Lin and colleagues leveraged the 32,609-participant Fu-CARE cohort to report a U-shaped association between the high-density-lipoprotein-cholesterol/low-density-lipoprotein-cholesterol(HDL-C/LDL-C)ratio and all-cause ...Lin and colleagues leveraged the 32,609-participant Fu-CARE cohort to report a U-shaped association between the high-density-lipoprotein-cholesterol/low-density-lipoprotein-cholesterol(HDL-C/LDL-C)ratio and all-cause mortality,with the lowest risk at 0.30–0.50[1].Their large sample and sex-specific restricted-cubic-spline modeling deserve praise,but several methodological issues temper causal inference and translational value.展开更多
文摘Lin and colleagues leveraged the 32,609-participant Fu-CARE cohort to report a U-shaped association between the high-density-lipoprotein-cholesterol/low-density-lipoprotein-cholesterol(HDL-C/LDL-C)ratio and all-cause mortality,with the lowest risk at 0.30–0.50[1].Their large sample and sex-specific restricted-cubic-spline modeling deserve praise,but several methodological issues temper causal inference and translational value.
