The necessary background as well as the details of simulation was presented to simulate and evaluate the performance of the ad hoc on-demand distance vector routing protocol in mobile ad hoc network with the help of t...The necessary background as well as the details of simulation was presented to simulate and evaluate the performance of the ad hoc on-demand distance vector routing protocol in mobile ad hoc network with the help of the network simulator NS2 using the common transmission range to deliver the data packets at the destination node. The number of participating nodes played an important role to predict the conditions for the best performance of the protocol with respect to throughput, delay, packet delivery ratio, drop packets, consumed and residual energy of the network. Further, the efforts can be put to control the transmission range dynamically and overheads for reducing the energy consumption in the network and improving its lifetime of the nodes and the lifespan of the network.展开更多
Background:The incidence of prostate cancer is increasing worldwide.A significant proportion of patients developmetastatic disease and are initially prescribed androgen deprivation therapy(ADT).However,subsequent sequ...Background:The incidence of prostate cancer is increasing worldwide.A significant proportion of patients developmetastatic disease and are initially prescribed androgen deprivation therapy(ADT).However,subsequent sequences of treatments in real-world settings that may improve overall survival remain an area of active investigation.Materials and methods:Data were collected from 384 patients presenting with de novo metastatic prostate cancer from 2011 to 2015 at a tertiary cancer center.Patients were categorized into surviving(n=232)and deceased(n=152)groups at the end of 3 years.Modified sequence pattern mining techniques(Generalized Sequential Pattern Mining and Sequential Pattern Discovery using Equivalence Classes)were applied to determine the exact order of the most frequent sets of treatments in each group.Results:Degarelix,as the initial form of ADT,was uniquely in the surviving group.The sequence of ADT followed by abiraterone and docetaxel was uniquely associated with a higher 3-year overall survival.Orchiectomy followed by fosfestrol was found to have a unique niche among surviving patients with a long duration of response to the initial ADT.Patients who received chemotherapy followed by radiotherapy and those who received radiotherapy followed by chemotherapy were found more frequently in the deceased group.Conclusions:We identified unique treatment sequences among surviving and deceased patients at the end of 3 years.Degarelix should be the preferred formof ADT.Patients who received ADT followed by abiraterone and chemotherapy showed better results.Patients requiring palliative radiation and chemotherapy in any sequence were significantlymore frequent in the deceased group,identifying the need to offer such patients the most efficacious agents and to target them in clinical trial design.展开更多
文摘The necessary background as well as the details of simulation was presented to simulate and evaluate the performance of the ad hoc on-demand distance vector routing protocol in mobile ad hoc network with the help of the network simulator NS2 using the common transmission range to deliver the data packets at the destination node. The number of participating nodes played an important role to predict the conditions for the best performance of the protocol with respect to throughput, delay, packet delivery ratio, drop packets, consumed and residual energy of the network. Further, the efforts can be put to control the transmission range dynamically and overheads for reducing the energy consumption in the network and improving its lifetime of the nodes and the lifespan of the network.
文摘Background:The incidence of prostate cancer is increasing worldwide.A significant proportion of patients developmetastatic disease and are initially prescribed androgen deprivation therapy(ADT).However,subsequent sequences of treatments in real-world settings that may improve overall survival remain an area of active investigation.Materials and methods:Data were collected from 384 patients presenting with de novo metastatic prostate cancer from 2011 to 2015 at a tertiary cancer center.Patients were categorized into surviving(n=232)and deceased(n=152)groups at the end of 3 years.Modified sequence pattern mining techniques(Generalized Sequential Pattern Mining and Sequential Pattern Discovery using Equivalence Classes)were applied to determine the exact order of the most frequent sets of treatments in each group.Results:Degarelix,as the initial form of ADT,was uniquely in the surviving group.The sequence of ADT followed by abiraterone and docetaxel was uniquely associated with a higher 3-year overall survival.Orchiectomy followed by fosfestrol was found to have a unique niche among surviving patients with a long duration of response to the initial ADT.Patients who received chemotherapy followed by radiotherapy and those who received radiotherapy followed by chemotherapy were found more frequently in the deceased group.Conclusions:We identified unique treatment sequences among surviving and deceased patients at the end of 3 years.Degarelix should be the preferred formof ADT.Patients who received ADT followed by abiraterone and chemotherapy showed better results.Patients requiring palliative radiation and chemotherapy in any sequence were significantlymore frequent in the deceased group,identifying the need to offer such patients the most efficacious agents and to target them in clinical trial design.
