The utilization of energy in building sectors comprises 30–40%of the entire global energy consumption.Most of the energy is being utilized for cooling&heating the buildings.These cooling and heating depend on the...The utilization of energy in building sectors comprises 30–40%of the entire global energy consumption.Most of the energy is being utilized for cooling&heating the buildings.These cooling and heating depend on the nature of climate for different places.In this,the detailed analysis of the building envelope across five areas(viz.Srinagar,Jaisalmer,New Delhi,Thiruvananthapuram and Bangalore)representing different climatic zones had been carried out.Simulations are performed for these locations using eQUEST and ANSYS software.Three of the result output from the eQUEST simulation are used to assess the different cases.These outputs are:total electrical energy consumption of the year,peak cooling load&peak heating load for a particular time of the year.Temperature variations and airflow for a fan with moisture influence are also simulated for five different locations by using the radiation model and shear stress transport in ANSYS.The internal temperature distribution in accordance with an occupant is also compared and discussed for the five regions.Lastly,the predicted mean vote and predicted percentage of dissatisfaction are found to be in the range of−0.50 to−0.99 for all zones that signifies 13%to 30%of people are dissatisfied with the indoor environment.展开更多
Dear Editor,Genome editing holds potential to cure human diseases.The first CRISPR/Cas9 gene therapy,Casgevy,may offer a definitive treatment for hemoglobinopathies through autologous transplantation of ex vivo genome...Dear Editor,Genome editing holds potential to cure human diseases.The first CRISPR/Cas9 gene therapy,Casgevy,may offer a definitive treatment for hemoglobinopathies through autologous transplantation of ex vivo genome-corrected hematopoietic stem cells.However,in vivo editing of solid tissues has been marred by organ failures and deaths,poorly predicted by animal studies.1 The lack of reliable preclinical tools for human-specific therapies,such as genome editing,has remained a critical unmet need.Preclinical safety testing of genome editing could benefit from complex tissue models that bear the human genome and reconstitute human responses.Given the kidney’s susceptibility to toxic reactions from investigational drugs,studies using human stem cell-derived kidney organoids may inform clinical trials and improve patient outcome.2 Here,kidney organoids serve as a preclinical testing platform for CRISPR/Cas9 genome editing via adeno-associated virus(AAV)delivery,a common strategy in clinical trials that have raised safety concerns due to viral toxicity.展开更多
文摘The utilization of energy in building sectors comprises 30–40%of the entire global energy consumption.Most of the energy is being utilized for cooling&heating the buildings.These cooling and heating depend on the nature of climate for different places.In this,the detailed analysis of the building envelope across five areas(viz.Srinagar,Jaisalmer,New Delhi,Thiruvananthapuram and Bangalore)representing different climatic zones had been carried out.Simulations are performed for these locations using eQUEST and ANSYS software.Three of the result output from the eQUEST simulation are used to assess the different cases.These outputs are:total electrical energy consumption of the year,peak cooling load&peak heating load for a particular time of the year.Temperature variations and airflow for a fan with moisture influence are also simulated for five different locations by using the radiation model and shear stress transport in ANSYS.The internal temperature distribution in accordance with an occupant is also compared and discussed for the five regions.Lastly,the predicted mean vote and predicted percentage of dissatisfaction are found to be in the range of−0.50 to−0.99 for all zones that signifies 13%to 30%of people are dissatisfied with the indoor environment.
文摘Dear Editor,Genome editing holds potential to cure human diseases.The first CRISPR/Cas9 gene therapy,Casgevy,may offer a definitive treatment for hemoglobinopathies through autologous transplantation of ex vivo genome-corrected hematopoietic stem cells.However,in vivo editing of solid tissues has been marred by organ failures and deaths,poorly predicted by animal studies.1 The lack of reliable preclinical tools for human-specific therapies,such as genome editing,has remained a critical unmet need.Preclinical safety testing of genome editing could benefit from complex tissue models that bear the human genome and reconstitute human responses.Given the kidney’s susceptibility to toxic reactions from investigational drugs,studies using human stem cell-derived kidney organoids may inform clinical trials and improve patient outcome.2 Here,kidney organoids serve as a preclinical testing platform for CRISPR/Cas9 genome editing via adeno-associated virus(AAV)delivery,a common strategy in clinical trials that have raised safety concerns due to viral toxicity.
