This study compared the effects on bone metabolism and morphology of pathological obesity induced by excessive fat intake in a non-hibernator(mice)versus healthy obesity due to pre-hibernation fattening in a hibernato...This study compared the effects on bone metabolism and morphology of pathological obesity induced by excessive fat intake in a non-hibernator(mice)versus healthy obesity due to pre-hibernation fattening in a hibernator(ground squirrels).Kunming mice were fed a high-fat diet to provide a model of pathological obesity(OB group).Daurian ground squirrels fattened naturally in their pre-hibernation season(PRE group)were used as a healthy obesity model.Micro-computed tomography(micro-CT)and three-point bending tests were used to determine the microstructure and mechanical properties of bone.Western blots were used to analyze protein expression levels related to bone metabolism(Runt-related transcription factor 2(RunX2),osteocalcin(OCN),alkaline phosphatase(ALP),osteoprotegerin(OPG),receptor activator of nuclear factor-κB ligand(RANKL),cathepsin K,matrix metallopeptidase 9(MMP9),patched protein homolog 1(Ptch1),phosphorylatedβ-catenin(P-β-catenin),and glycogen synthase kinase-3β(GSK-3β)).Compared with controls,there was no obvious bone loss in the OB mice,and the stiffness of the femur was increased significantly.Compared with summer active squirrels,bone formation was enhanced but the mechanical properties did not change in the PRE group squirrels.In OB mice,western blots showed significantly increased expression levels of all proteins except RunX2,OPG,and Ptch1.PRE ground squirrels showed significantly increased expression of most proteins except OCN and Ptch1,which decreased significantly,and P-β-catenin and OPG,which did not change.In conclusion,for non-hibernating mice,moderate obesity had a certain protective effect on bones,demonstrating two-way regulation,increasing both bone loss and bone formation.For pre-hibernating ground squirrels,the healthy obesity acquired before hibernation had a positive effect on the microstructure of bones,and also enhanced the expression levels of proteins related to bone formation,bone resorption,and Wnt signaling.展开更多
The newly emerging neural radiance fields(NeRF)methods can implicitly fulfill three-dimensional(3D)reconstruction via training a neural network to render novel-view images of a given scene with given posed images.The ...The newly emerging neural radiance fields(NeRF)methods can implicitly fulfill three-dimensional(3D)reconstruction via training a neural network to render novel-view images of a given scene with given posed images.The Instant Neural Graphics Primitives(Instant-NGP)method further improves the position encoding of NeRF.It obtains state-of-the-art efficiency.However,only a local pixel-wised loss is considered when training the Instant-NGP while overlooking the nonlocal structural information between pixels.Despite a good quantitative result,it leads to a poor visual effect,especially the completeness.Inspired by the stochastic structural similarity(S3IM)method that exploits nonlocal structural information of groups of pixels,this paper proposes a new method to improve the completeness of fast novel view synthesis.The proposed method first extends the thread-wised processing of the Instant-NGP to the processing in a customthread block(i.e.,a group of threads).Then,the relative dimensionless global error in synthesis,i.e.,Erreur Relative Globale Adimensionnelle de Synthese(ERGAS),of a group of pixels corresponding to a group of threads is computed and incorporated into the loss function.Extensive experiments validate the proposed method.It can obtain better quantitative results than the original Instant-NGP with fewer iteration steps.PSNR is increased by 1%.Amazing qualitative results are obtained,especially for delicate structures and details such as lines and continuous structures.With the dramatic improvements in the visual effects,our method can boost the practicability of implicit 3D reconstruction in applications such as self-driving and augmented reality.展开更多
Deployable Composite Thin-Walled Structures(DCTWS)are widely used in space applications due to their ability to compactly fold and self-deploy in orbit,enabled by cutouts.Cutout design is crucial for balancing structu...Deployable Composite Thin-Walled Structures(DCTWS)are widely used in space applications due to their ability to compactly fold and self-deploy in orbit,enabled by cutouts.Cutout design is crucial for balancing structural rigidity and flexibility,ensuring material integrity during large deformations,and providing adequate load-bearing capacity and stability once deployed.Most research has focused on optimizing cutout size and shape,while topology optimization offers a broader design space.However,the anisotropic properties of woven composite laminates,complex failure criteria,and multi-performance optimization needs have limited the exploration of topology optimization in this field.This work derives the sensitivities of bending stiffness,critical buckling load,and the failure index of woven composite materials with respect to element density,and formulates both single-objective and multi-objective topology optimization models using a linear weighted aggregation approach.The developed method was integrated with the commercial finite element software ABAQUS via a Python script,allowing efficient application to cutout design in various DCTWS configurations to maximize bending stiffness and critical buckling load under material failure constraints.Optimization of a classical tubular hinge resulted in improvements of 107.7%in bending stiffness and 420.5%in critical buckling load compared to level-set topology optimization results reported in the literature,validating the effectiveness of the approach.To facilitate future research and encourage the broader adoption of topology optimization techniques in DCTWS design,the source code for this work is made publicly available via a Git Hub link:https://github.com/jinhao-ok1/Topo-for-DCTWS.git.展开更多
A carbon‐doped TiO2/fly ash support(C‐TiO2/FAS)composite photocatalyst was successfully synthesized through sol impregnation and subsequent carbonization.The carbon dopants were derived from the organic species gene...A carbon‐doped TiO2/fly ash support(C‐TiO2/FAS)composite photocatalyst was successfully synthesized through sol impregnation and subsequent carbonization.The carbon dopants were derived from the organic species generated during the synthesis of the C‐TiO2/FAS composite.A series of analytical techniques,such as scanning electron microscopy(SEM),attenuated total reflection‐Fourier transform infrared(ATR‐FTIR)spectroscopy,X‐ray photoelectron spectroscopy(XPS),and ultraviolet‐visible diffuse reflectance spectroscopy(UV‐Vis DRS),were used to characterize the properties of the prepared samples.The results indicated that C‐TiO2 was successfully coated on the FAS surface.Coupling between C‐TiO2 and FAS resulted in the formation of Si–O–C and Al–O–Ti bonds at their interface.The formation of Si–O–C and Al–O–Ti bonds gave rise to a positive shift of the valence band edge of C‐TiO2 and enhanced its oxidation capability of photogenerated holes as well as photodegradation efficiency of methyl orange.Moreover,the C‐TiO2/FAS photocatalyst exhibited favorable reusability and separability.This work may provide a new route for tuning the electronic band structure of TiO2.展开更多
AIM: To investigate the differentiated whole genome expression profiling of gastric high- and low-grade intraepithelial neoplasia and early-stage adenocarcinoma.
This paper aims to assess the influence of moisture content changes during rainfall on the stability of loess high-fill slopes by taking a loess high-fill slope in Lanzhou City as an example.First,according to the moi...This paper aims to assess the influence of moisture content changes during rainfall on the stability of loess high-fill slopes by taking a loess high-fill slope in Lanzhou City as an example.First,according to the moisture content monitoring data collected from a slope online monitoring system,direct shear tests were performed on soil samples of different moisture content to determine the relationship between the shear strength parameters and moisture content.Next,a coupled hydro-mechanical model with soil shear strength related to moisture content was established and used to analyze 16 working conditions with various rainfall intensities and durations for two cases:shear strength parameters from the site exploration report and those from this study.Finally,the results from the two cases were compared regarding the changes in stresses and displacements after rainfall infiltration to analyze the influence of moisture content on the stability of loess high-fill slopes.The conclusions are as follows:(1)Segmental relationship equations of cohesion and angle of internal friction were established for loess with various moisture content.(2)Under the conditions of different rainfall intensities,significant differences were observed in the trends of slope stress and displacement changes.(3)The slope displacement occurred in the shallow soil layer within about 12.5 m from the slope top,and the plastic strain concentrated in the soil layer within about 6 m from the slope top.(4)The results of slope stability analyses based on moisture content monitoring data are more in line with the observed.展开更多
Inflammatory bowel disease(IBD)is a chronic relapsing-remitting systemic disease of the gastrointestinal tract,characterized by an inflammatory process.Gut mycobiota community dysbiosis has been reported that is close...Inflammatory bowel disease(IBD)is a chronic relapsing-remitting systemic disease of the gastrointestinal tract,characterized by an inflammatory process.Gut mycobiota community dysbiosis has been reported that is closely related to the development of IBD.Our previous findings indicated that polyphenol of the inner shell(BPIS)from foxtail millet bran could restore the gut microbiome and inhibit the progress of colorectal cancer(CRC).In the present study,we studied the anti-inflammatory potential of BPIS in the dextran sodium sulfate(DSS)-induced mouse colitis model.Data suggested that BPIS alleviated experimental colitis by restoring body weight,colonic length and protecting the epithelial architecture from damage by DSS.Moreover,we found that BPIS strengthened the gut barrier function and inhibited the activation of Wnt1/β-catenin pathway.Gene sequence analysis indicated that BPIS remodeled the overall structure of the gut mycobiota from colitis mice toward that of the normal counterparts,including 1 phylum and 9 genera.Interestingly,BPIS significantly increased the abundance of Aspergillus ruber.It further verified that BPIS significantly promoted the growth of A.ruber in vitro.Collectively,BPIS has great potential to develop into an effective against IBD drug.展开更多
A compact broadband Compton spectrometer with high spectral resolution has been designed to detect spectra of laser-driven high-flux gamma rays.The primary detection range of the gamma-ray spectrum is 0.5 MeV–13 MeV,...A compact broadband Compton spectrometer with high spectral resolution has been designed to detect spectra of laser-driven high-flux gamma rays.The primary detection range of the gamma-ray spectrum is 0.5 MeV–13 MeV,although a secondary harder gamma-ray region of 13 MeV–30MeV can also be covered.The Compton-scattered electrons are spectrally resolved using a curved surface detector and a nonuniform magnetic field produced by a pair of step-like magnets.This design allows a compact structure,a wider bandwidth,especially in the lower-energy region of 0.5 MeV–2 MeV,and optimum spectral resolution.The spectral resolution is 5%–10%in the range 4 MeV–13 MeV and better than 25%in the range 0.5MeV–4MeV(with an Al converter of 0.25mmthickness and a collimator of 1 cm inner diameter).Low-Z plastic materials are used on the inner surface of the spectrometer to suppress noise due to secondary X-ray fluorescence.The spectrometer can be adjusted flexibly via a specially designed mechanical component.An algorithmbased on a regularizationmethod has also been developed to reconstruct the gamma-ray spectrum from the scattered electrons.展开更多
Composite Thin-walled Lenticular Tube(CTLT)is increasingly utilized in small satellites missions as a lightweight,foldable,and rollable structural material that facilitates the construction of large deployable systems...Composite Thin-walled Lenticular Tube(CTLT)is increasingly utilized in small satellites missions as a lightweight,foldable,and rollable structural material that facilitates the construction of large deployable systems.The CTLT is initially flattened and coiled around a central hub for storage before launch,during which elastic energy is stored as deformation energy,allowing it to be self-deployed on demand for use in orbit.This work presents a comprehensive investigation into the coiling,storage and deployment behaviors of CTLT that wraps around a central hub.A nonlinear explicit dynamic finite element model was developed with both deformable CTLT and rigidbodies mechanisms including the central hub and guide rollers,as well as the complex interactions among them.The coiling mechanics characteristics such as stored strain energy and rotational moment were presented and validated against experimental data in the literature.Then,the dynamic deployment behaviors were analyzed in terms of two different deployment methods,namely,controlled deployment and free deployment.The effect of material property change during storage was also discussed through numerical experiments.展开更多
Correction to:Acta Geochim https://doi.org/10.1007/S11631-021-00477-Z The article“Variations of methane stable isotopic values from an Alpine peatland on the eastern Qinghai-Tibetan Plaleau"written by Qian Guo,H...Correction to:Acta Geochim https://doi.org/10.1007/S11631-021-00477-Z The article“Variations of methane stable isotopic values from an Alpine peatland on the eastern Qinghai-Tibetan Plaleau"written by Qian Guo,Haijun Peng,Bing Hong,Hu Yao,Yongxuan Zhu,Hanwei Ding,Ning An,Yetang Hong was originally published electronically on the publisher's internet portal(currently SpringerLink)on 3 June 2021.There were some errors in the published article which should be corrected.The authors apologize for these errors and any confusion caused.展开更多
To improve the quality of multimedia services and stimulate secure sensing in Internet of Things applications, such as healthcare and traffic monitoring, mobile crowdsensing(MCS) systems must address security threats ...To improve the quality of multimedia services and stimulate secure sensing in Internet of Things applications, such as healthcare and traffic monitoring, mobile crowdsensing(MCS) systems must address security threats such as jamming, spoofing and faked sensing attacks during both sensing and information exchange processes in large-scale dynamic and heterogeneous networks. In this article, we investigate secure mobile crowdsensing and present ways to use deep learning(DL) methods, such as stacked autoencoder, deep neural networks, convolutional neural networks, and deep reinforcement learning, to improve approaches to MCS security, including authentication, privacy protection, faked sensing countermeasures, intrusion detection and anti-jamming transmissions in MCS. We discuss the performance gain of these DLbased approaches compared to traditional security schemes and identify the challenges that must be addressed to implement these approaches in practical MCS systems.展开更多
Zinc-finger proteins play different roles in cancer;however,the function of zinc-finger protein ZNF575 in cancer remains unclear.In the present study,we aimed to determine the function and expression of ZNF575 in colo...Zinc-finger proteins play different roles in cancer;however,the function of zinc-finger protein ZNF575 in cancer remains unclear.In the present study,we aimed to determine the function and expression of ZNF575 in colorectal cancer.Proliferation assay,colony formation assay,and tumor model in mice were used to investigate the function of ZNF575 after ectopic expression of ZNF575 in colorectal cancer(CRC)cells.RNA sequencing,ChIP,and luciferase assays were used to investigate the mechanism behind ZNF575 regulation of CRC cell growth.The expression of ZNF575 was determined by IHC staining in 150 pairs of malignant CRC tissues,followed by prognosis analysis.We indicated that ectopic expression of ZNF575 inhibited CRC cell proliferation,colony formation and promoted cell apoptosis in vitro.Tumor growth in CRC was also impaired by ZNF575 in mice.RNA sequencing,follow-up western blotting,and qPCR results demonstrated the increase of p53,BAK,and PUMA in ZNF575-expressing CRC cells.Further results indicated that ZNF575 directly targeted the p53 promoter and promoted the transcription of p53.Downregulation of ZNF575 was confirmed in malignant tissues,and ZNF575 expression was positively correlated with the prognosis of CRC patients.The present study demonstrated the function,underlying mechanism,expression,and the prognosis-predicting role of ZNF575 in CRC,which indicated that ZNF575 would be a potential prognostic predictor and therapeutic target for CRC and other cancers.展开更多
This study aims to utilize the Small Baseline Subset Interferometric Synthetic Aperture Radar(SBAS-In SAR)technique and Google Earth optical remote sensing images to analyze the area within 20 km around the epicenter ...This study aims to utilize the Small Baseline Subset Interferometric Synthetic Aperture Radar(SBAS-In SAR)technique and Google Earth optical remote sensing images to analyze the area within 20 km around the epicenter of a M 3.9, earthquake that occurred in Tanchang County, Gansu Province, on December 28, 2020. The objective is to identify potential earthquake-induced landslides, assess their scale, and determine their impact range. The study results reveal the successful identification of two potential landslides in the 20 km radius around the epicenter. Through time-series deformation analysis, it was observed that these potential landslides were significantly influenced by both the earthquake and rainfall. Further estimation of these potential landslides indicates maximum depths of 7.4 m and 14.1 m for the failure surfaces, with volumes of 9.02 × 10~4m~3and 25.5 ×10~4m~3, respectively. Finally, based on the simulation analysis of Massflow software, the maximum thickness of soil accumulation in the final accumulation area after sliding of the potential landslide in Shangyaai is 12 m, the area of the final accumulation area is 1.75 × 10~4m~2, and the farthest movement distance is 1124 m. The maximum thickness of soil accumulation in the final accumulation area after sliding of the potential landslide in Wangshancun is 8 m, the area of the final accumulation area is 7.89 × 10~4m~2, and the farthest movement distance is 742 m.展开更多
Dopamine(DA)is a vital neurotransmitter,and accurate detection of its concentration is critical for both clinical diagnos-tics and neuroscience research.Due to its electrochemical activity,DA is commonly detected usin...Dopamine(DA)is a vital neurotransmitter,and accurate detection of its concentration is critical for both clinical diagnos-tics and neuroscience research.Due to its electrochemical activity,DA is commonly detected using electrochemical methods,which are favored for their simplicity,fast response time,and suitability for in vivo analysis.In this work,a highly sensitive DA electrochemical sensor was developed using an Au@MoS_(2)composite,created by modifying molybdenum disulfide(MoS_(2))nanosheets with gold nanoparticles through HAuCl_(4) reduction,and it was aimed at enhancing DA adsorption and improving detection performance.Scanning Electron Microscopy(SEM),transmission electron microscopy(TEM),Energy Dispersive Spectroscopy(EDS),X-ray photoelectron spectroscopy(XPS)and X-ray Diffraction(XRD)confirmed the suc-cessful synthesis of Au@MoS_(2)and the uniform distribution of gold nanoparticles across the MoS_(2)nanosheets.Then,the electrochemical characterization demonstrated that the Au@MoS_(2)/GCE exhibited distinct oxidation peaks in a 10μmol·L^(-1)DA solution,with significantly enhanced electrochemical activity compared to both unmodified GCE and pristine MoS_(2).Furthermore,differential pulse voltammetry(DPV)further revealed a strong linear relationship between DA concentration and the current response in the range of 800 nmol·L^(-1)to 10μmol·L^(-1),with a low detection limit(LOD)of 78.9 nmol·L^(-1)(S/N=3).Additionally,the sensor showed excellent selectivity against other interfering substances.Moreover,the laser-induced Au@MoS_(2)(LIAu@MoS_(2)),with its abundance of negatively charged surface defects,enabled the ultra-sensitive detection of the ultra-low concentrations of DA.In conclusion,the successfully fabricated Au@MoS_(2)based sensor offers advantages such as low cost,ease of operation,and scalability,making it a promising candidate for biosensing applications due to its enhanced DA detection capabilities.展开更多
Lithium-ion batteries(LIBs)have been widely applied in portable electronic devices and electric vehicles.With the booming of the respective markets,a huge quantity of spent LIBs that typically use either LiFePO_(4) or...Lithium-ion batteries(LIBs)have been widely applied in portable electronic devices and electric vehicles.With the booming of the respective markets,a huge quantity of spent LIBs that typically use either LiFePO_(4) or Li N_(x)Co_(y)Mn_(z)O_(2) cathode materials will be produced in the very near future,imposing significant pressure for the development of suitable disposal/recycling technologies,in terms of both environmental protection and resource reclaiming.In this review,we firstly do a comprehensive summary of the-state-of-art technologies to recycle Li N_(x)Co_(y)Mn_(z)O_(2) and LiFePO_(4)-based LIBs,in the aspects of pretreatment,hydrometallurgical recycling,and direct regeneration of the cathode materials.This closed-loop strategy for cycling cathode materials has been regarded as an ideal approach considering its economic benefit and environmental friendliness.Afterward,as for the exhausted anode materials,we focus on the utilization of exhausted anode materials to obtain other functional materials,such as graphene.Finally,the existing challenges in recycling the LiFePO_(4) and Li N_(x)Co_(y)Mn_(z)O_(2) cathodes and graphite anodes for industrial-scale application are discussed in detail;and the possible strategies for these issues are proposed.We expect this review can provide a roadmap towards better technologies for recycling LIBs,shed light on the future development of novel battery recycling technologies to promote the environmental benignity and economic viability of the battery industry and pave way for the large-scale application of LIBs in industrial fields in the near future.展开更多
Clouds are critical to the global radiation budget and hydrological cycle, but knowledge is still poor concerning the observed climatology of cloud-base height （CBH） in China. Based on fine-resolution sounding obser...Clouds are critical to the global radiation budget and hydrological cycle, but knowledge is still poor concerning the observed climatology of cloud-base height （CBH） in China. Based on fine-resolution sounding observations from the China Radiosonde Network （CRN）, the method used to estimate CBH was modified, and uncertainty analyses indicated that the CBH is good enough. The accuracy of CBH estimation is verified by the comparison between the sounding-derived CBHs and those estimated from the micro-pulse lidar and millimeter-wave cloud radar. As such, the CBH climatology was compiled for the period 2006-16. Overall, the CBH exhibits large geographic variability across China, at both 0800 Local Standard Time （LST） and 2000 LST, irrespective of season. In addition, the summertime cloud base tends to be elevated to higher altitudes in dry regions [i.e., Inner Mongolia and the North China Plain （NCP）]. By comparison, the Tibetan Plateau （TP）, Pearl River Delta （PRD） and Sichuan Basin （SCB） have relatively low CBHs （〈 2.4 km above ground level）. In terms of seasonality, the CBH reaches its maximum in summer and minimum in winter. A low cloud base tends to occur frequently （〉 70%） over the TP, PRD and SCB. In contrast, at most sites over the Yangtze River Delta （YRD） and the NCP, about half the cloud belongs to the high-cloud category. The CBH does not exhibit marked diurnal variation in summer, throughout all CRN sites, probably due to the persistent cloud coverage caused by the East Asia Summer Monsson. To the best of our knowledge, this is the first CBH climatology produced from sounding measurements in China, and provides a useful reference for obtaining observational cloud base information.展开更多
基金supported by the National Natural Science Foundation of China(Nos.31640072 and 31900338)the Natural Science Basic Research Program of Shaanxi(No.2020JM-428),China.
文摘This study compared the effects on bone metabolism and morphology of pathological obesity induced by excessive fat intake in a non-hibernator(mice)versus healthy obesity due to pre-hibernation fattening in a hibernator(ground squirrels).Kunming mice were fed a high-fat diet to provide a model of pathological obesity(OB group).Daurian ground squirrels fattened naturally in their pre-hibernation season(PRE group)were used as a healthy obesity model.Micro-computed tomography(micro-CT)and three-point bending tests were used to determine the microstructure and mechanical properties of bone.Western blots were used to analyze protein expression levels related to bone metabolism(Runt-related transcription factor 2(RunX2),osteocalcin(OCN),alkaline phosphatase(ALP),osteoprotegerin(OPG),receptor activator of nuclear factor-κB ligand(RANKL),cathepsin K,matrix metallopeptidase 9(MMP9),patched protein homolog 1(Ptch1),phosphorylatedβ-catenin(P-β-catenin),and glycogen synthase kinase-3β(GSK-3β)).Compared with controls,there was no obvious bone loss in the OB mice,and the stiffness of the femur was increased significantly.Compared with summer active squirrels,bone formation was enhanced but the mechanical properties did not change in the PRE group squirrels.In OB mice,western blots showed significantly increased expression levels of all proteins except RunX2,OPG,and Ptch1.PRE ground squirrels showed significantly increased expression of most proteins except OCN and Ptch1,which decreased significantly,and P-β-catenin and OPG,which did not change.In conclusion,for non-hibernating mice,moderate obesity had a certain protective effect on bones,demonstrating two-way regulation,increasing both bone loss and bone formation.For pre-hibernating ground squirrels,the healthy obesity acquired before hibernation had a positive effect on the microstructure of bones,and also enhanced the expression levels of proteins related to bone formation,bone resorption,and Wnt signaling.
基金supported in part by National Natural Science Foundation of China under Grant No.62473013Key Project of Science and Technology Innovation and Entrepreneurship of TDTEC(No.2022-TDZD004).
文摘The newly emerging neural radiance fields(NeRF)methods can implicitly fulfill three-dimensional(3D)reconstruction via training a neural network to render novel-view images of a given scene with given posed images.The Instant Neural Graphics Primitives(Instant-NGP)method further improves the position encoding of NeRF.It obtains state-of-the-art efficiency.However,only a local pixel-wised loss is considered when training the Instant-NGP while overlooking the nonlocal structural information between pixels.Despite a good quantitative result,it leads to a poor visual effect,especially the completeness.Inspired by the stochastic structural similarity(S3IM)method that exploits nonlocal structural information of groups of pixels,this paper proposes a new method to improve the completeness of fast novel view synthesis.The proposed method first extends the thread-wised processing of the Instant-NGP to the processing in a customthread block(i.e.,a group of threads).Then,the relative dimensionless global error in synthesis,i.e.,Erreur Relative Globale Adimensionnelle de Synthese(ERGAS),of a group of pixels corresponding to a group of threads is computed and incorporated into the loss function.Extensive experiments validate the proposed method.It can obtain better quantitative results than the original Instant-NGP with fewer iteration steps.PSNR is increased by 1%.Amazing qualitative results are obtained,especially for delicate structures and details such as lines and continuous structures.With the dramatic improvements in the visual effects,our method can boost the practicability of implicit 3D reconstruction in applications such as self-driving and augmented reality.
基金supported by the National Natural Science Foundation of China(No.12202295)the International(Regional)Cooperation and Exchange Projects of the National Natural Science Foundation of China(No.W2421002)+2 种基金the Sichuan Science and Technology Program(No.2025ZNSFSC0845)Zhejiang Provincial Natural Science Foundation of China(No.ZCLZ24A0201)the Fundamental Research Funds for the Provincial Universities of Zhejiang(No.GK249909299001-004)。
文摘Deployable Composite Thin-Walled Structures(DCTWS)are widely used in space applications due to their ability to compactly fold and self-deploy in orbit,enabled by cutouts.Cutout design is crucial for balancing structural rigidity and flexibility,ensuring material integrity during large deformations,and providing adequate load-bearing capacity and stability once deployed.Most research has focused on optimizing cutout size and shape,while topology optimization offers a broader design space.However,the anisotropic properties of woven composite laminates,complex failure criteria,and multi-performance optimization needs have limited the exploration of topology optimization in this field.This work derives the sensitivities of bending stiffness,critical buckling load,and the failure index of woven composite materials with respect to element density,and formulates both single-objective and multi-objective topology optimization models using a linear weighted aggregation approach.The developed method was integrated with the commercial finite element software ABAQUS via a Python script,allowing efficient application to cutout design in various DCTWS configurations to maximize bending stiffness and critical buckling load under material failure constraints.Optimization of a classical tubular hinge resulted in improvements of 107.7%in bending stiffness and 420.5%in critical buckling load compared to level-set topology optimization results reported in the literature,validating the effectiveness of the approach.To facilitate future research and encourage the broader adoption of topology optimization techniques in DCTWS design,the source code for this work is made publicly available via a Git Hub link:https://github.com/jinhao-ok1/Topo-for-DCTWS.git.
文摘A carbon‐doped TiO2/fly ash support(C‐TiO2/FAS)composite photocatalyst was successfully synthesized through sol impregnation and subsequent carbonization.The carbon dopants were derived from the organic species generated during the synthesis of the C‐TiO2/FAS composite.A series of analytical techniques,such as scanning electron microscopy(SEM),attenuated total reflection‐Fourier transform infrared(ATR‐FTIR)spectroscopy,X‐ray photoelectron spectroscopy(XPS),and ultraviolet‐visible diffuse reflectance spectroscopy(UV‐Vis DRS),were used to characterize the properties of the prepared samples.The results indicated that C‐TiO2 was successfully coated on the FAS surface.Coupling between C‐TiO2 and FAS resulted in the formation of Si–O–C and Al–O–Ti bonds at their interface.The formation of Si–O–C and Al–O–Ti bonds gave rise to a positive shift of the valence band edge of C‐TiO2 and enhanced its oxidation capability of photogenerated holes as well as photodegradation efficiency of methyl orange.Moreover,the C‐TiO2/FAS photocatalyst exhibited favorable reusability and separability.This work may provide a new route for tuning the electronic band structure of TiO2.
基金Supported by The specific grants of Public-Funded Projects in the Health Industry,Grant 200902002
文摘AIM: To investigate the differentiated whole genome expression profiling of gastric high- and low-grade intraepithelial neoplasia and early-stage adenocarcinoma.
基金supported by a grant from the Gansu Provincial Department of Natural Resources Science and Technology Innovation Talent Cultivation Project(2022–09)the Geological Disaster Prevention Projects of the Gansu Provincial Bureau of Geology and Mineral Resources,and Natural Science Foundation of Gansu Province(No.22JR5RA326).
文摘This paper aims to assess the influence of moisture content changes during rainfall on the stability of loess high-fill slopes by taking a loess high-fill slope in Lanzhou City as an example.First,according to the moisture content monitoring data collected from a slope online monitoring system,direct shear tests were performed on soil samples of different moisture content to determine the relationship between the shear strength parameters and moisture content.Next,a coupled hydro-mechanical model with soil shear strength related to moisture content was established and used to analyze 16 working conditions with various rainfall intensities and durations for two cases:shear strength parameters from the site exploration report and those from this study.Finally,the results from the two cases were compared regarding the changes in stresses and displacements after rainfall infiltration to analyze the influence of moisture content on the stability of loess high-fill slopes.The conclusions are as follows:(1)Segmental relationship equations of cohesion and angle of internal friction were established for loess with various moisture content.(2)Under the conditions of different rainfall intensities,significant differences were observed in the trends of slope stress and displacement changes.(3)The slope displacement occurred in the shallow soil layer within about 12.5 m from the slope top,and the plastic strain concentrated in the soil layer within about 6 m from the slope top.(4)The results of slope stability analyses based on moisture content monitoring data are more in line with the observed.
基金supported by the National Natural Science Foundation of China(U23A20526,32072220,32270420)Shanxi Province 136 Revitalization Medical Project Construction Funds(general surgery department),Science Foundation(202103021224011).
文摘Inflammatory bowel disease(IBD)is a chronic relapsing-remitting systemic disease of the gastrointestinal tract,characterized by an inflammatory process.Gut mycobiota community dysbiosis has been reported that is closely related to the development of IBD.Our previous findings indicated that polyphenol of the inner shell(BPIS)from foxtail millet bran could restore the gut microbiome and inhibit the progress of colorectal cancer(CRC).In the present study,we studied the anti-inflammatory potential of BPIS in the dextran sodium sulfate(DSS)-induced mouse colitis model.Data suggested that BPIS alleviated experimental colitis by restoring body weight,colonic length and protecting the epithelial architecture from damage by DSS.Moreover,we found that BPIS strengthened the gut barrier function and inhibited the activation of Wnt1/β-catenin pathway.Gene sequence analysis indicated that BPIS remodeled the overall structure of the gut mycobiota from colitis mice toward that of the normal counterparts,including 1 phylum and 9 genera.Interestingly,BPIS significantly increased the abundance of Aspergillus ruber.It further verified that BPIS significantly promoted the growth of A.ruber in vitro.Collectively,BPIS has great potential to develop into an effective against IBD drug.
基金ACKNOWLEDGMENTS This work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB16000000)the National Natural Science Foundation of China(Grant Nos.11775223,11375197,11605200,and 11275202)+1 种基金the Science Challenge Project(Grant No.TZ2016005)the Open Fund of the State Key Laboratory of High Field Laser Physics(SIOM).
文摘A compact broadband Compton spectrometer with high spectral resolution has been designed to detect spectra of laser-driven high-flux gamma rays.The primary detection range of the gamma-ray spectrum is 0.5 MeV–13 MeV,although a secondary harder gamma-ray region of 13 MeV–30MeV can also be covered.The Compton-scattered electrons are spectrally resolved using a curved surface detector and a nonuniform magnetic field produced by a pair of step-like magnets.This design allows a compact structure,a wider bandwidth,especially in the lower-energy region of 0.5 MeV–2 MeV,and optimum spectral resolution.The spectral resolution is 5%–10%in the range 4 MeV–13 MeV and better than 25%in the range 0.5MeV–4MeV(with an Al converter of 0.25mmthickness and a collimator of 1 cm inner diameter).Low-Z plastic materials are used on the inner surface of the spectrometer to suppress noise due to secondary X-ray fluorescence.The spectrometer can be adjusted flexibly via a specially designed mechanical component.An algorithmbased on a regularizationmethod has also been developed to reconstruct the gamma-ray spectrum from the scattered electrons.
基金co-supported by the National Natural Science Foundation of China(No.12202295)the Fundamental Research Funds for the Central Universities,China(No.YJ2021137)+1 种基金the Open Project of State Key Laboratory for Strength and Vibration of Mechanical Structures,Xi’an Jiaotong University,China(No.SV2021-KF-04)the Open Project of State Key Laboratory of Structural Analysis for Industrial Equipment,Dalian University of Technology,China(No.GZ22120)。
文摘Composite Thin-walled Lenticular Tube(CTLT)is increasingly utilized in small satellites missions as a lightweight,foldable,and rollable structural material that facilitates the construction of large deployable systems.The CTLT is initially flattened and coiled around a central hub for storage before launch,during which elastic energy is stored as deformation energy,allowing it to be self-deployed on demand for use in orbit.This work presents a comprehensive investigation into the coiling,storage and deployment behaviors of CTLT that wraps around a central hub.A nonlinear explicit dynamic finite element model was developed with both deformable CTLT and rigidbodies mechanisms including the central hub and guide rollers,as well as the complex interactions among them.The coiling mechanics characteristics such as stored strain energy and rotational moment were presented and validated against experimental data in the literature.Then,the dynamic deployment behaviors were analyzed in terms of two different deployment methods,namely,controlled deployment and free deployment.The effect of material property change during storage was also discussed through numerical experiments.
文摘Correction to:Acta Geochim https://doi.org/10.1007/S11631-021-00477-Z The article“Variations of methane stable isotopic values from an Alpine peatland on the eastern Qinghai-Tibetan Plaleau"written by Qian Guo,Haijun Peng,Bing Hong,Hu Yao,Yongxuan Zhu,Hanwei Ding,Ning An,Yetang Hong was originally published electronically on the publisher's internet portal(currently SpringerLink)on 3 June 2021.There were some errors in the published article which should be corrected.The authors apologize for these errors and any confusion caused.
基金supported in part by the National Natural Science Foundation of China under Grant 61671396 and 91638204in part by the open research fund of National Mobile Communications Research Laboratory,Southeast University(No.2018D08)in part by Science and Technology Innovation Project of Foshan City,China(Grant No.2015IT100095)
文摘To improve the quality of multimedia services and stimulate secure sensing in Internet of Things applications, such as healthcare and traffic monitoring, mobile crowdsensing(MCS) systems must address security threats such as jamming, spoofing and faked sensing attacks during both sensing and information exchange processes in large-scale dynamic and heterogeneous networks. In this article, we investigate secure mobile crowdsensing and present ways to use deep learning(DL) methods, such as stacked autoencoder, deep neural networks, convolutional neural networks, and deep reinforcement learning, to improve approaches to MCS security, including authentication, privacy protection, faked sensing countermeasures, intrusion detection and anti-jamming transmissions in MCS. We discuss the performance gain of these DLbased approaches compared to traditional security schemes and identify the challenges that must be addressed to implement these approaches in practical MCS systems.
基金supported by grants from Sichuan Provincial Science and Technology(2022NSFSC0742).
文摘Zinc-finger proteins play different roles in cancer;however,the function of zinc-finger protein ZNF575 in cancer remains unclear.In the present study,we aimed to determine the function and expression of ZNF575 in colorectal cancer.Proliferation assay,colony formation assay,and tumor model in mice were used to investigate the function of ZNF575 after ectopic expression of ZNF575 in colorectal cancer(CRC)cells.RNA sequencing,ChIP,and luciferase assays were used to investigate the mechanism behind ZNF575 regulation of CRC cell growth.The expression of ZNF575 was determined by IHC staining in 150 pairs of malignant CRC tissues,followed by prognosis analysis.We indicated that ectopic expression of ZNF575 inhibited CRC cell proliferation,colony formation and promoted cell apoptosis in vitro.Tumor growth in CRC was also impaired by ZNF575 in mice.RNA sequencing,follow-up western blotting,and qPCR results demonstrated the increase of p53,BAK,and PUMA in ZNF575-expressing CRC cells.Further results indicated that ZNF575 directly targeted the p53 promoter and promoted the transcription of p53.Downregulation of ZNF575 was confirmed in malignant tissues,and ZNF575 expression was positively correlated with the prognosis of CRC patients.The present study demonstrated the function,underlying mechanism,expression,and the prognosis-predicting role of ZNF575 in CRC,which indicated that ZNF575 would be a potential prognostic predictor and therapeutic target for CRC and other cancers.
基金supported by the Natural Science Foundation of Gansu Province (22JR5RA326)The geological disaster prevention projects of Gansu Provincial Bureau of Geology and Mineral Resources (2023-2-9)。
文摘This study aims to utilize the Small Baseline Subset Interferometric Synthetic Aperture Radar(SBAS-In SAR)technique and Google Earth optical remote sensing images to analyze the area within 20 km around the epicenter of a M 3.9, earthquake that occurred in Tanchang County, Gansu Province, on December 28, 2020. The objective is to identify potential earthquake-induced landslides, assess their scale, and determine their impact range. The study results reveal the successful identification of two potential landslides in the 20 km radius around the epicenter. Through time-series deformation analysis, it was observed that these potential landslides were significantly influenced by both the earthquake and rainfall. Further estimation of these potential landslides indicates maximum depths of 7.4 m and 14.1 m for the failure surfaces, with volumes of 9.02 × 10~4m~3and 25.5 ×10~4m~3, respectively. Finally, based on the simulation analysis of Massflow software, the maximum thickness of soil accumulation in the final accumulation area after sliding of the potential landslide in Shangyaai is 12 m, the area of the final accumulation area is 1.75 × 10~4m~2, and the farthest movement distance is 1124 m. The maximum thickness of soil accumulation in the final accumulation area after sliding of the potential landslide in Wangshancun is 8 m, the area of the final accumulation area is 7.89 × 10~4m~2, and the farthest movement distance is 742 m.
基金supported by the Young Talent Innovation Team Support Project from Zhengzhou University(No.32213280)the scientific research program of innovation platform in State Tobacco Monopoly Administrationthe State Key Program of National Natural Science Foundation of China(Grant No.32130083).
文摘Dopamine(DA)is a vital neurotransmitter,and accurate detection of its concentration is critical for both clinical diagnos-tics and neuroscience research.Due to its electrochemical activity,DA is commonly detected using electrochemical methods,which are favored for their simplicity,fast response time,and suitability for in vivo analysis.In this work,a highly sensitive DA electrochemical sensor was developed using an Au@MoS_(2)composite,created by modifying molybdenum disulfide(MoS_(2))nanosheets with gold nanoparticles through HAuCl_(4) reduction,and it was aimed at enhancing DA adsorption and improving detection performance.Scanning Electron Microscopy(SEM),transmission electron microscopy(TEM),Energy Dispersive Spectroscopy(EDS),X-ray photoelectron spectroscopy(XPS)and X-ray Diffraction(XRD)confirmed the suc-cessful synthesis of Au@MoS_(2)and the uniform distribution of gold nanoparticles across the MoS_(2)nanosheets.Then,the electrochemical characterization demonstrated that the Au@MoS_(2)/GCE exhibited distinct oxidation peaks in a 10μmol·L^(-1)DA solution,with significantly enhanced electrochemical activity compared to both unmodified GCE and pristine MoS_(2).Furthermore,differential pulse voltammetry(DPV)further revealed a strong linear relationship between DA concentration and the current response in the range of 800 nmol·L^(-1)to 10μmol·L^(-1),with a low detection limit(LOD)of 78.9 nmol·L^(-1)(S/N=3).Additionally,the sensor showed excellent selectivity against other interfering substances.Moreover,the laser-induced Au@MoS_(2)(LIAu@MoS_(2)),with its abundance of negatively charged surface defects,enabled the ultra-sensitive detection of the ultra-low concentrations of DA.In conclusion,the successfully fabricated Au@MoS_(2)based sensor offers advantages such as low cost,ease of operation,and scalability,making it a promising candidate for biosensing applications due to its enhanced DA detection capabilities.
基金supported by the National Natural Science Foundation of China(Nos.51072130,51502045 and 21905202)the Australian Research Council(ARC)through Discovery Early Career Researcher Award(DECRA,No.DE170100871)program。
文摘Lithium-ion batteries(LIBs)have been widely applied in portable electronic devices and electric vehicles.With the booming of the respective markets,a huge quantity of spent LIBs that typically use either LiFePO_(4) or Li N_(x)Co_(y)Mn_(z)O_(2) cathode materials will be produced in the very near future,imposing significant pressure for the development of suitable disposal/recycling technologies,in terms of both environmental protection and resource reclaiming.In this review,we firstly do a comprehensive summary of the-state-of-art technologies to recycle Li N_(x)Co_(y)Mn_(z)O_(2) and LiFePO_(4)-based LIBs,in the aspects of pretreatment,hydrometallurgical recycling,and direct regeneration of the cathode materials.This closed-loop strategy for cycling cathode materials has been regarded as an ideal approach considering its economic benefit and environmental friendliness.Afterward,as for the exhausted anode materials,we focus on the utilization of exhausted anode materials to obtain other functional materials,such as graphene.Finally,the existing challenges in recycling the LiFePO_(4) and Li N_(x)Co_(y)Mn_(z)O_(2) cathodes and graphite anodes for industrial-scale application are discussed in detail;and the possible strategies for these issues are proposed.We expect this review can provide a roadmap towards better technologies for recycling LIBs,shed light on the future development of novel battery recycling technologies to promote the environmental benignity and economic viability of the battery industry and pave way for the large-scale application of LIBs in industrial fields in the near future.
基金the Ministry of Science and Technology of China (Grant Nos. 2017YFC1501701, 2017YFC1501401, 2017YFA0603501 and 2016YFA0600403)the National Natural Science Foundation of China (Grant Nos. 91544217, 41771399 and 41471301)+1 种基金the Chinese Academy of Meteorological Sciences (Grant Nos. 2017Z005 and 2017R001)the Fundamental Research Funds for the Central Universities (Grant No. 2017STUD17)
文摘Clouds are critical to the global radiation budget and hydrological cycle, but knowledge is still poor concerning the observed climatology of cloud-base height （CBH） in China. Based on fine-resolution sounding observations from the China Radiosonde Network （CRN）, the method used to estimate CBH was modified, and uncertainty analyses indicated that the CBH is good enough. The accuracy of CBH estimation is verified by the comparison between the sounding-derived CBHs and those estimated from the micro-pulse lidar and millimeter-wave cloud radar. As such, the CBH climatology was compiled for the period 2006-16. Overall, the CBH exhibits large geographic variability across China, at both 0800 Local Standard Time （LST） and 2000 LST, irrespective of season. In addition, the summertime cloud base tends to be elevated to higher altitudes in dry regions [i.e., Inner Mongolia and the North China Plain （NCP）]. By comparison, the Tibetan Plateau （TP）, Pearl River Delta （PRD） and Sichuan Basin （SCB） have relatively low CBHs （〈 2.4 km above ground level）. In terms of seasonality, the CBH reaches its maximum in summer and minimum in winter. A low cloud base tends to occur frequently （〉 70%） over the TP, PRD and SCB. In contrast, at most sites over the Yangtze River Delta （YRD） and the NCP, about half the cloud belongs to the high-cloud category. The CBH does not exhibit marked diurnal variation in summer, throughout all CRN sites, probably due to the persistent cloud coverage caused by the East Asia Summer Monsson. To the best of our knowledge, this is the first CBH climatology produced from sounding measurements in China, and provides a useful reference for obtaining observational cloud base information.
