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Comparison of Baclofen and Tizanidine in Reducing Spasticity in Cerebral Palsy: A Randomized Control Trial 被引量:1
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作者 Nazmul Haque narayan saha +3 位作者 Tahmina Ahmed Bithi Debnath Abid Hossain Mollah Ekhlasur Rahman 《Open Journal of Pediatrics》 2020年第4期617-625,共9页
<strong>Background:</strong><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> Cerebral palsy is the m... <strong>Background:</strong><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> Cerebral palsy is the most common chronic motor disability that begins in childhood with the predominant motor abnormality</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> that</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> is spasticity</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">.</span></span></span><span><span><span style="font-family:""> <b><span style="font-family:Verdana;">Objective:</span></b><span style="font-family:Verdana;"> The purpose of the present study was to compare the efficacy of oral baclofen and oral tizanidine in reducing spasticity in cerebral palsy patients. </span><b><span style="font-family:Verdana;">Methodology: </span></b><span style="font-family:Verdana;">This randomized controlled trial was conducted from January 2010 to December 2011 and it was carried out in the Out Patient Department (OPD) of Pediatrics at Dhaka Medical College Hospital (DMCH), Dhaka, Bangladesh and Center for Neurodevelopment and Autism in Children (CNAC) of Bangabandhu Sheikh Mujib Medical University (B中央人民政府), Dhaka, Bangladesh. </span><b><span style="font-family:Verdana;">Results</span></b><span style="font-family:Verdana;">: A total number of 70 cerebral palsy children were recruited for this study of which 35 patients were in </span><span style="font-family:Verdana;">Tizanidine</span><span style="font-family:Verdana;"> group and 35 patients were in </span><span style="font-family:Verdana;">baclofen</span><span style="font-family:Verdana;"> group. </span><span style="font-family:Verdana;">Furthermore</span></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">,</span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;"> 70 cerebral palsy children were taken as control who were treated with </span><span style="font-family:Verdana;">placebo</span><span style="font-family:Verdana;">. Tizanidine had superior efficacy in reducing tone in spastic cerebral palsy over baclofen measured by using </span><span style="font-family:Verdana;">Modified</span><span style="font-family:Verdana;"> Ashworth scale in </span><span style="font-family:Verdana;">different</span> <span style="font-family:Verdana;">time period</span></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">s</span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;"> from AS score-3 to score-2 (p < 0.05). Tizanidine was also superior in joint angle improvement in spastic cerebral palsy measured by </span><span style="font-family:Verdana;">physician</span><span style="font-family:Verdana;"> rating scale from AS score-3 to score-2 (crouch p < 0.0001) and foot contact from AS score-3 to score-2 (p < 0.0001);but no statistically significant improvement in gross motor function. </span><span style="font-family:Verdana;">Adverse</span><span style="font-family:Verdana;"> effect </span><span style="font-family:Verdana;">w</span></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">as</span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;"> more in </span><span style="font-family:Verdana;">baclofen</span><span style="font-family:Verdana;"> group. </span><b><span style="font-family:Verdana;">Conclusion</span></b><span style="font-family:Verdana;">: For reducing generalized spasticity with regards to muscle tone, joint angle </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> improvement in gait in cerebral palsy patients, tizanidine has superior efficacy and less adverse effects than baclofen.</span></span></span></span> 展开更多
关键词 Cerebral Palsy SPASTICITY BACLOFEN TIZANIDINE
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Analysis of existing agroforestry practices in Madhupur Sal forest: an assessment based on ecological and economic perspectives
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作者 Mohammad Golam Kibria narayan saha 《Journal of Forestry Research》 SCIE CAS CSCD 2011年第4期533-542,共10页
A study was conducted in Madhupur sal forest of Tangail, Bangladesh to identify the suitable agroforestry practices of the area. Considering the ecological aspects of different agroforestry practices 10 sample plots ... A study was conducted in Madhupur sal forest of Tangail, Bangladesh to identify the suitable agroforestry practices of the area. Considering the ecological aspects of different agroforestry practices 10 sample plots (10 m× 10 m) from each land uses were taken, including natural forest to get a comparative scenario. The study showed that among the different agroforestry practices, Margalef and Shannon- Weiner index values are the maximum for pineapple agroforestry and lower for banana agroforestry, and Evenness index value is the maximum for lemon agroforestry. Determination of tree biomass in different land uses revealed that it is highest (3 078.6 kg/100 m^2) in natural forest followed by pineapple agroforestry, lemon agroforestry and banana agroforestry. Soil pH, moisture content, organic matter, organic carbon, phosphorus and total nitrogen showed statistically significant variation while bulk density, particle density, sulphur and potassium did not show any statistically significant variation among the land uses. Soil fertility status showed that pineapple agroforestry is more fertile than rest of other land uses. The Net Present Value (NPV) indicated that banana agroforestry is financially more profitable than other two systems, while the Benefit- Cost ratio (BCR) is higher in pineapple agroforestry (4.21 in participatory agroforestry and 3.35 in privately managed land). Even though banana agroforestry gives higher NPV, capital required for this practice is much higher. The findings suggest that pineapple agroforestry has a tendency towards becoming ecologically and economically more sound than other two practices as it has better ecological attributes and required comparatively low investment. 展开更多
关键词 BANGLADESH Sal forest AGROFORESTRY ecological attributes PROFITABILITY
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