期刊文献+
共找到9篇文章
< 1 >
每页显示 20 50 100
术后入ICU肥胖患者AKI风险及其进展为死亡预测研究 被引量:1
1
作者 李强 母国 +5 位作者 王文章 印婕 余璇 卢彬 李茜 周军 《陆军军医大学学报》 北大核心 2025年第10期1110-1125,共16页
目的本研究旨在通过机器学习算法构建肥胖患者术后急性肾损伤(acute kidney injury,AKI)风险预测模型及死亡风险预测模型,以提高对肥胖患者术后AKI的预警能力和预后评估水平,为临床医疗提供支持。方法研究从MIMIC-IV和eICU数据库中收集... 目的本研究旨在通过机器学习算法构建肥胖患者术后急性肾损伤(acute kidney injury,AKI)风险预测模型及死亡风险预测模型,以提高对肥胖患者术后AKI的预警能力和预后评估水平,为临床医疗提供支持。方法研究从MIMIC-IV和eICU数据库中收集术后入ICU的肥胖患者相关数据进行统计分析,最终纳入2520例肥胖术后入ICU患者(MIMIC-IV 670例,eICU 1850例)进行模型构建,包括一般资料、生命体征、实验室检查结果、手术类型、合并症及用药情况等。通过数据清洗和预处理,使用Boruta进行特征筛选,并采用GBM、GLM、KNN、NB、NNET、SVM和XGBoost等7种机器学习算法构建预测模型,通过交叉验证和外部验证评估模型性能。结果肥胖患者术后AKI风险预测模型中,SVM模型在测试集的AUC值达到0.80,外部验证AUC为0.71;死亡风险预测模型中,GBM模型表现最佳,测试集AUC值达到0.91。结论本研究成功构建了肥胖患者术后AKI风险及死亡风险预测模型,为临床医生提供了有力的辅助工具,有助于改善患者临床结局。 展开更多
关键词 肥胖患者 急性肾损伤 机器学习 风险预测 死亡预测
原文传递
术中持续气管导管套囊压力控制对腹腔镜子宫切除患者气道黏膜的保护作用
2
作者 刘育蓉 母国 +2 位作者 余璇 李强 卢彬 《实用医院临床杂志》 2025年第3期152-155,共4页
目的探讨持续控制气管导管套囊压力对腹腔镜子宫切除患者术后气道不适症状的影响。方法纳入全麻下行腹腔镜子宫切除术患者60例,按随机数字法分为A、B两组各30例,A组气管插管成功后使用换能器持续监测套囊压力但不进行套囊压力控制;B组... 目的探讨持续控制气管导管套囊压力对腹腔镜子宫切除患者术后气道不适症状的影响。方法纳入全麻下行腹腔镜子宫切除术患者60例,按随机数字法分为A、B两组各30例,A组气管插管成功后使用换能器持续监测套囊压力但不进行套囊压力控制;B组使用换能器持续监测并始终调整套囊压力维持在25~30 cmH_(2) O。记录两组患者插管时(T_(a))、气腹建立时(T_(b))、头低位时(T_(c))、气腹结束时(T_(d))、拔管时(T_(e))气管导管套囊压力;采用VAS评分评估术后拔管时(T_(1))、术后2 h(T_(2))、术后1 d(T_(3))、术后3 d(T_(4))咽痛程度;拔管时纤支镜观察套囊处黏膜情况;收集术后24 h内第1次痰液,记录痰隐血阳性例数。结果与A组比较,B组T_(b-e)时点套囊压力较低;T_(2)时点咽痛程度较轻;拔管时纤支镜观察气道黏膜损伤面膜点状充血、片状充血、黏膜破损和溃疡发生例数较少,痰隐血阳性例数较少(P<0.05)。结论术中持续套囊压力控制有助于降低腹腔镜子宫切除术患者气道不适。 展开更多
关键词 套囊压力 咽痛 插管法 气管内 腹腔镜
暂未订购
利拉鲁肽通过抑制NLRP3炎症小体信号通路改善脓毒症小鼠脑损伤
3
作者 郭焰 杨程杰 +4 位作者 母国 魏娜 陈烨 谢冰清 周军 《西南医科大学学报》 2025年第1期41-46,共6页
目的研究利拉鲁肽对脂多糖(lipopolysaccharide,LPS)诱导的脓毒症小鼠脑损伤的保护作用及机制。方法90只C57BL/6小鼠,随机分为3组(n=30):对照组(Control),脓毒症组(LPS),LPS+利拉鲁肽组(LPS+Lira)。LPS组和LPS+Lira组腹腔注射LPS(15 mg/... 目的研究利拉鲁肽对脂多糖(lipopolysaccharide,LPS)诱导的脓毒症小鼠脑损伤的保护作用及机制。方法90只C57BL/6小鼠,随机分为3组(n=30):对照组(Control),脓毒症组(LPS),LPS+利拉鲁肽组(LPS+Lira)。LPS组和LPS+Lira组腹腔注射LPS(15 mg/kg),Control组注射等量生理盐水。LPS+Lira组小鼠在LPS注射前2天皮下注射利拉鲁肽(200μg/kg),每天2次,连续3 d。结果3组小鼠的生存率、脑含水量、海马CA1区正常锥体细胞数、细胞凋亡率、氧化应激指标、炎症因子水平及相关蛋白表达水平进行比较,差异均具有统计学意义(P<0.05)。进一步两两比较显示,LPS组比Control组的生存率降低(P<0.05),脑含水量增加(P<0.05),海马CA1区正常锥体细胞数减少(P<0.05),细胞凋亡率增加(P<0.05),氧化应激和炎症因子水平升高(P<0.05),NLRP3、Casp1 p10、Caspase-3和Bax蛋白表达水平均增加(P<0.05),Bcl-2表达减少(P<0.05)。LPS+Lira组小鼠的各项指标较LPS组均明显改善(P<0.05)。结论利拉鲁肽通过抑制NLRP3/Cas⁃pase-1信号通路的激活,可减轻炎症反应、氧化应激及细胞凋亡,对LPS诱导的脓毒症脑损伤具有明显保护作用。 展开更多
关键词 脓毒症 脑损伤 利拉鲁肽 NLRP3炎性体
暂未订购
A study on key technologies of unmanned driving 被引量:16
4
作者 Xinyu Zhang Hongbo Gao +3 位作者 mu guo guopeng Li Yuchao Liu Deyi Li 《CAAI Transactions on Intelligence Technology》 2016年第1期4-13,共10页
Although the development of machine intelligence is far from simulating all the cognitive competence of our brains, still it is absolutely possible to peel the driving activity from people's cognitive activities and ... Although the development of machine intelligence is far from simulating all the cognitive competence of our brains, still it is absolutely possible to peel the driving activity from people's cognitive activities and then make the machine finish some low-level, complicated and lasting driving cognition by simulating our brains. The goal of driving is to replace drivers and free them from boring driving activities. Based on some studies on unmanned driving, this paper summarizes and analyzes the background, significance, research status and key technology of unmanned driving and the research group also introduces some research on brain cognition of driving and sensor placement of intelligent vehicles, which offers more meaningful reference to push the study of unmanned driving. 展开更多
关键词 Unmanned driving Brain cognition of driving Sensor placement Formalization of brain cognition
在线阅读 下载PDF
脑电双频指数监测在脑出血伴轻中度意识障碍患者丙泊酚全麻诱导中的应用 被引量:4
5
作者 曹露 李红 +3 位作者 母国 余璇 郑业英 缪冬梅 《实用医院临床杂志》 2022年第6期42-45,共4页
目的 研究脑电双频指数(BIS)监测在脑出血伴轻中度意识障碍的手术患者中丙泊酚全麻诱导的指导意义。方法 拟在全麻下行开颅手术的43例脑出血患者,GCS评分在8~15分,按随机数字表法分为B组(BIS监测下诱导组)21例和G组(按传统经验诱导组)2... 目的 研究脑电双频指数(BIS)监测在脑出血伴轻中度意识障碍的手术患者中丙泊酚全麻诱导的指导意义。方法 拟在全麻下行开颅手术的43例脑出血患者,GCS评分在8~15分,按随机数字表法分为B组(BIS监测下诱导组)21例和G组(按传统经验诱导组)22例。比较两组患者麻醉诱导过程中丙泊酚的使用量以及在诱导前(T_(0))、丙泊酚推注完即刻(T_(1))、气管插管即刻(T_(2))、插管后1min(T_(3))的BIS值、平均动脉压(MAP)、心率(HR)及血液中皮质醇、促肾上腺皮质激素(ACTH)浓度,同时记录BIS<40、心动过缓(HR≤60次/分)、心动过速(HR≥100次/分)、平均动脉压波动超过基础血压20%等不良事件发生率和血管活性药物使用情况。结果 B组的丙泊酚用量明显少于G组,BIS值明显高于G组(P<0.05);T_(1)时,两组患者的MAP均低于T0(P<0.05),且B组高于G组(P<0.05);B组T_(1)~T_(3)的HR均低于G组,低血压、低BIS等不良反应发生率少于G组(P<0.05)。结论 BIS监测应用于轻中度意识障碍的脑出血患者的麻醉诱导,可明显减少丙泊酚的用量,降低麻醉诱导期低BIS和低血压的发生率,麻醉诱导过程更平稳安全。 展开更多
关键词 脑电双频指数 丙泊酚 麻醉诱导 脑出血
暂未订购
术前面罩预适应不同实施者对患儿术前焦虑的影响 被引量:8
6
作者 母国 刘祥波 +1 位作者 陈米炼 欧册华 《临床麻醉学杂志》 CAS CSCD 北大核心 2020年第8期771-774,共4页
目的探讨术前面罩预适应对降低患儿术前焦虑的作用,并比较不同实施者的影响。方法纳入全麻下行腹腔镜疝囊修补或鞘状突高位结扎手术患儿105例,男81例,女24例,年龄2~7岁,BMI 18~23 kg/m^2,ASAⅠ或Ⅱ级。患儿随机分为三组:术前1 d由父母... 目的探讨术前面罩预适应对降低患儿术前焦虑的作用,并比较不同实施者的影响。方法纳入全麻下行腹腔镜疝囊修补或鞘状突高位结扎手术患儿105例,男81例,女24例,年龄2~7岁,BMI 18~23 kg/m^2,ASAⅠ或Ⅱ级。患儿随机分为三组:术前1 d由父母对患儿实施面罩预适应组(P组,n=37),术前1 d由麻醉科医师对患儿实施面罩预适应组(A组,n=35),不实施面罩预适应组(C组,n=33)。采用改良耶鲁焦虑量表(mYPAS)分别于进入等待区(T0)、与父母分离进入手术室时(T1)、麻醉诱导时(T2)、麻醉苏醒时(T3)评估患儿焦虑程度,T2时采用诱导合作量表(ICC)和面罩接受度评分(MAS)评估患儿诱导时的依从性。结果与T0时比较,T1时三组mYPAS评分均明显升高(P<0.05)。与T1时比较,T2时三组mYPAS评分明显升高(P<0.05)。与T2时比较,T3时三组mYPAS评分明显降低(P<0.05)。T1—T3时P组和A组mYPAS评分明显低于C组(P<0.05),T2时P组mYPAS评分明显低于A组(P<0.05)。T2时P组和A组ICC评分明显低于C组,且P组明显低于A组[P组(3.6±1.6)分,A组(4.6±1.8)分,C组(5.5±1.8)分,P<0.05]。T2时P组和A组MAS评分明显高于C组[P组(2.7±0.9)分,A组(2.8±0.8)分,C组(2.0±0.8)分,P<0.05],而P组和A组差异无统计学意义。结论面罩预适应能有效降低患儿术前焦虑,由父母术前1 d实施更能有效减轻患儿诱导时焦虑。 展开更多
关键词 术前焦虑 小儿 面罩 预适应
暂未订购
Combining Transcriptomics and Metabolomics to Uncover the Effects of High-Energy Lithium-Ion Beam Irradiation on Capsicum annuum L.
7
作者 Libo Xie Xue Wang +5 位作者 Luxiang Liu Chunmei Xu Yongdun Xie Hongchun Xiong Xinchun Han mu guo 《Phyton-International Journal of Experimental Botany》 SCIE 2023年第11期2947-2964,共18页
Hot pepper(Capsicum annuum L.)is consumed as one of the oldest domesticated crops all over the world.Although mutation breeding using radiation has been performed in hot peppers,little is known about the comparative a... Hot pepper(Capsicum annuum L.)is consumed as one of the oldest domesticated crops all over the world.Although mutation breeding using radiation has been performed in hot peppers,little is known about the comparative analysis of mutagenic effects at the molecular level by ion beam irradiation.To comprehend the response mechanism of hot pepper to the ion beam,we used a mutant with favorable economic characteristics induced by lithium-ion beam irradiation to investigate the biological effects.The results indicated that the lithium-ion beam had a positive effect on important agronomic traits,particularly yield unit,but had a negligible effect on the photosynthetic rate of hot pepper,with a specific influence on chlorophyll b rather than chlorophyll a.By RNA-Seq analysis,671 up-regulated and 376 down-regulated genes were identified as differentially expressed genes(DEGs)between irradiated and unirradiated hot pepper.Based on GO and KEGG network analysis,the auxin metabolic process was the common pathway in these two networks.A total of 118 potential reactive oxygen species(ROS)scavenging genes and 262 signal transduction genes were identified,suggesting a balance between antioxidant enzymes and enhanced ROS transduction.The amounts of 15 metabolite,involved in GABA pathways,secondary metabolism,carbohydrate metabolism,shikimate pathways,TCA cycles,nitrogen metabolism,glycerol metabolism and acetate pathways,were significantly changed in the ion beam irradiated sample.These results highlighted that the enriched pathways could play important roles in response to ion beam irradiation in hot pepper plants.In summary,these data provide valuable information for future research on ion beam irradiation and genomic studies in hot pepper. 展开更多
关键词 Capsicum annuum L PHYSIOLOGY TRANSCRIPTOMICS metabolomics lithium-ion beam
在线阅读 下载PDF
钻井液体系的优化
8
作者 揭家辉 牟果 《化工设计通讯》 CAS 2019年第3期233-233,共1页
依据地层的特点,选择最合理的钻井液体系,发挥钻井液的优势,保证钻井施工的顺利实施,达到最佳的钻井施工质量,满足油田勘探开发的需要。选择防漏防塌的钻井液体系,解决特殊井筒钻井施工的难点问题,提高钻井施工的效率。
关键词 钻井液体系 选择 使用 优化
在线阅读 下载PDF
Epidemiological Characteristics of Human Anthrax-China,2018-2021 被引量:12
9
作者 Huijuan Zhang Enmin Zhang +3 位作者 mu guo Jinrong He Wei Li Jianchun Wei 《China CDC weekly》 2022年第35期783-787,共5页
Introduction:The epidemic of human anthrax is at a low level in China in recent years,but the reported incidence increased in 2021.In order to understand the current landscape of research and knowledge about anthrax i... Introduction:The epidemic of human anthrax is at a low level in China in recent years,but the reported incidence increased in 2021.In order to understand the current landscape of research and knowledge about anthrax in China,the epidemiological characteristics of anthrax in humans from 2018 to 2021 were analyzed and the prevention and control suggestions were proposed.Methods:Surveillance data of anthrax in humans and livestock,together with human outbreaks data during 2018-2021,were collected and analyzed by descriptive statistics methods.The number and proportion of outbreaks,cases and deaths by provincial-level administrative divisions(PLADs),clinical types,and contributing factors were calculated.Results:A total of 1,244 cases of human anthrax and 53 outbreaks were reported from 2018 to 2021 in China.While the incidence of anthrax declined from 2018 to 2020,it increased in 2021.The regions of anthrax were mainly located in the west and the northeast PLADs of China,though cases were reported in some central and eastern PLADs in 2021.Young and middle-aged men involved in animal husbandry were found to be at a higher risk of anthrax.All the reported outbreaks were associated with the exposure of infected livestock.A total of 296 livestock anthrax cases were reported.Conclusions:The increased incidence and wider geographical distribution of human anthrax in 2021 were found to be the result of inadequate supervision of diseased animals as well as updated diagnostic criteria.As such,the monitoring of risk factors and emergency preparation procedures should be strengthened at the national level.In addition,it is also critical to strengthen health education for high-risk occupational groups and strengthen professional training for local clinicians.Finally,more measures should be carried out to strengthen anthrax surveillance in livestock husbandry. 展开更多
关键词 PREVENTION HUSBANDRY STRENGTHENED
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部