<strong>Introduction:</strong> The involvement of the endothelial dysfunction (ED) in arterial hypotension (AHPT) post of spinal anesthesia (SA) has not been established. <strong>Objective: </stro...<strong>Introduction:</strong> The involvement of the endothelial dysfunction (ED) in arterial hypotension (AHPT) post of spinal anesthesia (SA) has not been established. <strong>Objective: </strong>To determine if there is a relationship between ED and AHPT observed during the 1st 15 minutes after SA. <strong>Population and Methods:</strong> The study concerned 40 people who were to benefit from a programmed herniorrhaphy under SA and 40 controls (SA<sup>-</sup>). The correlations between mean plasma concentrations of endothelin-1 (CmET-1, pg/ml) and Vascular Cell Adhesion Molecule-1 (CmVCAM-1, pg/ml) taken from SA<sup>+</sup> one hour before (H0), then 15 minutes after the SA (H15) and the mean arterial pression (AMP, mmHg) with heart rate (bpm) were analyzed (p < 5%). <strong>Results:</strong> CmET-1 and CmVCAM-1 of SA<sup>-</sup> were 1.07 and 3.34, respectively, compared to 1.12 (p = 0.735) and 3.57 (p = 0.862) in SA<sup>+</sup> at H0 and H15. In SA+, at H15, CmET-1 was 1.13 (p = 0.823) and CmVCAM-1 was 3.57 (p = 0.257). In SA<sup>-</sup>, a negative correlation existed between CmET-1 and CmVCAM-1 (r = -0.438;p = 0.005). Conversely, in SA<sup>+</sup>, whether at H0 (r = -0.31;p = 0.051) or at H15 (r = 0.024;p = 0.883), no correlation existed between CmET-1 and CmVCAM-1, nor between MAP and ED markers (r = 0.111;p = 0.325). <strong>Conclusion: </strong>These results show that there is no relationship between the AHPT which occurs during the first fifteen minutes post SA, CmVCAM-1 and CmET-1. Moreover, these data suggest that ED is not involved in AHPT post SA.展开更多
文摘<strong>Introduction:</strong> The involvement of the endothelial dysfunction (ED) in arterial hypotension (AHPT) post of spinal anesthesia (SA) has not been established. <strong>Objective: </strong>To determine if there is a relationship between ED and AHPT observed during the 1st 15 minutes after SA. <strong>Population and Methods:</strong> The study concerned 40 people who were to benefit from a programmed herniorrhaphy under SA and 40 controls (SA<sup>-</sup>). The correlations between mean plasma concentrations of endothelin-1 (CmET-1, pg/ml) and Vascular Cell Adhesion Molecule-1 (CmVCAM-1, pg/ml) taken from SA<sup>+</sup> one hour before (H0), then 15 minutes after the SA (H15) and the mean arterial pression (AMP, mmHg) with heart rate (bpm) were analyzed (p < 5%). <strong>Results:</strong> CmET-1 and CmVCAM-1 of SA<sup>-</sup> were 1.07 and 3.34, respectively, compared to 1.12 (p = 0.735) and 3.57 (p = 0.862) in SA<sup>+</sup> at H0 and H15. In SA+, at H15, CmET-1 was 1.13 (p = 0.823) and CmVCAM-1 was 3.57 (p = 0.257). In SA<sup>-</sup>, a negative correlation existed between CmET-1 and CmVCAM-1 (r = -0.438;p = 0.005). Conversely, in SA<sup>+</sup>, whether at H0 (r = -0.31;p = 0.051) or at H15 (r = 0.024;p = 0.883), no correlation existed between CmET-1 and CmVCAM-1, nor between MAP and ED markers (r = 0.111;p = 0.325). <strong>Conclusion: </strong>These results show that there is no relationship between the AHPT which occurs during the first fifteen minutes post SA, CmVCAM-1 and CmET-1. Moreover, these data suggest that ED is not involved in AHPT post SA.
