Context: In case of diabetes, persistent and chronic hyperglycaemia may generate free radicals and reactive oxygen species (ROS), which trigger an oxidative stress. Garlic (Allium sativum) is a rich source of bioactiv...Context: In case of diabetes, persistent and chronic hyperglycaemia may generate free radicals and reactive oxygen species (ROS), which trigger an oxidative stress. Garlic (Allium sativum) is a rich source of bioactive compounds and is used in folk medicine for the treatment of various diseases, including diabetes. Besides, α-tocopherol and magnesium have been shown to possess antioxidative properties. Objective: Protective effects of either a garlic aqueous extract or an association of α-tocopherol and magnesium association upon oxidative stress and dysfunctions in kidney and brain of alloxan-diabetic rats were investigated. Results: Both garlic extract and the combination of α-tocopherol and magnesium were found to normalize many parameters which were shifted to pathological values as a consequence of the alloxan-induced diabetes: plasma creatinine and urea levels were decreased, protein leakage in urine was reduced and cortisol level was brought back to control value. In addition, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) activities, which were lowered in kidney and brain of diabetic animals, were restored by both treatments and, consequently, level of lipids peroxidation was reduced in these organs, as compared to diabetic animals. Conclusion: Both garlic extract and α-tocopherol + magnesium association display beneficial effects upon nephropathy and oxidative stress in alloxan-diabetic rats. The protective effect of garlic is mainly attributed to antioxidant properties and the presence of phenolic acids and flavonoids.展开更多
The present study examined the antilithiasic activity of the hydromethanolic extract of Polygonum maritimum aerial parts(Pm).The chromatographic analysis made it possible to identify 30 compounds,namely gallic acid,(+...The present study examined the antilithiasic activity of the hydromethanolic extract of Polygonum maritimum aerial parts(Pm).The chromatographic analysis made it possible to identify 30 compounds,namely gallic acid,(+)-catechin,three isomers of myricetin deoxyhexoside,quercetin pentoside,and quercitrin as the major molecules.The microscopic and macroscopic observations together with the plasma and urinary parameters as well as the histological analysis revealed that the use of Pm extracts(37.5 and 50 mg/kg)during 15 days significantly improved the elevated pH,hyperoxaluria,hypercalcemia,and decreased the urinary volume,when compared to the ethylene glycol group(EG-group).In addition,the microscopic examination revealed that the large crystals and oxalic aggregates detected in urinary,induced by EG(ethylene glycol),were mitigated by Pm-administration.Furthermore,the Pm supplement significantly restored the levels of urea,uric acid,and creatinine,and also led to a strong diuresis which helped remove crystal debris.These results were reinforced by the histological study.The current study highlighted the potential use of Pm for its remarkable beneficial effect during the various lithogenic stages as well as for improving kidney function.展开更多
文摘Context: In case of diabetes, persistent and chronic hyperglycaemia may generate free radicals and reactive oxygen species (ROS), which trigger an oxidative stress. Garlic (Allium sativum) is a rich source of bioactive compounds and is used in folk medicine for the treatment of various diseases, including diabetes. Besides, α-tocopherol and magnesium have been shown to possess antioxidative properties. Objective: Protective effects of either a garlic aqueous extract or an association of α-tocopherol and magnesium association upon oxidative stress and dysfunctions in kidney and brain of alloxan-diabetic rats were investigated. Results: Both garlic extract and the combination of α-tocopherol and magnesium were found to normalize many parameters which were shifted to pathological values as a consequence of the alloxan-induced diabetes: plasma creatinine and urea levels were decreased, protein leakage in urine was reduced and cortisol level was brought back to control value. In addition, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) activities, which were lowered in kidney and brain of diabetic animals, were restored by both treatments and, consequently, level of lipids peroxidation was reduced in these organs, as compared to diabetic animals. Conclusion: Both garlic extract and α-tocopherol + magnesium association display beneficial effects upon nephropathy and oxidative stress in alloxan-diabetic rats. The protective effect of garlic is mainly attributed to antioxidant properties and the presence of phenolic acids and flavonoids.
基金The authors express their appreciation to the Researchers Supporting Project(RSP 2023R17)at King Saud University,Riyadh,Saudi Arabiathe Ministry of Science and Innovation of Spain for the Ram´on y Cajal grant RYC2020-030546-I/AEI/10.13039/501100011033 and the European Social Fund。
文摘The present study examined the antilithiasic activity of the hydromethanolic extract of Polygonum maritimum aerial parts(Pm).The chromatographic analysis made it possible to identify 30 compounds,namely gallic acid,(+)-catechin,three isomers of myricetin deoxyhexoside,quercetin pentoside,and quercitrin as the major molecules.The microscopic and macroscopic observations together with the plasma and urinary parameters as well as the histological analysis revealed that the use of Pm extracts(37.5 and 50 mg/kg)during 15 days significantly improved the elevated pH,hyperoxaluria,hypercalcemia,and decreased the urinary volume,when compared to the ethylene glycol group(EG-group).In addition,the microscopic examination revealed that the large crystals and oxalic aggregates detected in urinary,induced by EG(ethylene glycol),were mitigated by Pm-administration.Furthermore,the Pm supplement significantly restored the levels of urea,uric acid,and creatinine,and also led to a strong diuresis which helped remove crystal debris.These results were reinforced by the histological study.The current study highlighted the potential use of Pm for its remarkable beneficial effect during the various lithogenic stages as well as for improving kidney function.
