当前,大规模室外基础设施的数字化需求持续扩大,基于深度学习的自动扫描到建筑信息模型(scanning to building information modeling, Scan2BIM)通过卓越的特征学习能力和自动化流程显著提升了建模精度和构建速度,在结构复杂的室外场景...当前,大规模室外基础设施的数字化需求持续扩大,基于深度学习的自动扫描到建筑信息模型(scanning to building information modeling, Scan2BIM)通过卓越的特征学习能力和自动化流程显著提升了建模精度和构建速度,在结构复杂的室外场景重建中发挥了关键作用.文中介绍了Scan2BIM的4大核心模块及其相关研究进展.其中,针对3D点云获取模块,从采集设备与采集来源2个维度概括了3D点云数据采集的技术发展,并着重梳理了代表性3D点云数据集;根据学习方式的不同,将大规模点云对齐算法划分为基于优化和深度学习2大类,并从精准度、计算效率、鲁棒性等多维度对比分析了相关工作;在点云分割模块中,分别对点云全景分割和点云实例分割算法通过统一的评估指标进行了整理归纳;对于BIM自动化建模,简述了BIM核心互操作标准体系,并分类总结了多种几何实体建模与关系建模算法.最后,通过深入分析和前瞻性探讨,指出了现阶段大规模室外场景建模的高效性、精准性、泛化性与统一性的无法有效结合的问题;未来将重点围绕多源数据融合建模、精度与鲁棒性协同优化、端到端Scan2BIM通用框架构建以及大模型应用与探索等方向展开.展开更多
In concentric annular pipes,the difference in curvature between the inner and outer wall surfaces creates significant variations in the heat transfer characteristics of the two surfaces.The simplifications of the Ditt...In concentric annular pipes,the difference in curvature between the inner and outer wall surfaces creates significant variations in the heat transfer characteristics of the two surfaces.The simplifications of the Dittus-Boelter equation for circular pipes make it unsuitable for the complex flow induced by the geometry and heat transfer coupling effects in annular pipes.This prevents it from accurately predicting the turbulent heat transfer in concentric annular pipes.This paper used realizableκ–εand low Reynolds number models to conduct numerical simulations of turbulent convective heat transfer in concentric annular pipes and circular pipes.The results indicated that the local heat transfer coefficient and Nusselt number of the inner wall surface of the annular pipe were both higher than those of the outer wall surface.The Darcy resistance coefficient decreased upon increasing the Reynolds number and increased with the inner diameter-to-outer diameter ratio.When using the equivalent diameter as the characteristic scale,the turbulent heat transfer correlation obtained from circular pipes produced significant errors when used to approximate the turbulent convective heat transfer in concentric annular pipes.This error was greater for the inner wall surface,especially when the inner and outer diameters were relatively small,as the Nusselt number error on the inner wall surface reached 60.62%.The error of the Nusselt number on the outer wall surface reached 19.51%.展开更多
Cellular mechanotransduction characterized by the transformation of mechanical stimuli into biochemical signals,represents a pivotal and complex process underpinning a multitude of cellular functionalities.This proces...Cellular mechanotransduction characterized by the transformation of mechanical stimuli into biochemical signals,represents a pivotal and complex process underpinning a multitude of cellular functionalities.This process is integral to diverse biological phenomena,including embryonic development,cell migration,tissue regeneration,and disease pathology,particularly in the context of cancer metastasis and cardiovascular diseases.Despite the profound biological and clinical significance of mechanotransduction,our understanding of this complex process remains incomplete.The recent development of advanced optical techniques enables in-situ force measurement and subcellular manipulation from the outer cell membrane to the organelles inside a cell.In this review,we delved into the current state-of-the-art techniques utilized to probe cellular mechanobiology,their principles,applications,and limitations.We mainly examined optical methodologies to quantitatively measure the mechanical properties of cells during intracellular transport,cell adhesion,and migration.We provided an introductory overview of various conventional and optical-based techniques for probing cellular mechanics.These techniques have provided into the dynamics of mechanobiology,their potential to unravel mechanistic intricacies and implications for therapeutic intervention.展开更多
Metachromatic leukodystrophy(MLD)is an inherited disease caused by a deficiency of the enzyme arylsulfatase A(ARSA).Lentivirus-modified autologous hematopoietic stem cell gene therapy(HSCGT)has recently been approved ...Metachromatic leukodystrophy(MLD)is an inherited disease caused by a deficiency of the enzyme arylsulfatase A(ARSA).Lentivirus-modified autologous hematopoietic stem cell gene therapy(HSCGT)has recently been approved for clinical use in pre and early symptomatic children with MLD to increase ARSA activity.Unfortunately,this advanced therapy is not available for most patients with MLD who have progressed to more advanced symptomatic stages at diagnosis.Patients with late-onset juvenile MLD typically present with a slower neurological progression of symptoms and represent a significant burden to the economy and healthcare system,whereas those with early onset infantile MLD die within a few years of symptom onset.We conducted a pilot study to determine the safety and benefit of HSCGT in patients with postsymptomatic juvenile MLD and report preliminary results.The safety profile of HSCGT was favorable in this long-term follow-up over 9 years.The most common adverse events(AEs)within 2 months of HSCGT were related to busulfan conditioning,and all AEs resolved.No HSCGT-related AEs and no evidence of distorted hematopoietic differentiation during long-term follow-up for up to 9.6 years.Importantly,to date,patients have maintained remarkably improved ARSA activity with a stable disease state,including increased Functional Independence Measure(FIM)score and decreased magnetic resonance imaging(MRI)lesion score.This long-term follow-up pilot study suggests that HSCGT is safe and provides clinical benefit to patients with postsymptomatic juvenile MLD.展开更多
In this study,a transfer learning-based neural network approach to predict ignition delays for a variety of fuels is proposed to meet the demand for accurate combustion analysis.A comprehensive dataset of ignition del...In this study,a transfer learning-based neural network approach to predict ignition delays for a variety of fuels is proposed to meet the demand for accurate combustion analysis.A comprehensive dataset of ignition delays was generated using a random sampling technique across different temperatures and pressures,focusing on hydrocarbon fuels with 1-4 carbon atoms.Two machine learning models,an artificial neural network and a graph convolutional network,are trained on this dataset,and their prediction performance was evaluated.A transfer learning framework was subsequently developed,enabling the models trained on smaller molecules(1-3 carbon atoms)to predict ignition delays for larger molecules(4 carbon atoms)with minimal additional data.The proposed framework demonstrated reliable and high prediction accuracy,achieving a high level of reliability for fuels with limited experimental measurements.This approach offers significant potential to streamline the prediction of ignition delays for novel fuels,reducing the dependence on resource-intensive experiments and complex simulations while contributing to the advancement of clean and efficient energy technologies.展开更多
文摘当前,大规模室外基础设施的数字化需求持续扩大,基于深度学习的自动扫描到建筑信息模型(scanning to building information modeling, Scan2BIM)通过卓越的特征学习能力和自动化流程显著提升了建模精度和构建速度,在结构复杂的室外场景重建中发挥了关键作用.文中介绍了Scan2BIM的4大核心模块及其相关研究进展.其中,针对3D点云获取模块,从采集设备与采集来源2个维度概括了3D点云数据采集的技术发展,并着重梳理了代表性3D点云数据集;根据学习方式的不同,将大规模点云对齐算法划分为基于优化和深度学习2大类,并从精准度、计算效率、鲁棒性等多维度对比分析了相关工作;在点云分割模块中,分别对点云全景分割和点云实例分割算法通过统一的评估指标进行了整理归纳;对于BIM自动化建模,简述了BIM核心互操作标准体系,并分类总结了多种几何实体建模与关系建模算法.最后,通过深入分析和前瞻性探讨,指出了现阶段大规模室外场景建模的高效性、精准性、泛化性与统一性的无法有效结合的问题;未来将重点围绕多源数据融合建模、精度与鲁棒性协同优化、端到端Scan2BIM通用框架构建以及大模型应用与探索等方向展开.
基金Supported by the Major Program of the National Natural Science Foundation of China(Grant No.51736007).
文摘In concentric annular pipes,the difference in curvature between the inner and outer wall surfaces creates significant variations in the heat transfer characteristics of the two surfaces.The simplifications of the Dittus-Boelter equation for circular pipes make it unsuitable for the complex flow induced by the geometry and heat transfer coupling effects in annular pipes.This prevents it from accurately predicting the turbulent heat transfer in concentric annular pipes.This paper used realizableκ–εand low Reynolds number models to conduct numerical simulations of turbulent convective heat transfer in concentric annular pipes and circular pipes.The results indicated that the local heat transfer coefficient and Nusselt number of the inner wall surface of the annular pipe were both higher than those of the outer wall surface.The Darcy resistance coefficient decreased upon increasing the Reynolds number and increased with the inner diameter-to-outer diameter ratio.When using the equivalent diameter as the characteristic scale,the turbulent heat transfer correlation obtained from circular pipes produced significant errors when used to approximate the turbulent convective heat transfer in concentric annular pipes.This error was greater for the inner wall surface,especially when the inner and outer diameters were relatively small,as the Nusselt number error on the inner wall surface reached 60.62%.The error of the Nusselt number on the outer wall surface reached 19.51%.
基金the funding from Start-up Fundings of Ocean University of China(862401013154 and 862401013155)Laboratory for Marine Drugs and Bioproducts Qingdao Marine Science and Technology Center(LMDBCXRC202401 and LMDBCXRC202402)+1 种基金Taishan Scholar Youth Expert Program of Shandong Province(tsqn202306102 and tsqn202312105)Shandong Provincial Overseas Excellent Young Scholar Program(2024HWYQ-042 and 2024HWYQ-043)for supporting this work.
文摘Cellular mechanotransduction characterized by the transformation of mechanical stimuli into biochemical signals,represents a pivotal and complex process underpinning a multitude of cellular functionalities.This process is integral to diverse biological phenomena,including embryonic development,cell migration,tissue regeneration,and disease pathology,particularly in the context of cancer metastasis and cardiovascular diseases.Despite the profound biological and clinical significance of mechanotransduction,our understanding of this complex process remains incomplete.The recent development of advanced optical techniques enables in-situ force measurement and subcellular manipulation from the outer cell membrane to the organelles inside a cell.In this review,we delved into the current state-of-the-art techniques utilized to probe cellular mechanobiology,their principles,applications,and limitations.We mainly examined optical methodologies to quantitatively measure the mechanical properties of cells during intracellular transport,cell adhesion,and migration.We provided an introductory overview of various conventional and optical-based techniques for probing cellular mechanics.These techniques have provided into the dynamics of mechanobiology,their potential to unravel mechanistic intricacies and implications for therapeutic intervention.
基金supported in part by Poland Fundacja SiepomagaJS Foundation (Hong Kong)+1 种基金Shenzhen Li Weibo Charity FoundationTaiwan Rare Disease Foundation。
文摘Metachromatic leukodystrophy(MLD)is an inherited disease caused by a deficiency of the enzyme arylsulfatase A(ARSA).Lentivirus-modified autologous hematopoietic stem cell gene therapy(HSCGT)has recently been approved for clinical use in pre and early symptomatic children with MLD to increase ARSA activity.Unfortunately,this advanced therapy is not available for most patients with MLD who have progressed to more advanced symptomatic stages at diagnosis.Patients with late-onset juvenile MLD typically present with a slower neurological progression of symptoms and represent a significant burden to the economy and healthcare system,whereas those with early onset infantile MLD die within a few years of symptom onset.We conducted a pilot study to determine the safety and benefit of HSCGT in patients with postsymptomatic juvenile MLD and report preliminary results.The safety profile of HSCGT was favorable in this long-term follow-up over 9 years.The most common adverse events(AEs)within 2 months of HSCGT were related to busulfan conditioning,and all AEs resolved.No HSCGT-related AEs and no evidence of distorted hematopoietic differentiation during long-term follow-up for up to 9.6 years.Importantly,to date,patients have maintained remarkably improved ARSA activity with a stable disease state,including increased Functional Independence Measure(FIM)score and decreased magnetic resonance imaging(MRI)lesion score.This long-term follow-up pilot study suggests that HSCGT is safe and provides clinical benefit to patients with postsymptomatic juvenile MLD.
基金supported by National Natural Science Foundation of China(Grant No.52106171)Natural Science Foundation of Shanghai(23ZR1435300).
文摘In this study,a transfer learning-based neural network approach to predict ignition delays for a variety of fuels is proposed to meet the demand for accurate combustion analysis.A comprehensive dataset of ignition delays was generated using a random sampling technique across different temperatures and pressures,focusing on hydrocarbon fuels with 1-4 carbon atoms.Two machine learning models,an artificial neural network and a graph convolutional network,are trained on this dataset,and their prediction performance was evaluated.A transfer learning framework was subsequently developed,enabling the models trained on smaller molecules(1-3 carbon atoms)to predict ignition delays for larger molecules(4 carbon atoms)with minimal additional data.The proposed framework demonstrated reliable and high prediction accuracy,achieving a high level of reliability for fuels with limited experimental measurements.This approach offers significant potential to streamline the prediction of ignition delays for novel fuels,reducing the dependence on resource-intensive experiments and complex simulations while contributing to the advancement of clean and efficient energy technologies.
