The dense integration of residential distributed photovoltaic(PV)systems into three-phase,four-wire low-voltage(LV)distribution networks results in reverse power flow and three-phase imbalance,leading to voltage viola...The dense integration of residential distributed photovoltaic(PV)systems into three-phase,four-wire low-voltage(LV)distribution networks results in reverse power flow and three-phase imbalance,leading to voltage violations that hinder the growth of rural distributed PV systems.Traditional voltage droop-based control methods regulate PV power output solely based on local voltage measurements at the point of PV connection.Due to a lack of global coordination and optimization,their efficiency is often subpar.This paper presents a centralized coordinated active/reactive power control strategy for PV inverters in rural LV distribution feeders with high PV penetration.The strategy optimizes residential PV inverter reactive and active power control to enhance voltage quality.It uses sensitivity coefficients derived from the inverse Jacobian matrix to assign adjustment weights to individual PV units and iteratively optimize their power outputs.The control sequence prioritizes reactive power increases;if the coefficients are below average or the inverters reach capacity,active power is curtailed until voltage issues are resolved.A simulation based on a real 37-node rural distribution network shows that the proposed method significantly reduces PV curtailment.Typical daily results indicate a curtailment rate of 1.47%,which is significantly lower than the 15.4%observed with the voltage droop-based control method.The total daily PV power output(measured every 15 min)increases from 5.55 to 6.41 MW,improving PV hosting capacity.展开更多
Changes in intestinal microecology play a crucial role in the pathogenesis and progression of metabolic diseases.Lycium barbarum polysaccharide(LBP)and quinoa ultrafine powder diet is a promising sources of prebiotics...Changes in intestinal microecology play a crucial role in the pathogenesis and progression of metabolic diseases.Lycium barbarum polysaccharide(LBP)and quinoa ultrafine powder diet is a promising sources of prebiotics.However,the potential synergistic effects of combining them as a microbiota-targeted dietary supplement to mitigate lipid accumulation in nonalcoholic fatty liver disease(NAFLD)remain unclear.Our study aims to provide evidence for the application food/nutrient synergy interventions in NAFLD management,and also to support the clarification of these mechanisms.Following 12 weeks of a high-fat diet(HFD)-inducing NAFLD and an 11-week intervention in rats,the combination of LBP and quinoa ultrafine powder significantly decreased hepatocyte lipid accumulation and improved lipid metabolism disorders compared with those using either LBP or quinoa ultrafine powder alone.The combination increased beneficial intestinal microbiota,such as Lactobacillus acidophilus,Roseburia,Ruminococcus 2,and Prevotella,promoting the production of short-chain fatty acids,notably butyric acid,and then activated AMP-activated protein kinase/sterol regulatory element-binding protein 1C/stearoyl-CoA desaturase 1(AMPK/SREBP-1C/SCD-1)signaling.Combining LBP with quinoa ultrafine powder is a promising microbiota-targeted dietary supplement for ameliorating lipid disorders in NAFLD.展开更多
BACKGROUND Complicated crown–root fracture (CRF) involves severe injury to the crown, root,and pulp, and may be accompanied by multiple root fractures. The loss of a toothhas lifelong consequences for children and te...BACKGROUND Complicated crown–root fracture (CRF) involves severe injury to the crown, root,and pulp, and may be accompanied by multiple root fractures. The loss of a toothhas lifelong consequences for children and teenagers, but the maintenance of pulphealth and the calcific healing of multiple root fractures are rarely reported in theliterature.CASE SUMMARY This case reports healing of a permanent tooth with complicated crown–root andadditional root fractures, in which pulp health was maintained. A 10-year-old girlfell and fractured the root of her maxillary left central incisor at the cervical level.After the coronal fragment was repositioned, the tooth was splinted until thetooth was no longer mobile, 2 years later. Eight years after treatment, the toothhas remained asymptomatic with vital pulp and localized gingival overgrowth.Cone-beam computed tomography revealed not only calcified healing of the CRFbut also spontaneous healing in an additional undiagnosed root fracture. Thefracture line on the enamel could not be healed by hard tissue and formed agroove in the cervical crown. It was speculated that the groove was related to thelocalized gingival overgrowth.CONCLUSION This case provides a clinical perspective of the treatment of a tooth with acomplicated CRF and an additional root fracture.展开更多
The practical application of lithium-sulfur(Li-S)batteries is still impeded by the severe shuttle effect of lithium polysulfides(LiPSs)and sluggish reaction kinetics of active sulfur.Designing catalytic carriers with ...The practical application of lithium-sulfur(Li-S)batteries is still impeded by the severe shuttle effect of lithium polysulfides(LiPSs)and sluggish reaction kinetics of active sulfur.Designing catalytic carriers with abundant active sites and strong chemisorption capability for LiPSs,is regarded as effective strategy to address these issues.Herein,Se-doping is introduced into the nitrogen-doped carbon coated CoP composite(Se-CoP@NC)to generate structural defects,which effectively enlarges the lattice spacing of CoP and reduces the conversion reaction energy barriers of LiPSs.Meanwhile,Se-doping sites bridges the interface of CoP and nitrogen-doped carbon,accelerating the charge transfer behavior and conversion reaction kinetics of LiPSs.Benefiting from the structural advantages,the assembled Li-S batteries with S/Se-CoP@NC as cathode exhibit high reversible capacity of 779.6 mAh/g at 0.5 C after 500 cycles,and high specific capacity of 805.9 mAh/g at 2 C.Even under extreme conditions(high sulfur-loading content of 6.9 mg/cm^(2);lean electrolyte dosage of 7μL/mg),the corresponding Li-S batteries also keep high reversible areal capacity of 4.5 mAh/cm^(2) after 100 cycles at 0.1 C.This work will inspire the design of metal compounds-based catalysts from atomic level to facilitate the practicability of Li-S batteries.展开更多
Dear editor,As of 2023,the domestic cat population in China reached 65 million,surpassing dogs to become the most numerous companion animal in the country.Feline calicivirus(FCV)infection,one of the three most prevale...Dear editor,As of 2023,the domestic cat population in China reached 65 million,surpassing dogs to become the most numerous companion animal in the country.Feline calicivirus(FCV)infection,one of the three most prevalent infectious diseases in cats,poses a severe threat to feline health.FCV,classified under the Caliciviridae family(genus Vesivirus).展开更多
Streptococcus suis serotype 2(SS2)is an emerging zoonotic pathogen that causes meningitis in humans and pigs.This pathogen generates substantial economic losses in the swine industry while posing a significant threat ...Streptococcus suis serotype 2(SS2)is an emerging zoonotic pathogen that causes meningitis in humans and pigs.This pathogen generates substantial economic losses in the swine industry while posing a significant threat to public health security.The mechanisms through which SS2 penetrates the brain and induces meningitis remain incompletely understood.This study examines the role and mechanism of SS2 collagenase-like protease(Clp)in facilitating bacterial passage across the blood-brain barrier(BBB).The research demonstrates that SS2 Clp enhanced virulence and tissue colonization while promoting BBB degradation in mice.The Δclp mutant exhibited reduced ability to traverse human brain microvascular endothelial(hCMEC/D3)cell monolayers compared to wild-type SS2,while the addition of recombinant protein rClp increased permeability.Furthermore,rClp significantly enhanced SS2 adhesion to hCMEC/D3,suppressed the expression of intercellular tight junction proteins ZO-1,Occludin,and Claudin-5 independent of its enzyme activity,and triggered hCMEC/D3 apoptosis through cell receptor ligand apoptosis and mitochondrial apoptosis pathways,partially dependent on its enzyme activity,leading to BBB disruption and enhanced permeability.Additionally,Clp enhanced the infiltration of macrophages(F4/80+),monocytes(F4/80-Ly6C+),and neutrophils(Ly6G+)into the brain following SS2 infection.These findings establish that SS2 Clp is essential for bacterial passage across the BBB,offering a theoretical foundation for improved prevention and treatment strategies for SS2-induced meningitis.展开更多
Small interfering RNA(siRNA),a promising revolutionary therapy,faces delivery obstacles due to its poor targeting,strong charge negativity and macromolecular nature.Clinical-approved siRNAs can now only be delivered t...Small interfering RNA(siRNA),a promising revolutionary therapy,faces delivery obstacles due to its poor targeting,strong charge negativity and macromolecular nature.Clinical-approved siRNAs can now only be delivered to the liver mediated by the chemically conjugated N-acetylgalactosamine(GalNAc)ligand,the conjugate can be effectively uptaken into cells through interaction with asialoglycoprotein receptor(ASGPR)highly expressed on liver hepatocytes.To further explore an efficient non-hepatic targeted delivery strategy,in this study,we designed a delivery system that chemically conjugated p53 siRNA to renal tubular cell-targeting peptides for targeting the kidney,which was suitable for industrial transformation.Results showed that peptide-siRNA conjugate could specifically enter renal tubular epithelial cells and silence target genes.In cisplatin-induced acute kidney injury(AKI)mice,peptide-siRNA conjugate blocked the p53-mediated apoptotic pathway and alleviated renal damage.The innovative proposed system to conjugate kidney-targeting peptides with siRNA achieved the efficient kidney-targeted delivery of si RNA and provided a prospective choice for treating AKI.展开更多
BACKGROUND Hepatocellular carcinoma(HCC)ranks as the fourth leading cause of cancerrelated deaths in China,and the treatment options are limited.The cyclic guanosine monophosphate-adenosine monophosphate synthase(cGAS...BACKGROUND Hepatocellular carcinoma(HCC)ranks as the fourth leading cause of cancerrelated deaths in China,and the treatment options are limited.The cyclic guanosine monophosphate-adenosine monophosphate synthase(cGAS)activates the stimulator of interferon gene(STING)signaling pathway as a crucial immune response pathway in the cytoplasm,which detects cytoplasmic DNA to regulate innate and adaptive immune responses.As a potential therapeutic target,cGASSTING pathway markedly inhibits tumor cell proliferation and metastasis,with its activation being particularly relevant in HCC.However,prolonged pathway activation may lead to an immunosuppressive tumor microenvironment,which fostering the invasion or metastasis of liver tumor cells.AIM To investigate the dual-regulation mechanism of cGAS-STING in HCC.METHODS This review was conducted according to the PRISMA guidelines.The study conducted a comprehensive search for articles related to HCC on PubMed and Web of Science databases.Through rigorous screening and meticulous analysis of the retrieved literature,the research aimed to summarize and elucidate the impact of the cGAS-STING pathway on HCC tumors.RESULTS All authors collaboratively selected studies for inclusion,extracted data,and the initial search of online databases yielded 1445 studies.After removing duplicates,remaining 964 records were screened.Ultimately,55 articles met the inclusion criteria and were included in this review.CONCLUSION Acute inflammation can have a few inhibitory effects on cancer,while chronic inflammation generally promotes its progression.Extended cGAS-STING pathway activation will result in a suppressive tumor microenvironment.展开更多
The demand for anisotropic aerogels with excellent comprehensive properties in cutting-edge fields such as aerospace is growing.Based on the above background,a novel heterocyclic para-aramid nanofiber/reduced graphene...The demand for anisotropic aerogels with excellent comprehensive properties in cutting-edge fields such as aerospace is growing.Based on the above background,a novel heterocyclic para-aramid nanofiber/reduced graphene oxide(HPAN/rGO)composite aerogel was prepared by combining electrospinning and unidirectional freeze-drying.The anisotropic HPAN/rGO composite aerogel exhibited a honeycomb morphology in the direction perpendicular to the growth of ice crystals,and a through-well structure of directed microchannels in the direction parallel to the temperature gradient.By varying the mass ratio of HPAN/rGO,a composite aerogel with an ultra-low density of 5.34-7.81 mg·cm^(-3) and an ultra-high porosity of 98%-99%was obtained.Benefiting from the anisotropic structure,the radial and axial thermal conductivities of HPAN/rGO-3 composite aerogel were 29.37 and 44.35 mW·m^(-1)·K^(-1),respectively.A combination of software simulation and experiments was used to analyze the effect of anisotropic structures on the thermal insulation properties of aerogels.Moreover,due to the intrinsic self-extinguishing properties of heterocyclic para-aramid and the protection of the graphene carbon layer,the composite aerogel also exhibits excellent flame retardancy properties,and its total heat release rate(THR)was only 5.8 kJ·g^(-1),which is far superior to many reported aerogels.Therefore,ultralight anisotropic HPAN/rGO composite aerogels with excellent high-temperature thermal insulation and flame retardancy properties have broad application prospects in complex environments such as aerospace.展开更多
In the paper,copepod universal formulas are applied to construct a copepod individual-based model(IBM),and a genetic algorithm(GA)is incorporated in the formulas with genes as species parameters.The IBM initially cons...In the paper,copepod universal formulas are applied to construct a copepod individual-based model(IBM),and a genetic algorithm(GA)is incorporated in the formulas with genes as species parameters.The IBM initially constructs the individuals with all possible genes similar to the original state of natural selection.Climate-averaged temperature and chlorophyll a(Chl a)time series at the surface layer of fixed points in the Georges Bank(GB)and the Gulf of Maine(GOM)are taken as the model environment.The IBM has been running for 50 a in the environment without inter-annual change.The IBM results indicate that some of the life history traits of the top ten abundant species output by the IBM in the GB and the GOM are consistent with the real species Calanus finmarchicus,Pseudocalanus spp.,Centropages typicus,and Centropages hamatus in terms of reproduction strategy,time to reach the maximum abundance,water temperature preference,and adult body mass.The study of the top ten abundant species with multidimensional scaling(MDS)and clustering analysis(CA)methods indicates that reproduction strategy is the basis for grouping.For the species taking the broadcasting strategy,both GB and GOM environments tend to choose smallbodied species with cold-water preference,such as Pseudocalanus spp.;for the species taking the egg-carrying strategies,the GB environment selects large-bodied species with cold-water preference,such as C.finmarchicus,while the GOM environment selects medium-bodied species with warm-water preference,such as Centropages spp.(C.typicus and C.hamatus).After gene mutation is added to the IBM,the model result gets simple,which needs to be further improved.The significance of the paper lies in systematically studying the impact of GB and GOM environments on the evolutionary life history traits of copepods for the first time.展开更多
Photo-responsive metal-organic frameworks(MOFs)have evoked considerable attention due to their potential application in inkless printing paper.However,the poor cycling performance and low printing resolution greatly i...Photo-responsive metal-organic frameworks(MOFs)have evoked considerable attention due to their potential application in inkless printing paper.However,the poor cycling performance and low printing resolution greatly inhibit their practical application.Herein,a novel MOF based on naphthalenediimide derivate moiety,[La(H_(2)O)(BINDI)_(0.5)(DMF)_(3)][NO_(3)](1,H_(4)BINDI=N,N'-bis(5-isophthalic acid)naphthalenediimide),was successfully synthesized for inkless erasable printing.This material exhibits reversible photochromic behavior and good stability.The inkless printing paper coated with 1 delivers high resolution reaching up to 0.2 mm,comparable to commercial printers.Furthermore,the stable framework and suitable reversibility enable excellent cycling performance with 197 cycles,surpassing almost all reported MOFs.This work sheds light on new opportunities in designing outstanding photochromic MOFs for ink-free printing.展开更多
Objective:To evaluate the nursing value of mechanical expectoration drainage combined with traditional Chinese medicine acupoint application in children with pediatric bronchial pneumonia.Methods:A total of 62 childre...Objective:To evaluate the nursing value of mechanical expectoration drainage combined with traditional Chinese medicine acupoint application in children with pediatric bronchial pneumonia.Methods:A total of 62 children with pediatric bronchial pneumonia treated from May 2024 to May 2025 were selected as samples and randomly divided into groups using a random number table.Group A received mechanical expectoration drainage combined with traditional Chinese medicine acupoint application nursing,while Group B received conventional nursing.Lung function,symptom disappearance time,nursing satisfaction,and inflammatory indicators were compared between the two groups.Results:The maximum vital capacity(FVC),forced expiratory volume in one second(FEV),peak expiratory flow(PEF),and maximal mid-expiratory flow(MMEF)in Group A were all higher than those in Group B,with p<0.05;the symptom disappearance time in Group A was shorter than that in Group B,and nursing satisfaction was higher in Group A than in Group B,with p<0.05;the procalcitonin(PCT),white blood cell count(WBC),and serum amyloid A(SAA)levels in Group A were lower than those in Group B,with p<0.05.Conclusion:The application of mechanical expectoration drainage combined with traditional Chinese medicine acupoint application nursing in the care of children with pediatric bronchial pneumonia reduces inflammation levels,shortens symptom disappearance time,and improves lung function.展开更多
Aflatoxin B1(AFB1)is a carcinogenic toxin naturally produced in most food crops that severely threaten human health,and effective methods are urgent to improve the detection accuracy.Herein an indirect competitive imm...Aflatoxin B1(AFB1)is a carcinogenic toxin naturally produced in most food crops that severely threaten human health,and effective methods are urgent to improve the detection accuracy.Herein an indirect competitive immunosorbent approach was elaborately developed based on high-affinity immunoglobulin G(IgG)coupled CuO-anchored Fe_(3)O_(4)nanozymes for precise and ultrasensitive detection of AFB_(1)in food crops including peanut,corn and wheat.The high-affinity nanozymes were fabricated by the assembly of inner core Fe_(3)O_(4)nanoparticles and mesoporous silica capping layer,Cu O further situated within large aperture of the coating layer via in-situ growth,and then conjugated with ligand rabbit anti-mouse Ig G,which can specifically bind with AFB_(1).The results showed the hybrid high-affinity nanozymes displayed enhanced peroxidasemimic activities and catalytic performances,achieving a linear range of 0.06-61.93(lg(ng/mL))and a detection limit of 0.0037 ng/mL,30 times better than that of the conventional enzyme-linked immunosorbent assay.The constructed nanozymes were successfully applied to the detection of AFB_(1)in food products with an average spiked recovery of 96.53%and relative standard deviations less than 2.8%.Therefore,the accurate hybrid nanozymes may serve for AFB_(1)detection in various foods in future.展开更多
The equilibrium melting point(T_(m)^(0))is a crucial thermodynamic parameter for characterizing the crystallization and melting behavior of semi-crystalline polymers.However,the direct measurement of T_(m)^(0) poses a...The equilibrium melting point(T_(m)^(0))is a crucial thermodynamic parameter for characterizing the crystallization and melting behavior of semi-crystalline polymers.However,the direct measurement of T_(m)^(0) poses a significant challenge because of the difficulty in physically fabricating fully-extended chain crystals of high-molecular-weight polymers.Therefore,various extrapolation equations for T_(m)^(0) have been proposed that utilize the thermal properties of ordinary folded-chain lamellae.Among these,the Gibbs-Thomson equation is one of the most commonly employed for modeling.Despite its widespread use,there are notable variations in the T_(m)^(0) values obtained by different research groups,even when based on similar samples.This raises questions about the validity and accuracy of using the Gibbs-Thomson equation to linearly extrapolate T_(m)^(0).In this study,we prepared a series of oligomer extended-chain crystals(ECCs)of poly(butylene succinate)(PBS)and used their properties for Gibbs-Thomson fitting.The results reveal a perfect linear relationship,with an extrapolated T_(m)^(0) value of 136.08℃.The basal surface free energy of the oligomer ECCs was calculated as 0.084 J/m^(2),which is approximately twice that of folded-chain lamellae.This difference is attributed to the aggregation of highly mobile free tails on the crystal surface.The two structural features of oligomer ECCs—large thickness and fixed surface—better fulfill the conditions for applying the Gibbs-Thomson equation,ensuring its validity and accuracy.Therefore,we believe that the Gibbs-Thomson fit can produce reliable results when sufficient high-quality data are used.展开更多
Spinal disorders are diseases caused by congenital, degenerative, postural errors, trauma, and external evils that result in lesions of bones, discs, ligaments, and muscles, thus compressing the nerves. Spine-related ...Spinal disorders are diseases caused by congenital, degenerative, postural errors, trauma, and external evils that result in lesions of bones, discs, ligaments, and muscles, thus compressing the nerves. Spine-related diseases include scoliosis, intervertebral disc herniation, intervertebral stenosis, spinal fracture, ankylosing spondylitis, spinal cord injury, spinal tumour, etc., which seriously affect people’s daily life. This paper summarises the relevant studies on the treatment of spinal diseases by Tongzhu therapy. The mechanism of action of Tongzhu therapy in treating spinal diseases is closely related to the control of inflammatory factors, the improvement of local microcirculation, analgesia, and the promotion of nerve repair. This paper describes the application and modern mechanism of Tongzhu therapy in the treatment of spinal diseases, which will provide a direction for future research on Tongzhu therapy.展开更多
Chronic intermittent hypobaric hypoxia(CIHH)is known to have an anti-hypertensive effect, which might be related to modulation of the baroreflex in rats with renal vascular hypertension(RVH). In this study, RVH was in...Chronic intermittent hypobaric hypoxia(CIHH)is known to have an anti-hypertensive effect, which might be related to modulation of the baroreflex in rats with renal vascular hypertension(RVH). In this study, RVH was induced by the 2-kidney-1-clip method(2 K1 C) in adult male Sprague-Dawley rats. The rats were then treated with hypobaric hypoxia simulating 5000 m altitude for 6 h/day for 28 days. The arterial blood pressure(ABP), heart rate(HR), and renal sympathetic nerve activity(RSNA) were measured before and after microinjection of L-arginine into the nucleus tractus solitarii(NTS) in anesthetized rats.Evoked excitatory postsynaptic currents(eEPSCs) and spontaneous EPSCs(sEPSCs) were recorded in anterogradely-labeled NTS neurons receiving baroreceptor afferents. We measured the protein expression of neuronal nitric oxide synthase(nNOS) and endothelial NOS(eNOS) in the NTS. The results showed that the ABP in RVH rats was significantly lower after CIHH treatment. The inhibition of ABP, HR, and RSNA induced by L-arginine was less in RVH rats than in sham rats, and greater in the CIHHtreated RVH rats than the untreated RVH rats. The eEPSC amplitude in NTS neurons receiving baroreceptor afferents was lower in the RVH rats than in the sham rats and recovered after CIHH. The protein expression of nNOS and e NOS in the NTS was lower in the RVH rats than in the sham rats and this decrease was reversed by CIHH. In short, CIHH treatment decreases ABP in RVH rats via upregulating NOS expression in the NTS.展开更多
Landslide displacement prediction can enhance the efficacy of landslide monitoring system,and the prediction of the periodic displacement is particularly challenging.In the previous studies,static regression models(e....Landslide displacement prediction can enhance the efficacy of landslide monitoring system,and the prediction of the periodic displacement is particularly challenging.In the previous studies,static regression models(e.g.,support vector machine(SVM))were mostly used for predicting the periodic displacement.These models may have bad performances,when the dynamic features of landslide triggers are incorporated.This paper proposes a method for predicting the landslide displacement in a dynamic manner,based on the gated recurrent unit(GRU)neural network and complete ensemble empirical decomposition with adaptive noise(CEEMDAN).The CEEMDAN is used to decompose the training data,and the GRU is subsequently used for predicting the periodic displacement.Implementation procedures of the proposed method were illustrated by a case study in the Caojiatuo landslide area,and SVM was also adopted for the periodic displacement prediction.This case study shows that the predictors obtained by SVM are inaccurate,as the landslide displacement is in a pronouncedly step-wise manner.By contrast,the accuracy can be significantly improved using the dynamic predictive method.This paper reveals the significance of capturing the dynamic features of the inputs in the training process,when the machine learning models are adopted to predict the landslide displacement.展开更多
Drought stress is the main limiting plant growth factor in arid and semiarid regions.The Lanzhou lily(Lilium davidii var.unicolor)is the only sweet-tasting lily grown in these regions of China that offers highly edibl...Drought stress is the main limiting plant growth factor in arid and semiarid regions.The Lanzhou lily(Lilium davidii var.unicolor)is the only sweet-tasting lily grown in these regions of China that offers highly edible,medicinal,health,and ornamental value.The Tresor lily is an ornamental flower known for its strong resistance.Plants were grown under three different drought intensity treatments,namely,being watered at intervals of 5,15,and 25 d(either throughout the study or during specific growth stages).We measured the biomass,leaf area,photosynthetic response,chlorophyll content(SPAD value),and osmoregulation of both the Lanzhou lily and the Tresor lily(Lilium‘Tresor’).Additionally,we employed RNA sequencing(RNA-Seq)and qRT-PCR to investigate transcriptomic changes of the Lanzhou lily in response to drought stress.Results showed that under drought stress,the decreasing rate in the Lanzhou lily bulb weight was lower than the corresponding Tresor lily bulb rate;the net photosynthetic rate,transpiration rate,and stomatal conductance of the Lanzhou lily were all higher compared to the Tresor lily;osmoregulation constituents,such as glucose,fructose,sucrose,trehalose,and soluble sugar,in the Lanzhou lily were comparatively higher;PYL,NCED,and ERS genes were significantly expressed in the Lanzhou lily.Under moderate drought,the biosynthesis of flavonoids,circadian rhythms,and the tryptophan metabolism pathway of the Lanzhou lily were all significant.Under severe drought stress,fatty acid elongation,photosynthetic antenna protein,plant hormone signal transduction,flavone and flavonol biosynthesis,and the carotenoid biosynthesis pathway were all significant.The Lanzhou lily adapted to drought stress by coordinating its organs and the unique role of its bulb,regulating photosynthesis,increasing osmolyte content,activating circadian rhythms,signal transduction,fatty acid elongation metabolism,and phenylalanine and flavonoid metabolic pathways,which may collectively be the main adaptation strategy and mechanisms used by the Lanzhou lily under drought stress.展开更多
The safety of lithium-ion batteries is an essential concern where instant and accurate temperature sensing is critical.It is generally desired to put sensors inside batteries for instant sensing.However,the transmissi...The safety of lithium-ion batteries is an essential concern where instant and accurate temperature sensing is critical.It is generally desired to put sensors inside batteries for instant sensing.However,the transmission of internal measurement outside batteries without interfering their normal state is a non-trivial task due to the harsh electrochemical environment,the particular packaging structures and the intrinsic electromagnetic shielding problems of batteries.In this work,a novel in-situ temperature sensing framework is proposed by incorporating temperature sensors with a novel signal transmission solution.The signal transmission solution uses a self-designed integrated-circuit which modulates the internal measurements outside battery via its positive pole without package breaking.Extensive experimental results validate the noninterference properties of the proposed framework.Our proposed in-situ temperature measurement by the self-designed signal modulation solution has a promising potential for in-situ battery health monitoring and thus promoting the development of smart batteries.展开更多
With the large-scale commercial launch of fifth generation(5G)mobile network,the development of new services and applications catering to the year 2030,along with the deep convergence of information,communication,and ...With the large-scale commercial launch of fifth generation(5G)mobile network,the development of new services and applications catering to the year 2030,along with the deep convergence of information,communication,and data technologies(ICDT),and the lessons and experiences from 5G practice will drive the evolution of the next generation of mobile networks.This article surveys the history and driving forces of the evolution of the mobile network architecture and proposes a logical function architecture for sixth generation(6G)mobile network.The proposed 6G network architecture is termed SOLIDS(related to the following basic features:soft,on-demand fulfillment,lite,native intelligence,digital twin,and native security),which can support self-generation,self-healing,self-evolution,and self-immunity without human involvement and address the primary issues in the legacy 5G network(e.g.,high cost,high power consumption,and highly complicated operation and maintenance),significantly well.展开更多
基金supported by the Provincial Industrial Science and Technology Project of State Grid Jiangsu Electric Power Co.,Ltd.of China,grant number JC2024118.
文摘The dense integration of residential distributed photovoltaic(PV)systems into three-phase,four-wire low-voltage(LV)distribution networks results in reverse power flow and three-phase imbalance,leading to voltage violations that hinder the growth of rural distributed PV systems.Traditional voltage droop-based control methods regulate PV power output solely based on local voltage measurements at the point of PV connection.Due to a lack of global coordination and optimization,their efficiency is often subpar.This paper presents a centralized coordinated active/reactive power control strategy for PV inverters in rural LV distribution feeders with high PV penetration.The strategy optimizes residential PV inverter reactive and active power control to enhance voltage quality.It uses sensitivity coefficients derived from the inverse Jacobian matrix to assign adjustment weights to individual PV units and iteratively optimize their power outputs.The control sequence prioritizes reactive power increases;if the coefficients are below average or the inverters reach capacity,active power is curtailed until voltage issues are resolved.A simulation based on a real 37-node rural distribution network shows that the proposed method significantly reduces PV curtailment.Typical daily results indicate a curtailment rate of 1.47%,which is significantly lower than the 15.4%observed with the voltage droop-based control method.The total daily PV power output(measured every 15 min)increases from 5.55 to 6.41 MW,improving PV hosting capacity.
基金funded by the Key Research Project of Ningxia(2021BEG03031)National Natural Science Foundation(82560643)Scientific Research Funding Project of Ningxia Medical University(XT2025025).
文摘Changes in intestinal microecology play a crucial role in the pathogenesis and progression of metabolic diseases.Lycium barbarum polysaccharide(LBP)and quinoa ultrafine powder diet is a promising sources of prebiotics.However,the potential synergistic effects of combining them as a microbiota-targeted dietary supplement to mitigate lipid accumulation in nonalcoholic fatty liver disease(NAFLD)remain unclear.Our study aims to provide evidence for the application food/nutrient synergy interventions in NAFLD management,and also to support the clarification of these mechanisms.Following 12 weeks of a high-fat diet(HFD)-inducing NAFLD and an 11-week intervention in rats,the combination of LBP and quinoa ultrafine powder significantly decreased hepatocyte lipid accumulation and improved lipid metabolism disorders compared with those using either LBP or quinoa ultrafine powder alone.The combination increased beneficial intestinal microbiota,such as Lactobacillus acidophilus,Roseburia,Ruminococcus 2,and Prevotella,promoting the production of short-chain fatty acids,notably butyric acid,and then activated AMP-activated protein kinase/sterol regulatory element-binding protein 1C/stearoyl-CoA desaturase 1(AMPK/SREBP-1C/SCD-1)signaling.Combining LBP with quinoa ultrafine powder is a promising microbiota-targeted dietary supplement for ameliorating lipid disorders in NAFLD.
基金Supported by 2021 Disciplinary Construction Project in School of Dentistry,Anhui Medical University,No.2021kqxkFY05.
文摘BACKGROUND Complicated crown–root fracture (CRF) involves severe injury to the crown, root,and pulp, and may be accompanied by multiple root fractures. The loss of a toothhas lifelong consequences for children and teenagers, but the maintenance of pulphealth and the calcific healing of multiple root fractures are rarely reported in theliterature.CASE SUMMARY This case reports healing of a permanent tooth with complicated crown–root andadditional root fractures, in which pulp health was maintained. A 10-year-old girlfell and fractured the root of her maxillary left central incisor at the cervical level.After the coronal fragment was repositioned, the tooth was splinted until thetooth was no longer mobile, 2 years later. Eight years after treatment, the toothhas remained asymptomatic with vital pulp and localized gingival overgrowth.Cone-beam computed tomography revealed not only calcified healing of the CRFbut also spontaneous healing in an additional undiagnosed root fracture. Thefracture line on the enamel could not be healed by hard tissue and formed agroove in the cervical crown. It was speculated that the groove was related to thelocalized gingival overgrowth.CONCLUSION This case provides a clinical perspective of the treatment of a tooth with acomplicated CRF and an additional root fracture.
基金the financial support from the National Natural Science Foundation of China(No.52101250)the S&T program of Hebei(Nos.215A4401D and 225A4404D)+5 种基金the Collaborative Innovation Center of Marine Science and Technology of Hainan University(No.XTCX2022HYC14)the Fundamental Research Funds for the Hebei University(No.2021YWF11)the Science Research Project of Hebei Education Department(No.QN2024087)the Xingtai City Natural Science Foundation(No.2023ZZ027)the Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education),College of Chemistry,Nankai Universitypartially supported by the Pico Election Microscopy Center of Hainan University。
文摘The practical application of lithium-sulfur(Li-S)batteries is still impeded by the severe shuttle effect of lithium polysulfides(LiPSs)and sluggish reaction kinetics of active sulfur.Designing catalytic carriers with abundant active sites and strong chemisorption capability for LiPSs,is regarded as effective strategy to address these issues.Herein,Se-doping is introduced into the nitrogen-doped carbon coated CoP composite(Se-CoP@NC)to generate structural defects,which effectively enlarges the lattice spacing of CoP and reduces the conversion reaction energy barriers of LiPSs.Meanwhile,Se-doping sites bridges the interface of CoP and nitrogen-doped carbon,accelerating the charge transfer behavior and conversion reaction kinetics of LiPSs.Benefiting from the structural advantages,the assembled Li-S batteries with S/Se-CoP@NC as cathode exhibit high reversible capacity of 779.6 mAh/g at 0.5 C after 500 cycles,and high specific capacity of 805.9 mAh/g at 2 C.Even under extreme conditions(high sulfur-loading content of 6.9 mg/cm^(2);lean electrolyte dosage of 7μL/mg),the corresponding Li-S batteries also keep high reversible areal capacity of 4.5 mAh/cm^(2) after 100 cycles at 0.1 C.This work will inspire the design of metal compounds-based catalysts from atomic level to facilitate the practicability of Li-S batteries.
基金supported by grants from the National Key Research and Development Program of China(Grant No.2022YFD1800100)National Natural Science Foundation of China(Grant No.32272982)Natural Science Foundation of Shanghai(Grant No.23ZR1477100).
文摘Dear editor,As of 2023,the domestic cat population in China reached 65 million,surpassing dogs to become the most numerous companion animal in the country.Feline calicivirus(FCV)infection,one of the three most prevalent infectious diseases in cats,poses a severe threat to feline health.FCV,classified under the Caliciviridae family(genus Vesivirus).
基金supported by the National Key Research and Development Program of China(2021FYD1800405)the National Natural Science Foundation of China(32072823).
文摘Streptococcus suis serotype 2(SS2)is an emerging zoonotic pathogen that causes meningitis in humans and pigs.This pathogen generates substantial economic losses in the swine industry while posing a significant threat to public health security.The mechanisms through which SS2 penetrates the brain and induces meningitis remain incompletely understood.This study examines the role and mechanism of SS2 collagenase-like protease(Clp)in facilitating bacterial passage across the blood-brain barrier(BBB).The research demonstrates that SS2 Clp enhanced virulence and tissue colonization while promoting BBB degradation in mice.The Δclp mutant exhibited reduced ability to traverse human brain microvascular endothelial(hCMEC/D3)cell monolayers compared to wild-type SS2,while the addition of recombinant protein rClp increased permeability.Furthermore,rClp significantly enhanced SS2 adhesion to hCMEC/D3,suppressed the expression of intercellular tight junction proteins ZO-1,Occludin,and Claudin-5 independent of its enzyme activity,and triggered hCMEC/D3 apoptosis through cell receptor ligand apoptosis and mitochondrial apoptosis pathways,partially dependent on its enzyme activity,leading to BBB disruption and enhanced permeability.Additionally,Clp enhanced the infiltration of macrophages(F4/80+),monocytes(F4/80-Ly6C+),and neutrophils(Ly6G+)into the brain following SS2 infection.These findings establish that SS2 Clp is essential for bacterial passage across the BBB,offering a theoretical foundation for improved prevention and treatment strategies for SS2-induced meningitis.
基金supported by the National Key Technologies Research and Development Plan(No.2021YFE0106900)the National Natural Science Foundation of China(No.82173769)+1 种基金the Basic Research Cooperation Project of Beijing,Tianjin,Hebei from the Natural Science Foundation of Tianjin(No.20JCZXJC00070)the Applied Basic Research Multi-investment Foundation of Tianjin(No.21JCYBJC01540)。
文摘Small interfering RNA(siRNA),a promising revolutionary therapy,faces delivery obstacles due to its poor targeting,strong charge negativity and macromolecular nature.Clinical-approved siRNAs can now only be delivered to the liver mediated by the chemically conjugated N-acetylgalactosamine(GalNAc)ligand,the conjugate can be effectively uptaken into cells through interaction with asialoglycoprotein receptor(ASGPR)highly expressed on liver hepatocytes.To further explore an efficient non-hepatic targeted delivery strategy,in this study,we designed a delivery system that chemically conjugated p53 siRNA to renal tubular cell-targeting peptides for targeting the kidney,which was suitable for industrial transformation.Results showed that peptide-siRNA conjugate could specifically enter renal tubular epithelial cells and silence target genes.In cisplatin-induced acute kidney injury(AKI)mice,peptide-siRNA conjugate blocked the p53-mediated apoptotic pathway and alleviated renal damage.The innovative proposed system to conjugate kidney-targeting peptides with siRNA achieved the efficient kidney-targeted delivery of si RNA and provided a prospective choice for treating AKI.
基金Supported by the National Natural Science Foundation of China,No.81973840the Sichuan Provincial Administration of Traditional Chinese Medicine Major Science and Technology projects,No.2021XYCZ004。
文摘BACKGROUND Hepatocellular carcinoma(HCC)ranks as the fourth leading cause of cancerrelated deaths in China,and the treatment options are limited.The cyclic guanosine monophosphate-adenosine monophosphate synthase(cGAS)activates the stimulator of interferon gene(STING)signaling pathway as a crucial immune response pathway in the cytoplasm,which detects cytoplasmic DNA to regulate innate and adaptive immune responses.As a potential therapeutic target,cGASSTING pathway markedly inhibits tumor cell proliferation and metastasis,with its activation being particularly relevant in HCC.However,prolonged pathway activation may lead to an immunosuppressive tumor microenvironment,which fostering the invasion or metastasis of liver tumor cells.AIM To investigate the dual-regulation mechanism of cGAS-STING in HCC.METHODS This review was conducted according to the PRISMA guidelines.The study conducted a comprehensive search for articles related to HCC on PubMed and Web of Science databases.Through rigorous screening and meticulous analysis of the retrieved literature,the research aimed to summarize and elucidate the impact of the cGAS-STING pathway on HCC tumors.RESULTS All authors collaboratively selected studies for inclusion,extracted data,and the initial search of online databases yielded 1445 studies.After removing duplicates,remaining 964 records were screened.Ultimately,55 articles met the inclusion criteria and were included in this review.CONCLUSION Acute inflammation can have a few inhibitory effects on cancer,while chronic inflammation generally promotes its progression.Extended cGAS-STING pathway activation will result in a suppressive tumor microenvironment.
基金supported by the National Key R&D Program of China(No.2021YFB3700103).
文摘The demand for anisotropic aerogels with excellent comprehensive properties in cutting-edge fields such as aerospace is growing.Based on the above background,a novel heterocyclic para-aramid nanofiber/reduced graphene oxide(HPAN/rGO)composite aerogel was prepared by combining electrospinning and unidirectional freeze-drying.The anisotropic HPAN/rGO composite aerogel exhibited a honeycomb morphology in the direction perpendicular to the growth of ice crystals,and a through-well structure of directed microchannels in the direction parallel to the temperature gradient.By varying the mass ratio of HPAN/rGO,a composite aerogel with an ultra-low density of 5.34-7.81 mg·cm^(-3) and an ultra-high porosity of 98%-99%was obtained.Benefiting from the anisotropic structure,the radial and axial thermal conductivities of HPAN/rGO-3 composite aerogel were 29.37 and 44.35 mW·m^(-1)·K^(-1),respectively.A combination of software simulation and experiments was used to analyze the effect of anisotropic structures on the thermal insulation properties of aerogels.Moreover,due to the intrinsic self-extinguishing properties of heterocyclic para-aramid and the protection of the graphene carbon layer,the composite aerogel also exhibits excellent flame retardancy properties,and its total heat release rate(THR)was only 5.8 kJ·g^(-1),which is far superior to many reported aerogels.Therefore,ultralight anisotropic HPAN/rGO composite aerogels with excellent high-temperature thermal insulation and flame retardancy properties have broad application prospects in complex environments such as aerospace.
基金The National Natural Science Foundation of China Project under contract No.42206150the Technology Development Program of Shanghai Ocean University under contract No.A2-2006-20-200207.
文摘In the paper,copepod universal formulas are applied to construct a copepod individual-based model(IBM),and a genetic algorithm(GA)is incorporated in the formulas with genes as species parameters.The IBM initially constructs the individuals with all possible genes similar to the original state of natural selection.Climate-averaged temperature and chlorophyll a(Chl a)time series at the surface layer of fixed points in the Georges Bank(GB)and the Gulf of Maine(GOM)are taken as the model environment.The IBM has been running for 50 a in the environment without inter-annual change.The IBM results indicate that some of the life history traits of the top ten abundant species output by the IBM in the GB and the GOM are consistent with the real species Calanus finmarchicus,Pseudocalanus spp.,Centropages typicus,and Centropages hamatus in terms of reproduction strategy,time to reach the maximum abundance,water temperature preference,and adult body mass.The study of the top ten abundant species with multidimensional scaling(MDS)and clustering analysis(CA)methods indicates that reproduction strategy is the basis for grouping.For the species taking the broadcasting strategy,both GB and GOM environments tend to choose smallbodied species with cold-water preference,such as Pseudocalanus spp.;for the species taking the egg-carrying strategies,the GB environment selects large-bodied species with cold-water preference,such as C.finmarchicus,while the GOM environment selects medium-bodied species with warm-water preference,such as Centropages spp.(C.typicus and C.hamatus).After gene mutation is added to the IBM,the model result gets simple,which needs to be further improved.The significance of the paper lies in systematically studying the impact of GB and GOM environments on the evolutionary life history traits of copepods for the first time.
基金supported by the National Natural Science Foundation of China(Nos.21905142 and 22035003)the Programme of Introducing Talents of Discipline to Universities(No.B18030)。
文摘Photo-responsive metal-organic frameworks(MOFs)have evoked considerable attention due to their potential application in inkless printing paper.However,the poor cycling performance and low printing resolution greatly inhibit their practical application.Herein,a novel MOF based on naphthalenediimide derivate moiety,[La(H_(2)O)(BINDI)_(0.5)(DMF)_(3)][NO_(3)](1,H_(4)BINDI=N,N'-bis(5-isophthalic acid)naphthalenediimide),was successfully synthesized for inkless erasable printing.This material exhibits reversible photochromic behavior and good stability.The inkless printing paper coated with 1 delivers high resolution reaching up to 0.2 mm,comparable to commercial printers.Furthermore,the stable framework and suitable reversibility enable excellent cycling performance with 197 cycles,surpassing almost all reported MOFs.This work sheds light on new opportunities in designing outstanding photochromic MOFs for ink-free printing.
文摘Objective:To evaluate the nursing value of mechanical expectoration drainage combined with traditional Chinese medicine acupoint application in children with pediatric bronchial pneumonia.Methods:A total of 62 children with pediatric bronchial pneumonia treated from May 2024 to May 2025 were selected as samples and randomly divided into groups using a random number table.Group A received mechanical expectoration drainage combined with traditional Chinese medicine acupoint application nursing,while Group B received conventional nursing.Lung function,symptom disappearance time,nursing satisfaction,and inflammatory indicators were compared between the two groups.Results:The maximum vital capacity(FVC),forced expiratory volume in one second(FEV),peak expiratory flow(PEF),and maximal mid-expiratory flow(MMEF)in Group A were all higher than those in Group B,with p<0.05;the symptom disappearance time in Group A was shorter than that in Group B,and nursing satisfaction was higher in Group A than in Group B,with p<0.05;the procalcitonin(PCT),white blood cell count(WBC),and serum amyloid A(SAA)levels in Group A were lower than those in Group B,with p<0.05.Conclusion:The application of mechanical expectoration drainage combined with traditional Chinese medicine acupoint application nursing in the care of children with pediatric bronchial pneumonia reduces inflammation levels,shortens symptom disappearance time,and improves lung function.
基金supported by the Scientific and Technological Project of Henan Province(232102321117)National Natural Science Foundation of China(82202198)+2 种基金the National Engineering Research Center of Wheat and Corn Further Processing of Henan University of Technology(NL2022010)Project of Basic Research Fund of Henan Provincial Institute of Medical and Pharmacological Sciences(2023BP0106)the Innovative Funds Plan of Henan University of Technology(2020ZKCJ23)。
文摘Aflatoxin B1(AFB1)is a carcinogenic toxin naturally produced in most food crops that severely threaten human health,and effective methods are urgent to improve the detection accuracy.Herein an indirect competitive immunosorbent approach was elaborately developed based on high-affinity immunoglobulin G(IgG)coupled CuO-anchored Fe_(3)O_(4)nanozymes for precise and ultrasensitive detection of AFB_(1)in food crops including peanut,corn and wheat.The high-affinity nanozymes were fabricated by the assembly of inner core Fe_(3)O_(4)nanoparticles and mesoporous silica capping layer,Cu O further situated within large aperture of the coating layer via in-situ growth,and then conjugated with ligand rabbit anti-mouse Ig G,which can specifically bind with AFB_(1).The results showed the hybrid high-affinity nanozymes displayed enhanced peroxidasemimic activities and catalytic performances,achieving a linear range of 0.06-61.93(lg(ng/mL))and a detection limit of 0.0037 ng/mL,30 times better than that of the conventional enzyme-linked immunosorbent assay.The constructed nanozymes were successfully applied to the detection of AFB_(1)in food products with an average spiked recovery of 96.53%and relative standard deviations less than 2.8%.Therefore,the accurate hybrid nanozymes may serve for AFB_(1)detection in various foods in future.
基金financially supported by the National Natural Science Foundation of China(Nos.22473113 and 22173116).
文摘The equilibrium melting point(T_(m)^(0))is a crucial thermodynamic parameter for characterizing the crystallization and melting behavior of semi-crystalline polymers.However,the direct measurement of T_(m)^(0) poses a significant challenge because of the difficulty in physically fabricating fully-extended chain crystals of high-molecular-weight polymers.Therefore,various extrapolation equations for T_(m)^(0) have been proposed that utilize the thermal properties of ordinary folded-chain lamellae.Among these,the Gibbs-Thomson equation is one of the most commonly employed for modeling.Despite its widespread use,there are notable variations in the T_(m)^(0) values obtained by different research groups,even when based on similar samples.This raises questions about the validity and accuracy of using the Gibbs-Thomson equation to linearly extrapolate T_(m)^(0).In this study,we prepared a series of oligomer extended-chain crystals(ECCs)of poly(butylene succinate)(PBS)and used their properties for Gibbs-Thomson fitting.The results reveal a perfect linear relationship,with an extrapolated T_(m)^(0) value of 136.08℃.The basal surface free energy of the oligomer ECCs was calculated as 0.084 J/m^(2),which is approximately twice that of folded-chain lamellae.This difference is attributed to the aggregation of highly mobile free tails on the crystal surface.The two structural features of oligomer ECCs—large thickness and fixed surface—better fulfill the conditions for applying the Gibbs-Thomson equation,ensuring its validity and accuracy.Therefore,we believe that the Gibbs-Thomson fit can produce reliable results when sufficient high-quality data are used.
文摘Spinal disorders are diseases caused by congenital, degenerative, postural errors, trauma, and external evils that result in lesions of bones, discs, ligaments, and muscles, thus compressing the nerves. Spine-related diseases include scoliosis, intervertebral disc herniation, intervertebral stenosis, spinal fracture, ankylosing spondylitis, spinal cord injury, spinal tumour, etc., which seriously affect people’s daily life. This paper summarises the relevant studies on the treatment of spinal diseases by Tongzhu therapy. The mechanism of action of Tongzhu therapy in treating spinal diseases is closely related to the control of inflammatory factors, the improvement of local microcirculation, analgesia, and the promotion of nerve repair. This paper describes the application and modern mechanism of Tongzhu therapy in the treatment of spinal diseases, which will provide a direction for future research on Tongzhu therapy.
基金supported by the National Natural Science Foundation of China(31071002,31271223,31671184,and 81800308)the National Basic Research Development Program of China(2012CB518200)the Natural Science Foundation of Hebei Province(C2012206001),China
文摘Chronic intermittent hypobaric hypoxia(CIHH)is known to have an anti-hypertensive effect, which might be related to modulation of the baroreflex in rats with renal vascular hypertension(RVH). In this study, RVH was induced by the 2-kidney-1-clip method(2 K1 C) in adult male Sprague-Dawley rats. The rats were then treated with hypobaric hypoxia simulating 5000 m altitude for 6 h/day for 28 days. The arterial blood pressure(ABP), heart rate(HR), and renal sympathetic nerve activity(RSNA) were measured before and after microinjection of L-arginine into the nucleus tractus solitarii(NTS) in anesthetized rats.Evoked excitatory postsynaptic currents(eEPSCs) and spontaneous EPSCs(sEPSCs) were recorded in anterogradely-labeled NTS neurons receiving baroreceptor afferents. We measured the protein expression of neuronal nitric oxide synthase(nNOS) and endothelial NOS(eNOS) in the NTS. The results showed that the ABP in RVH rats was significantly lower after CIHH treatment. The inhibition of ABP, HR, and RSNA induced by L-arginine was less in RVH rats than in sham rats, and greater in the CIHHtreated RVH rats than the untreated RVH rats. The eEPSC amplitude in NTS neurons receiving baroreceptor afferents was lower in the RVH rats than in the sham rats and recovered after CIHH. The protein expression of nNOS and e NOS in the NTS was lower in the RVH rats than in the sham rats and this decrease was reversed by CIHH. In short, CIHH treatment decreases ABP in RVH rats via upregulating NOS expression in the NTS.
基金The authors appreciate the financial support provided by the Natural Science Foundation of China(No.41807294)This study was also financially supported by China Geological Survey Project(Nos.DD20190716 and 0001212020CC60002)。
文摘Landslide displacement prediction can enhance the efficacy of landslide monitoring system,and the prediction of the periodic displacement is particularly challenging.In the previous studies,static regression models(e.g.,support vector machine(SVM))were mostly used for predicting the periodic displacement.These models may have bad performances,when the dynamic features of landslide triggers are incorporated.This paper proposes a method for predicting the landslide displacement in a dynamic manner,based on the gated recurrent unit(GRU)neural network and complete ensemble empirical decomposition with adaptive noise(CEEMDAN).The CEEMDAN is used to decompose the training data,and the GRU is subsequently used for predicting the periodic displacement.Implementation procedures of the proposed method were illustrated by a case study in the Caojiatuo landslide area,and SVM was also adopted for the periodic displacement prediction.This case study shows that the predictors obtained by SVM are inaccurate,as the landslide displacement is in a pronouncedly step-wise manner.By contrast,the accuracy can be significantly improved using the dynamic predictive method.This paper reveals the significance of capturing the dynamic features of the inputs in the training process,when the machine learning models are adopted to predict the landslide displacement.
基金the Gansu Science and Technology Major Project(Grant No.182D2NA010)the Science and Technology Service Network Initiative of the Chinese Academy of Sciences(Grant No.KFJ-STS-QYZD-120)the Key R&D plan of the Ningxia Hui Autonomous Region(Grant No.2019BBF02018)for the funding they provided。
文摘Drought stress is the main limiting plant growth factor in arid and semiarid regions.The Lanzhou lily(Lilium davidii var.unicolor)is the only sweet-tasting lily grown in these regions of China that offers highly edible,medicinal,health,and ornamental value.The Tresor lily is an ornamental flower known for its strong resistance.Plants were grown under three different drought intensity treatments,namely,being watered at intervals of 5,15,and 25 d(either throughout the study or during specific growth stages).We measured the biomass,leaf area,photosynthetic response,chlorophyll content(SPAD value),and osmoregulation of both the Lanzhou lily and the Tresor lily(Lilium‘Tresor’).Additionally,we employed RNA sequencing(RNA-Seq)and qRT-PCR to investigate transcriptomic changes of the Lanzhou lily in response to drought stress.Results showed that under drought stress,the decreasing rate in the Lanzhou lily bulb weight was lower than the corresponding Tresor lily bulb rate;the net photosynthetic rate,transpiration rate,and stomatal conductance of the Lanzhou lily were all higher compared to the Tresor lily;osmoregulation constituents,such as glucose,fructose,sucrose,trehalose,and soluble sugar,in the Lanzhou lily were comparatively higher;PYL,NCED,and ERS genes were significantly expressed in the Lanzhou lily.Under moderate drought,the biosynthesis of flavonoids,circadian rhythms,and the tryptophan metabolism pathway of the Lanzhou lily were all significant.Under severe drought stress,fatty acid elongation,photosynthetic antenna protein,plant hormone signal transduction,flavone and flavonol biosynthesis,and the carotenoid biosynthesis pathway were all significant.The Lanzhou lily adapted to drought stress by coordinating its organs and the unique role of its bulb,regulating photosynthesis,increasing osmolyte content,activating circadian rhythms,signal transduction,fatty acid elongation metabolism,and phenylalanine and flavonoid metabolic pathways,which may collectively be the main adaptation strategy and mechanisms used by the Lanzhou lily under drought stress.
基金This work was supported by the Beijing Municipal Science and Technology Commission(Grant Z191100002719007)the National Natural Science Foundation of China(Grant 11672341).
文摘The safety of lithium-ion batteries is an essential concern where instant and accurate temperature sensing is critical.It is generally desired to put sensors inside batteries for instant sensing.However,the transmission of internal measurement outside batteries without interfering their normal state is a non-trivial task due to the harsh electrochemical environment,the particular packaging structures and the intrinsic electromagnetic shielding problems of batteries.In this work,a novel in-situ temperature sensing framework is proposed by incorporating temperature sensors with a novel signal transmission solution.The signal transmission solution uses a self-designed integrated-circuit which modulates the internal measurements outside battery via its positive pole without package breaking.Extensive experimental results validate the noninterference properties of the proposed framework.Our proposed in-situ temperature measurement by the self-designed signal modulation solution has a promising potential for in-situ battery health monitoring and thus promoting the development of smart batteries.
基金the National Key Research and Development Program of China(2020YFB1806800).
文摘With the large-scale commercial launch of fifth generation(5G)mobile network,the development of new services and applications catering to the year 2030,along with the deep convergence of information,communication,and data technologies(ICDT),and the lessons and experiences from 5G practice will drive the evolution of the next generation of mobile networks.This article surveys the history and driving forces of the evolution of the mobile network architecture and proposes a logical function architecture for sixth generation(6G)mobile network.The proposed 6G network architecture is termed SOLIDS(related to the following basic features:soft,on-demand fulfillment,lite,native intelligence,digital twin,and native security),which can support self-generation,self-healing,self-evolution,and self-immunity without human involvement and address the primary issues in the legacy 5G network(e.g.,high cost,high power consumption,and highly complicated operation and maintenance),significantly well.
