As an emerging strategy in antitumor therapy,photodynamic therapy(PDT)has garnered significant attention in recent years for the treatment of various malignant tumors.This is due to its low side effects,superior spati...As an emerging strategy in antitumor therapy,photodynamic therapy(PDT)has garnered significant attention in recent years for the treatment of various malignant tumors.This is due to its low side effects,superior spatial selectivity,and maximum preservation of normal tissue function.However,the hypoxic nature of tumors,continuous oxygen consumption,and microvascular damage associated with PDT treatment have impeded its development.Therefore,the focus of antitumor therapy has shifted towards enhancing the efficacy of PDT by addressing tumor hypoxia.The objective of this review is to assess and summarize the recent advancements in tumor treatment using synergistic therapy strategies(PDT+X,where X represents photothermal therapy,chemodynamic therapy,chemotherapy,immunotherapy,Photoacoustic therapy,etc.)that overcome hypoxia.Additionally,this review aims to outline the advantages and disadvantages of various collaborative methods for improving tumor hypoxia,while also discussing the challenges that lie ahead for future research.展开更多
基金This work was supported by the Natural Science Foundation of Hunan Province(2022JJ30798)the Guiding Project of Hunan Health Commission(202202083650)+1 种基金the extracurricular Scientific Research and Training Program for Medical Students of Central South University(202229KT1824 and 202229KT1845)Additionally,we acknowledge the support from the platform of Clinical Research Center For Medical Imaging In Hunan Province(2020SK4001).
文摘As an emerging strategy in antitumor therapy,photodynamic therapy(PDT)has garnered significant attention in recent years for the treatment of various malignant tumors.This is due to its low side effects,superior spatial selectivity,and maximum preservation of normal tissue function.However,the hypoxic nature of tumors,continuous oxygen consumption,and microvascular damage associated with PDT treatment have impeded its development.Therefore,the focus of antitumor therapy has shifted towards enhancing the efficacy of PDT by addressing tumor hypoxia.The objective of this review is to assess and summarize the recent advancements in tumor treatment using synergistic therapy strategies(PDT+X,where X represents photothermal therapy,chemodynamic therapy,chemotherapy,immunotherapy,Photoacoustic therapy,etc.)that overcome hypoxia.Additionally,this review aims to outline the advantages and disadvantages of various collaborative methods for improving tumor hypoxia,while also discussing the challenges that lie ahead for future research.
