The Ugi multicomponent reaction represents a highly efficient synthetic transformation,wherein all four reactants(isocyanides,amine,aldehyde or ketone and a nucleophile)are combined in one pot under mild conditions.Th...The Ugi multicomponent reaction represents a highly efficient synthetic transformation,wherein all four reactants(isocyanides,amine,aldehyde or ketone and a nucleophile)are combined in one pot under mild conditions.This reaction exhibits remarkable synthetic prowess,allowing for the rapid assembly of diverse and potent building blocks in organic chemistry and natural product synthesis.This minireview focuses on Ugi multicomponent reactions and highlights their applicability to the total synthesis of natural products and analogs.展开更多
基金the National Natural Science Foundation of China(Nos.82273795 and 22201051)Science and Technology Program of Guangzhou(No.2023A04J0074)Plan on Enhancing Scientific Research at GMU for financial support on this research.
文摘The Ugi multicomponent reaction represents a highly efficient synthetic transformation,wherein all four reactants(isocyanides,amine,aldehyde or ketone and a nucleophile)are combined in one pot under mild conditions.This reaction exhibits remarkable synthetic prowess,allowing for the rapid assembly of diverse and potent building blocks in organic chemistry and natural product synthesis.This minireview focuses on Ugi multicomponent reactions and highlights their applicability to the total synthesis of natural products and analogs.
