Objective:To evaluate the wound healing effect of aqueous extract of Crotalaria verrucosa(C. verrucosa) in rats.Methods:Three wound models including incision,excision and dead space wounds were used in this study.The ...Objective:To evaluate the wound healing effect of aqueous extract of Crotalaria verrucosa(C. verrucosa) in rats.Methods:Three wound models including incision,excision and dead space wounds were used in this study.The parameters studied were breaking strength in incision models,granulation tissue dry weight,breaking strength and hydroxyproline content in dead space wounds,percentage of wound contraction and period of epithelialization in excision wound model.Results:Two doses of the extract with and without dexamethasone showed significant increases in mean hydroxyproline,total protein content and dry weight of granulation tissue but it was higher with dose 800 mg/kg comparing with the control.The dexamethasone treated group showed a significant(P【0.001) reduction in the wound breaking strength when compared to control group in incision type of wound model.Coadministration of C.verrucosa with dexamethasone significantly(P【0.001) increased the breaking strength compared to the dexamethasone treated only group.In excision wound model,the percentage of the wound contraction was significantly(P【0.01) increased by two doses of test extract on all the days except the lower dose which exhibited only on 12th,16th days of drug treatment and it also reversed the dexamethasone suppressed wound contraction.It significantly(P【0.001) reduced the time required for epithelialization and reversed the epithelialization delaying effect of dexamethasone (P【0.001).Conclusions:C.verrucosa was found to possess significant wound healing property. This was evident by decrease in the period of epithelialization,increase in the rate of wound contraction,skin breaking strength,and granulation tissue dry weight content.Hence C. verrucosa could be a good wound healing agent.展开更多
We demonstrate a new nonuniform mesh finite difference method to obtain accurate solutions for the elliptic partial differential equations in two dimensions with nonlinear first-order partial derivative terms.The meth...We demonstrate a new nonuniform mesh finite difference method to obtain accurate solutions for the elliptic partial differential equations in two dimensions with nonlinear first-order partial derivative terms.The method will be based on a geometric grid network area and included among the most stable differencing scheme in which the nine-point spatial finite differences are implemented,thus arriving at a compact formulation.In general,a third order of accuracy has been achieved and a fourth-order truncation error in the solution values will follow as a particular case.The efficiency of using geometric mesh ratio parameter has been shown with the help of illustrations.The convergence of the scheme has been established using the matrix analysis,and irreducibility is proved with the help of strongly connected characteristics of the iteration matrix.The difference scheme has been applied to test convection diffusion equation,steady state Burger’s equation,ocean model and a semi-linear elliptic equation.The computational results confirm the theoretical order and accuracy of the method.展开更多
文摘Objective:To evaluate the wound healing effect of aqueous extract of Crotalaria verrucosa(C. verrucosa) in rats.Methods:Three wound models including incision,excision and dead space wounds were used in this study.The parameters studied were breaking strength in incision models,granulation tissue dry weight,breaking strength and hydroxyproline content in dead space wounds,percentage of wound contraction and period of epithelialization in excision wound model.Results:Two doses of the extract with and without dexamethasone showed significant increases in mean hydroxyproline,total protein content and dry weight of granulation tissue but it was higher with dose 800 mg/kg comparing with the control.The dexamethasone treated group showed a significant(P【0.001) reduction in the wound breaking strength when compared to control group in incision type of wound model.Coadministration of C.verrucosa with dexamethasone significantly(P【0.001) increased the breaking strength compared to the dexamethasone treated only group.In excision wound model,the percentage of the wound contraction was significantly(P【0.01) increased by two doses of test extract on all the days except the lower dose which exhibited only on 12th,16th days of drug treatment and it also reversed the dexamethasone suppressed wound contraction.It significantly(P【0.001) reduced the time required for epithelialization and reversed the epithelialization delaying effect of dexamethasone (P【0.001).Conclusions:C.verrucosa was found to possess significant wound healing property. This was evident by decrease in the period of epithelialization,increase in the rate of wound contraction,skin breaking strength,and granulation tissue dry weight content.Hence C. verrucosa could be a good wound healing agent.
文摘We demonstrate a new nonuniform mesh finite difference method to obtain accurate solutions for the elliptic partial differential equations in two dimensions with nonlinear first-order partial derivative terms.The method will be based on a geometric grid network area and included among the most stable differencing scheme in which the nine-point spatial finite differences are implemented,thus arriving at a compact formulation.In general,a third order of accuracy has been achieved and a fourth-order truncation error in the solution values will follow as a particular case.The efficiency of using geometric mesh ratio parameter has been shown with the help of illustrations.The convergence of the scheme has been established using the matrix analysis,and irreducibility is proved with the help of strongly connected characteristics of the iteration matrix.The difference scheme has been applied to test convection diffusion equation,steady state Burger’s equation,ocean model and a semi-linear elliptic equation.The computational results confirm the theoretical order and accuracy of the method.
