Worldwide,more than one million people die each year from hepatitis C virus(HCV)related diseases,and over 300 million people are chronically infected with hepatitis B or C.Egypt used to be on the top of the countries ...Worldwide,more than one million people die each year from hepatitis C virus(HCV)related diseases,and over 300 million people are chronically infected with hepatitis B or C.Egypt used to be on the top of the countries with heavy HCV burden.Some countries are making advances in elimination of HCV,yet multiple factors preventing progress;remain for the majority.These factors include lack of global funding sources for treatment,late diagnosis,poor data,and inadequate screening.Treatment of HCV in Egypt has become one of the top national priorities since 2007.Egypt started a national treatment program intending to provide cure for Egyptian HCV-infected patients.Mass HCV treatment program had started using Pegylated interferon and ribavirin between 2007 and 2014.Yet,with the development of highly-effective direct acting antivirals(DAAs)for HCV,elimination of viral hepatitis has become a real possibility.The Egyptian National Committee for the Control of Viral Hepatitis did its best to provide Egyptian HCV patients with DAAs.Egypt adopted a strategy that represents a model of care that could help other countries with high HCV prevalence rate in their battle against HCV.This review covers the effects of HCV management in Egyptian real life settings and the outcome of different treatment protocols.Also,it deals with the current and future strategies for HCV prevention and screening as well as the challenges facing HCV elimination and the prospect of future eradication of HCV.展开更多
BACKGROUND Bowel ultrasound and magnetic resonance enterography(MRE)are decisive medical imaging modalities for diagnosing and locating bowel lesions with its extramural extent and complications.They assess the degree...BACKGROUND Bowel ultrasound and magnetic resonance enterography(MRE)are decisive medical imaging modalities for diagnosing and locating bowel lesions with its extramural extent and complications.They assess the degree of activity,help clinicians to identify patients in need of surgery,and can be used for patient follow-up.AIM To compare the role of MRE and bowel ultrasound in diagnosis and follow-up of inflammatory bowel disease(IBD)patients in Egypt.METHODS The study was conducted on 40 patients with IBD.All patients were subjected to clinical assessment,laboratory investigations,bowel ultrasound,MRE,and colonoscopy up to the terminal ileum with biopsies for histopathological examination.RESULTS This study was conducted on 14 patients(35%)with ulcerative colitis and 26 patients(65%)with Crohn's disease;34(85%)of these patients had active disease.Bowel ultrasound detected different bowel lesions with the following accuracies:ileum(85%),large bowel(70%),fistula(95%),stricture and proximal dilatation(95%)and abscesses(100%).Also,it showed that statistically significance of bowel ultrasound in differentiation between remission and activity of IBD in comparison to MRE and colonoscopy.CONCLUSION In comparison to MRE,bowel ultrasound is a useful,non-invasive,and feasible bedside imaging tool for the detection of inflammation,detection of complications,and follow-up of IBD patients when performed by the attending physician.展开更多
Hepatocellular carcinoma(HCC)is the sixth most common primary malignancy worldwide,and the third most common cause of death among cancers worldwide.HCC occurs in several pre-existing conditions,including hepatitis C,h...Hepatocellular carcinoma(HCC)is the sixth most common primary malignancy worldwide,and the third most common cause of death among cancers worldwide.HCC occurs in several pre-existing conditions,including hepatitis C,hepatitis B virus,and non-alcoholic cirrhosis.Egypt used to be the country with the heaviest hepatitis C virus(HCV)burden.The relationship between HCV and HCC is an important research area.In Egypt,HCC is a significant public health problem.A possible cause for the increasing rates of detection of HCC in Egypt is the mass screening program that was carried by the government for detecting and treating HCV.A multidisciplinary approach is now widely applied to HCC management in health centers all over Egypt.Different treatment modalities are available in Egypt,with success rates comparable to global rates.The Egyptian health authorities have made the elimination of HCV from Egypt a special priority,and this approach should lead to a decrease in number of HCC cases in the near future.In this article we review the current situation of HCC in Egypt,including epidemiological aspects,relevant risk factors for HCC development,strategies,and efforts established by health authorities for the screening and prevention of both HCV and HCC in Egypt.We highlight the different modalities for HCC treatment.展开更多
During the early phase of the coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),diagnosis was difficult due to the diversity in symptoms and imaging findi...During the early phase of the coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),diagnosis was difficult due to the diversity in symptoms and imaging findings and the variability of disease presentation.Pulmonary manifestations are reportedly the main clinical presentations of COVID-19 patients.Scientists are working hard on a myriad of clinical,epidemiological,and biological aspects to better understand SARS-CoV-2 infection,aiming to mitigate the ongoing disaster.Many reports have documented the involvement of various body systems and organs apart from the respiratory tract including the gastrointestinal,liver,immune system,renal,and neurological systems.Such involvement will result in diverse presentations related to effects on these systems.Other presentations such as coagulation defects and cutaneous manifestation may also occur.Patients with specific comorbidities including obesity,diabetes,and hypertension have increased morbidity and mortality risks with COVID-19.展开更多
文摘Worldwide,more than one million people die each year from hepatitis C virus(HCV)related diseases,and over 300 million people are chronically infected with hepatitis B or C.Egypt used to be on the top of the countries with heavy HCV burden.Some countries are making advances in elimination of HCV,yet multiple factors preventing progress;remain for the majority.These factors include lack of global funding sources for treatment,late diagnosis,poor data,and inadequate screening.Treatment of HCV in Egypt has become one of the top national priorities since 2007.Egypt started a national treatment program intending to provide cure for Egyptian HCV-infected patients.Mass HCV treatment program had started using Pegylated interferon and ribavirin between 2007 and 2014.Yet,with the development of highly-effective direct acting antivirals(DAAs)for HCV,elimination of viral hepatitis has become a real possibility.The Egyptian National Committee for the Control of Viral Hepatitis did its best to provide Egyptian HCV patients with DAAs.Egypt adopted a strategy that represents a model of care that could help other countries with high HCV prevalence rate in their battle against HCV.This review covers the effects of HCV management in Egyptian real life settings and the outcome of different treatment protocols.Also,it deals with the current and future strategies for HCV prevention and screening as well as the challenges facing HCV elimination and the prospect of future eradication of HCV.
文摘BACKGROUND Bowel ultrasound and magnetic resonance enterography(MRE)are decisive medical imaging modalities for diagnosing and locating bowel lesions with its extramural extent and complications.They assess the degree of activity,help clinicians to identify patients in need of surgery,and can be used for patient follow-up.AIM To compare the role of MRE and bowel ultrasound in diagnosis and follow-up of inflammatory bowel disease(IBD)patients in Egypt.METHODS The study was conducted on 40 patients with IBD.All patients were subjected to clinical assessment,laboratory investigations,bowel ultrasound,MRE,and colonoscopy up to the terminal ileum with biopsies for histopathological examination.RESULTS This study was conducted on 14 patients(35%)with ulcerative colitis and 26 patients(65%)with Crohn's disease;34(85%)of these patients had active disease.Bowel ultrasound detected different bowel lesions with the following accuracies:ileum(85%),large bowel(70%),fistula(95%),stricture and proximal dilatation(95%)and abscesses(100%).Also,it showed that statistically significance of bowel ultrasound in differentiation between remission and activity of IBD in comparison to MRE and colonoscopy.CONCLUSION In comparison to MRE,bowel ultrasound is a useful,non-invasive,and feasible bedside imaging tool for the detection of inflammation,detection of complications,and follow-up of IBD patients when performed by the attending physician.
文摘Hepatocellular carcinoma(HCC)is the sixth most common primary malignancy worldwide,and the third most common cause of death among cancers worldwide.HCC occurs in several pre-existing conditions,including hepatitis C,hepatitis B virus,and non-alcoholic cirrhosis.Egypt used to be the country with the heaviest hepatitis C virus(HCV)burden.The relationship between HCV and HCC is an important research area.In Egypt,HCC is a significant public health problem.A possible cause for the increasing rates of detection of HCC in Egypt is the mass screening program that was carried by the government for detecting and treating HCV.A multidisciplinary approach is now widely applied to HCC management in health centers all over Egypt.Different treatment modalities are available in Egypt,with success rates comparable to global rates.The Egyptian health authorities have made the elimination of HCV from Egypt a special priority,and this approach should lead to a decrease in number of HCC cases in the near future.In this article we review the current situation of HCC in Egypt,including epidemiological aspects,relevant risk factors for HCC development,strategies,and efforts established by health authorities for the screening and prevention of both HCV and HCC in Egypt.We highlight the different modalities for HCC treatment.
文摘During the early phase of the coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),diagnosis was difficult due to the diversity in symptoms and imaging findings and the variability of disease presentation.Pulmonary manifestations are reportedly the main clinical presentations of COVID-19 patients.Scientists are working hard on a myriad of clinical,epidemiological,and biological aspects to better understand SARS-CoV-2 infection,aiming to mitigate the ongoing disaster.Many reports have documented the involvement of various body systems and organs apart from the respiratory tract including the gastrointestinal,liver,immune system,renal,and neurological systems.Such involvement will result in diverse presentations related to effects on these systems.Other presentations such as coagulation defects and cutaneous manifestation may also occur.Patients with specific comorbidities including obesity,diabetes,and hypertension have increased morbidity and mortality risks with COVID-19.
