Hydroxylapatite(HAp),owing to its excellent biocompatibility,is a promising carrier for lanthanide ions to encourage antibacterial activity.However,hydroxylapatite powder would still require modification to ensure the...Hydroxylapatite(HAp),owing to its excellent biocompatibility,is a promising carrier for lanthanide ions to encourage antibacterial activity.However,hydroxylapatite powder would still require modification to ensure the optimal integration of antibacterial characteristics.In this study,Sm-doped nano-hydroxylapatite(SmHAp)was synthesized by spontaneous mineralization of amorphous SmHAp precursors,which ensures a homogeneous distribution of Sm^(3+)within bulk SmHAp.Powder X-ray diffraction and its Pawley fitting results for SmHAp indicate the lattice substitution of Ca^(2+)with Sm^(3+),resulting in the lattice distortion in SmHAp compared to pure HAp.Meanwhile,polymer-encapsulated Sm-doped nano-hydroxylapatite composite(p_SmHAp)was synthesized by a dual-step polymerization involving UV curing of an outer crust and heat treatment for bulk reaction completion.Irgacure 2959 and a toluene solution of AIBN were used as catalysts for the radical polymerization process.The antibacterial property of p_SmHAp was evaluated by observing the growth of Sporosarcina pasteurii(ATCC 11859)both in the solid and the liquid medium,correlating with the Sm fraction and SmHAp's crystallinity in p_SmHAp.These bacteriostatic rings'diameters exceed 20 mm,demonstrating that p_SmHAp with a SmHAP/p_SmHAp mass ratio of 0.1 and Sm/(Ca+Sm)molar ratio of 0.05-0.1 effectively releases Sm^(3+),serving as a strong antibacterial agent.展开更多
基金Project supported by the Fundamental and Applied Fundamental Research Major Program of Guangdong Province,China(2019B030302013)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA0430205)+2 种基金the Guangdong Basic and Applied Basic Research Foundation(2021A1515011531)the Science and Technology Planning Project of Guangdong Province,China(2023B1212060044,2023B1212060048)the Market Readiness Assistance Grant of Singapore(04INS000458C15000E01)。
文摘Hydroxylapatite(HAp),owing to its excellent biocompatibility,is a promising carrier for lanthanide ions to encourage antibacterial activity.However,hydroxylapatite powder would still require modification to ensure the optimal integration of antibacterial characteristics.In this study,Sm-doped nano-hydroxylapatite(SmHAp)was synthesized by spontaneous mineralization of amorphous SmHAp precursors,which ensures a homogeneous distribution of Sm^(3+)within bulk SmHAp.Powder X-ray diffraction and its Pawley fitting results for SmHAp indicate the lattice substitution of Ca^(2+)with Sm^(3+),resulting in the lattice distortion in SmHAp compared to pure HAp.Meanwhile,polymer-encapsulated Sm-doped nano-hydroxylapatite composite(p_SmHAp)was synthesized by a dual-step polymerization involving UV curing of an outer crust and heat treatment for bulk reaction completion.Irgacure 2959 and a toluene solution of AIBN were used as catalysts for the radical polymerization process.The antibacterial property of p_SmHAp was evaluated by observing the growth of Sporosarcina pasteurii(ATCC 11859)both in the solid and the liquid medium,correlating with the Sm fraction and SmHAp's crystallinity in p_SmHAp.These bacteriostatic rings'diameters exceed 20 mm,demonstrating that p_SmHAp with a SmHAP/p_SmHAp mass ratio of 0.1 and Sm/(Ca+Sm)molar ratio of 0.05-0.1 effectively releases Sm^(3+),serving as a strong antibacterial agent.
