Objectives:To gather updated information on the traditional uses,phytochemistry,and pharmacological activities of Valeriana jatamansi Jones.Background:V.jatamansi is indigenous to the Himalayas immensely used as tradi...Objectives:To gather updated information on the traditional uses,phytochemistry,and pharmacological activities of Valeriana jatamansi Jones.Background:V.jatamansi is indigenous to the Himalayas immensely used as traditional folk remedy.It contains a variety of secondary metabolites that give it a high medicinal and therapeutic values.For the purpose of collecting relevant information on V.jatamansi,a comprehensive literature search was conducted.Based on ethnobotanical sources and historical records,traditional uses were compiled.Scientific articles and databases were consulted for phytochemical data.In order to assess the plant’s therapeutic properties,pharmacological studies were reviewed.Summary:The botanical is known for its ethnobotanical uses ranging from sedative and anxiolytic effects to treating insomnia,epilepsy,and gastrointestinal disorders.Indigenous healing practices rely heavily on its traditional uses.Based on the phytochemical analysis,it contains a diverse array of bioactive compounds,including sesquiterpenoids and iridoids.Valerenic acid and jatamansinol,among other compounds,contribute to its therapeutic potential.A broad spectrum of pharmacological activities is found including anxiety-relieving,sedative,anti-inflammatory,neuroprotective,and antimicrobial effects.Outlook:Based on the evidence supporting ethnomedicinal uses of V.jatamansi,its immense biopotential and multiple pharmacological roles,standard clinical trials are required to evaluate its therapeutic potential.展开更多
Background:The severe acute respiratory syndrome Coronavirus-2 causing COVID-19 viral infection was first reported in late December 2019,spreading swiftly across all over the world.WHO declared it a pandemic by March ...Background:The severe acute respiratory syndrome Coronavirus-2 causing COVID-19 viral infection was first reported in late December 2019,spreading swiftly across all over the world.WHO declared it a pandemic by March 2020.Many problems emerged worldwide healthcare system and economic burden due to viral outbreak.High transmission rate and infectious nature make COVID-19 pandemic.Effectively managing outbreak and controlling spread is challenging.Despite valiant efforts to contain the COVID-19 outbreak,the situation has deteriorated to the point that there were no viable preventive therapies to treat this disease.Developing effective treatment for COVID-19 has been a complex and ongoing endeavor.Objective:The aim of this systematic review is to evaluate the structure,epidemiology,pathophysiology,po-tential therapeutic treatments,and preventive measures adopted in Traditional Chinese Medicine(TCM)in the management of Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)virus.Methods:A systematic methodology has been adopted in this study following PRISMA guidelines.Several key-words like“COVID-19”“SARS-CoV-2”“Coronavirus”and“Traditional Chinese Medicine”were searched in var-ious databases like ScienceDirect,Google Scholar,PubMed,and ResearchGate during the time span of 2010-2023.Clinical trials and studies relevant to this study were identified through a systematic search strategy fol-lowing PRISMA methodology.Results:In this systematic review,after careful evaluation and reviewing of literature through PRISMA guidelines,145 relevant studies were identified,reviewed and included in this systematic review.A detailed study has been summarized on virus structure,etiology,epidemiology characteristics,pathophysiology,and potential therapeutic treatments and preventive measures adopted in traditional medicinal system in the treatment of infected COVID-19 patients.Conclusion:SARS-CoV-2 transmission dynamics and pathogenesis were revealed by the etiology analysis.COVID-19 symptoms and severe disease outcomes can be managed with certain repurposed drugs,traditional medicinal system and antivirals,which have been shown to be effective in treating COVID-19 infection.展开更多
文摘Objectives:To gather updated information on the traditional uses,phytochemistry,and pharmacological activities of Valeriana jatamansi Jones.Background:V.jatamansi is indigenous to the Himalayas immensely used as traditional folk remedy.It contains a variety of secondary metabolites that give it a high medicinal and therapeutic values.For the purpose of collecting relevant information on V.jatamansi,a comprehensive literature search was conducted.Based on ethnobotanical sources and historical records,traditional uses were compiled.Scientific articles and databases were consulted for phytochemical data.In order to assess the plant’s therapeutic properties,pharmacological studies were reviewed.Summary:The botanical is known for its ethnobotanical uses ranging from sedative and anxiolytic effects to treating insomnia,epilepsy,and gastrointestinal disorders.Indigenous healing practices rely heavily on its traditional uses.Based on the phytochemical analysis,it contains a diverse array of bioactive compounds,including sesquiterpenoids and iridoids.Valerenic acid and jatamansinol,among other compounds,contribute to its therapeutic potential.A broad spectrum of pharmacological activities is found including anxiety-relieving,sedative,anti-inflammatory,neuroprotective,and antimicrobial effects.Outlook:Based on the evidence supporting ethnomedicinal uses of V.jatamansi,its immense biopotential and multiple pharmacological roles,standard clinical trials are required to evaluate its therapeutic potential.
文摘Background:The severe acute respiratory syndrome Coronavirus-2 causing COVID-19 viral infection was first reported in late December 2019,spreading swiftly across all over the world.WHO declared it a pandemic by March 2020.Many problems emerged worldwide healthcare system and economic burden due to viral outbreak.High transmission rate and infectious nature make COVID-19 pandemic.Effectively managing outbreak and controlling spread is challenging.Despite valiant efforts to contain the COVID-19 outbreak,the situation has deteriorated to the point that there were no viable preventive therapies to treat this disease.Developing effective treatment for COVID-19 has been a complex and ongoing endeavor.Objective:The aim of this systematic review is to evaluate the structure,epidemiology,pathophysiology,po-tential therapeutic treatments,and preventive measures adopted in Traditional Chinese Medicine(TCM)in the management of Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)virus.Methods:A systematic methodology has been adopted in this study following PRISMA guidelines.Several key-words like“COVID-19”“SARS-CoV-2”“Coronavirus”and“Traditional Chinese Medicine”were searched in var-ious databases like ScienceDirect,Google Scholar,PubMed,and ResearchGate during the time span of 2010-2023.Clinical trials and studies relevant to this study were identified through a systematic search strategy fol-lowing PRISMA methodology.Results:In this systematic review,after careful evaluation and reviewing of literature through PRISMA guidelines,145 relevant studies were identified,reviewed and included in this systematic review.A detailed study has been summarized on virus structure,etiology,epidemiology characteristics,pathophysiology,and potential therapeutic treatments and preventive measures adopted in traditional medicinal system in the treatment of infected COVID-19 patients.Conclusion:SARS-CoV-2 transmission dynamics and pathogenesis were revealed by the etiology analysis.COVID-19 symptoms and severe disease outcomes can be managed with certain repurposed drugs,traditional medicinal system and antivirals,which have been shown to be effective in treating COVID-19 infection.
