Acquired immune deficiency syndrome(AIDS)is the name used to describe several potentially life-threatening infections and disorders that happen when HIV has severely compromised the immune system.The primary effect of...Acquired immune deficiency syndrome(AIDS)is the name used to describe several potentially life-threatening infections and disorders that happen when HIV has severely compromised the immune system.The primary effect of HIV is to decrease host immunity,exposing the host to external pathogens.The development of pharmaceutical drugs that directly cure the infection is crucial because of the current wide-ranging epidemic of HIV.Most therapeutic anti-HIV drugs are nucleosides.However,their high toxicity and potential for drug resistance restrict their use.Many of the most effective clinical drugs used to inhibit HIV,the activation of latent HIV,and AIDS have been obtained from natural sources.This review focuses on potential natural medicinal products for treating and managing HIV and AIDS.Notwithstanding,further clinical research studies are needed to understand the subject and its dynamics.展开更多
Vitamin D,with its diverse molecular pathways and immunomodulatory properties,has become a crucial tool in the prevention and treatment of various cancers.It controls angiogenesis,apoptosis,differentiation,and cellula...Vitamin D,with its diverse molecular pathways and immunomodulatory properties,has become a crucial tool in the prevention and treatment of various cancers.It controls angiogenesis,apoptosis,differentiation,and cellular proliferation,inhibiting cancer through immune surveillance,DNA repair,and tumor suppression genes.Additionally,vitamin D signaling impacts tumor growth and metastasis in various cancer types by interacting with key oncogenic pathways like Wnt/β-catenin,NF-κB,PI3K/Akt,and p53.This review demonstrates the molecular and therapeutic implications of vitamin D in oncology,focusing on its potential as a safe,adjuvant treatment method.It emphasizes the role of vitamin D in epigenetic modification,its impact on tumor microenvironment,and its synergistic benefits when combined with immune checkpoint inhibitors and chemotherapeutic drugs.Despite promising results,genetic variations in the VDR gene continue to cause issues with bioavailability,ideal dosage,and interindividual response variability.The review also proposes future research on vitamin D's potentiality as a therapeutic adjuvant in various malignancies,including colorectal,prostate,and breast cancers,and suggests the development of non-calcemic vitamin D analogs and the incorporation of vitamin D-based methods into personalized oncology treatments.展开更多
基金funding this work through the Large Research Group Project under grant number RGP.02/513/45.
文摘Acquired immune deficiency syndrome(AIDS)is the name used to describe several potentially life-threatening infections and disorders that happen when HIV has severely compromised the immune system.The primary effect of HIV is to decrease host immunity,exposing the host to external pathogens.The development of pharmaceutical drugs that directly cure the infection is crucial because of the current wide-ranging epidemic of HIV.Most therapeutic anti-HIV drugs are nucleosides.However,their high toxicity and potential for drug resistance restrict their use.Many of the most effective clinical drugs used to inhibit HIV,the activation of latent HIV,and AIDS have been obtained from natural sources.This review focuses on potential natural medicinal products for treating and managing HIV and AIDS.Notwithstanding,further clinical research studies are needed to understand the subject and its dynamics.
文摘Vitamin D,with its diverse molecular pathways and immunomodulatory properties,has become a crucial tool in the prevention and treatment of various cancers.It controls angiogenesis,apoptosis,differentiation,and cellular proliferation,inhibiting cancer through immune surveillance,DNA repair,and tumor suppression genes.Additionally,vitamin D signaling impacts tumor growth and metastasis in various cancer types by interacting with key oncogenic pathways like Wnt/β-catenin,NF-κB,PI3K/Akt,and p53.This review demonstrates the molecular and therapeutic implications of vitamin D in oncology,focusing on its potential as a safe,adjuvant treatment method.It emphasizes the role of vitamin D in epigenetic modification,its impact on tumor microenvironment,and its synergistic benefits when combined with immune checkpoint inhibitors and chemotherapeutic drugs.Despite promising results,genetic variations in the VDR gene continue to cause issues with bioavailability,ideal dosage,and interindividual response variability.The review also proposes future research on vitamin D's potentiality as a therapeutic adjuvant in various malignancies,including colorectal,prostate,and breast cancers,and suggests the development of non-calcemic vitamin D analogs and the incorporation of vitamin D-based methods into personalized oncology treatments.
