BACKGROUND Unexplained infertility(UI)is usually used for any heterosexual couple who failed to have a successful clinical pregnancy without identifying clear causes after they undergo all standard fertility tests.Evi...BACKGROUND Unexplained infertility(UI)is usually used for any heterosexual couple who failed to have a successful clinical pregnancy without identifying clear causes after they undergo all standard fertility tests.Evidence shows that leptin is one of the most accurate biomarkers for UI.Nevertheless,conflicting results regarding leptin levels in women with UI have been reported.AIM To find the serum leptin levels in women with UI.METHODS All studies written in English and conducted before April 30,2021 from PubMed/MEDLINE,Embase,Cochrane Central Register of Controlled Trials,ClinicalTrials.gov,Google Scholar,OpenGrey,OATD,and the infertility conference abstract were included.Studies were found eligible if they provided the mean and standard deviation of leptin for the case group and control group.The quality assessment of individual studies was evaluated using the Joanna Briggs Institute Quality Assessment Tool.Data synthesis and statistical analysis were done using STATA software version 16.RESULTS A total of 378 studies were reviewed,and just six studies that fulfilled the eligibility criteria were included in this meta-analysis.The pooled result showed that leptin levels were significantly higher in women with UI compared to fertile women,with a standardized mean difference of 0.97(95%confidence interval:-0.49-2.43).However,heterogeneity across studies was highly significant(P<0.00001;I2=98.8%).CONCLUSION The results of this study suggest that leptin levels are elevated in women with UI compared with fertile women;hence,leptin could be a potential biomarker for UI in women,and it may be useful for identifying women with a high risk of infertility.展开更多
BACKGROUND There are three main forms of leishmaniasis in humans:cutaneous leishmaniasis(CL),visceral leishmaniasis(VL),and mucocutaneous leishmaniasis.The prevalence of human leishmaniasis varies widely in different ...BACKGROUND There are three main forms of leishmaniasis in humans:cutaneous leishmaniasis(CL),visceral leishmaniasis(VL),and mucocutaneous leishmaniasis.The prevalence of human leishmaniasis varies widely in different countries and different regions of the same country.To date,there is no overall estimation of the prevalence of human leishmaniasis in Sudan.AIM To determine the pooled prevalence of human leishmaniasis and the disease risk factors among Sudanese citizens.METHODS From all articles written in English or Arabic languages conducted before the 4th of August 2021 from[Scopus,Web of Science,PubMed,and MEDLINE,African Journals Online(AJOL),ResearchGate,direct Google search,Google Scholar,and universities websites], just 20 articles with a total of 230960 participants were eligible for thisstudy. Data synthesis and analysis were done using STATA software, version 16. EndNotecitation manager version X9.3.3 and Reference Citation Analysis (RCA) were used to remove theduplicated studies and manage the citation respectively.RESULTSThe overall pooled prevalence of human leishmaniasis in Sudan was 21% (with confidence interval12%-30%). CL was the most common type of leishmaniasis in Sudan, with a pooled prevalence of26% followed by VL (18%). Nevertheless, the pooled prevalence of human leishmaniasis in Sudanwas higher in males compared with females (60% vs 40%). The current results revealed that thepeople in the age group between 15 and 44 were the most affected group (60%), and central Sudanhas the highest pooled prevalence of human leishmaniasis (27%) compared with other regions ofSudan. Finally, the prevalence of human leishmaniasis seems to decrease with time.CONCLUSIONThis study showed that human leishmaniasis infection is still endemic in many regions in Sudanand highly prevalent in central and eastern Sudan, and CL is the most prevalent in the country.Males and adults were more susceptible to infection compared with females and children.However, the human leishmaniasis prevalence decreased relatively over time.展开更多
BACKGROUND Female infertility with unknown causes(unexplained)remains one of the mysteries in the reproductive health field,where the diagnostic evidence is still weak and the proposed treatments still work with unkno...BACKGROUND Female infertility with unknown causes(unexplained)remains one of the mysteries in the reproductive health field,where the diagnostic evidence is still weak and the proposed treatments still work with unknown methods.However,several studies have proposed some possible causes and risk factors for unexplained female infertility.AIM To characterize and identify factors associated with unexplained infertility in Sudanese women.METHODS A matched(age and body mass index)case-control study was conducted from March 2021 to February 2022.The study samples were 210 women with unexplained infertility(UI)and 190 fertile women of reproductive age who were attending the maternity hospitals and fertility clinics in Khartoum,Sudan.The risk factors of unexplained infertility were identified using a structured,pretested questionnaire containing information on socio-demographic variables,anthropometrics,clinical diagnosis of infertility,behavioral factors,physical activity assessment,diversity,and consumption of different food groups by the study participants.RESULTS The results showed a higher proportion of women diagnosed with UI were residents of rural areas than controls(21.4%vs 11.1%,P<0.05),and previous miscarriages and/or abortions were more common in fertile women compared with infertile women(13.16%vs 5.71%,P<0.05).Additionally,infertile women had a significantly(P<0.05)higher proportion of family history of infertility(explained and unexplained)compared with controls.Finally,after controlling for the effects of potentially confounding variables using multivariable logistic regression analysis,only marital status,family history of infertility,use of modern contraceptives,smoking,caffeine consumption,physical activity level,meals consumed,other vitamin-A-rich fruits and vegetables,and other vegetables were found to be significant(P<0.05)factors associated with unexplained infertility among Sudanese women.CONCLUSION Married women with a family history of infertility who smoke and consume a high amount of caffeine,who live a sedentary lifestyle,and who consume more than two meals free of vitamin-Arich fruits and/or vegetables and/or other vegetables per day are at the highest risk of developing unexplained infertility.展开更多
BACKGROUND The excessive concentration of leptin has negative effects on all aspects of female reproduction.Despite this established relationship,the exact role of leptin in women’s fertility is not clear enough and ...BACKGROUND The excessive concentration of leptin has negative effects on all aspects of female reproduction.Despite this established relationship,the exact role of leptin in women’s fertility is not clear enough and needs more clarification.AIM To evaluate the serum leptin levels in Sudanese women and to ascertain the relationship between serum leptin levels and unexplained infertility(UI).METHODS A matched(age and body mass index)case-control study was conducted from March 2021 to February 2022.The study samples were 210 women with UI and 190 fertile women of reproductive age who were attending the maternity hospitals and fertility clinics in Khartoum state Sudan.The serum concentration of leptin and other serum biomarkers were determined using enzyme-linked immunosorbent assays.RESULTS The results showed that there was a highly statistically significant difference between the two groups(P<0.001)for all examined eight biomarkers.Whereby,leptin,luteinizing hormone(LH)/follicular stimulating hormone(FSH)ratio,prolactin hormone(PRL)and testosterone(T)were significantly higher in the UI group compared with the control group.In contrast,FSH and estradiol(E2)/T ratio were significantly lower in the UI group than in the control group and the effect size test for the difference between the two groups was very large(effect size>0.80),for leptin level,LH/FSH ratio,PRL level,and E2/T ratio,and large(effect size 0.50-≤0.80)for FSH and T.CONCLUSION This study reveals that leptin could be a potential biomarker for UI in Sudanese women and it may be useful for identifying women with a high risk of infertility.展开更多
BACKGROUND Leishmaniasis is a neglected zoonotic disease,endemic in Sudan.Estimating this disease is very important to inform the health care policymakers and the governments to apply proper health and economic polici...BACKGROUND Leishmaniasis is a neglected zoonotic disease,endemic in Sudan.Estimating this disease is very important to inform the health care policymakers and the governments to apply proper health and economic policies.AIM To find out the frequency and distribution of human leishmaniasis based on sex and age for 5 years in the West Kordofan state,Sudan.METHODS A 5-year retrospective study from 2016 through 2020 was carried out using local hospital records of leishmaniasis patients.The positive results were recorded after performing at least one of the following leishmaniasis standard tests:direct agglutination test,enzyme-linked immunosorbent assay and leishmania skin test.The sex and age of each patient were recorded.The collected data were analyzed using STATA package version 16.RESULTS A total of 162443 patient records from 2016 to 2020 were retrieved.Of these,4.39%were found to be positive for leishmaniasis.The disease has been more common in males(65.3%)than in females(34.7%).The highest reported prevalence(6.58%)was in patients 15-44 years,and the lowest prevalence(1.95%)was among patients≥65 years.CONCLUSION The results of the current study indicate that leishmaniasis is endemic in the study area even though the numbers of patients in the 5 consecutive years were varying.In addition,the disease was common in males and adults.The interpretation of these findings should take into consideration the absence of information about some important confounding factors.展开更多
文摘BACKGROUND Unexplained infertility(UI)is usually used for any heterosexual couple who failed to have a successful clinical pregnancy without identifying clear causes after they undergo all standard fertility tests.Evidence shows that leptin is one of the most accurate biomarkers for UI.Nevertheless,conflicting results regarding leptin levels in women with UI have been reported.AIM To find the serum leptin levels in women with UI.METHODS All studies written in English and conducted before April 30,2021 from PubMed/MEDLINE,Embase,Cochrane Central Register of Controlled Trials,ClinicalTrials.gov,Google Scholar,OpenGrey,OATD,and the infertility conference abstract were included.Studies were found eligible if they provided the mean and standard deviation of leptin for the case group and control group.The quality assessment of individual studies was evaluated using the Joanna Briggs Institute Quality Assessment Tool.Data synthesis and statistical analysis were done using STATA software version 16.RESULTS A total of 378 studies were reviewed,and just six studies that fulfilled the eligibility criteria were included in this meta-analysis.The pooled result showed that leptin levels were significantly higher in women with UI compared to fertile women,with a standardized mean difference of 0.97(95%confidence interval:-0.49-2.43).However,heterogeneity across studies was highly significant(P<0.00001;I2=98.8%).CONCLUSION The results of this study suggest that leptin levels are elevated in women with UI compared with fertile women;hence,leptin could be a potential biomarker for UI in women,and it may be useful for identifying women with a high risk of infertility.
文摘BACKGROUND There are three main forms of leishmaniasis in humans:cutaneous leishmaniasis(CL),visceral leishmaniasis(VL),and mucocutaneous leishmaniasis.The prevalence of human leishmaniasis varies widely in different countries and different regions of the same country.To date,there is no overall estimation of the prevalence of human leishmaniasis in Sudan.AIM To determine the pooled prevalence of human leishmaniasis and the disease risk factors among Sudanese citizens.METHODS From all articles written in English or Arabic languages conducted before the 4th of August 2021 from[Scopus,Web of Science,PubMed,and MEDLINE,African Journals Online(AJOL),ResearchGate,direct Google search,Google Scholar,and universities websites], just 20 articles with a total of 230960 participants were eligible for thisstudy. Data synthesis and analysis were done using STATA software, version 16. EndNotecitation manager version X9.3.3 and Reference Citation Analysis (RCA) were used to remove theduplicated studies and manage the citation respectively.RESULTSThe overall pooled prevalence of human leishmaniasis in Sudan was 21% (with confidence interval12%-30%). CL was the most common type of leishmaniasis in Sudan, with a pooled prevalence of26% followed by VL (18%). Nevertheless, the pooled prevalence of human leishmaniasis in Sudanwas higher in males compared with females (60% vs 40%). The current results revealed that thepeople in the age group between 15 and 44 were the most affected group (60%), and central Sudanhas the highest pooled prevalence of human leishmaniasis (27%) compared with other regions ofSudan. Finally, the prevalence of human leishmaniasis seems to decrease with time.CONCLUSIONThis study showed that human leishmaniasis infection is still endemic in many regions in Sudanand highly prevalent in central and eastern Sudan, and CL is the most prevalent in the country.Males and adults were more susceptible to infection compared with females and children.However, the human leishmaniasis prevalence decreased relatively over time.
文摘BACKGROUND Female infertility with unknown causes(unexplained)remains one of the mysteries in the reproductive health field,where the diagnostic evidence is still weak and the proposed treatments still work with unknown methods.However,several studies have proposed some possible causes and risk factors for unexplained female infertility.AIM To characterize and identify factors associated with unexplained infertility in Sudanese women.METHODS A matched(age and body mass index)case-control study was conducted from March 2021 to February 2022.The study samples were 210 women with unexplained infertility(UI)and 190 fertile women of reproductive age who were attending the maternity hospitals and fertility clinics in Khartoum,Sudan.The risk factors of unexplained infertility were identified using a structured,pretested questionnaire containing information on socio-demographic variables,anthropometrics,clinical diagnosis of infertility,behavioral factors,physical activity assessment,diversity,and consumption of different food groups by the study participants.RESULTS The results showed a higher proportion of women diagnosed with UI were residents of rural areas than controls(21.4%vs 11.1%,P<0.05),and previous miscarriages and/or abortions were more common in fertile women compared with infertile women(13.16%vs 5.71%,P<0.05).Additionally,infertile women had a significantly(P<0.05)higher proportion of family history of infertility(explained and unexplained)compared with controls.Finally,after controlling for the effects of potentially confounding variables using multivariable logistic regression analysis,only marital status,family history of infertility,use of modern contraceptives,smoking,caffeine consumption,physical activity level,meals consumed,other vitamin-A-rich fruits and vegetables,and other vegetables were found to be significant(P<0.05)factors associated with unexplained infertility among Sudanese women.CONCLUSION Married women with a family history of infertility who smoke and consume a high amount of caffeine,who live a sedentary lifestyle,and who consume more than two meals free of vitamin-Arich fruits and/or vegetables and/or other vegetables per day are at the highest risk of developing unexplained infertility.
基金the Pan African University of Life and Earth Sciences Institutethe African Union for financial supportthe University of Ibadan for hosting this Ph D program
文摘BACKGROUND The excessive concentration of leptin has negative effects on all aspects of female reproduction.Despite this established relationship,the exact role of leptin in women’s fertility is not clear enough and needs more clarification.AIM To evaluate the serum leptin levels in Sudanese women and to ascertain the relationship between serum leptin levels and unexplained infertility(UI).METHODS A matched(age and body mass index)case-control study was conducted from March 2021 to February 2022.The study samples were 210 women with UI and 190 fertile women of reproductive age who were attending the maternity hospitals and fertility clinics in Khartoum state Sudan.The serum concentration of leptin and other serum biomarkers were determined using enzyme-linked immunosorbent assays.RESULTS The results showed that there was a highly statistically significant difference between the two groups(P<0.001)for all examined eight biomarkers.Whereby,leptin,luteinizing hormone(LH)/follicular stimulating hormone(FSH)ratio,prolactin hormone(PRL)and testosterone(T)were significantly higher in the UI group compared with the control group.In contrast,FSH and estradiol(E2)/T ratio were significantly lower in the UI group than in the control group and the effect size test for the difference between the two groups was very large(effect size>0.80),for leptin level,LH/FSH ratio,PRL level,and E2/T ratio,and large(effect size 0.50-≤0.80)for FSH and T.CONCLUSION This study reveals that leptin could be a potential biomarker for UI in Sudanese women and it may be useful for identifying women with a high risk of infertility.
文摘BACKGROUND Leishmaniasis is a neglected zoonotic disease,endemic in Sudan.Estimating this disease is very important to inform the health care policymakers and the governments to apply proper health and economic policies.AIM To find out the frequency and distribution of human leishmaniasis based on sex and age for 5 years in the West Kordofan state,Sudan.METHODS A 5-year retrospective study from 2016 through 2020 was carried out using local hospital records of leishmaniasis patients.The positive results were recorded after performing at least one of the following leishmaniasis standard tests:direct agglutination test,enzyme-linked immunosorbent assay and leishmania skin test.The sex and age of each patient were recorded.The collected data were analyzed using STATA package version 16.RESULTS A total of 162443 patient records from 2016 to 2020 were retrieved.Of these,4.39%were found to be positive for leishmaniasis.The disease has been more common in males(65.3%)than in females(34.7%).The highest reported prevalence(6.58%)was in patients 15-44 years,and the lowest prevalence(1.95%)was among patients≥65 years.CONCLUSION The results of the current study indicate that leishmaniasis is endemic in the study area even though the numbers of patients in the 5 consecutive years were varying.In addition,the disease was common in males and adults.The interpretation of these findings should take into consideration the absence of information about some important confounding factors.
