AIM： To evaluate ocular surface changes and its correlation with the central corneal subbasal nerve fibre layer in chronic glaucoma patients. METHODS： A prospective comparative study of ocular surface evaluation wa...AIM： To evaluate ocular surface changes and its correlation with the central corneal subbasal nerve fibre layer in chronic glaucoma patients. METHODS： A prospective comparative study of ocular surface evaluation was performed in 50 eyes of 25 patients using two or more antiglaucoma medications for at least 6too and 50 eyes of 25 normal subjects without any ocular problems as controls. The study parameters evaluated included visual acuity, intraocular pressure, ocular surface evaluation parameters [fluorescein break-up time （FTBUT）, Schirmer＇s I test, ocular surface staining scores and ocular surface disease index score （OSDI）], central corneal sensation （Cochet Bonnett aesthesiometer）, central subbasal nerve fiber layer density （SBNFLD） by confocal microscopy. RESULTS： The mean values in the glaucoma cases and control groups respectively were as follows： OSDI score （35.89±16.07/6.02±3.84; P=-0.001）, Schirmer＇s I test score （7.632.64 mm/12.86±1.93 mm; P=-0.001）, FTBUT （9.442.76s/11.8±1.88s; P=0.001）, corneal （5.7±2.33/ 1.1±0.58; P=0.001） and conjunctival staining score （5.061.94/0.84±0.46; P=0.001）, corneal sensitivity （4.68±0.44/5.07±0.37; P=0.076）, mean subbasal nerve fiber number （3.58±0.99/5.40±1.70; P=0.001）, SBNFL length （1101.44±287.56 pm/1963.70±562.56 pro; P=0.001） and density （6883.941798.03 pm/mm/12 273.153516.04 pm/mm2; P=O.O01）. Dry eye severity of level 2 and 3 was seen in 66% of glaucoma group. Corneal （/=0.86） and conjunctival staining （R2=0.71） and OSDI score （R=0.67） showed statistically significant negative correlation with central corneal SBNFLD while FTBUT （R==0.84）, corneal sensitivity （/=0.52） showed positive correlation to central corneal SBNFLD in the long term topical antiglaucoma medication group. CONCLUSION： Ocular surface changes and antiglaucoma therapy induced dry eye is found to be associated with decreased SBNFLD in eyes on long term topical antiglaucoma medications.展开更多
Allogenic haematological stem cell transplantation (allo-SCT) from a human leukocyte antigen (HLA) matched related or unrelated donor is used as a curative therapy for a large number of malignant and non-malignant hae...Allogenic haematological stem cell transplantation (allo-SCT) from a human leukocyte antigen (HLA) matched related or unrelated donor is used as a curative therapy for a large number of malignant and non-malignant haematological diseases. The curative effect of allo-SCT is achieved by graft versus leukaemia effect while the downside of the graft versus patient activity is the graft-versus-host-disease (GVHD), a major reason for mortality and morbidity. The search of articles for this review had been accomplished using Ovid, Medline, Embase, Pubmed and was supplemented by retrieving cross references also. Electronic literature search for English language articles with full text access was performed using graft versus host disease, ocular, management, dry eyes as key words. This review has been intended to explicate the classification, pathogenesis, risk factors and management of ocular graft versus host disease.展开更多
Cysticercosis is a preventable and eradicable cause of blindness endemic in the Indian subcontinent, South- East Asia and other developing countries. Ocular and orbital cysticercosis has varied presentations depending...Cysticercosis is a preventable and eradicable cause of blindness endemic in the Indian subcontinent, South- East Asia and other developing countries. Ocular and orbital cysticercosis has varied presentations depending upon the site of involvement, number of lesion and the host immune response. In this article we present a review of the various clinical manifestations, diagnosis and management protocol for orbital and ocular cysticercosis. Owing to its varied presentation, cysticercosis may pose a diagnostic challenge to the health professionals. Early diagnosis and management can prevent the vision loss and optimize visual outcomes.展开更多
基金Supported by the Institute Research Grant of All India Institute of Medical Sciences,New Delhi 110029,India
文摘AIM： To evaluate ocular surface changes and its correlation with the central corneal subbasal nerve fibre layer in chronic glaucoma patients. METHODS： A prospective comparative study of ocular surface evaluation was performed in 50 eyes of 25 patients using two or more antiglaucoma medications for at least 6too and 50 eyes of 25 normal subjects without any ocular problems as controls. The study parameters evaluated included visual acuity, intraocular pressure, ocular surface evaluation parameters [fluorescein break-up time （FTBUT）, Schirmer＇s I test, ocular surface staining scores and ocular surface disease index score （OSDI）], central corneal sensation （Cochet Bonnett aesthesiometer）, central subbasal nerve fiber layer density （SBNFLD） by confocal microscopy. RESULTS： The mean values in the glaucoma cases and control groups respectively were as follows： OSDI score （35.89±16.07/6.02±3.84; P=-0.001）, Schirmer＇s I test score （7.632.64 mm/12.86±1.93 mm; P=-0.001）, FTBUT （9.442.76s/11.8±1.88s; P=0.001）, corneal （5.7±2.33/ 1.1±0.58; P=0.001） and conjunctival staining score （5.061.94/0.84±0.46; P=0.001）, corneal sensitivity （4.68±0.44/5.07±0.37; P=0.076）, mean subbasal nerve fiber number （3.58±0.99/5.40±1.70; P=0.001）, SBNFL length （1101.44±287.56 pm/1963.70±562.56 pro; P=0.001） and density （6883.941798.03 pm/mm/12 273.153516.04 pm/mm2; P=O.O01）. Dry eye severity of level 2 and 3 was seen in 66% of glaucoma group. Corneal （/=0.86） and conjunctival staining （R2=0.71） and OSDI score （R=0.67） showed statistically significant negative correlation with central corneal SBNFLD while FTBUT （R==0.84）, corneal sensitivity （/=0.52） showed positive correlation to central corneal SBNFLD in the long term topical antiglaucoma medication group. CONCLUSION： Ocular surface changes and antiglaucoma therapy induced dry eye is found to be associated with decreased SBNFLD in eyes on long term topical antiglaucoma medications.
文摘Allogenic haematological stem cell transplantation (allo-SCT) from a human leukocyte antigen (HLA) matched related or unrelated donor is used as a curative therapy for a large number of malignant and non-malignant haematological diseases. The curative effect of allo-SCT is achieved by graft versus leukaemia effect while the downside of the graft versus patient activity is the graft-versus-host-disease (GVHD), a major reason for mortality and morbidity. The search of articles for this review had been accomplished using Ovid, Medline, Embase, Pubmed and was supplemented by retrieving cross references also. Electronic literature search for English language articles with full text access was performed using graft versus host disease, ocular, management, dry eyes as key words. This review has been intended to explicate the classification, pathogenesis, risk factors and management of ocular graft versus host disease.
文摘Cysticercosis is a preventable and eradicable cause of blindness endemic in the Indian subcontinent, South- East Asia and other developing countries. Ocular and orbital cysticercosis has varied presentations depending upon the site of involvement, number of lesion and the host immune response. In this article we present a review of the various clinical manifestations, diagnosis and management protocol for orbital and ocular cysticercosis. Owing to its varied presentation, cysticercosis may pose a diagnostic challenge to the health professionals. Early diagnosis and management can prevent the vision loss and optimize visual outcomes.
