The analytical model for springback in arc bending of sheet metal can serve as an excellent design support.The amount of springback is considerably influenced by the geometrical and the material parameters associated ...The analytical model for springback in arc bending of sheet metal can serve as an excellent design support.The amount of springback is considerably influenced by the geometrical and the material parameters associated with the sheet metal.In addition,the applied load during the bending also has a significant influence.Although a number of numerical techniques have been used for this purpose,only few analytical models that can provide insight into the phenomenon are available.A phenomenological model for predicting the springback in arc bending was proposed based on strain as well as deformation energy based approaches.The results of the analytical model were compared with the published experimental as well as FE results of the authors,and the agreement was found to be satisfactory.展开更多
Electromagnetic forming （EMF） is a high velocity forming process that uses impulse magnetic force. Coil is an important component of EMF system which needs to be designed depending on application. Flat spiral coils ...Electromagnetic forming （EMF） is a high velocity forming process that uses impulse magnetic force. Coil is an important component of EMF system which needs to be designed depending on application. Flat spiral coils are generally used for electromagnetic forming of sheet metals. However, with this type of coil the central portion of the workpiece experiences marginal magnetic force. This leads to in-sufficient deformation at this portion and other problems like air entrapment. In this study, a conceptual design of flat coil was proposed for better distribution of magnetic forces over the workpiece. Comparative analysis of distribution of magnetic force, magnetic field and current density using the proposed and the existing coil designs were carried out using FEM. The result indicates that the proposed coil design produces comparatively better magnetic force distribution over the workpiece. Calculation of self-inductance of such coils was also carried out and was compared with FE simulation.展开更多
A definitive understanding of the interplay between protein binding/migration and membrane curvature evolution is emerging but needs further study.The mechanisms defining such phenomena are critical to intracellular t...A definitive understanding of the interplay between protein binding/migration and membrane curvature evolution is emerging but needs further study.The mechanisms defining such phenomena are critical to intracellular transport and trafficking of proteins.Among trafficking modalities,exosomes have drawn attention in cancer research as these nano-sized naturally occurring vehicles are implicated in intercellular communication in the tumor microenvironment,suppressing anti-tumor immunity and preparing the metastatic niche for progression.A significant question in the field is how the release and composition of tumor exosomes are regulated.In this perspective article,we explore how physical factors such as geometry and tissue mechanics regulate cell cortical tension to influence exosome production by co-opting the biophysics as well as the signaling dynamics of intracellular trafficking pathways and how these exosomes contribute to the suppression of anti-tumor immunity and promote metastasis.We describe a multiscale modeling approach whose impact goes beyond the fundamental investigation of specific cellular processes toward actual clinical translation.Exosomal mechanisms are critical to developing and approving liquid biopsy technologies,poised to transform future non-invasive,longitudinal profiling of evolving tumors and resistance to cancer therapies to bring us one step closer to the promise of personalized medicine.展开更多
文摘The analytical model for springback in arc bending of sheet metal can serve as an excellent design support.The amount of springback is considerably influenced by the geometrical and the material parameters associated with the sheet metal.In addition,the applied load during the bending also has a significant influence.Although a number of numerical techniques have been used for this purpose,only few analytical models that can provide insight into the phenomenon are available.A phenomenological model for predicting the springback in arc bending was proposed based on strain as well as deformation energy based approaches.The results of the analytical model were compared with the published experimental as well as FE results of the authors,and the agreement was found to be satisfactory.
文摘Electromagnetic forming （EMF） is a high velocity forming process that uses impulse magnetic force. Coil is an important component of EMF system which needs to be designed depending on application. Flat spiral coils are generally used for electromagnetic forming of sheet metals. However, with this type of coil the central portion of the workpiece experiences marginal magnetic force. This leads to in-sufficient deformation at this portion and other problems like air entrapment. In this study, a conceptual design of flat coil was proposed for better distribution of magnetic forces over the workpiece. Comparative analysis of distribution of magnetic force, magnetic field and current density using the proposed and the existing coil designs were carried out using FEM. The result indicates that the proposed coil design produces comparatively better magnetic force distribution over the workpiece. Calculation of self-inductance of such coils was also carried out and was compared with FE simulation.
基金received funding from the National Institutes of Health under R35GM136259 and U01CA250044supported by the National Cancer Institute and Leidos Biomedical Research,Inc.under contract 15X008 with Frederick National Laboratory for Cancer Research.Computational resources were partly available from the extreme science and engineering discovery environment(XSEDE)under grant MCB200101.
文摘A definitive understanding of the interplay between protein binding/migration and membrane curvature evolution is emerging but needs further study.The mechanisms defining such phenomena are critical to intracellular transport and trafficking of proteins.Among trafficking modalities,exosomes have drawn attention in cancer research as these nano-sized naturally occurring vehicles are implicated in intercellular communication in the tumor microenvironment,suppressing anti-tumor immunity and preparing the metastatic niche for progression.A significant question in the field is how the release and composition of tumor exosomes are regulated.In this perspective article,we explore how physical factors such as geometry and tissue mechanics regulate cell cortical tension to influence exosome production by co-opting the biophysics as well as the signaling dynamics of intracellular trafficking pathways and how these exosomes contribute to the suppression of anti-tumor immunity and promote metastasis.We describe a multiscale modeling approach whose impact goes beyond the fundamental investigation of specific cellular processes toward actual clinical translation.Exosomal mechanisms are critical to developing and approving liquid biopsy technologies,poised to transform future non-invasive,longitudinal profiling of evolving tumors and resistance to cancer therapies to bring us one step closer to the promise of personalized medicine.
