Diffuse large B cell primary hepatic lymphoma is a rare disease with limited available information regarding treatment strategy. Although the liver contains lymphoid tissue and is an important site for lymphocytes act...Diffuse large B cell primary hepatic lymphoma is a rare disease with limited available information regarding treatment strategy. Although the liver contains lymphoid tissue and is an important site for lymphocytes activation, primary hepatic lymphoma is rare. Host factors make the liver a poor environment for malignant lymphoma development. Its coexistence with human immunodeficiency virus(HIV) infection increases morbidity and mortality risks. Additionally, jaundice increases chances of developing adverse effects from chemotherapy. Here, we report a case of diffuse large B cell primary hepatic lymphoma in a 32-year-old HIV positive man. Due to elevated liver enzyme levels and jaundice, the patient was initially treated with an R-DHAP regimen, which was replaced with an R-CHOP regimen. Restaging images with a positron emission tomography scan after the latest chemotherapy cycle confirmed remission. This is the first report of complete remission of primary hepatic diffuse large B cell lymphoma in an HIV positive patient in the English literature.展开更多
Strongyloides stercoralis,a soil transmitted helminth infection,affects millions with varying prevalence worldwide.A large number of affected hosts are asymptomatic.Symptoms pertaining to pulmonary and gastrointestina...Strongyloides stercoralis,a soil transmitted helminth infection,affects millions with varying prevalence worldwide.A large number of affected hosts are asymptomatic.Symptoms pertaining to pulmonary and gastrointestinal involvement may be present.Manifestations of involvement beyond lung and intestine can be seen with dissemination of infection and lethal hyperinfection.Immunosuppression secondary to use of steroids or other immunosuppressants and coexistence of human T-lymphotropic virus type-1 are the known risk factors for dissemination and hyperinfection.Diagnostic modalities comprise stool examination,serology and molecular testing.Stool tests are inexpensive but are limited by low sensitivity,whereas serologic and molecular tests are more precise but at the expense of higher cost.Treatment with Ivermectin or Albendazole as an alternative is safe and efficacious.We present a rare case of acute pancreatitis secondary to Strongyloides.High index of suspicion in patients specifically from endemic countries of origin and lack of other common etiologies of acute pancreatitis may help in early diagnosis and prompt treatment of this potentially fatal infection.展开更多
文摘Diffuse large B cell primary hepatic lymphoma is a rare disease with limited available information regarding treatment strategy. Although the liver contains lymphoid tissue and is an important site for lymphocytes activation, primary hepatic lymphoma is rare. Host factors make the liver a poor environment for malignant lymphoma development. Its coexistence with human immunodeficiency virus(HIV) infection increases morbidity and mortality risks. Additionally, jaundice increases chances of developing adverse effects from chemotherapy. Here, we report a case of diffuse large B cell primary hepatic lymphoma in a 32-year-old HIV positive man. Due to elevated liver enzyme levels and jaundice, the patient was initially treated with an R-DHAP regimen, which was replaced with an R-CHOP regimen. Restaging images with a positron emission tomography scan after the latest chemotherapy cycle confirmed remission. This is the first report of complete remission of primary hepatic diffuse large B cell lymphoma in an HIV positive patient in the English literature.
文摘Strongyloides stercoralis,a soil transmitted helminth infection,affects millions with varying prevalence worldwide.A large number of affected hosts are asymptomatic.Symptoms pertaining to pulmonary and gastrointestinal involvement may be present.Manifestations of involvement beyond lung and intestine can be seen with dissemination of infection and lethal hyperinfection.Immunosuppression secondary to use of steroids or other immunosuppressants and coexistence of human T-lymphotropic virus type-1 are the known risk factors for dissemination and hyperinfection.Diagnostic modalities comprise stool examination,serology and molecular testing.Stool tests are inexpensive but are limited by low sensitivity,whereas serologic and molecular tests are more precise but at the expense of higher cost.Treatment with Ivermectin or Albendazole as an alternative is safe and efficacious.We present a rare case of acute pancreatitis secondary to Strongyloides.High index of suspicion in patients specifically from endemic countries of origin and lack of other common etiologies of acute pancreatitis may help in early diagnosis and prompt treatment of this potentially fatal infection.
