An optically active bulky aromatic diacid chiral monomer, （2S）-4-[（4-methyl-2-phthalimidylpentanoylamino）benzoylamino]isophthalic acid （1）, containing a rigid phthalimide and flexible L-leucine pendent group was...An optically active bulky aromatic diacid chiral monomer, （2S）-4-[（4-methyl-2-phthalimidylpentanoylamino）benzoylamino]isophthalic acid （1）, containing a rigid phthalimide and flexible L-leucine pendent group was synthesized in five steps. A fast and clean method for direct polyamidation reaction of monomer 1 with various aromatic diamines under microwave irradiation and conventional heating was performed. The polymerization reactions provided optically active polyamides with high yields and inherent viscosities in the range of 0.36-0.74 dL/g. Their thermal properties were evaluated by thermogravimetric analysis （TGA） and differential scanning calorimetry. TGA thermograms show that the polymers are thermally stable, 10% weight loss temperatures are in excess of 385℃, and char yields at 800℃ are higher than 56%. The data obtained from TGA were used to study the kinetics of thermal decomposition of the resulting polymers. The interpretation of kinetic parameters （E, AH, AS and AG） of thermal decomposition stages was evaluated using Coats and Redfern equation.展开更多
In this study,Au nanoparticles/poly 5-[（2-hydroxynaphthalen-l-yl）diazenyl]isophthalic acid film modified glassy carbon electrode（AuNPs/poly（NDI）/GCE） has shown excellent electrocatalytic activity toward the oxid...In this study,Au nanoparticles/poly 5-[（2-hydroxynaphthalen-l-yl）diazenyl]isophthalic acid film modified glassy carbon electrode（AuNPs/poly（NDI）/GCE） has shown excellent electrocatalytic activity toward the oxidation of adrenaline（ADR）,paracetamol（PAC）,and tryptophan（Trp）.The bare glassy carbon electrode（GCE） fails to separate the oxidation peak potentials of these molecules,while the poly（NDI） film modified electrode can resolve them.Electrochemical impedance spectroscopy（EIS）indicates that the charge transfer resistance of the bare electrode decreases as 5-[（2-hydroxynaphthalen-l-yl）diazenyl]isophthalic acid is electropolymerized on the bare electrode.Furthermore,EIS exhibits enhancement of electron transfer kinetics between analytes and the electrode after electrodeposition of Au nanoparticles.Differential pulse voltammetry results show that the electrocatalytic current increases linearly in the ranges of 0.01-680.0 μmol L^-1 for ADR,0.05-498.0 μmol L^-1 for PAC,and 3.0-632.0 μmol L^-1 for Trp;with detection limits（S/N = 3） of 0.009 μmol L^-1,0.005 μmol L^-1,and 0.09 μmol L^-1 for ADR,PAC,and Trp,respectively.The proposed method has been successfully applied for simultaneous determination of ADR,PAC,and Trp in biological samples.展开更多
The development of efficient drug delivery systems is essential for improving the efficacy and safety of cancer drugs,particularly for aggressive and difficult-totreat cancers.Covalent organic frameworks(COFs)are emer...The development of efficient drug delivery systems is essential for improving the efficacy and safety of cancer drugs,particularly for aggressive and difficult-totreat cancers.Covalent organic frameworks(COFs)are emerging as innovative porous nanomaterials in drug delivery systems(DDS),due to their unique properties,including the metal-free organic skeleton,predetermined structures and pore geometries,high porosity,large surface area,facile surface modification potential,and good biocompatibility.These characteristics make COFs excellent candidates for improving drug delivery by enhancing drug loading capacity and enabling precise encapsulation.This review emphasizes the importance of donor-acceptor-based COFs,which provide channels for charge transportation,and we also explore how theπ-conjugated skeleton of COFs enhances its long-acting fluorescent properties and facilitates drug uptake via cell endocytosis.While this review primarily focuses on recent advancements in COF-based targeted DDS,it also acknowledges the challenges posed by the diverse pore geometries in porous materials and discusses potential solutions.Further,it underlines the potential of developing future drug carriers that can successfully and specifically target cancer cells,improving treatment efficiency while reducing adverse side effects.展开更多
基金supported by the Research Affairs Division Isfahan University of Technology(IUT),IsfahanNational Elite Foundation(NEF) and Center of Excellency in Sensors and Green Chemistry Research(IUT).
文摘An optically active bulky aromatic diacid chiral monomer, （2S）-4-[（4-methyl-2-phthalimidylpentanoylamino）benzoylamino]isophthalic acid （1）, containing a rigid phthalimide and flexible L-leucine pendent group was synthesized in five steps. A fast and clean method for direct polyamidation reaction of monomer 1 with various aromatic diamines under microwave irradiation and conventional heating was performed. The polymerization reactions provided optically active polyamides with high yields and inherent viscosities in the range of 0.36-0.74 dL/g. Their thermal properties were evaluated by thermogravimetric analysis （TGA） and differential scanning calorimetry. TGA thermograms show that the polymers are thermally stable, 10% weight loss temperatures are in excess of 385℃, and char yields at 800℃ are higher than 56%. The data obtained from TGA were used to study the kinetics of thermal decomposition of the resulting polymers. The interpretation of kinetic parameters （E, AH, AS and AG） of thermal decomposition stages was evaluated using Coats and Redfern equation.
文摘In this study,Au nanoparticles/poly 5-[（2-hydroxynaphthalen-l-yl）diazenyl]isophthalic acid film modified glassy carbon electrode（AuNPs/poly（NDI）/GCE） has shown excellent electrocatalytic activity toward the oxidation of adrenaline（ADR）,paracetamol（PAC）,and tryptophan（Trp）.The bare glassy carbon electrode（GCE） fails to separate the oxidation peak potentials of these molecules,while the poly（NDI） film modified electrode can resolve them.Electrochemical impedance spectroscopy（EIS）indicates that the charge transfer resistance of the bare electrode decreases as 5-[（2-hydroxynaphthalen-l-yl）diazenyl]isophthalic acid is electropolymerized on the bare electrode.Furthermore,EIS exhibits enhancement of electron transfer kinetics between analytes and the electrode after electrodeposition of Au nanoparticles.Differential pulse voltammetry results show that the electrocatalytic current increases linearly in the ranges of 0.01-680.0 μmol L^-1 for ADR,0.05-498.0 μmol L^-1 for PAC,and 3.0-632.0 μmol L^-1 for Trp;with detection limits（S/N = 3） of 0.009 μmol L^-1,0.005 μmol L^-1,and 0.09 μmol L^-1 for ADR,PAC,and Trp,respectively.The proposed method has been successfully applied for simultaneous determination of ADR,PAC,and Trp in biological samples.
基金Isfahan University Of TechnologyNational Research Foundation of Korea,Grant/Award Number:2018R1A3B1052702。
文摘The development of efficient drug delivery systems is essential for improving the efficacy and safety of cancer drugs,particularly for aggressive and difficult-totreat cancers.Covalent organic frameworks(COFs)are emerging as innovative porous nanomaterials in drug delivery systems(DDS),due to their unique properties,including the metal-free organic skeleton,predetermined structures and pore geometries,high porosity,large surface area,facile surface modification potential,and good biocompatibility.These characteristics make COFs excellent candidates for improving drug delivery by enhancing drug loading capacity and enabling precise encapsulation.This review emphasizes the importance of donor-acceptor-based COFs,which provide channels for charge transportation,and we also explore how theπ-conjugated skeleton of COFs enhances its long-acting fluorescent properties and facilitates drug uptake via cell endocytosis.While this review primarily focuses on recent advancements in COF-based targeted DDS,it also acknowledges the challenges posed by the diverse pore geometries in porous materials and discusses potential solutions.Further,it underlines the potential of developing future drug carriers that can successfully and specifically target cancer cells,improving treatment efficiency while reducing adverse side effects.
