Worldwide women have to cope up with heavy burden of unwanted pregnancies, mistimed, unplanned, with risk to their health. Their children and families also suf-fer. Such pregnancies are root cause of induced abortions...Worldwide women have to cope up with heavy burden of unwanted pregnancies, mistimed, unplanned, with risk to their health. Their children and families also suf-fer. Such pregnancies are root cause of induced abortions （safe/unsafe） and grave consequences. Women, their partners can, for most part, prevent unwanted pregnancies by using contraceptives. However many women either do not use any contraceptive or use methods, with high failure rates. These women account for 82% of pregnancies that are not desired. Remaining unintended pregnancies occur among women who use modern contraceptive, either because they had diffculty using method consistently or because of failure. Helping women, their partner use modern contracep-tives effectively is essential in achieving Millennium Development Goals for improving women’s health, reducing poverty. If all women in developing countries use modern contraceptives, there would be 22 million less unplanned births, 25 million fewer induced, 15 million fewer unsafe abortions, 90000 less maternal deaths and 390000 less children losing their mothers. Also making abortion services broadly legal, by understand-ing size, type of unmet needs, most important by creating awareness in communities can surely help tackle this problem to a large extent.展开更多
Advances in prenatal screening have significantly improved the early detection of fetal anomalies and chromosomal abnormalities.Among these,first-trimester soft markers have emerged as valuable indicators of potential...Advances in prenatal screening have significantly improved the early detection of fetal anomalies and chromosomal abnormalities.Among these,first-trimester soft markers have emerged as valuable indicators of potential adverse outcomes.This review explores the clinical relevance of key markers—including increased nuchal translucency(NT),nasal bone hypoplasia,tricuspid regurgitation,aberrant right subclavian artery,and abnormal ductus venosus flow—and their associations with aneuploidy,structural malformations,and pregnancy complications such as preeclampsia and fetal growth restriction.We emphasize the importance of interpreting soft markers within a comprehensive clinical context,rather than in isolation,and examine their underlying pathophysiological mechanisms and associated statistical risks.Particular attention is given to the integration of soft marker findings with advanced screening techniques,including cell-free DNA(cfDNA)testing and maternal serum biochemistry,to improve diagnostic accuracy.In addition,we review current recommendations for clinical management,such as the use of follow-up diagnostic procedures like chorionic villus sampling or amniocentesis,and the role of multidisciplinary counselling in high-risk pregnancies.Future research should aim to validate novel soft markers and promote the standardization of screening protocols to enhance maternal and fetal outcomes.展开更多
The world is in the midst of a major health crisis as coronavirus disease 2019(COVID-19)continues to spread at an alarming rate and claim an ever-increasing number of lives.Some countries are experiencing their fifth ...The world is in the midst of a major health crisis as coronavirus disease 2019(COVID-19)continues to spread at an alarming rate and claim an ever-increasing number of lives.Some countries are experiencing their fifth or sixth waves of COVID-19 transmission,with no end to this situation in the foreseeable future.1 The COVID-19 pandemic has affected every segment of the population.The effects of COVID-19 on pregnant women and adolescents as well as geriatric,child,and even mental health have been reported.2s However,there have been few studies of the im.pact on the health and wellbeing of the unborn fetus.While direct effects on abortion,preterm delivery,premature rupture of membranes,preeclampsia,and fetal growth restriction have been described,4 indirect effects on fetal health are less evident but far more disturbing and damaging.展开更多
文摘Worldwide women have to cope up with heavy burden of unwanted pregnancies, mistimed, unplanned, with risk to their health. Their children and families also suf-fer. Such pregnancies are root cause of induced abortions （safe/unsafe） and grave consequences. Women, their partners can, for most part, prevent unwanted pregnancies by using contraceptives. However many women either do not use any contraceptive or use methods, with high failure rates. These women account for 82% of pregnancies that are not desired. Remaining unintended pregnancies occur among women who use modern contraceptive, either because they had diffculty using method consistently or because of failure. Helping women, their partner use modern contracep-tives effectively is essential in achieving Millennium Development Goals for improving women’s health, reducing poverty. If all women in developing countries use modern contraceptives, there would be 22 million less unplanned births, 25 million fewer induced, 15 million fewer unsafe abortions, 90000 less maternal deaths and 390000 less children losing their mothers. Also making abortion services broadly legal, by understand-ing size, type of unmet needs, most important by creating awareness in communities can surely help tackle this problem to a large extent.
文摘Advances in prenatal screening have significantly improved the early detection of fetal anomalies and chromosomal abnormalities.Among these,first-trimester soft markers have emerged as valuable indicators of potential adverse outcomes.This review explores the clinical relevance of key markers—including increased nuchal translucency(NT),nasal bone hypoplasia,tricuspid regurgitation,aberrant right subclavian artery,and abnormal ductus venosus flow—and their associations with aneuploidy,structural malformations,and pregnancy complications such as preeclampsia and fetal growth restriction.We emphasize the importance of interpreting soft markers within a comprehensive clinical context,rather than in isolation,and examine their underlying pathophysiological mechanisms and associated statistical risks.Particular attention is given to the integration of soft marker findings with advanced screening techniques,including cell-free DNA(cfDNA)testing and maternal serum biochemistry,to improve diagnostic accuracy.In addition,we review current recommendations for clinical management,such as the use of follow-up diagnostic procedures like chorionic villus sampling or amniocentesis,and the role of multidisciplinary counselling in high-risk pregnancies.Future research should aim to validate novel soft markers and promote the standardization of screening protocols to enhance maternal and fetal outcomes.
文摘The world is in the midst of a major health crisis as coronavirus disease 2019(COVID-19)continues to spread at an alarming rate and claim an ever-increasing number of lives.Some countries are experiencing their fifth or sixth waves of COVID-19 transmission,with no end to this situation in the foreseeable future.1 The COVID-19 pandemic has affected every segment of the population.The effects of COVID-19 on pregnant women and adolescents as well as geriatric,child,and even mental health have been reported.2s However,there have been few studies of the im.pact on the health and wellbeing of the unborn fetus.While direct effects on abortion,preterm delivery,premature rupture of membranes,preeclampsia,and fetal growth restriction have been described,4 indirect effects on fetal health are less evident but far more disturbing and damaging.
