Waist circumference(WC),which is a simple and effective indicator of central obesity,has been proved to be closely related to many chronic diseases,such as hypertension,diabetes,dyslipidemia,cardiovascular,cerebrovasc...Waist circumference(WC),which is a simple and effective indicator of central obesity,has been proved to be closely related to many chronic diseases,such as hypertension,diabetes,dyslipidemia,cardiovascular,cerebrovascular diseases,and so on^([1]).展开更多
Background:The available evidence regarding the benefits of percutaneous coronary intervention(PCI)on patients receiving dialysis with coronary artery disease(CAD)is limited and inconsistent.This study aimed to evalua...Background:The available evidence regarding the benefits of percutaneous coronary intervention(PCI)on patients receiving dialysis with coronary artery disease(CAD)is limited and inconsistent.This study aimed to evaluate the association between PCI and clinical outcomes as compared with medical therapy alone in patients undergoing dialysis with CAD in China.Methods:This multicenter,retrospective study was conducted in 30 tertiary medical centers across 12 provinces in China from January 2015 to June 2021 to include patients on dialysis with CAD.The primary outcome was major adverse cardiovascular events(MACE),defined as a composite of cardiovascular death,non-fatal myocardial infarction,and non-fatal stroke.Secondary outcomes included all-cause death,the individual components of MACE,and Bleeding Academic Research Consortium criteria types 2,3,or 5 bleeding.Multivariable Cox proportional hazard models were used to assess the association between PCI and outcomes.Inverse probability of treatment weighting(IPTW)and propensity score matching(PSM)were performed to account for potential between-group differences.Results:Of the 1146 patients on dialysis with significant CAD,821(71.6%)underwent PCI.After a median follow-up of 23.0 months,PCI was associated with a 43.0%significantly lower risk for MACE(33.9%[n=278]vs.43.7%[n=142];adjusted hazards ratio 0.57,95%confidence interval 0.45-0.71),along with a slightly increased risk for bleeding outcomes that did not reach statistical significance(11.1%vs.8.3%;adjusted hazards ratio 1.31,95%confidence interval,0.82-2.11).Furthermore,PCI was associated with a significant reduction in all-cause and cardiovascular mortalities.Subgroup analysis did not modify the association of PCI with patient outcomes.These primary findings were consistent across IPTW,PSM,and competing risk analyses.Conclusion:This study indicated that PCI in patients on dialysis with CAD was significantly associated with lower MACE and mortality when comparing with those with medical therapy alone,albeit with a slightly increased risk for bleeding events that did not reach statistical significance.展开更多
Dear Editor,Atrial fibrillation(AF)is the most common sustained arrhythmia,frequently presenting with symptoms such as palpitations,fatigue,and shortness of breath(Lippi et al.,2021).AF is categorized into two distinc...Dear Editor,Atrial fibrillation(AF)is the most common sustained arrhythmia,frequently presenting with symptoms such as palpitations,fatigue,and shortness of breath(Lippi et al.,2021).AF is categorized into two distinct phenotypes:paroxysmal atrial fibrillation(PAF)and persistent atrial fibrillation(PsAF).展开更多
Introduction:All countries face the potential threat of imported polioviruses,including both wild type and circulating vaccine-derived polioviruses.In response,we conducted a province-level assessment in China to eval...Introduction:All countries face the potential threat of imported polioviruses,including both wild type and circulating vaccine-derived polioviruses.In response,we conducted a province-level assessment in China to evaluate the risk of importation and transmission of type 1 wild poliovirus(WPV1)and type 2 vaccine-derived poliovirus(VDPV2).Methods:Distinct risk assessment tools for WPV1 and VDPV2 were employed,incorporating three primary indicators—population immunity,poliovirus surveillance,and importation risk.WPV1 was assessed using 13 secondary indicators,whereas VDPV2 utilized 21 secondary indicators.Assessments used comprehensive provincial data from the preceding five years.Scores(S-values)were derived from the secondary indicators’criteria and ratings,and used to classify the provincial-level administrative divisions(PLADs)into three risk categories:high,medium,and low.The top 10%of PLADs were designated as highrisk,with the remaining provinces equally distributed into medium-and low-risk categories.Results:In 2023,Xizang,Qinghai,and Xinjiang PLADs faced the highest risk of WPV1 importation and transmission;Xizang,Shaanxi,and Hainan PLADs were at the greatest risk for VDPV2 importation and transmission.Conclusions:Risk assessment for VDPV2 importation and transmission has identified a distinct set of high-risk provinces compared to those identified by WPV1 risk assessment.Preventive and proactive response measures tailored to the specific risks should be implemented to maintain China’s polio-free status.展开更多
基金funded by National Health Commission of the People’s Republic of China Medical Reform Major Program:China National Chronic Diseases and Nutrition Surveillance of Adults(2015–2017)(No.201519-B)Public Health Emergency Project Nutrition Health and Healthy Diet Campaign(No.102393220020070000012)。
文摘Waist circumference(WC),which is a simple and effective indicator of central obesity,has been proved to be closely related to many chronic diseases,such as hypertension,diabetes,dyslipidemia,cardiovascular,cerebrovascular diseases,and so on^([1]).
基金National High Level Hospital Clinical Research Funding(No.2024-NHLHCRF-YS-01)Capital’s Founds for Health Improvement and Research(No.2022-1-4062)+5 种基金Beijing Research Ward Construction Clinical Research Project(No.2022-YJXBF-04-03)Science Foundation of China-Japan Friendship Hospital(No.2020-HX-40)National Natural Science Foundation of China(No.82270352)National High Level Hospital Clinical Research Funding(No.2024-NHLHCRF-JBGS-WZ-06)Chinese Society of Cardiology’s Foundation(No.CSCF2021B02)National Key Clinical Specialty Construction Project(No.2020-QTL-009)
文摘Background:The available evidence regarding the benefits of percutaneous coronary intervention(PCI)on patients receiving dialysis with coronary artery disease(CAD)is limited and inconsistent.This study aimed to evaluate the association between PCI and clinical outcomes as compared with medical therapy alone in patients undergoing dialysis with CAD in China.Methods:This multicenter,retrospective study was conducted in 30 tertiary medical centers across 12 provinces in China from January 2015 to June 2021 to include patients on dialysis with CAD.The primary outcome was major adverse cardiovascular events(MACE),defined as a composite of cardiovascular death,non-fatal myocardial infarction,and non-fatal stroke.Secondary outcomes included all-cause death,the individual components of MACE,and Bleeding Academic Research Consortium criteria types 2,3,or 5 bleeding.Multivariable Cox proportional hazard models were used to assess the association between PCI and outcomes.Inverse probability of treatment weighting(IPTW)and propensity score matching(PSM)were performed to account for potential between-group differences.Results:Of the 1146 patients on dialysis with significant CAD,821(71.6%)underwent PCI.After a median follow-up of 23.0 months,PCI was associated with a 43.0%significantly lower risk for MACE(33.9%[n=278]vs.43.7%[n=142];adjusted hazards ratio 0.57,95%confidence interval 0.45-0.71),along with a slightly increased risk for bleeding outcomes that did not reach statistical significance(11.1%vs.8.3%;adjusted hazards ratio 1.31,95%confidence interval,0.82-2.11).Furthermore,PCI was associated with a significant reduction in all-cause and cardiovascular mortalities.Subgroup analysis did not modify the association of PCI with patient outcomes.These primary findings were consistent across IPTW,PSM,and competing risk analyses.Conclusion:This study indicated that PCI in patients on dialysis with CAD was significantly associated with lower MACE and mortality when comparing with those with medical therapy alone,albeit with a slightly increased risk for bleeding events that did not reach statistical significance.
基金supported by the National Natural Science Foundation of China(31500828).
文摘Dear Editor,Atrial fibrillation(AF)is the most common sustained arrhythmia,frequently presenting with symptoms such as palpitations,fatigue,and shortness of breath(Lippi et al.,2021).AF is categorized into two distinct phenotypes:paroxysmal atrial fibrillation(PAF)and persistent atrial fibrillation(PsAF).
基金Supported by the Evaluation of 2 Polio Vaccine Strategy Switches in China(JY22-3-10).
文摘Introduction:All countries face the potential threat of imported polioviruses,including both wild type and circulating vaccine-derived polioviruses.In response,we conducted a province-level assessment in China to evaluate the risk of importation and transmission of type 1 wild poliovirus(WPV1)and type 2 vaccine-derived poliovirus(VDPV2).Methods:Distinct risk assessment tools for WPV1 and VDPV2 were employed,incorporating three primary indicators—population immunity,poliovirus surveillance,and importation risk.WPV1 was assessed using 13 secondary indicators,whereas VDPV2 utilized 21 secondary indicators.Assessments used comprehensive provincial data from the preceding five years.Scores(S-values)were derived from the secondary indicators’criteria and ratings,and used to classify the provincial-level administrative divisions(PLADs)into three risk categories:high,medium,and low.The top 10%of PLADs were designated as highrisk,with the remaining provinces equally distributed into medium-and low-risk categories.Results:In 2023,Xizang,Qinghai,and Xinjiang PLADs faced the highest risk of WPV1 importation and transmission;Xizang,Shaanxi,and Hainan PLADs were at the greatest risk for VDPV2 importation and transmission.Conclusions:Risk assessment for VDPV2 importation and transmission has identified a distinct set of high-risk provinces compared to those identified by WPV1 risk assessment.Preventive and proactive response measures tailored to the specific risks should be implemented to maintain China’s polio-free status.
