BACKGROUND Antiangiogenic agents(AAs)are increasingly used to treat malignant tumors and have been associated with gastrointestinal(GI)bleeding and perforation.Elective surgeries and endoscopy are recommended to be de...BACKGROUND Antiangiogenic agents(AAs)are increasingly used to treat malignant tumors and have been associated with gastrointestinal(GI)bleeding and perforation.Elective surgeries and endoscopy are recommended to be delayed for 31 d until after AAs treatment.Data regarding the safety of endoscopy while on antiangiogenic agents is extremely limited.No guidelines are in place to address the concern about withholding these anti-angiogenic drugs.AIM To evaluate the risks of endoscopy in patients on antiangiogenic agents from 2015 to 2020 at our institution.METHODS This is a single centered retrospective study approved by the institutional review board statement of the institution.Patients that underwent endoscopy within 28 d of antiangiogenic agents’treatment were included in the study.Primary outcome of interest was death,and secondary outcomes included perforation and GI bleeding.Data were analyzed utilizing descriptive statistics.Fifty-nine patients were included in the final analysis and a total of eighty-five procedures were performed that were characterized as low risk and high risk.RESULTS Among the 59 patients a total of 85 endoscopic procedures were performed with 24(28.2%)categorized as high-risk and 61(71.8%)procedures as low-risk.Of the total number of patients,(50%)were on bevacizumab and the rest were on imatinib(11.7%),lenvatinib(6.7%)and,ramucirumab(5%).The average duration between administration of AAs and the performance of endoscopic procedures was 9.9 d.No procedure-related adverse events were noted among our study population.We did observe two deaths with one patient,on lenvatinib for metastatic hepatocellular carcinoma,who had persistent bleeding despite esophageal variceal banding and died 4 d later from hemorrhagic shock.Another patient was diagnosed with acute myeloid leukemia died 24 d after an esophagogastroduodenoscopy with biopsy after transition to comfort care.CONCLUSION As per this single center retrospective study,the rate of endoscopic procedure-related adverse events and death within 28 d of AA administration appears to be low.展开更多
Metal clusters with circularly polarized luminescent(CPL)activity have potential applications in security encoding,encrypted transmission,information stor-age,and so on.However,constructing CPL-active metal clusters o...Metal clusters with circularly polarized luminescent(CPL)activity have potential applications in security encoding,encrypted transmission,information stor-age,and so on.However,constructing CPL-active metal clusters on a large scale using self-assembly-based synthetic approaches has been challenging.Herein,we present a collaborative strategy to assem-ble a chiral cyclic hydrogen-bonding(HB)platform(γ-cyclodextrin(γ-CD))onto a photoluminescent sil-ver cluster to form a supramolecular adduct(Ag_(6)@γ-CD).The Ag6@γ-CD fully leverages the advantages of its individual components and exhibits notable CPL activity.Single-crystal X-ray diffraction and sys-tematic photoluminescence investigation reveal that the cyclic HB motif formed between Ag_(6)andγ-CD effectively promotes the population of the first ex-cited state(S 1)and facilitates supramolecular chiral transfer fromγ-CD to Ag_(6),resulting in the boosted CPL lighting.Furthermore,the decagram-scale synthesis of a functionalized adduct has been accomplished using mechanochemistry techniques,providing a material guarantee for the practical applications.展开更多
The development of effective adsorbent materials for capturing organic dyes and iodine is crucial to reduce the environmental impact and ensure human health.In this context,a two-dimensional(2D)Co3-based metal-organic...The development of effective adsorbent materials for capturing organic dyes and iodine is crucial to reduce the environmental impact and ensure human health.In this context,a two-dimensional(2D)Co3-based metal-organic framework SDU-CP-7(SDU=Shandong University,CP=coordination polymer)was rationally designed with 4-(4-carboxyphenyl)-1,2,4-triazole(Hcpt)and 2,4,6-tri(4-pyridinyl)-1,3,5-triazine(tpt)as organic linkers.The SDU-CP-7 was comprehensively characterized using single-crystal X-ray diffraction analysis,thermogravimetric analysis,Fourier transform infrared spectroscopy,Raman spectroscopy,powder X-ray diffraction analysis and UV-vis spectroscopy.Molecular docking was conducted to elucidate potential binding sites on SDU-CP-7 for effective interactions with RhB and ST.Featuring negatively charged surface and trigonal microporous channels,SDU-CP-7 exhibits excellent adsorption capacities for organic dyes(919.2 mg/g for Rhodamine B and 1565 mg/g for Safranine T)as well as iodine(563.0 mg/g in solution and 1100 mg/g in the vapor phase).The exceptional adsorption performance of SDU-CP-7 for cationic dyes can be ascribed to the electrostatic interaction facilitated by negatively charged zeta potential and the size-matching principle,whereas the pyridine active sites in channels significantly enhance the binding affinity for iodine.Moreover,SDU-CP-7 can serve as chromatographic column filters for the rapid adsorption and separation of dyes.The results demonstrate excellent selective adsorption performance of SDU-CP-7,highlighting its potential for environmental and industrial applications.展开更多
文摘BACKGROUND Antiangiogenic agents(AAs)are increasingly used to treat malignant tumors and have been associated with gastrointestinal(GI)bleeding and perforation.Elective surgeries and endoscopy are recommended to be delayed for 31 d until after AAs treatment.Data regarding the safety of endoscopy while on antiangiogenic agents is extremely limited.No guidelines are in place to address the concern about withholding these anti-angiogenic drugs.AIM To evaluate the risks of endoscopy in patients on antiangiogenic agents from 2015 to 2020 at our institution.METHODS This is a single centered retrospective study approved by the institutional review board statement of the institution.Patients that underwent endoscopy within 28 d of antiangiogenic agents’treatment were included in the study.Primary outcome of interest was death,and secondary outcomes included perforation and GI bleeding.Data were analyzed utilizing descriptive statistics.Fifty-nine patients were included in the final analysis and a total of eighty-five procedures were performed that were characterized as low risk and high risk.RESULTS Among the 59 patients a total of 85 endoscopic procedures were performed with 24(28.2%)categorized as high-risk and 61(71.8%)procedures as low-risk.Of the total number of patients,(50%)were on bevacizumab and the rest were on imatinib(11.7%),lenvatinib(6.7%)and,ramucirumab(5%).The average duration between administration of AAs and the performance of endoscopic procedures was 9.9 d.No procedure-related adverse events were noted among our study population.We did observe two deaths with one patient,on lenvatinib for metastatic hepatocellular carcinoma,who had persistent bleeding despite esophageal variceal banding and died 4 d later from hemorrhagic shock.Another patient was diagnosed with acute myeloid leukemia died 24 d after an esophagogastroduodenoscopy with biopsy after transition to comfort care.CONCLUSION As per this single center retrospective study,the rate of endoscopic procedure-related adverse events and death within 28 d of AA administration appears to be low.
基金supported by the National Natural Science Foundation of China(grant nos.22325105,52261135637,22201159,22171164,92361301)the Natural Science Foundation of Shandong Province(grant nos.ZR2019ZD45,ZR2020ZD35,ZR2022QB008)the Instrument Improvement Funds of Shandong University Public Technology Platform(grant no.ts20220102).M.A.acknowledge the financial support through the Researchers Supporting Project number(grant no.RSP2024R147),King Saud University,Riyadh,Saudi Arabia.The Center for Structural and Property Analysis of Shandong University for analytical characterization is also acknowledged.
文摘Metal clusters with circularly polarized luminescent(CPL)activity have potential applications in security encoding,encrypted transmission,information stor-age,and so on.However,constructing CPL-active metal clusters on a large scale using self-assembly-based synthetic approaches has been challenging.Herein,we present a collaborative strategy to assem-ble a chiral cyclic hydrogen-bonding(HB)platform(γ-cyclodextrin(γ-CD))onto a photoluminescent sil-ver cluster to form a supramolecular adduct(Ag_(6)@γ-CD).The Ag6@γ-CD fully leverages the advantages of its individual components and exhibits notable CPL activity.Single-crystal X-ray diffraction and sys-tematic photoluminescence investigation reveal that the cyclic HB motif formed between Ag_(6)andγ-CD effectively promotes the population of the first ex-cited state(S 1)and facilitates supramolecular chiral transfer fromγ-CD to Ag_(6),resulting in the boosted CPL lighting.Furthermore,the decagram-scale synthesis of a functionalized adduct has been accomplished using mechanochemistry techniques,providing a material guarantee for the practical applications.
基金support from National Natural Science Foundation of China(22371166,22325105,92361301,52261135637,22171164)Natural Science Foundation of Shandong Province(ZR2023MB007)support through the Researchers Supporting Project number(RSP2024R147),King Saud University,Riyadh,Saudi Arabia.
文摘The development of effective adsorbent materials for capturing organic dyes and iodine is crucial to reduce the environmental impact and ensure human health.In this context,a two-dimensional(2D)Co3-based metal-organic framework SDU-CP-7(SDU=Shandong University,CP=coordination polymer)was rationally designed with 4-(4-carboxyphenyl)-1,2,4-triazole(Hcpt)and 2,4,6-tri(4-pyridinyl)-1,3,5-triazine(tpt)as organic linkers.The SDU-CP-7 was comprehensively characterized using single-crystal X-ray diffraction analysis,thermogravimetric analysis,Fourier transform infrared spectroscopy,Raman spectroscopy,powder X-ray diffraction analysis and UV-vis spectroscopy.Molecular docking was conducted to elucidate potential binding sites on SDU-CP-7 for effective interactions with RhB and ST.Featuring negatively charged surface and trigonal microporous channels,SDU-CP-7 exhibits excellent adsorption capacities for organic dyes(919.2 mg/g for Rhodamine B and 1565 mg/g for Safranine T)as well as iodine(563.0 mg/g in solution and 1100 mg/g in the vapor phase).The exceptional adsorption performance of SDU-CP-7 for cationic dyes can be ascribed to the electrostatic interaction facilitated by negatively charged zeta potential and the size-matching principle,whereas the pyridine active sites in channels significantly enhance the binding affinity for iodine.Moreover,SDU-CP-7 can serve as chromatographic column filters for the rapid adsorption and separation of dyes.The results demonstrate excellent selective adsorption performance of SDU-CP-7,highlighting its potential for environmental and industrial applications.
