Almost every life form,from the tiniest bacterium to humans,is mechanosensitive,implying it can use mechani-cal stresses to trigger certain physiological responses in the form of electric signals.Mechanotransduction l...Almost every life form,from the tiniest bacterium to humans,is mechanosensitive,implying it can use mechani-cal stresses to trigger certain physiological responses in the form of electric signals.Mechanotransduction largely relies on ion channels that respond to mechanical forces,such as the epithelial sodium channels/degenerins,tran-sient receptor potential channel,and the two-pore domain potassium channel.Piezo1 and Piezo2 proteins were discovered to be the biggest non-selective mechanosensitive cation channels in the cell membrane.A substantial amount of research has previously been published on the Piezo channel’s function in touch sensation,balance,and cardiovascular regression.However,the mechanistic perspective must be refined to fully understand the role of Piezo proteins in tissue engineering.This review centers on the latest insights into the structure of Piezo chan-nels,activation mechanisms,and its interactions with cytoskeletal components,by emphasizing the physiological activities of Piezo channels in different tissues.The study also places focus on the possibilities of targeting this cation channel family as a tissue regeneration aid.展开更多
Wound closing is one of the widely performed and prominent clinical practices in the surgical intervention process.A physician or surgeon has several options ranging from surgical sutures and adhesive strips to fibrin...Wound closing is one of the widely performed and prominent clinical practices in the surgical intervention process.A physician or surgeon has several options ranging from surgical sutures and adhesive strips to fibrin glue for effective wound closure to close the commonly occurring surgical cuts and deep skin tissue injuries.However,all the commercially available wound closure devices have some limitations in each and another perspective.From the beginning of the late 90s,surgical staples got tremendous attention as efficient wound closure devices for their time-effective and sufficient mechanical strength,performance feasibility,fewer chances of surgical site infection and require minimal expertise characteristics in consideration of remote location.Even in the context of the recent COVID19 pandemic,the clinical acceptance and patient compliance for the staples have increased due to minimizing the chances of prolonged interaction between the patient and physicians.The surgical staples application is extensive and diversified,ranging from common external cuts to highly complex surgery procedures like laparoscopic appendectomy,intestinal anastomosis,etc.Thus,in this literature review,we try to give a comprehensive glimpse of the development and current state-of-the-art surgical staples in consideration with research from a commercial point of view.On a special note,this review also describes a very brief outline of the regulatory aspects and some common internationally acceptable‘de jure standards for the development of commercially viable surgical staples.展开更多
Tissue engineering is a well-proven technique for the creation of functional alternatives for regenerative medicine and plays a critical role in patient treatment.Several natural-origin biopolymers such as chitosan,hy...Tissue engineering is a well-proven technique for the creation of functional alternatives for regenerative medicine and plays a critical role in patient treatment.Several natural-origin biopolymers such as chitosan,hyaluronic acid,gelatin,collagen,etc.are extensively explored for various biomedical applications.Among,these polymers are exclusively investigated in tissue engineering applications due to their highly favorable properties,such as high biocompatibility,slow degradation,mechanical tenability,structural similarity with native tissues,bioactivity,etc.The present review summarizes the recent advances of biopolymers in bone tissue engineering It also covers the topic of natural polymer modification to achieve superior characteristics primarily mechanical properties towards bone regeneration and discussed the best methods for dealing with them.Therefore,the review can drive the development of biomimetic materials for futuristic applications.展开更多
文摘Almost every life form,from the tiniest bacterium to humans,is mechanosensitive,implying it can use mechani-cal stresses to trigger certain physiological responses in the form of electric signals.Mechanotransduction largely relies on ion channels that respond to mechanical forces,such as the epithelial sodium channels/degenerins,tran-sient receptor potential channel,and the two-pore domain potassium channel.Piezo1 and Piezo2 proteins were discovered to be the biggest non-selective mechanosensitive cation channels in the cell membrane.A substantial amount of research has previously been published on the Piezo channel’s function in touch sensation,balance,and cardiovascular regression.However,the mechanistic perspective must be refined to fully understand the role of Piezo proteins in tissue engineering.This review centers on the latest insights into the structure of Piezo chan-nels,activation mechanisms,and its interactions with cytoskeletal components,by emphasizing the physiological activities of Piezo channels in different tissues.The study also places focus on the possibilities of targeting this cation channel family as a tissue regeneration aid.
文摘Wound closing is one of the widely performed and prominent clinical practices in the surgical intervention process.A physician or surgeon has several options ranging from surgical sutures and adhesive strips to fibrin glue for effective wound closure to close the commonly occurring surgical cuts and deep skin tissue injuries.However,all the commercially available wound closure devices have some limitations in each and another perspective.From the beginning of the late 90s,surgical staples got tremendous attention as efficient wound closure devices for their time-effective and sufficient mechanical strength,performance feasibility,fewer chances of surgical site infection and require minimal expertise characteristics in consideration of remote location.Even in the context of the recent COVID19 pandemic,the clinical acceptance and patient compliance for the staples have increased due to minimizing the chances of prolonged interaction between the patient and physicians.The surgical staples application is extensive and diversified,ranging from common external cuts to highly complex surgery procedures like laparoscopic appendectomy,intestinal anastomosis,etc.Thus,in this literature review,we try to give a comprehensive glimpse of the development and current state-of-the-art surgical staples in consideration with research from a commercial point of view.On a special note,this review also describes a very brief outline of the regulatory aspects and some common internationally acceptable‘de jure standards for the development of commercially viable surgical staples.
文摘Tissue engineering is a well-proven technique for the creation of functional alternatives for regenerative medicine and plays a critical role in patient treatment.Several natural-origin biopolymers such as chitosan,hyaluronic acid,gelatin,collagen,etc.are extensively explored for various biomedical applications.Among,these polymers are exclusively investigated in tissue engineering applications due to their highly favorable properties,such as high biocompatibility,slow degradation,mechanical tenability,structural similarity with native tissues,bioactivity,etc.The present review summarizes the recent advances of biopolymers in bone tissue engineering It also covers the topic of natural polymer modification to achieve superior characteristics primarily mechanical properties towards bone regeneration and discussed the best methods for dealing with them.Therefore,the review can drive the development of biomimetic materials for futuristic applications.
