Traditionally,macroautophagy(autophagy)is viewed as a pathway of cell survival.Autophagy ensures the elimination of damaged or unwanted cytosolic components and provides a source of cellular nutrients during periods o...Traditionally,macroautophagy(autophagy)is viewed as a pathway of cell survival.Autophagy ensures the elimination of damaged or unwanted cytosolic components and provides a source of cellular nutrients during periods of stress.Interestingly,autophagy can also directly intersect with,and impact,other major pathways of cellular function.Here,we will review the contribution of autophagy to pathways of antigen presentation.The autophagy machinery acts to modulate both MHCⅠ and MHCⅡ antigen presentation.As such autophagy is an important participant in pathways that elicit host cell immunity and the elimination of infectious pathogens.展开更多
基金supported by a National Health and Medical Research Council of Australia Career Development Award.
文摘Traditionally,macroautophagy(autophagy)is viewed as a pathway of cell survival.Autophagy ensures the elimination of damaged or unwanted cytosolic components and provides a source of cellular nutrients during periods of stress.Interestingly,autophagy can also directly intersect with,and impact,other major pathways of cellular function.Here,we will review the contribution of autophagy to pathways of antigen presentation.The autophagy machinery acts to modulate both MHCⅠ and MHCⅡ antigen presentation.As such autophagy is an important participant in pathways that elicit host cell immunity and the elimination of infectious pathogens.
