Objective: to observe the therapeutic effect of plantain on calcium oxalate stone in urinary system of rats. Methods: rats were randomly divided into four groups: normal group, calcium oxalate stone model group, Paish...Objective: to observe the therapeutic effect of plantain on calcium oxalate stone in urinary system of rats. Methods: rats were randomly divided into four groups: normal group, calcium oxalate stone model group, Paishi granule treatment group and Plantago asiatica treatment group. Except for normal group, the other three groups were all given model-making agents (1% ethylene glycol and 2% ammonium chloride) for gastric lavage and model-making. Paishi granule treatment group and Plantago asiatica treatment group were treated with drugs while model-making. At the end of the experiment, the contents of calcium ions (Ca2+) and magnesium ions (Mg2+) in urine and calcium ions and urea nitrogen (BUN) in serum of rats in each group were detected. Results: compared with the model group, Plantago asiatica treatment group and Paishi granule treatment group can improve the life and mental state of rats, increase the micturition volume of rats, increase the excretion of calcium ions and magnesium ions in urine, and reduce the content of calcium ions and urea nitrogen in serum. Conclusion: the ethanol extract of Plantago asiatica can inhibit the formation of calcium oxalate stone by promoting the excretion of Ca2+, Mg2+ and BUN in urine and body, which is beneficial to the treatment of renal calcium oxalate stone in rats.展开更多
文摘Objective: to observe the therapeutic effect of plantain on calcium oxalate stone in urinary system of rats. Methods: rats were randomly divided into four groups: normal group, calcium oxalate stone model group, Paishi granule treatment group and Plantago asiatica treatment group. Except for normal group, the other three groups were all given model-making agents (1% ethylene glycol and 2% ammonium chloride) for gastric lavage and model-making. Paishi granule treatment group and Plantago asiatica treatment group were treated with drugs while model-making. At the end of the experiment, the contents of calcium ions (Ca2+) and magnesium ions (Mg2+) in urine and calcium ions and urea nitrogen (BUN) in serum of rats in each group were detected. Results: compared with the model group, Plantago asiatica treatment group and Paishi granule treatment group can improve the life and mental state of rats, increase the micturition volume of rats, increase the excretion of calcium ions and magnesium ions in urine, and reduce the content of calcium ions and urea nitrogen in serum. Conclusion: the ethanol extract of Plantago asiatica can inhibit the formation of calcium oxalate stone by promoting the excretion of Ca2+, Mg2+ and BUN in urine and body, which is beneficial to the treatment of renal calcium oxalate stone in rats.
