Objective:To evaluate the quality of Lygodium japonicum(Thunb.)Sw.(L.japonicum,Hai Jin Sha)by comparing its components without stewed(W)and stewed(S)using ultra-high-performance liquid chromatography(UHPLC)and chemome...Objective:To evaluate the quality of Lygodium japonicum(Thunb.)Sw.(L.japonicum,Hai Jin Sha)by comparing its components without stewed(W)and stewed(S)using ultra-high-performance liquid chromatography(UHPLC)and chemometric analysis.Additionally,network pharmacology was employed to investigate the possible mechanisms of action of L.japonicum in the urinary calculi(UC)treatment.Methods:A fingerprinting method was established to identify components through UHPLC-tandem mass spectrometry.Chemometric techniques were used to compare the L.japonicum extraction methods.Furthermore,various network pharmacological approaches were used to identify and analyze the potential targets of the identified components in relation to UC.Results:The W and S extracts were distributed into two distinct clusters.Significant differences in the levels of protocatechuic aldehyde,caffeic acid,and p-coumaric acid were observed between S and W.Network pharmacology analysis revealed that the primary targets of L.japonicum in the UC treatment were serum albumin and epidermal growth factor receptors,with potential active components including protocatechuic acid and caffeic acid.Conclusion:This study comprehensively examined the therapeutic components of L.japonicum before and after boiling,shedding light on its potential mechanisms of action in UC treatment.These findings offer valuable insights into the development and utilization of L.japonicum resources.展开更多
To theoretically research the influence of a varied Al component on the active layer of AlGaN photocathodes,the first principle based on density functional theory is used to calculate the formation energy and band str...To theoretically research the influence of a varied Al component on the active layer of AlGaN photocathodes,the first principle based on density functional theory is used to calculate the formation energy and band structure of AlxGa（1-x）N with x at 0,0.125,0.25,0.325,and 0.5.The calculation results show that the formation energy declines along with the Al component rise,while the band gap is increasing with Al component increasing.AlxGa（1-x）N with x at 0,0.125,0.25,0.325,and 0.5 are direct band gap semiconductors,and their absorption coefficient curves have the same variation tendency.For further study,we designed two kinds of reflection-mode AlGaN photocathode samples.Sample 1 has an AlxGa（1-x）N active layer with varied Al component ranging from0.5 to 0 and decreasing from the bulk to the surface,while sample 2 has an AlxGa（1-x）N active layer with the fixed Al component of 0.25.Using the multi-information measurement system,we measured the spectral response of the activated samples at room temperature.Their photocathode parameters were obtained by fitting quantum efficiency curves.Results show that sample 1 has a better spectral response than sample 2 at the range of short-wavelength.This work provides a reference for the structure design of the AlGaN photocathode.展开更多
基金supported by Ministry of Industry and Information Technology of the People's Republic of China 2022 Industrial Technology Basic Public Service Platform Project-Traditional Chinese Medicine Whole Industry Chain Quality and Technology Service Platform(2022-230-221)Foshan Nanhai District Key Area Science and Technology Research Project[Nanke(2023)20-18].
文摘Objective:To evaluate the quality of Lygodium japonicum(Thunb.)Sw.(L.japonicum,Hai Jin Sha)by comparing its components without stewed(W)and stewed(S)using ultra-high-performance liquid chromatography(UHPLC)and chemometric analysis.Additionally,network pharmacology was employed to investigate the possible mechanisms of action of L.japonicum in the urinary calculi(UC)treatment.Methods:A fingerprinting method was established to identify components through UHPLC-tandem mass spectrometry.Chemometric techniques were used to compare the L.japonicum extraction methods.Furthermore,various network pharmacological approaches were used to identify and analyze the potential targets of the identified components in relation to UC.Results:The W and S extracts were distributed into two distinct clusters.Significant differences in the levels of protocatechuic aldehyde,caffeic acid,and p-coumaric acid were observed between S and W.Network pharmacology analysis revealed that the primary targets of L.japonicum in the UC treatment were serum albumin and epidermal growth factor receptors,with potential active components including protocatechuic acid and caffeic acid.Conclusion:This study comprehensively examined the therapeutic components of L.japonicum before and after boiling,shedding light on its potential mechanisms of action in UC treatment.These findings offer valuable insights into the development and utilization of L.japonicum resources.
基金supported by the National Natural Science Foundation of China(Nos.61308089,6144005)the Public Technology Applied Research Project of Zhejiang Province(No.2013C31068)
文摘To theoretically research the influence of a varied Al component on the active layer of AlGaN photocathodes,the first principle based on density functional theory is used to calculate the formation energy and band structure of AlxGa（1-x）N with x at 0,0.125,0.25,0.325,and 0.5.The calculation results show that the formation energy declines along with the Al component rise,while the band gap is increasing with Al component increasing.AlxGa（1-x）N with x at 0,0.125,0.25,0.325,and 0.5 are direct band gap semiconductors,and their absorption coefficient curves have the same variation tendency.For further study,we designed two kinds of reflection-mode AlGaN photocathode samples.Sample 1 has an AlxGa（1-x）N active layer with varied Al component ranging from0.5 to 0 and decreasing from the bulk to the surface,while sample 2 has an AlxGa（1-x）N active layer with the fixed Al component of 0.25.Using the multi-information measurement system,we measured the spectral response of the activated samples at room temperature.Their photocathode parameters were obtained by fitting quantum efficiency curves.Results show that sample 1 has a better spectral response than sample 2 at the range of short-wavelength.This work provides a reference for the structure design of the AlGaN photocathode.
