Non-alcoholic fatty liver disease(NAFLD)is emerging as a common cause of chronic liver disease in children and adults.NAFLD can progress to steatohepa-titis and potentially even hepatocellular carcinoma.Early identifi...Non-alcoholic fatty liver disease(NAFLD)is emerging as a common cause of chronic liver disease in children and adults.NAFLD can progress to steatohepa-titis and potentially even hepatocellular carcinoma.Early identification of pati-ents at risk for progressive disease is crucial for managing NAFLD.Recent studies have identified long noncoding RNAs(lncRNAs),circular RNAs,and microRNAs as playing important roles in the pathogenesis of NAFLD.These noncoding RNAs are involved in modulating several metabolic pathways such as hepatic glucose and lipid metabolism,oxidative stress,and even carcinogenesis.Elevated levels of lncARSR and lncRNA nuclear-enriched abundant transcript 1 have been found in patients with NAFLD.In addition,lncRNAs such as PRYP4-3 and RP11-128N14.5 can distinguish patients with NAFLD from healthy indi-viduals.Increased MEG3 expression has been observed in both NAFLD and non-alcoholic steatohepatitis,suggesting that it may help predict patients at risk for disease progression.With advances in transcriptomics,we may discover additional targets to help in the identification and prognostication of NAFLD.展开更多
Hepatocellular carcinoma is one of the leading malignancies worldwide.Early detection of hepatocellular carcinoma and its management in the form of liver transplantation offers an attractive treatment option.The Milan...Hepatocellular carcinoma is one of the leading malignancies worldwide.Early detection of hepatocellular carcinoma and its management in the form of liver transplantation offers an attractive treatment option.The Milan criteria,proposed by Mazzaferro et al,have been the standard for selecting patients with hepatocellular carcinoma for transplantation.Recently,several studies have shown that even patients selected outside the Milan criteria can undergo transplantation with a relatively good outcome.This article examines the currently existing criteria other than the Milan criteria and also evaluates use of alpha-fetoprotein and positron emission tomography scans to predict the chance of recurrence.展开更多
As the internet grows in popularity and therefore also in size more and more transmission takes place mainly because the technology is more readily available and applications have become more user friendly allowing en...As the internet grows in popularity and therefore also in size more and more transmission takes place mainly because the technology is more readily available and applications have become more user friendly allowing entry to less sophisticated user over a broad spectrum. Most data transfer are mainly text based not secure and vulnerable to various forms of security risks. So the model that uses SSH for securing channel like intranet/internet which provides client authentication encryption and decryption with high degree of security by transferring the data in an encrypted format, up on this model enhances the efficiency of data transmission by encrypting or decrypting the data with AES in Counter Mode. AES is a symmetric key encryption standard. Moreover the permutation controlled by data can be performed at high speed in generic cpu. This scheme also expands the key space without costing more to run. And also finally through the combination of secure shell (ssh) and AES (Counter Mode) not only enhances the security of communication channel. It also provides various applications like remote user creation, remote user deletion, remote command execution, remote system shutdown, remote file transfer applications in a highly secure manner.展开更多
lncRNAs forms a part of the non coding part of human genome. This term denotes specific non coding RNAs with nucleotide length more than 200. They have been shown to affect various physiological and pathological proce...lncRNAs forms a part of the non coding part of human genome. This term denotes specific non coding RNAs with nucleotide length more than 200. They have been shown to affect various physiological and pathological processes within the human body. Of interest is their role in malignant transformation in several cancers. In this review, the role of lncRNAs in GI cancers namely pancreatic cancer, gastric cancer, hepatocellular cancer and colorectal cancer have been explained in brief. These lncRNAs have shown to be useful as a marker for detection and prognosis of various malignancies. They also have shown to have therapeutic potential. Various relevant lncRNAs in each section has also been mentioned.展开更多
Background: Filarial disease has a very high prevalence in South East Asian region especially India. It commonly presents as an affliction of the lymphatic system like acute lymphangitis and chronic lymphedema. Presen...Background: Filarial disease has a very high prevalence in South East Asian region especially India. It commonly presents as an affliction of the lymphatic system like acute lymphangitis and chronic lymphedema. Presentation of lymphatic filariasis as a subcutaneous nodule is a rare but previously reported scenario. Aim: We discuss a case with incidental detection of filaria in a subcutaneous nodule following excision biopsy. Case Presentation: 20-year-old male patient presented with subcutaneous swelling in left lower chest. Undergoing excision biopsy for same and on histopathological examination was found to be an encysted filarial worm. Conclusion: Such rare presentation of filariasis has been reported earlier also and should be kept in mind.展开更多
文摘Non-alcoholic fatty liver disease(NAFLD)is emerging as a common cause of chronic liver disease in children and adults.NAFLD can progress to steatohepa-titis and potentially even hepatocellular carcinoma.Early identification of pati-ents at risk for progressive disease is crucial for managing NAFLD.Recent studies have identified long noncoding RNAs(lncRNAs),circular RNAs,and microRNAs as playing important roles in the pathogenesis of NAFLD.These noncoding RNAs are involved in modulating several metabolic pathways such as hepatic glucose and lipid metabolism,oxidative stress,and even carcinogenesis.Elevated levels of lncARSR and lncRNA nuclear-enriched abundant transcript 1 have been found in patients with NAFLD.In addition,lncRNAs such as PRYP4-3 and RP11-128N14.5 can distinguish patients with NAFLD from healthy indi-viduals.Increased MEG3 expression has been observed in both NAFLD and non-alcoholic steatohepatitis,suggesting that it may help predict patients at risk for disease progression.With advances in transcriptomics,we may discover additional targets to help in the identification and prognostication of NAFLD.
文摘Hepatocellular carcinoma is one of the leading malignancies worldwide.Early detection of hepatocellular carcinoma and its management in the form of liver transplantation offers an attractive treatment option.The Milan criteria,proposed by Mazzaferro et al,have been the standard for selecting patients with hepatocellular carcinoma for transplantation.Recently,several studies have shown that even patients selected outside the Milan criteria can undergo transplantation with a relatively good outcome.This article examines the currently existing criteria other than the Milan criteria and also evaluates use of alpha-fetoprotein and positron emission tomography scans to predict the chance of recurrence.
文摘As the internet grows in popularity and therefore also in size more and more transmission takes place mainly because the technology is more readily available and applications have become more user friendly allowing entry to less sophisticated user over a broad spectrum. Most data transfer are mainly text based not secure and vulnerable to various forms of security risks. So the model that uses SSH for securing channel like intranet/internet which provides client authentication encryption and decryption with high degree of security by transferring the data in an encrypted format, up on this model enhances the efficiency of data transmission by encrypting or decrypting the data with AES in Counter Mode. AES is a symmetric key encryption standard. Moreover the permutation controlled by data can be performed at high speed in generic cpu. This scheme also expands the key space without costing more to run. And also finally through the combination of secure shell (ssh) and AES (Counter Mode) not only enhances the security of communication channel. It also provides various applications like remote user creation, remote user deletion, remote command execution, remote system shutdown, remote file transfer applications in a highly secure manner.
文摘lncRNAs forms a part of the non coding part of human genome. This term denotes specific non coding RNAs with nucleotide length more than 200. They have been shown to affect various physiological and pathological processes within the human body. Of interest is their role in malignant transformation in several cancers. In this review, the role of lncRNAs in GI cancers namely pancreatic cancer, gastric cancer, hepatocellular cancer and colorectal cancer have been explained in brief. These lncRNAs have shown to be useful as a marker for detection and prognosis of various malignancies. They also have shown to have therapeutic potential. Various relevant lncRNAs in each section has also been mentioned.
文摘Background: Filarial disease has a very high prevalence in South East Asian region especially India. It commonly presents as an affliction of the lymphatic system like acute lymphangitis and chronic lymphedema. Presentation of lymphatic filariasis as a subcutaneous nodule is a rare but previously reported scenario. Aim: We discuss a case with incidental detection of filaria in a subcutaneous nodule following excision biopsy. Case Presentation: 20-year-old male patient presented with subcutaneous swelling in left lower chest. Undergoing excision biopsy for same and on histopathological examination was found to be an encysted filarial worm. Conclusion: Such rare presentation of filariasis has been reported earlier also and should be kept in mind.
