The close proximity and the necessity of coordination between multiple high-voltage direct currents(HVDCs)raise the issue of grid partitioning in multi-infeed HVDC systems.A multi-objective partition strategy is propo...The close proximity and the necessity of coordination between multiple high-voltage direct currents(HVDCs)raise the issue of grid partitioning in multi-infeed HVDC systems.A multi-objective partition strategy is proposed in this paper.Several types of relationships to be coordinated and complemented are analyzed and formulated using quantitative indices.According to the graph theory,the HVDC partition is transformed into a graph-cut problem and solved via the spectral clustering algorithm.Finally,the proposed method is validated for a practical multi-HVDC grid,confirming its feasibility and effectiveness.展开更多
Unmanned Aerial Vehicles(UAvs)as aerial base stations to provide communication services for ground users is a flexible and cost-effective paradigm in B5G.Besides,dynamic resource allocation and multi-connectivity can ...Unmanned Aerial Vehicles(UAvs)as aerial base stations to provide communication services for ground users is a flexible and cost-effective paradigm in B5G.Besides,dynamic resource allocation and multi-connectivity can be adopted to further harness the potentials of UAVs in improving communication capacity,in such situations such that the interference among users becomes a pivotal disincentive requiring effective solutions.To this end,we investigate the Joint UAV-User Association,Channel Allocation,and transmission Power Control(J-UACAPC)problem in a multi-connectivity-enabled UAV network with constrained backhaul links,where each UAV can determine the reusable channels and transmission power to serve the selected ground users.The goal was to mitigate co-channel interference while maximizing long-term system utility.The problem was modeled as a cooperative stochastic game with hybrid discrete-continuous action space.A Multi-Agent Hybrid Deep Reinforcement Learning(MAHDRL)algorithm was proposed to address this problem.Extensive simulation results demonstrated the effectiveness of the proposed algorithm and showed that it has a higher system utility than the baseline methods.展开更多
The new energy power generation is becoming increasingly important in the power system.Such as photovoltaic power generation has become a research hotspot,however,due to the characteristics of light radiation changes,...The new energy power generation is becoming increasingly important in the power system.Such as photovoltaic power generation has become a research hotspot,however,due to the characteristics of light radiation changes,photovoltaic power generation is unstable and random,resulting in a low utilization rate and directly affecting the stability of the power grid.To solve this problem,this paper proposes a coordinated control strategy for a newenergy power generation system with a hybrid energy storage unit based on the lithium iron phosphate-supercapacitor hybrid energy storage unit.Firstly,the variational mode decomposition algorithm is used to separate the high and low frequencies of the power signal,which is conducive to the rapid and accurate suppression of the power fluctuation of the energy storage system.Secondly,the fuzzy control algorithm is introduced to balance the power between energy storage.In this paper,the actual data is used for simulation,and the simulation results show that the strategy realizes the effective suppression of the bus voltage fluctuation and the accurate control of the internal state of the energy storage unit,effectively avoiding problems such as overshoot and over-discharge,and can significantly improve the stability of the photovoltaic power generation systemand the stability of the Direct Current bus.It is of great significance to promote the development of collaborative control technology for photovoltaic hybrid energy storage units.展开更多
BACKGROUND Chronic enteropathy associated with solute carrier organic anion transporter family member 2A1(SLCO2A1)(CEAS)is a rare autosomal recessive hereditary disease characterized by anemia,hypoproteinemia,abdomina...BACKGROUND Chronic enteropathy associated with solute carrier organic anion transporter family member 2A1(SLCO2A1)(CEAS)is a rare autosomal recessive hereditary disease characterized by anemia,hypoproteinemia,abdominal pain,diarrhea,and multiple shallow ulcers in the small intestine.Genetic analysis for SLCO2A1 mutations has identified more than 10 variant types,including the mostly reported c.940+1G>A splice site mutation.CASE SUMMARY Herein,we described a 33-year-old female patient who was admitted for anemia,edema,and a positive fecal occult blood test,unaccompanied by abdominal pain and diarrhea.She was diagnosed with CEAS due to compound heterozygous variants,c.940+1G>cA(splice-5)and c.1658T>A(p.Ile553Asn)in SLCO2A1,which had not been previously reported.Importantly,we reviewed 132 reported CEAS patients,which showed that anemia(87.3%)and hypoproteinemia(81%)were the most common symptoms.Nearly 25.8%of patients only had a positive result of fecal occult blood,without any symptoms of gastrointestinal bleeding.CONCLUSION In conclusion,fecal tests should be repeated in patients with anemia and edema to find clues for chronic enteropathy,including the rare cause-CEAS.展开更多
Vascular oxidative stress serves as a pathological foundation for various vascular injury-related diseases,including atherosclerosis,hypertension,restenosis,and abdominal aortic aneurysms.Recent studies have indicated...Vascular oxidative stress serves as a pathological foundation for various vascular injury-related diseases,including atherosclerosis,hypertension,restenosis,and abdominal aortic aneurysms.Recent studies have indicated that intestinal flora-derived metabolites,especially phenylacetylglutamine(PAGln)and phenylacetylglycine(PAGly),may contribute to the promotion of thrombosis,heart failure,and other related conditions.Aucubin(AU),an iridoid glycoside,has been shown to exhibit anti-cardiovascular properties.Nevertheless,the precise role and underlying mechanisms by which AU mitigates PAGly-induced vascular injury remain poorly understood.Our results indicated that PAGln/PAGly promoted oxidative stress in vascular endothelial cells(ECs)and vascular smooth muscle cells(VSMCs)in vitro and in vivo.Network pharmacology suggest that AU may possess the capacity to regulate lipid and atherosclerosis,and reactive oxygen species(ROS)processes.We found that AU penetrated the blood vessels and mitigated oxidative stress induced by PAGln/PAGly.Mechanistically,combining the results from intersection analysis between the targets of AU and vascular diseases and molecular docking,we found that tumor necrosis factor(TNF)may be the potential target of AU.Further DARTS and molecular docking analysis demonstrated that AU bound to recombinant TNF-α,and AU could interact with multiple amino acid residues of TNF-α,including Asn-92 and Phe-144.Additionally,PAGly upregulated the level of soluble TNF-α(sTNF-α)in mouse VSMCs and plasma,and promoted the interaction between sTNF-αand TNF receptor 1(TNFR1),whereas AU inhibited this interaction.Both AU and Infliximab,a specific monoclonal antibody of TNF-α,inhibit TNF-α-induced ROS production.In summary,our results revealed that TNF-αis a cellular target of AU,and the interaction between AU and s TNF-αmay mitigate PAGln/PAGly-induced vascular oxidative stress by inhibiting the interaction of TNF-α-TNFR1.展开更多
A collaborative optimization method for the sintering schedule of ternary cathode materials was proposed under microscopic coupling constraints.An oxygen vacancy concentration prediction model based on microscopic the...A collaborative optimization method for the sintering schedule of ternary cathode materials was proposed under microscopic coupling constraints.An oxygen vacancy concentration prediction model based on microscopic thermodynamics and a growth kinetics model based on neural networks were established.Then,optimization formulations were constructed in three stages to obtain an optimal sintering schedule that minimized energy consumption for different requirements.Simulations demonstrate that the models accurately predict the oxygen vacancy concentrations and grain size,with root mean square errors of approximately 5%and 3%,respectively.Furthermore,the optimized sintering schedule not only meets the required quality standards but also reduces sintering time by 12.31%and keeping temperature by 11.96%.This research provides new insights and methods for the preparation of ternary cathode materials.展开更多
In the industrial roller kiln,the time-delay characteristic in heat transfer causes the temperature field to be affected by both the current and historical temperature states.It presents a poor control performance and...In the industrial roller kiln,the time-delay characteristic in heat transfer causes the temperature field to be affected by both the current and historical temperature states.It presents a poor control performance and brings a significant challenge to the process precise control.Considering high complexity of precise modeling,a data-driven time-delay optimal control method for temperature field of roller kiln is proposed based on a large amount of process data.First,the control challenges and problem description brought by time-delay are demonstrated,where the cost function for the time-delay partial differential equation system is constructed.To obtain the optimal control law,the policy iteration in adaptive dynamic programming is adopted to design the time-delay temperature field controller,and neural network is used for the critic network in policy iteration to approximate the optimal time-delay cost function.The closed-loop system stability is proved by designing the Lyapunov function which contains the time-delay information.Finally,through establishing the time-delay temperature field model for roller kiln,the effectiveness and convergence of the proposed method is verified and proved.展开更多
基金supported by the Science and Technology Project of State Grid Corporation of China:“Control Strategy Optimization Technology for Large-Scale Photovoltaic Power Generation on the Sending-end and Receiving-end of DC Power System”(4000-201934198A-0-0-00)
文摘The close proximity and the necessity of coordination between multiple high-voltage direct currents(HVDCs)raise the issue of grid partitioning in multi-infeed HVDC systems.A multi-objective partition strategy is proposed in this paper.Several types of relationships to be coordinated and complemented are analyzed and formulated using quantitative indices.According to the graph theory,the HVDC partition is transformed into a graph-cut problem and solved via the spectral clustering algorithm.Finally,the proposed method is validated for a practical multi-HVDC grid,confirming its feasibility and effectiveness.
基金supported in part by the National Natural Science Foundation of China(grant nos.61971365,61871339,62171392)Digital Fujian Province Key Laboratory of IoT Communication,Architecture and Safety Technology(grant no.2010499)+1 种基金the State Key Program of the National Natural Science Foundation of China(grant no.61731012)the Natural Science Foundation of Fujian Province of China No.2021J01004.
文摘Unmanned Aerial Vehicles(UAvs)as aerial base stations to provide communication services for ground users is a flexible and cost-effective paradigm in B5G.Besides,dynamic resource allocation and multi-connectivity can be adopted to further harness the potentials of UAVs in improving communication capacity,in such situations such that the interference among users becomes a pivotal disincentive requiring effective solutions.To this end,we investigate the Joint UAV-User Association,Channel Allocation,and transmission Power Control(J-UACAPC)problem in a multi-connectivity-enabled UAV network with constrained backhaul links,where each UAV can determine the reusable channels and transmission power to serve the selected ground users.The goal was to mitigate co-channel interference while maximizing long-term system utility.The problem was modeled as a cooperative stochastic game with hybrid discrete-continuous action space.A Multi-Agent Hybrid Deep Reinforcement Learning(MAHDRL)algorithm was proposed to address this problem.Extensive simulation results demonstrated the effectiveness of the proposed algorithm and showed that it has a higher system utility than the baseline methods.
基金supported by the State Grid Corporation of China Science and Technology Project,grant number 52270723000900K.
文摘The new energy power generation is becoming increasingly important in the power system.Such as photovoltaic power generation has become a research hotspot,however,due to the characteristics of light radiation changes,photovoltaic power generation is unstable and random,resulting in a low utilization rate and directly affecting the stability of the power grid.To solve this problem,this paper proposes a coordinated control strategy for a newenergy power generation system with a hybrid energy storage unit based on the lithium iron phosphate-supercapacitor hybrid energy storage unit.Firstly,the variational mode decomposition algorithm is used to separate the high and low frequencies of the power signal,which is conducive to the rapid and accurate suppression of the power fluctuation of the energy storage system.Secondly,the fuzzy control algorithm is introduced to balance the power between energy storage.In this paper,the actual data is used for simulation,and the simulation results show that the strategy realizes the effective suppression of the bus voltage fluctuation and the accurate control of the internal state of the energy storage unit,effectively avoiding problems such as overshoot and over-discharge,and can significantly improve the stability of the photovoltaic power generation systemand the stability of the Direct Current bus.It is of great significance to promote the development of collaborative control technology for photovoltaic hybrid energy storage units.
基金Supported by the National Natural Science Foundation of China(General Program),No.82000493Peking University People’s Hospital Scientific Research Development Funds,No.RDJP2023-09.
文摘BACKGROUND Chronic enteropathy associated with solute carrier organic anion transporter family member 2A1(SLCO2A1)(CEAS)is a rare autosomal recessive hereditary disease characterized by anemia,hypoproteinemia,abdominal pain,diarrhea,and multiple shallow ulcers in the small intestine.Genetic analysis for SLCO2A1 mutations has identified more than 10 variant types,including the mostly reported c.940+1G>A splice site mutation.CASE SUMMARY Herein,we described a 33-year-old female patient who was admitted for anemia,edema,and a positive fecal occult blood test,unaccompanied by abdominal pain and diarrhea.She was diagnosed with CEAS due to compound heterozygous variants,c.940+1G>cA(splice-5)and c.1658T>A(p.Ile553Asn)in SLCO2A1,which had not been previously reported.Importantly,we reviewed 132 reported CEAS patients,which showed that anemia(87.3%)and hypoproteinemia(81%)were the most common symptoms.Nearly 25.8%of patients only had a positive result of fecal occult blood,without any symptoms of gastrointestinal bleeding.CONCLUSION In conclusion,fecal tests should be repeated in patients with anemia and edema to find clues for chronic enteropathy,including the rare cause-CEAS.
基金supported by the National Key Research and Development Program of China(2022YFF1100300)National Natural Science Foundation of China(32272328)+2 种基金Natural Science Foundation of Hebei Province(H2024206177)Hebei Provincial Key Laboratory of Nutrition and Health(2023YDYY-KF05)College Students’Innovative Entrepreneurial Training Plan Program of Hebei Medical University(USIP2023232)。
文摘Vascular oxidative stress serves as a pathological foundation for various vascular injury-related diseases,including atherosclerosis,hypertension,restenosis,and abdominal aortic aneurysms.Recent studies have indicated that intestinal flora-derived metabolites,especially phenylacetylglutamine(PAGln)and phenylacetylglycine(PAGly),may contribute to the promotion of thrombosis,heart failure,and other related conditions.Aucubin(AU),an iridoid glycoside,has been shown to exhibit anti-cardiovascular properties.Nevertheless,the precise role and underlying mechanisms by which AU mitigates PAGly-induced vascular injury remain poorly understood.Our results indicated that PAGln/PAGly promoted oxidative stress in vascular endothelial cells(ECs)and vascular smooth muscle cells(VSMCs)in vitro and in vivo.Network pharmacology suggest that AU may possess the capacity to regulate lipid and atherosclerosis,and reactive oxygen species(ROS)processes.We found that AU penetrated the blood vessels and mitigated oxidative stress induced by PAGln/PAGly.Mechanistically,combining the results from intersection analysis between the targets of AU and vascular diseases and molecular docking,we found that tumor necrosis factor(TNF)may be the potential target of AU.Further DARTS and molecular docking analysis demonstrated that AU bound to recombinant TNF-α,and AU could interact with multiple amino acid residues of TNF-α,including Asn-92 and Phe-144.Additionally,PAGly upregulated the level of soluble TNF-α(sTNF-α)in mouse VSMCs and plasma,and promoted the interaction between sTNF-αand TNF receptor 1(TNFR1),whereas AU inhibited this interaction.Both AU and Infliximab,a specific monoclonal antibody of TNF-α,inhibit TNF-α-induced ROS production.In summary,our results revealed that TNF-αis a cellular target of AU,and the interaction between AU and s TNF-αmay mitigate PAGln/PAGly-induced vascular oxidative stress by inhibiting the interaction of TNF-α-TNFR1.
基金supported by the National Natural Science Foundation of China(No.62033014)the Application Projects of Integrated Standardization and New Paradigm for Intelligent Manufacturing from the Ministry of Industry and Information Technology of China in 2016,and the Fundamental Research Funds for the Central Universities of Central South University,China(No.2021zzts0700).
文摘A collaborative optimization method for the sintering schedule of ternary cathode materials was proposed under microscopic coupling constraints.An oxygen vacancy concentration prediction model based on microscopic thermodynamics and a growth kinetics model based on neural networks were established.Then,optimization formulations were constructed in three stages to obtain an optimal sintering schedule that minimized energy consumption for different requirements.Simulations demonstrate that the models accurately predict the oxygen vacancy concentrations and grain size,with root mean square errors of approximately 5%and 3%,respectively.Furthermore,the optimized sintering schedule not only meets the required quality standards but also reduces sintering time by 12.31%and keeping temperature by 11.96%.This research provides new insights and methods for the preparation of ternary cathode materials.
基金supported in part by the Key Program of National Natural Science Foundation of China(62033014)the Application Projects of Integrated Standardization and New Paradigm for Intelligent Manufacturing from the Ministry of Industry and Information Technology of China in 2016the Fundamental Research Funds for the Central Universities of Central South University(2021zzts0700).
文摘In the industrial roller kiln,the time-delay characteristic in heat transfer causes the temperature field to be affected by both the current and historical temperature states.It presents a poor control performance and brings a significant challenge to the process precise control.Considering high complexity of precise modeling,a data-driven time-delay optimal control method for temperature field of roller kiln is proposed based on a large amount of process data.First,the control challenges and problem description brought by time-delay are demonstrated,where the cost function for the time-delay partial differential equation system is constructed.To obtain the optimal control law,the policy iteration in adaptive dynamic programming is adopted to design the time-delay temperature field controller,and neural network is used for the critic network in policy iteration to approximate the optimal time-delay cost function.The closed-loop system stability is proved by designing the Lyapunov function which contains the time-delay information.Finally,through establishing the time-delay temperature field model for roller kiln,the effectiveness and convergence of the proposed method is verified and proved.
