Over the years, there has been a great deal of interest in developing artificial enzymesthat hydrolyse amide bond of peptides and proteins. Recently, we found that Pd(Ⅱ)complexes bind to the sulfur atom of S-methylcy...Over the years, there has been a great deal of interest in developing artificial enzymesthat hydrolyse amide bond of peptides and proteins. Recently, we found that Pd(Ⅱ)complexes bind to the sulfur atom of S-methylcysteine or methionine in peptides andpromote the selective hydrolysis of the adjacent amide bond on the carboxyl side of an-choring side chain. The half-lives of certain hydrolysis reactions are as short as展开更多
基金Project supported by the National Natural Science Foundation of China.
文摘Over the years, there has been a great deal of interest in developing artificial enzymesthat hydrolyse amide bond of peptides and proteins. Recently, we found that Pd(Ⅱ)complexes bind to the sulfur atom of S-methylcysteine or methionine in peptides andpromote the selective hydrolysis of the adjacent amide bond on the carboxyl side of an-choring side chain. The half-lives of certain hydrolysis reactions are as short as
