4 proteins （heat shock protein 27, glucoseregulated protein, prohibitin, protein disulfide isomerase A3） making up marker pattern which was able to class the patient-team and normal-team. These marker patterns yielded 95.7% sensitivity and 92.5% specificity, respectively. The proteins over-expressed in serum of preoperative patients were obviously down-regulated. CONCLUSION： Specific protein markers of gastric cancer can be used for the quick diagnosis of gastric cancer and judgment of prognosis. SELDI-TOF-MS is a useful tool for the detection and identification of new protein markers in serum.
基金supported by the Health Industry Key Research Project of Tianjin Municipality,China(12KG132)the Science and Technology Plan Project of Tianjin Municipality,China(13ZCZDSY01900)
文摘In order to characterize sleep and the cognitive patterns in patients with acute minor thalamic infarction （AMTI）, we enrolled 27 patients with AMTI and 12 mat- ched healthy individuals. Questionnaires about sleep and cognition as well as polysomnography （PSG） were performed on days 14 and 90 post-stroke. Compared to heal- thy controls, in patients with AMTI, hyposomnia was more prevalent; sleep architecture was disrupted as indicated by decreased sleep efficiency, increased sleep latency, and decreased non-rapid eye movement sleep stages 2 and 3; more sleep-related breathing disorders occurred; and cog- nitive functions were worse, especially memory. While sleep apnea and long-delay memory recovered to a large extent in the patients, other sleep and cognitive function deficit often persisted. Patients with AMTI are at an increased risk for hyposomnia, sleep structure disturbance, sleep apnea, and memory deficits. Although these abnormalities improved over time, the slow and incomplete improvement suggest that early management should be considered in these patients.
基金the Fundamental Research Funds for the Central Universities(No.30920021108)Open Foundation of Hypervelocity Impact Research Center of CARDC(20200106).
文摘Reactive Materials(RMs),a new material with structural and energy release characteristics under shockinduced chemical reactions,are promising in extensive applications in national defense and military fields.They can increase the lethality of warheads due to their dual functionality.This paper focuses on the energy release characteristics of RM casings prepared by alloy melting and casting process under explosive loading.Explosion experiments of RM and conventional 2A12 aluminum alloy casings were conducted in free field to capture the explosive fireballs,temperature distribution,peak overpressure of the air shock wave and the fracture morphology of fragments of reactive material(RM)warhead casings by using high-speed camera,infrared thermal imager temperature and peak overpressure testing and scanning electron microscope.Results showed that an increase of both the fireball temperature and air shock wave were observed in all RM casings compared to conventional 2A12 aluminum ally casings.The RM casings can improve the peak overpressure of the air shock wave under explosion loading,though the results are different with different charge ratios.According to the energy release characteristics of the RM,increasing the thickness of RM casings will increase the peak overpressure of the near-field air shock wave,while reducing the thickness will increase the peak overpressure of the far-field air shock wave.
基金supported by grants from the National Natural Science Foundation of China (NSFC) (Grants Nos. 81621091, 31370201)
文摘Enterovirus A71(EV-A71)is one of the main causative agents of hand,foot and mouth disease(HFMD)and it also causes severe neurologic complications in infected children.The interactions between some viruses and the host mitochondria are crucial for virus replication and pathogenicity.In this study,it was observed that EV-A71 infection resulted in a perinuclear redistribution of the mitochondria.The mitochondria rearrangement was found to require the microtubule network,the dynein complex and a low cytosolic calcium concentration.Subsequently,the EV-A71 non-structural protein 2BC was identified as the viral protein capable of inducing mitochondria clustering.The protein was found localized on mitochondria and interacted with the mitochondrial Rho GTPase 1(RHOT1)that is a key protein required for attachment between the mitochondria and the motor proteins,which are responsible for the control of mitochondria movement.Additionally,suppressing mitochondria clustering by treating cells with nocodazole,EHNA,thapsigargin or A23187 consistently inhibited EV?A71 replication,indicating that mitochondria recruitment played a crucial role in the EV-A71 life cycle.This study identified a novel function of the EV-A71 2BC protein and provided a potential model for the regulation of mitochondrial motility in EV-A71 infection.
文摘We report the secondary X(γ)radiation from the accelerator in a normal operating state and activated X(γ)radiation from the accelerator devices when the accelerator stops operating in the cancer treatment facility of the Shanghai Proton and Heavy Ion Center(SPHIC).These radiation measurements show us the structural radiation distribution along the beam lines and devices inside the accelerator room when the beam is on and off and can support the radiation protection design of the accelerator facility used for cancer treatment and help evaluate the accumulated radiation dose in the case of an emergency,such as a personal safety system failure or a radiation accident.The radiation dose rate measured in this facility shows that the facility is safe from the radiation protection point.After shooting the quality assurance(QA)beam,the radiation dose rate in the treatment room was also measured to investigate the radiation dose space distribution and decay time dependence.In addition,the time period before safely entering the treatment room after determining the shooting of the QA beam is recommended to be approximately 5 min.
基金financially supported by the National Natural Science Foundation of China(No.51002133)
文摘A novel and simple chemical reaction method was developed to synthesize dendrite-like La（OH）3 nanostructures which was composed of centripetal arranged La（OH）3 nanorods with diameters of 50-100 nm and lengths of several micrometers. The effect of different alkaline sources on the morphology of La（OH）3 nanostructures was investigated. It is indicated that diethyl- enetriamine acts not only as an alkaline source, but also as a surfactant which induces the centripetal growth of La（OH）3 nanostructures. Moreover, dendrite-like La203 nanostructures were prepared by the calcination of La（OH）3 nanostructures at 750 ℃. The morphology, structure, and composition of the as-synthesized products were characterized by transmission electron microscopy （SEM）, high-resolution transmission electron microscopy, field emission scanning electron microscopy （FESEM）, and X-ray powder diffraction （XRD）.
基金Supported by Special Project for Scientific Research of General Administration of Quality Supervision,Inspection and Quarantine of the People's Republic of China(201210209)China Agriculture Research System(CARS-21)
文摘[Objectives] A simple and reliable HPLC fingerprint method was developed for the identification of dried barks of Ilex rotunda and I. godajam. [Methods] Nine batches of dried barks of I. rotunda,and seven batches of dried barks of I. godajam collected from different pharmacies and arboretums in different regions of China were used to establish fingerprints. The software Similarity Evaluation System of Chromatographic Fingerprints of Traditional Chinese Medicine( 2004 A Edition) was used to evaluate the fingerprints. [Results]The fingerprints of dried barks of I. rotunda and I. godajam were established. Methodological study met the technical requirements of fingerprints. The similarities of the fingerprints of dried barks of I. rotunda and I. godajam were all more than 0. 8 and 0. 9 respectively. There were 31 and 28 common peaks in I. rotunda and I. godajam,which could be classified into two clusters by principal component analysis( PCA) and hierarchical cluster analysis. [Conclusions] The feasibility and advantages of used HPLC fingerprints were verified,and the results indicated that the HPLC fingerprint as a characteristic distinguishing method combining similarity evaluation,principal component analysis and hierarchical cluster analysis can be successfully used to identify the authenticity of dried barks of I. rotunda and I. godajam.
文摘A class of upwind finite volume element method based on tetrahedron partition is put forward for a nonlinear convection diffusion problem. Some techniques, such as calculus of variations, commutating operators and the a priori estimate, are adopted. The a priori error estimate in L2-norm and H1-norm is derived to determine the error between the approximate solution and the true solution.
基金National Natural Science Foundation of China(grant no.31501598 and 31772241)Key Projects of Sichuan Provincial Education Department.
文摘False smut is a destructive grain disease of rice worldwide,characterized by false smut balls formed in rice flowers.Here we identified a small secreted protein UV_1261 contributing to virulence of Ustilaginoidea virens,the causal agent of this disease.The sequence of UV_1261 was highly conserved among isolates of U.virens and absent in other fungi.UV_1261 encodes a protein targeted to plant chloroplasts.Its expression exhibited a bimodal pattern during pathogenesis.Ectopic expression of UV_1261 in Nicotiana benthamiana and Arabidopsis led to suppression of flg22-induced ROS burst,callose deposition,and expression of defense-related genes,as well as enhanced susceptibility to powdery mildew in Arabidopsis.Down-regulation of UV_1261 via exogenous siRNA treatment resulted in reduced number of false smut balls.Consistently,stably knocking-down UV_1261 caused less number of false smut balls associated with higher expression of defense-related genes in rice flower.Taken together,our data demonstrate that UV_1261 is a core effector of U.virens essential for virulence and suppressing defense in rice flower,and thus may serve as a potential molecular target for controlling rice false smut disease.
基金supported by the Science and Technology Program of Shaanxi province(grant number:2020SF-114).
文摘Aim:To identify serum biomarkers for non-small cell lung cancer(NSCLC)and assess their potential for early diagnosis.Methods:MB-WCX coupled with MALDI-TOF MS was utilized to profile serum samples from 64 NSCLC patients and 64 healthy subjects,followed by ClinProTools software and Liquid chromatography-electrospray ionization-tandem mass spectrometry(LC-ESI-MS/MS)for recognition and characterization of differentially expressed peaks.Enzyme-linked immunosorbent assay(ELISA)confirmed protein concentrations,while The Cancer Genome Atlas(TCGA)database was leveraged for validation of candidate biomarkers in a larger cohort.Results:39 distinct proteomic m/z peaks were identified for NSCLC subjects,with five of these peaks significantly distinguishing NSCLC from healthy controls(HC).A model developed using the GA(Genetic Algorithm)with ClinProt data demonstrated a sensitivity of 84.72%and a specificity of 88.68%in identifying NSCLC patients.Peaks 2 through 5 were observed to be downregulated in the NSCLC group.Notably,a peptide peak,Peak 1,with an m/z value of 1,866,identified as a fragment of TUBB,was upregulated in NSCLC.ELISA validated the increased serum TUBB levels in NSCLC patients(P<0.001).Furthermore,analysis of TUBB expression in lung cancer tissues through TCGA data revealed elevated TUBB expression in lung cancer tissues.Conclusions:Serum TUBB is identified as a potential diagnostic biomarker for NSCLC,which may benefit early diagnosis and enhance the survival rate of NSCLC patients.
基金financially supported by the National Natural Science Foundation of China(No.81303207)CAMS Innovation Fund for Medical Sciences(CIFMS,No.2016-I2M-1-007)
文摘Two new compounds, named lyciumlignan D(1) and lyciumphenyl propanoid A(2), along with seven known compounds, were isolated from the root bark of Lycium chinense. Their structures were elucidated using spectroscopic data(UV, IR, HR-ESI-MS, 1D and 2D NMR, CD), as well as by comparison with those of the literature. Compounds 3–9 were isolated from this genus for the first time. In the in vitro assay, compounds 3, 6, and 7 exhibited stronger anti-inflammatory effects than the positive control curcumin at a concentration of 10 μmol/L.
基金Project supported by the Natural Science Foundation of Shandong Province,China(No.ZR2012AQ015)
文摘In cellular networks, users communicate with each other through their respective base stations(BSs).Conventionally, users are assumed to be in different cells. BSs serve as decode-and-forward(DF) relay nodes to users.In addition to this type of conventional user, we recognize that there are scenarios users who want to communicate with each other are located in the same cell. This gives rise to the scenario of intra-cell communication. In this case, a BS can behave as a two-way relay to achieve information exchange instead of using conventional DF relay.We consider a multi-cell orthogonal frequency division multiple access(OFDMA) network that comprises these two types of users. We are interested in resource allocation between them. Specifically, we jointly optimize subcarrier assignment, subcarrier pairing, and power allocation to maximize the weighted sum rate. We consider the resource allocation problem at BSs when the end users' power is fixed. We solve the problem approximately through Lagrange dual decomposition. Simulation results show that the proposed schemes outperform other existing schemes.
基金This work was supported by the National Natural Science Foundation of China under grants 11371229, 11571026 and 11501326, and by the China Scholarship Council （File No. 2013083Y0102）.
文摘We develop a fast stochastic Galerkin method for an optimal control problem governed by a random space-fractional diffusion equation with deterministic constrained control. Optimal control problems governed by a fractional diffusion equation tends to provide a better description for transport or conduction processes in heterogeneous media. Howev- er, the fractional control problem introduces significant computation complexity due to the nonlocal nature of fractional differential operators, and this is further worsen by the large number of random space dimensions to discretize the probability space. We ap- proximate the optimality system by a gradient algorithm combined with the stochastic Galerkin method through the discretization with respect to both the spatial space and the probability space. The resulting linear system can be decoupled for the random and spatial variable, and thus solved separately. A fast preconditioned Bi-Conjugate Gradient Stabilized method is developed to efficiently solve the decoupled systems derived from the fractional diffusion operators in the spatial space. Numerical experiments show the utility of the method.
