The number of multi-drug-resistant bacteria has increased over the last few decades,which has caused a detrimental impact on public health worldwide.In resolving antibiotic resistance development among different bacte...The number of multi-drug-resistant bacteria has increased over the last few decades,which has caused a detrimental impact on public health worldwide.In resolving antibiotic resistance development among different bacterial communities,new antimicrobial agents and nanoparticle-based strategies need to be designed foreseeing the slow discovery of new functioning antibiotics.Advanced research studies have revealed the significant disinfection potential of two-dimensional nanomaterials(2D NMs)to be severed as effective antibacterial agents due to their unique physicochemical properties.This review covers the current research progress of 2D NMs-based antibacterial strategies based on an inclusive explanation of 2D NMs’impact as antibacterial agents,including a detailed introduction to each possible well-known antibacterial mechanism.The impact of the physicochemical properties of 2D NMs on their antibacterial activities has been deliberated while explaining the toxic effects of 2D NMs and discussing their biomedical significance,dysbiosis,and cellular nanotoxicity.Adding to the challenges,we also discussed the major issues regarding the current quality and availability of nanotoxicity data.However,smart advancements are required to fabricate biocompatible 2D antibacterial NMs and exploit their potential to combat bacterial resistance clinically.展开更多
In the present time, coronavirus disease COVID-19 has become prevalent across the globe and declared as a pandemic by the world health organization(WHO) [1]. As of now, many vaccines and medicines are in the approval ...In the present time, coronavirus disease COVID-19 has become prevalent across the globe and declared as a pandemic by the world health organization(WHO) [1]. As of now, many vaccines and medicines are in the approval process or at different stages of preclinical investigations to coup with the COVID-19 [2]. Coronavirus has a spike protein, which tends to bind with receptors present in the lung tissues, and that helps in its entry to the cells and replication inside [3]. Therefore, we are in need to design the multivalent nanomaterials, which can act as receptors to bind with spike protein of virus and stop its replication(Fig. 1).展开更多
Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the...Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations.展开更多
基金supported by the Science and Technology Innovation Commission of Shenzhen,China(20231121191245001 and JCYJ20210324095607021 to HX)the Special Project of Key Fields of Universities in Guangdong Province,China(2021ZDZX2047 to HX).
文摘The number of multi-drug-resistant bacteria has increased over the last few decades,which has caused a detrimental impact on public health worldwide.In resolving antibiotic resistance development among different bacterial communities,new antimicrobial agents and nanoparticle-based strategies need to be designed foreseeing the slow discovery of new functioning antibiotics.Advanced research studies have revealed the significant disinfection potential of two-dimensional nanomaterials(2D NMs)to be severed as effective antibacterial agents due to their unique physicochemical properties.This review covers the current research progress of 2D NMs-based antibacterial strategies based on an inclusive explanation of 2D NMs’impact as antibacterial agents,including a detailed introduction to each possible well-known antibacterial mechanism.The impact of the physicochemical properties of 2D NMs on their antibacterial activities has been deliberated while explaining the toxic effects of 2D NMs and discussing their biomedical significance,dysbiosis,and cellular nanotoxicity.Adding to the challenges,we also discussed the major issues regarding the current quality and availability of nanotoxicity data.However,smart advancements are required to fabricate biocompatible 2D antibacterial NMs and exploit their potential to combat bacterial resistance clinically.
基金financial support from the European Union’s Horizon 2020 program under grant 839177 (PEPREP)financial support from the Ministry of Science and Technology of China (2016YFA0201600, 2016YFE0133100)the Science Fund for Creative Research Groups of the National Natural Science Foundation of China (11621505)。
文摘In the present time, coronavirus disease COVID-19 has become prevalent across the globe and declared as a pandemic by the world health organization(WHO) [1]. As of now, many vaccines and medicines are in the approval process or at different stages of preclinical investigations to coup with the COVID-19 [2]. Coronavirus has a spike protein, which tends to bind with receptors present in the lung tissues, and that helps in its entry to the cells and replication inside [3]. Therefore, we are in need to design the multivalent nanomaterials, which can act as receptors to bind with spike protein of virus and stop its replication(Fig. 1).
基金supported by the National Natural Science Foundation of China (11621505, 11435002, 31671016)
文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations.
