Ginger(Zingiber officinale)essential oil(G_(EO))was loaded into nanoliposome(NL_(P))for smart release in simulated in-vitro digestion.Optimal conditions for the fabrication of NL_(p)-G_(EO) were determined according t...Ginger(Zingiber officinale)essential oil(G_(EO))was loaded into nanoliposome(NL_(P))for smart release in simulated in-vitro digestion.Optimal conditions for the fabrication of NL_(p)-G_(EO) were determined according to physical stability,size distribution and particle size.Morphological analyses(atomic force microscopy(AFM)and scan-ning electron microscopy(SEM))confirmed the results of the dynamic light scattering(DLS).Structural evalu-ation(differential Scanning Calorimetry(DSC)and Fourier-transform infrared spectroscopy(FTIR))demonstrated the interaction between G_(EO) and NL_(P).Additionally,the approximate size and loading capacity of optimized NL_(p)-G_(EO)(100 nm)was 100 nm and 66.24%.NL_(p)-G_(EO) release under oral,gastric,and intestinal conditions showed that over 90%of the nutraceutical was released after exposure to model gastrointestinal conditions.Finally,NL_(p)-G_(EO) structure showed an improved antioxidant,UV stability and reduced cytotoxicity on cell lines(human colon cancer(HT-29))and normal human umbilical vein endothelial cells(HUVEC).As an innovative smart sustained-release system in simulated in-vitro digestion,NL_(P)-G_(EO) would be a potential practical option in the food and pharmaceutical industries.展开更多
文摘Ginger(Zingiber officinale)essential oil(G_(EO))was loaded into nanoliposome(NL_(P))for smart release in simulated in-vitro digestion.Optimal conditions for the fabrication of NL_(p)-G_(EO) were determined according to physical stability,size distribution and particle size.Morphological analyses(atomic force microscopy(AFM)and scan-ning electron microscopy(SEM))confirmed the results of the dynamic light scattering(DLS).Structural evalu-ation(differential Scanning Calorimetry(DSC)and Fourier-transform infrared spectroscopy(FTIR))demonstrated the interaction between G_(EO) and NL_(P).Additionally,the approximate size and loading capacity of optimized NL_(p)-G_(EO)(100 nm)was 100 nm and 66.24%.NL_(p)-G_(EO) release under oral,gastric,and intestinal conditions showed that over 90%of the nutraceutical was released after exposure to model gastrointestinal conditions.Finally,NL_(p)-G_(EO) structure showed an improved antioxidant,UV stability and reduced cytotoxicity on cell lines(human colon cancer(HT-29))and normal human umbilical vein endothelial cells(HUVEC).As an innovative smart sustained-release system in simulated in-vitro digestion,NL_(P)-G_(EO) would be a potential practical option in the food and pharmaceutical industries.
