Cancer genomics has led to the discovery of numerous oncogenes and tumor suppressor genes that play critical roles in cancer development and progression.Oncogenes promote cell growth and proliferation,whereas tumor su...Cancer genomics has led to the discovery of numerous oncogenes and tumor suppressor genes that play critical roles in cancer development and progression.Oncogenes promote cell growth and proliferation,whereas tumor suppressor genes inhibit cell growth and division.The dysregulation of these genes can lead to the development of cancer.Recent studies have focused on non-coding RNAs(ncRNAs),including circular RNA(circRNA),long non-coding RNA(lncRNA),and microRNA(miRNA),as therapeutic targets for cancer.In this article,we discuss the oncogenes and tumor suppressor genes of ncRNAs associated with different types of cancer and their potential as therapeutic targets.Here,we highlight the mechanisms of action of these genes and their clinical applications in cancer treatment.Understanding the molecular mechanisms underlying cancer development and identifying specific therapeutic targets are essential steps towards the development of effective cancer treatments.展开更多
A novel Yb3+-doped double-clad silica fibre with rectangular inner cladding was designed and developed by using the modified chemical vapour deposition process, solution-doping and optical machining all together. The ...A novel Yb3+-doped double-clad silica fibre with rectangular inner cladding was designed and developed by using the modified chemical vapour deposition process, solution-doping and optical machining all together. The dimensions of the inner cladding are 100 × 70 μm, and Yb^(3+)-doped concentration in the core is about 0.24 wt. %. The operation of the fibre laser pumped by inner cladding is reported. The threshold of the laser is 34mW.When the pump power launched is 141mW, the laser output is 84mW at the wavelength 1075.6nm, and the slope efficiency is 77%.展开更多
Objective:To determine whether electro-acupuncture (EA) therapy could improve the cognitive functions of amyloid precursor protein Swedish mutation (APPswe)/presenilin 1 deleted in exon 9 (PS1dE9) mice and examine whe...Objective:To determine whether electro-acupuncture (EA) therapy could improve the cognitive functions of amyloid precursor protein Swedish mutation (APPswe)/presenilin 1 deleted in exon 9 (PS1dE9) mice and examine whether EA treatment could attenuate neuroinflammation by targeting the toll-like receptor 4 (TLR4)/myeloid differentiation primary response factor 88 (MyD88) signaling pathway.Methods:Twenty-seven double transgenic APPswe/PS1dE9 mice were randomly allocated into three groups:an Alzheimer's disease model group (AD group),a medication group (M group) and an EA treatment group (EA group).Each group contained nine mice,and nine wild-type mice were used in a normal group (N group).The animals in the M group were treated with oral administrations of 0.92 mg/kg donepezil hydrochloride for 15 days.For animals in the EA group,EA treatments were used on the Yintang (GV 29) and Baihui (GV 20) acupoints for 20 minutes,and the Shuigou (GV 26) acupoint was pricked without needle retention following EA treatments.Following treatments,the spatial learning and memory of the mice were measured using the Morris water maze test.The expression levels of TLR4,MyD88,nuclear factor kappa B (NF-κB) and inducible nitric oxide synthase (iNOS) were analyzed by immunohistochemical staining and western blot.Results:The escape latencies of the M and EA groups were significantly lower than those of the AD group (vs M,P =.002;vs EA,P <.001).Moreover,compared with the AD group,the numbers of platform crossings was higher (vs M,P =.038;vs EA,P =.008) and the latency time for target quadrants was longer (vs M,P =.002;vs EA,P =.001) in the M and EA groups (P <.05).Furthermore,in the M and EA groups,the expression levels of TLR4,MyD88,NF-κB and iNOS decreased significantly compared with those of the AD group (all P <.01).Conclusion:EA treatment enhanced the memory and learning abilities of APPswe/PS1dE9 mice by regulating the TLR4/MyD88 inflammatory signaling pathway.展开更多
In recent years,attacks against crowded places such as campuses and theaters have had a frequent and negative impact on the security and stability of society.In such an event,the crowd will be subjected to high psycho...In recent years,attacks against crowded places such as campuses and theaters have had a frequent and negative impact on the security and stability of society.In such an event,the crowd will be subjected to high psychological stress and their emotions will rapidly spread to others.This paper establishes the attack-escape evacuation simulation model(AEES-SFM),based on the social force model,to consider emotion spreading under attack.In this model,(1)the attack-escape driving force is considered for the interaction between an attacker and evacuees and(2)emotion spreading among the evacuees is considered to modify the value of the psychological force.To validate the simulation,several experiments were carried out at a university in China.Comparing the simulation and experimental results,it is found that the simulation results are similar to the experimental results when considering emotion spreading.Therefore,the AEES-SFM is proved to be effective.By comparing the results of the evacuation simulation without emotion spreading,the emotion spreading model reduces the evacuation time and the number of casualties by about 30%,which is closer to the real experimental results.The results are still applicable in the case of a 40-person evacuation.This paper provides theoretical support and practical guidance for campus response to violent attacks.展开更多
Objective:To explore the mechanism of the treatment of abnormal uterine bleeding with Radix Paeoniae Rubra-Cortex Moutan.Methods:To search the effective elements and action targets of paeony peony skin drug pair by se...Objective:To explore the mechanism of the treatment of abnormal uterine bleeding with Radix Paeoniae Rubra-Cortex Moutan.Methods:To search the effective elements and action targets of paeony peony skin drug pair by searching the pharmacology platform of traditional Chinese medicine system;to select the disease targets of abnormal uterine bleeding by searching the human gene information database;to select the common targets of drugs and diseases by R language,to construct the interaction network of drugs compounds action targets diseases by using the software of Cytoscape;to construct the protein-protein interaction network by using the string platform The interaction network(PPI)was used to visualize the results,and the bio information package of Bioconductor was used to analyze go function enrichment and KEGG pathway.Results:This study included 16 compounds and 67 key targets.After enrichment analysis,87 go functional items and 116 KEGG signaling pathways were obtained.Quercetin,scutellarin,kaempferol and stigmasterol in Radix Paeoniae Rubra-Cortex Moutan directly act on interleukin-6,epidermal growth factor receptor,cystatin 3,mitogen activated protein kinase 8,vascular endothelial growth factor and other related targets,and are mainly enriched in Kaposi sarcoma associated herpesvirus infection and hepatis B.Age-range,TNF and other signal pathways.Conclusion:Radix Paeoniae Rubra-Cortex Moutan may play the role of anti-cell proliferation and apoptosis,protection of vascular endothelium,anti-inflammatory response,regulation of hormone secretion,and improvement of antioxidant activity through multi-component and multi-target,and play the role of treatment of abnormal uterine bleeding.展开更多
Hot deformation with high strain rate has been paid more attention due to its high efficiency and low cost,however,the strain rate dependent dynamic recrystallization(DRX)and texture evolution in hot deformation proce...Hot deformation with high strain rate has been paid more attention due to its high efficiency and low cost,however,the strain rate dependent dynamic recrystallization(DRX)and texture evolution in hot deformation process,which affect the formability of metals,are lack of study.In this work,the DRX behavior and texture evolution of Mg-8Gd-1Er-0.5Zr alloy hot compressed with strain rates of 0.1 s^(−1),1 s^(−1),10 s^(−1) and 50 s^(−1) are studied,and the corresponding dominant mechanisms for DRX and texture weakening are discussed.Results indicated the DRX fraction was 20%and the whole texture intensity was 16.89 MRD when the strain rate was 0.1 s^(−1),but they were 76%and 6.55 MRD,respectively,when the strain rate increased to 50 s^(−1).The increment of DRX fraction is suggested to result from the reduced DRX critical strain and the increased dislocation density as well as velocity,while the weakened whole texture is attributed to the increased DRX grains.At the low strain rate of 0.1 s^(−1),discontinuous DRX(DDRX)was the dominant,but the whole texture was controlled by the deformed grains with the preferred orientation of{0001}⊥CD,because the number of DDRX grains was limited.At the high strain rate of 50 s^(−1),continuous DRX(CDRX)and twin-induced DRX(TDRX)were promoted,and more DRX grains resulted in orientation randomization.The whole texture was mainly weakened by CDRX and TDRX grains,in which CDRX plays a major role.The results of present work are significant for understanding the hot workability of Mg-RE alloys with a high strain rate.展开更多
Acoustic-vortex(AV)tweezers ensure stable particle trapping at a zero-pressure center,while particle assembly between two vortex cores is still prevented by the high-potential barrier.Although a one-dimensional low-pr...Acoustic-vortex(AV)tweezers ensure stable particle trapping at a zero-pressure center,while particle assembly between two vortex cores is still prevented by the high-potential barrier.Although a one-dimensional low-pressure attractive path of particle assembly can be constructed by the interference between two independent cylindrical Bessel beams,it remains challenging to create two-dimensional(2D)neighboring vortexes using a source array in practical applications.In this paper,a three-step phase-reversal strategy of 2D particle assembly based on the synchronized evolution of a centrosymmetric array of M off-axis acoustic vortexes(OA-AVs)with a preset radial offset is proposed based on a ring array of planar sources.By introducing initial vortex phase differences of-2π/M and+2π/M to the vortex array,low-pressure patterns of an M-sided regular polygon and M-branched star are formed by connecting the vortex cores and the field center before and after the tangent state of adjacent OA-AVs.Center-oriented particle assembly is finally realized by a central AV constructed by coincident in-phase OA-AVs.The capability of particle manipulation in the lateral and radial directions is demonstrated by low-pressure patterns with acoustic radiation forces pointing to the field center during a synchronized central approach.The field evolution is certified by experimental field measurements for OA-AVs with different vo rtex numbers,initial vortex phase differences,and radial offsets using a ring array of 16 planar sources.The feasibility of particle assembly in two dimensions is also verified by the accurate manipulation of four particles using the low-pressure patterns of a four-sided polygon,a four-branched star,and a central AV in experiments.The three-step strategy paves a new way for 2D particle assembly based on the synchronize d evolution of centrosymmetric OA-AVs using a simplified single-sided source array,exhibiting excellent potential for the precise navigation and manipulation of cells and particles in biomedical applications.展开更多
The contradiction between mechanical properties and thermal conductivity of magnesium alloys is a roadblock for their widespread applications.In this study,we developed a hot-extruded Mg-8Gd-1Er-8Zn-1Mn alloy with hig...The contradiction between mechanical properties and thermal conductivity of magnesium alloys is a roadblock for their widespread applications.In this study,we developed a hot-extruded Mg-8Gd-1Er-8Zn-1Mn alloy with high-strength and high-thermal-conductivity via dual-phase,W-phase andα-Mn,synergistically strengthening.The alloy extruded at 300℃ exhibited the yield strength and elongation of 372 MPa and 12%,respectively,it simultaneously demonstrated a high thermal conductivity of 134.3W/(m·K).After extrusion,the original coarse W-phase in the alloy was broken into near-spheroidal particles,which reduced the probability of electron scattering.In addition,a large number of solute atoms dynamically precipitated in the form of nanoscale rod-like W-phase andα-Mn,makingα-Mg matrix revert to a nearly periodic arrangement state.The high yield strength of the alloy is predominantly determined by grain boundary strengthening as well as W-phase andα-Mn dual-phase strengthening.Notably,the strategy of dual-phase strengthening provides a valuable approach for developing structure-function integrated Mg alloys.展开更多
The discharge from wastewater treatment plants (WWTPs) into the receiving river is of concern for the health of the ecosystem. In this study, the microbial </span><span style="font-size:12px;font-family:...The discharge from wastewater treatment plants (WWTPs) into the receiving river is of concern for the health of the ecosystem. In this study, the microbial </span><span style="font-size:12px;font-family:Verdana;">diversity impact of Fuxin Meng (FM) WWTP was completed with three pairs of primers. At the time of impact assessment, biochemical tests were carried</span><span style="font-size:12px;font-family:Verdana;"> out as well to investigate the water quality downstream and upstream FMWWTP. The general results showed this plant increased downstream biochemical oxygen demand (BOD) and chemical oxygen demand (COD) by 4.3- and 8.1-fold respectively, in comparison with the upstream. The microbial diversity impact from the plant was also investigated with three pairs of universal primers targeting rRNA genes and the internal transcribed spacer (ITS) by high-throughput sequencing. The downstream diversity of the bacterial and fungal communities was generally higher than upstream, with the exception of the eukaryotic community. Both biochemical and microbial assessments suggested that FMWWTP deteriorate Xi River water quality, potentially acting as a pollutive source. Of the receiving water. Accordingly, it was necessary to improve the operation of WWTP to live up to the environmental quality standards.展开更多
Hepatic ischemia reperfusion injury (HIRI) is a clinical condition which may lead to cellular injury and organ dysfunction. The role of nitric oxide (NO) in HIRI is complicated and inconclusive. NO produced by endothe...Hepatic ischemia reperfusion injury (HIRI) is a clinical condition which may lead to cellular injury and organ dysfunction. The role of nitric oxide (NO) in HIRI is complicated and inconclusive. NO produced by endothelial nitric oxide synthase (eNOS) activation plays a protective role during early HIRI. But eNOS overexpression and the resulting excessive NO bioavailability can aggravate liver injury. NO induced by inducible nitric oxide synthase (iNOS) may have either a protective or a deleterious effect during the early phase of HIRI, but it may protect the liver during late HIRI. Here, we reviewed the latest findings on the role of NO during HIRI: (1) NO exerts a protective effect against HIRI by increasing NO bioavailability, downregulating p53 gene expression, decreasing inflammatory chemokines, reducing ROS via inhibiting the mitochondrial respiratory chain, activating sGC-GTP-cGMP signal pathway to reduce liver cell apoptosis, and regulating hepatic immune functions; (2) eNOS protects against HIRI by increasing NO levels, several eNOS/NO signal pathways (such as Akt-eNOS/NO, AMPK-eNOS/NO and HIF-1 alpha-eNOS/NO) participating in the anti-HIRI process, and inhibiting over-expression of eNOS also protects against HIRI; and (3) the inhibition of iNOS prevents HIRI. Thus, the adverse effects of NO should be avoided, but its positive effect in the clinical treatment of diseases associated with HIRI should be recognized.展开更多
The optimization of flow control devices in a single-slab continuous casting tundish was carried out by physical modeling, and the optimized scheme was presented. With the optimal tundish configuration, the minimum re...The optimization of flow control devices in a single-slab continuous casting tundish was carried out by physical modeling, and the optimized scheme was presented. With the optimal tundish configuration, the minimum residence time of liquid steel was increased by 1.4 times, the peak concentration time was increased by 97%, and the dead volume fraction was decreased by 72%. A mathematical model for molten steel in the tundish was established by using the fluid dynamics package Fluent. The velocity field, concentration field, and the resi-dence time distribution （RTD） curves of molten steel flow before and after optimization were obtained. Experimental results showed that the reasonable configuration with flow control devices can improve the fluid flow characteristics in the tundish. The results of industrial applica-tion show that the nonmetallic inclusion area ratio in casting slabs is decreased by 32% with the optimal tundish configuration.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.:81973171,82103985,and 82373710)the National Key Research and Development Program of China(Grant No.:2020YFA0509404)+2 种基金the Natural Science Foundation of Jiangsu Provincial Colleges and Universities(Grant No.:21KJB350005)the Open Project of Chinese Materia Medica FirstClass Discipline of Nanjing University of Chinese Medicine(Grant No.:2020YLXK002)Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.
文摘Cancer genomics has led to the discovery of numerous oncogenes and tumor suppressor genes that play critical roles in cancer development and progression.Oncogenes promote cell growth and proliferation,whereas tumor suppressor genes inhibit cell growth and division.The dysregulation of these genes can lead to the development of cancer.Recent studies have focused on non-coding RNAs(ncRNAs),including circular RNA(circRNA),long non-coding RNA(lncRNA),and microRNA(miRNA),as therapeutic targets for cancer.In this article,we discuss the oncogenes and tumor suppressor genes of ncRNAs associated with different types of cancer and their potential as therapeutic targets.Here,we highlight the mechanisms of action of these genes and their clinical applications in cancer treatment.Understanding the molecular mechanisms underlying cancer development and identifying specific therapeutic targets are essential steps towards the development of effective cancer treatments.
基金Supported by the National Natural Science Foundation of China under Grant No.69877006Tianjin Natural Science Foundation(003600911)。
文摘A novel Yb3+-doped double-clad silica fibre with rectangular inner cladding was designed and developed by using the modified chemical vapour deposition process, solution-doping and optical machining all together. The dimensions of the inner cladding are 100 × 70 μm, and Yb^(3+)-doped concentration in the core is about 0.24 wt. %. The operation of the fibre laser pumped by inner cladding is reported. The threshold of the laser is 34mW.When the pump power launched is 141mW, the laser output is 84mW at the wavelength 1075.6nm, and the slope efficiency is 77%.
基金the National Natural Science Foundation of China(81473774).
文摘Objective:To determine whether electro-acupuncture (EA) therapy could improve the cognitive functions of amyloid precursor protein Swedish mutation (APPswe)/presenilin 1 deleted in exon 9 (PS1dE9) mice and examine whether EA treatment could attenuate neuroinflammation by targeting the toll-like receptor 4 (TLR4)/myeloid differentiation primary response factor 88 (MyD88) signaling pathway.Methods:Twenty-seven double transgenic APPswe/PS1dE9 mice were randomly allocated into three groups:an Alzheimer's disease model group (AD group),a medication group (M group) and an EA treatment group (EA group).Each group contained nine mice,and nine wild-type mice were used in a normal group (N group).The animals in the M group were treated with oral administrations of 0.92 mg/kg donepezil hydrochloride for 15 days.For animals in the EA group,EA treatments were used on the Yintang (GV 29) and Baihui (GV 20) acupoints for 20 minutes,and the Shuigou (GV 26) acupoint was pricked without needle retention following EA treatments.Following treatments,the spatial learning and memory of the mice were measured using the Morris water maze test.The expression levels of TLR4,MyD88,nuclear factor kappa B (NF-κB) and inducible nitric oxide synthase (iNOS) were analyzed by immunohistochemical staining and western blot.Results:The escape latencies of the M and EA groups were significantly lower than those of the AD group (vs M,P =.002;vs EA,P <.001).Moreover,compared with the AD group,the numbers of platform crossings was higher (vs M,P =.038;vs EA,P =.008) and the latency time for target quadrants was longer (vs M,P =.002;vs EA,P =.001) in the M and EA groups (P <.05).Furthermore,in the M and EA groups,the expression levels of TLR4,MyD88,NF-κB and iNOS decreased significantly compared with those of the AD group (all P <.01).Conclusion:EA treatment enhanced the memory and learning abilities of APPswe/PS1dE9 mice by regulating the TLR4/MyD88 inflammatory signaling pathway.
基金Project supported by the National Natural Science Foundation of China(Grant No.72274208)。
文摘In recent years,attacks against crowded places such as campuses and theaters have had a frequent and negative impact on the security and stability of society.In such an event,the crowd will be subjected to high psychological stress and their emotions will rapidly spread to others.This paper establishes the attack-escape evacuation simulation model(AEES-SFM),based on the social force model,to consider emotion spreading under attack.In this model,(1)the attack-escape driving force is considered for the interaction between an attacker and evacuees and(2)emotion spreading among the evacuees is considered to modify the value of the psychological force.To validate the simulation,several experiments were carried out at a university in China.Comparing the simulation and experimental results,it is found that the simulation results are similar to the experimental results when considering emotion spreading.Therefore,the AEES-SFM is proved to be effective.By comparing the results of the evacuation simulation without emotion spreading,the emotion spreading model reduces the evacuation time and the number of casualties by about 30%,which is closer to the real experimental results.The results are still applicable in the case of a 40-person evacuation.This paper provides theoretical support and practical guidance for campus response to violent attacks.
基金Fundamental Scientific Research Business Expenses of the Institute of Basic Theories of Traditional Chinese Medicine,China Academy of Chinese Medical Sciences(No.YZ-202006,YZ-1859)。
文摘Objective:To explore the mechanism of the treatment of abnormal uterine bleeding with Radix Paeoniae Rubra-Cortex Moutan.Methods:To search the effective elements and action targets of paeony peony skin drug pair by searching the pharmacology platform of traditional Chinese medicine system;to select the disease targets of abnormal uterine bleeding by searching the human gene information database;to select the common targets of drugs and diseases by R language,to construct the interaction network of drugs compounds action targets diseases by using the software of Cytoscape;to construct the protein-protein interaction network by using the string platform The interaction network(PPI)was used to visualize the results,and the bio information package of Bioconductor was used to analyze go function enrichment and KEGG pathway.Results:This study included 16 compounds and 67 key targets.After enrichment analysis,87 go functional items and 116 KEGG signaling pathways were obtained.Quercetin,scutellarin,kaempferol and stigmasterol in Radix Paeoniae Rubra-Cortex Moutan directly act on interleukin-6,epidermal growth factor receptor,cystatin 3,mitogen activated protein kinase 8,vascular endothelial growth factor and other related targets,and are mainly enriched in Kaposi sarcoma associated herpesvirus infection and hepatis B.Age-range,TNF and other signal pathways.Conclusion:Radix Paeoniae Rubra-Cortex Moutan may play the role of anti-cell proliferation and apoptosis,protection of vascular endothelium,anti-inflammatory response,regulation of hormone secretion,and improvement of antioxidant activity through multi-component and multi-target,and play the role of treatment of abnormal uterine bleeding.
基金supported by the Nation Key Research and Development Program of China(No.2021YFB3701100).
文摘Hot deformation with high strain rate has been paid more attention due to its high efficiency and low cost,however,the strain rate dependent dynamic recrystallization(DRX)and texture evolution in hot deformation process,which affect the formability of metals,are lack of study.In this work,the DRX behavior and texture evolution of Mg-8Gd-1Er-0.5Zr alloy hot compressed with strain rates of 0.1 s^(−1),1 s^(−1),10 s^(−1) and 50 s^(−1) are studied,and the corresponding dominant mechanisms for DRX and texture weakening are discussed.Results indicated the DRX fraction was 20%and the whole texture intensity was 16.89 MRD when the strain rate was 0.1 s^(−1),but they were 76%and 6.55 MRD,respectively,when the strain rate increased to 50 s^(−1).The increment of DRX fraction is suggested to result from the reduced DRX critical strain and the increased dislocation density as well as velocity,while the weakened whole texture is attributed to the increased DRX grains.At the low strain rate of 0.1 s^(−1),discontinuous DRX(DDRX)was the dominant,but the whole texture was controlled by the deformed grains with the preferred orientation of{0001}⊥CD,because the number of DDRX grains was limited.At the high strain rate of 50 s^(−1),continuous DRX(CDRX)and twin-induced DRX(TDRX)were promoted,and more DRX grains resulted in orientation randomization.The whole texture was mainly weakened by CDRX and TDRX grains,in which CDRX plays a major role.The results of present work are significant for understanding the hot workability of Mg-RE alloys with a high strain rate.
基金funded by the National Nature Science Foundation of China(11934009,12174198,and 12227808)the Natural Science Foundation of Jiangsu Province,China(BE2022814)+2 种基金the Universal Technology for Primary and Secondary Schoolsthe National Research Institute for Teaching Materialsthe Qing Lan Project of Jiangsu Province,China。
文摘Acoustic-vortex(AV)tweezers ensure stable particle trapping at a zero-pressure center,while particle assembly between two vortex cores is still prevented by the high-potential barrier.Although a one-dimensional low-pressure attractive path of particle assembly can be constructed by the interference between two independent cylindrical Bessel beams,it remains challenging to create two-dimensional(2D)neighboring vortexes using a source array in practical applications.In this paper,a three-step phase-reversal strategy of 2D particle assembly based on the synchronized evolution of a centrosymmetric array of M off-axis acoustic vortexes(OA-AVs)with a preset radial offset is proposed based on a ring array of planar sources.By introducing initial vortex phase differences of-2π/M and+2π/M to the vortex array,low-pressure patterns of an M-sided regular polygon and M-branched star are formed by connecting the vortex cores and the field center before and after the tangent state of adjacent OA-AVs.Center-oriented particle assembly is finally realized by a central AV constructed by coincident in-phase OA-AVs.The capability of particle manipulation in the lateral and radial directions is demonstrated by low-pressure patterns with acoustic radiation forces pointing to the field center during a synchronized central approach.The field evolution is certified by experimental field measurements for OA-AVs with different vo rtex numbers,initial vortex phase differences,and radial offsets using a ring array of 16 planar sources.The feasibility of particle assembly in two dimensions is also verified by the accurate manipulation of four particles using the low-pressure patterns of a four-sided polygon,a four-branched star,and a central AV in experiments.The three-step strategy paves a new way for 2D particle assembly based on the synchronize d evolution of centrosymmetric OA-AVs using a simplified single-sided source array,exhibiting excellent potential for the precise navigation and manipulation of cells and particles in biomedical applications.
基金supported by the Nation Key Research and Development Program of China(No.2021YFB3701100).
文摘The contradiction between mechanical properties and thermal conductivity of magnesium alloys is a roadblock for their widespread applications.In this study,we developed a hot-extruded Mg-8Gd-1Er-8Zn-1Mn alloy with high-strength and high-thermal-conductivity via dual-phase,W-phase andα-Mn,synergistically strengthening.The alloy extruded at 300℃ exhibited the yield strength and elongation of 372 MPa and 12%,respectively,it simultaneously demonstrated a high thermal conductivity of 134.3W/(m·K).After extrusion,the original coarse W-phase in the alloy was broken into near-spheroidal particles,which reduced the probability of electron scattering.In addition,a large number of solute atoms dynamically precipitated in the form of nanoscale rod-like W-phase andα-Mn,makingα-Mg matrix revert to a nearly periodic arrangement state.The high yield strength of the alloy is predominantly determined by grain boundary strengthening as well as W-phase andα-Mn dual-phase strengthening.Notably,the strategy of dual-phase strengthening provides a valuable approach for developing structure-function integrated Mg alloys.
文摘The discharge from wastewater treatment plants (WWTPs) into the receiving river is of concern for the health of the ecosystem. In this study, the microbial </span><span style="font-size:12px;font-family:Verdana;">diversity impact of Fuxin Meng (FM) WWTP was completed with three pairs of primers. At the time of impact assessment, biochemical tests were carried</span><span style="font-size:12px;font-family:Verdana;"> out as well to investigate the water quality downstream and upstream FMWWTP. The general results showed this plant increased downstream biochemical oxygen demand (BOD) and chemical oxygen demand (COD) by 4.3- and 8.1-fold respectively, in comparison with the upstream. The microbial diversity impact from the plant was also investigated with three pairs of universal primers targeting rRNA genes and the internal transcribed spacer (ITS) by high-throughput sequencing. The downstream diversity of the bacterial and fungal communities was generally higher than upstream, with the exception of the eukaryotic community. Both biochemical and microbial assessments suggested that FMWWTP deteriorate Xi River water quality, potentially acting as a pollutive source. Of the receiving water. Accordingly, it was necessary to improve the operation of WWTP to live up to the environmental quality standards.
基金The Hunan Administration of Traditional Chinese Medicine(Grant No.2021017)the Natural Science Foundation of Hunan Province(Grant No.2021JJ30419)+2 种基金the Education Department of Hunan Province(Grant No.20B443)the Changsha Science and Technology Plan other Science and Technology Innovation Platform Project(Grant No.kh2201062)the Hunan Graduate Scientific Research Innovation Project(Grant No.2021CX29)。
基金Supported by National Natural Science Foundation of China,No.81260504,No.81660151 and No.81660751Science Foundation of Science Commission of Jiangxi Province,China,No.20161BBG70067School Teaching Reform Fund of Nanchang University,No.NCUJGLX-14-1-111
文摘Hepatic ischemia reperfusion injury (HIRI) is a clinical condition which may lead to cellular injury and organ dysfunction. The role of nitric oxide (NO) in HIRI is complicated and inconclusive. NO produced by endothelial nitric oxide synthase (eNOS) activation plays a protective role during early HIRI. But eNOS overexpression and the resulting excessive NO bioavailability can aggravate liver injury. NO induced by inducible nitric oxide synthase (iNOS) may have either a protective or a deleterious effect during the early phase of HIRI, but it may protect the liver during late HIRI. Here, we reviewed the latest findings on the role of NO during HIRI: (1) NO exerts a protective effect against HIRI by increasing NO bioavailability, downregulating p53 gene expression, decreasing inflammatory chemokines, reducing ROS via inhibiting the mitochondrial respiratory chain, activating sGC-GTP-cGMP signal pathway to reduce liver cell apoptosis, and regulating hepatic immune functions; (2) eNOS protects against HIRI by increasing NO levels, several eNOS/NO signal pathways (such as Akt-eNOS/NO, AMPK-eNOS/NO and HIF-1 alpha-eNOS/NO) participating in the anti-HIRI process, and inhibiting over-expression of eNOS also protects against HIRI; and (3) the inhibition of iNOS prevents HIRI. Thus, the adverse effects of NO should be avoided, but its positive effect in the clinical treatment of diseases associated with HIRI should be recognized.
文摘The optimization of flow control devices in a single-slab continuous casting tundish was carried out by physical modeling, and the optimized scheme was presented. With the optimal tundish configuration, the minimum residence time of liquid steel was increased by 1.4 times, the peak concentration time was increased by 97%, and the dead volume fraction was decreased by 72%. A mathematical model for molten steel in the tundish was established by using the fluid dynamics package Fluent. The velocity field, concentration field, and the resi-dence time distribution （RTD） curves of molten steel flow before and after optimization were obtained. Experimental results showed that the reasonable configuration with flow control devices can improve the fluid flow characteristics in the tundish. The results of industrial applica-tion show that the nonmetallic inclusion area ratio in casting slabs is decreased by 32% with the optimal tundish configuration.
