Objectives:Cycling economy is associated with muscle strength in athletes.However,the relationship between strength capacity(i.e.maximal and explosive strength)and cycling economy in previously untrained but healthy i...Objectives:Cycling economy is associated with muscle strength in athletes.However,the relationship between strength capacity(i.e.maximal and explosive strength)and cycling economy in previously untrained but healthy individuals remains unclear.Therefore,this study aimed to assess the associations between cycling economy and strength performance in a population of recreationally active but untrained healthy individuals.Methods:A total of 155 recreationally active individuals(95 males and 60 females)were included.Strength capacity was assessed through an incremental one-repetition maximum test,from which the one-repetition maximum,mean propulsive velocity,and mean propulsive power were derived as strength indices.Cycling economy was assessed using a step protocol on a cycle ergometer and gross oxygen cost and caloric unit cost were determined at submaximal intensities.Results:Marginal R^(2) ranged between 0.013 and 0.062 for the gross oxygen cost and between 0.022 and 0.103 for the gross caloric unit cost,respectively.Greater cycling economy is related to higher strength levels.However,the relationship is relatively weak,explaining only 1.3–6.2%of the variance in gross oxygen cost and 2.2–10.3%of the variance in gross caloric unit cost.Conclusions:Greater cycling economy in recreationally active males and females is related to higher strength levels(i.e.one-repetition maximum,mean propulsive velocity,mean propulsive power).展开更多
As the concept of“exercise is medicine”has grown in recent years,there is an urgent need for translational research in thefield of exercise science that bridges the gaps between basic scientific discoveries(e.g.,detai...As the concept of“exercise is medicine”has grown in recent years,there is an urgent need for translational research in thefield of exercise science that bridges the gaps between basic scientific discoveries(e.g.,detailing the physiological,biological and molecular responses to exercise)and its application to improving human health and targeting specific disease pathophysiology.Translational research is also needed to bridge the gap between clinical trials describing the health benefits of exercise and the underlying mechanisms to change and optimize clinical practice,health promotion,and exercise guidelines.Therefore,with the new peer-reviewed,open-access academic journal“Translational Exercise Biomedicine”,we aim to further personalize and advance exercise prescription and improve physically active lifestyles for prevention and therapy.展开更多
The scientific interest of exercise medicine for the treatment of cancer is ever expanding.Recently published and updated guidelines for exercise training in cancer patients by the American College of Sports Medicine(...The scientific interest of exercise medicine for the treatment of cancer is ever expanding.Recently published and updated guidelines for exercise training in cancer patients by the American College of Sports Medicine(ACSM),the Clinical Oncol-ogy Society of Australia(COSA)or the Exercise and Sports Science Australia(ESSA)are leading the way towards an indi-vidualized approach for exercise prescription.These guidelines provide physicians and therapists with a comprehensive and detailed overview about the beneficial effects of exercise training and,more so,summarize the evidence on potential dose-response mechanisms,including pathways of exercise-induced stimuli to counteract tumour microenvironmental pathologies.However,the most optimal types and doses of exercise training across the cancer disease and treatment continuum are yet to be determined.Therefore,the purpose of this narrative review was to illustrate the current implications but also limitations of exercise training during the different stages of cancer therapy,as well as to discuss necessary future directions.As a second purpose,special attention will be given to the current role of exercise in the treatment of cancer in Germany.展开更多
Concurrent exercise and metformin administration may reduce the acute and chronic effects of exercise on glucose metabolism in the patients with type 2 diabetes(T2D).However,several studies suggest that combing metfor...Concurrent exercise and metformin administration may reduce the acute and chronic effects of exercise on glucose metabolism in the patients with type 2 diabetes(T2D).However,several studies suggest that combing metformin and exercise treatment may have neither additive effect nor even cause adverse effects in T2D patients.This case report aimed to highlight the challenges associated with prescribing exercise to type 2 diabetes patients undergoing metformin treatment.A 67-years old woman was followed-up for five months,including assessment of the acute and chronic glucose and lactate metabolism induced by concomitant exercise and metformin.The findings were four-fold:1)During a high-intensity interval training bout,blood glucose systematically decreased,while blood lactate concentrations fluctuated randomly;2)Basal blood lactate levels were well above 2 mmol/L on days with medication only;3)Combined exercise and metformin administration induced additive effects on the normalization of glucose and 4)high levels of physical activity had a positive impact on the continuous glucose fluctuations,while decreased levels of physical activity induced a large fluctuation of glucose due to home confinement of an infectious disease caused by the SARS-CoV-2 virus.Our findings showed that when combined with exercise and metformin treatment for T2D patients,exercise may contribute to improving glycemic control while metformin may elevate lactate levels in the long term.The observed results underline the need to prescribe exercise and monitor lactate levels for reducing possible risks associated with metformin treatment and reinforce the importance of tailoring exercise therapy.展开更多
文摘Objectives:Cycling economy is associated with muscle strength in athletes.However,the relationship between strength capacity(i.e.maximal and explosive strength)and cycling economy in previously untrained but healthy individuals remains unclear.Therefore,this study aimed to assess the associations between cycling economy and strength performance in a population of recreationally active but untrained healthy individuals.Methods:A total of 155 recreationally active individuals(95 males and 60 females)were included.Strength capacity was assessed through an incremental one-repetition maximum test,from which the one-repetition maximum,mean propulsive velocity,and mean propulsive power were derived as strength indices.Cycling economy was assessed using a step protocol on a cycle ergometer and gross oxygen cost and caloric unit cost were determined at submaximal intensities.Results:Marginal R^(2) ranged between 0.013 and 0.062 for the gross oxygen cost and between 0.022 and 0.103 for the gross caloric unit cost,respectively.Greater cycling economy is related to higher strength levels.However,the relationship is relatively weak,explaining only 1.3–6.2%of the variance in gross oxygen cost and 2.2–10.3%of the variance in gross caloric unit cost.Conclusions:Greater cycling economy in recreationally active males and females is related to higher strength levels(i.e.one-repetition maximum,mean propulsive velocity,mean propulsive power).
文摘As the concept of“exercise is medicine”has grown in recent years,there is an urgent need for translational research in thefield of exercise science that bridges the gaps between basic scientific discoveries(e.g.,detailing the physiological,biological and molecular responses to exercise)and its application to improving human health and targeting specific disease pathophysiology.Translational research is also needed to bridge the gap between clinical trials describing the health benefits of exercise and the underlying mechanisms to change and optimize clinical practice,health promotion,and exercise guidelines.Therefore,with the new peer-reviewed,open-access academic journal“Translational Exercise Biomedicine”,we aim to further personalize and advance exercise prescription and improve physically active lifestyles for prevention and therapy.
文摘The scientific interest of exercise medicine for the treatment of cancer is ever expanding.Recently published and updated guidelines for exercise training in cancer patients by the American College of Sports Medicine(ACSM),the Clinical Oncol-ogy Society of Australia(COSA)or the Exercise and Sports Science Australia(ESSA)are leading the way towards an indi-vidualized approach for exercise prescription.These guidelines provide physicians and therapists with a comprehensive and detailed overview about the beneficial effects of exercise training and,more so,summarize the evidence on potential dose-response mechanisms,including pathways of exercise-induced stimuli to counteract tumour microenvironmental pathologies.However,the most optimal types and doses of exercise training across the cancer disease and treatment continuum are yet to be determined.Therefore,the purpose of this narrative review was to illustrate the current implications but also limitations of exercise training during the different stages of cancer therapy,as well as to discuss necessary future directions.As a second purpose,special attention will be given to the current role of exercise in the treatment of cancer in Germany.
基金We thank Hui Zuo and Tao Zhang for their help in managing the patient.This work was supported by the China Postdoctoral Science Foundation(2021M692090)Guided Scientific Research Project of Shiyan Science and Technology Bureau(21Y17)Shanghai Philosophy and Social Science Planning Project(2022ZTY003).
文摘Concurrent exercise and metformin administration may reduce the acute and chronic effects of exercise on glucose metabolism in the patients with type 2 diabetes(T2D).However,several studies suggest that combing metformin and exercise treatment may have neither additive effect nor even cause adverse effects in T2D patients.This case report aimed to highlight the challenges associated with prescribing exercise to type 2 diabetes patients undergoing metformin treatment.A 67-years old woman was followed-up for five months,including assessment of the acute and chronic glucose and lactate metabolism induced by concomitant exercise and metformin.The findings were four-fold:1)During a high-intensity interval training bout,blood glucose systematically decreased,while blood lactate concentrations fluctuated randomly;2)Basal blood lactate levels were well above 2 mmol/L on days with medication only;3)Combined exercise and metformin administration induced additive effects on the normalization of glucose and 4)high levels of physical activity had a positive impact on the continuous glucose fluctuations,while decreased levels of physical activity induced a large fluctuation of glucose due to home confinement of an infectious disease caused by the SARS-CoV-2 virus.Our findings showed that when combined with exercise and metformin treatment for T2D patients,exercise may contribute to improving glycemic control while metformin may elevate lactate levels in the long term.The observed results underline the need to prescribe exercise and monitor lactate levels for reducing possible risks associated with metformin treatment and reinforce the importance of tailoring exercise therapy.
