Memory CD8 T cells are crucial components of the host immune response against intracellular pathogens and tumors.While the transcriptional and epigenetic programs underlying memory CD8 T-cell differentiation are well ...Memory CD8 T cells are crucial components of the host immune response against intracellular pathogens and tumors.While the transcriptional and epigenetic programs underlying memory CD8 T-cell differentiation are well known,the extrinsic cues that dictate the acquisition of memory CD8 T-cell fate are relatively understudied.Sun et al.[1]revealed a previously unappreciated role of CCR2+monocytes in promoting memory CD8+T-cell fate via membrane-bound TGF-β.展开更多
文摘Memory CD8 T cells are crucial components of the host immune response against intracellular pathogens and tumors.While the transcriptional and epigenetic programs underlying memory CD8 T-cell differentiation are well known,the extrinsic cues that dictate the acquisition of memory CD8 T-cell fate are relatively understudied.Sun et al.[1]revealed a previously unappreciated role of CCR2+monocytes in promoting memory CD8+T-cell fate via membrane-bound TGF-β.
