A photoredox-catalyzed synthesis ofα,α-difluoromethyl sulfones from sulfur dioxide with readily available gem–difluoroalkenes is reported.This protocol features mild reaction conditions,broad substrate scope and go...A photoredox-catalyzed synthesis ofα,α-difluoromethyl sulfones from sulfur dioxide with readily available gem–difluoroalkenes is reported.This protocol features mild reaction conditions,broad substrate scope and good functional group compatibility,giving rise to the targetα,α-difluoromethyl sulfones in moderate to excellent yields.Mechanistic studies indicate that this reaction is initiated by an aryl radical with the insertion of sulfur dioxide.展开更多
基金Financial support from National Natural Science Foundation of China(Nos.22201202,22171206 and 22371201)Natural Science Foundation of Zhejiang Province(No.LZ23B020001)+2 种基金Open Foundation of Hunan Provincial Key Laboratory of Controllable Preparation and Functional Application of Fine Polymers(No.E22307)Open Research Fund of School of Chemistry and Chemical Engineering,Henan Normal University(No.2020ZD04)Open Research Fund of Key Laboratory of the Ministry of Education for Advanced Catalysis Materials and Zhejiang Key Laboratory for Reactive Chemistry on Solid Surfaces,Zhejiang Normal University。
文摘A photoredox-catalyzed synthesis ofα,α-difluoromethyl sulfones from sulfur dioxide with readily available gem–difluoroalkenes is reported.This protocol features mild reaction conditions,broad substrate scope and good functional group compatibility,giving rise to the targetα,α-difluoromethyl sulfones in moderate to excellent yields.Mechanistic studies indicate that this reaction is initiated by an aryl radical with the insertion of sulfur dioxide.
