Objective To investigate the association between vitamin D deficiency and risk of gestational diabetes rnellitus(GDM)in pregnant Chinese women.Methods A nested case-control study was conducted.Clinical and biochemical...Objective To investigate the association between vitamin D deficiency and risk of gestational diabetes rnellitus(GDM)in pregnant Chinese women.Methods A nested case-control study was conducted.Clinical and biochemical data were analyzed for 200 subjects with GDM and 200 subjects with normal glucose tolerance(NGT).Results The median(interquartile range)serum 25-hydroxyvitamin D(25OHD)levels were 22.39(17.67,29.38)and 25.86(19.09,34.88)nmol/L in the GDM and NGT groups,respectively.Rates of 25OHD deficiency or insufficiency were significantly higher in the GDM group than in the NGT group.Subjects with 25OHD levels〈25 nmol/L had a 1.g-fold higher risk of GDM compared with subjects with higher vitamin D levels.In the GDM group,serum 25OHD was independently associated with HbAlc and insulin resistance after adjusting for confounding factors.In the NGT group,serum 25OHD was independently associated with fasting plasma glucose and systolic blood pressure after adjusting for maternal age and other confounding factors.Conclusion 2SOHD insufficiency is very common in Chinese women.Low 25OHD status may be associated with insulin resistance and act as a risk factor for GDM.展开更多
基金partially supported by grants from the National Natural Science Foundation Project of China(grants 30971369,81170674,and 81070630)
文摘Objective To investigate the association between vitamin D deficiency and risk of gestational diabetes rnellitus(GDM)in pregnant Chinese women.Methods A nested case-control study was conducted.Clinical and biochemical data were analyzed for 200 subjects with GDM and 200 subjects with normal glucose tolerance(NGT).Results The median(interquartile range)serum 25-hydroxyvitamin D(25OHD)levels were 22.39(17.67,29.38)and 25.86(19.09,34.88)nmol/L in the GDM and NGT groups,respectively.Rates of 25OHD deficiency or insufficiency were significantly higher in the GDM group than in the NGT group.Subjects with 25OHD levels〈25 nmol/L had a 1.g-fold higher risk of GDM compared with subjects with higher vitamin D levels.In the GDM group,serum 25OHD was independently associated with HbAlc and insulin resistance after adjusting for confounding factors.In the NGT group,serum 25OHD was independently associated with fasting plasma glucose and systolic blood pressure after adjusting for maternal age and other confounding factors.Conclusion 2SOHD insufficiency is very common in Chinese women.Low 25OHD status may be associated with insulin resistance and act as a risk factor for GDM.
