In the past decades,diazaphospholene hydrides(DAP-H)have emerged as powerful catalysts for a variety of reductive transformations.However,the radical processes with DAPs as catalysts are extremely rare.Herein,a DAP-ca...In the past decades,diazaphospholene hydrides(DAP-H)have emerged as powerful catalysts for a variety of reductive transformations.However,the radical processes with DAPs as catalysts are extremely rare.Herein,a DAP-catalyzed radical process of aryl halides to accessγ-spirolactams through a XAT/1,5-HAT/radical addition/HAT process is presented.This reaction features metal-free conditions and broad functional group tolerance,leading toγ-spirolactams in good yields.展开更多
Purpose The aim of this study was to explore the relationships between single-nucleotide polymorphisms(SNPs)of crucial molecules in the cGAS-STING signalling pathway and the susceptibility to,induction chemotherapy re...Purpose The aim of this study was to explore the relationships between single-nucleotide polymorphisms(SNPs)of crucial molecules in the cGAS-STING signalling pathway and the susceptibility to,induction chemotherapy response of,and prognosis of acute myeloid leukaemia(AML)in Chinese patients.Methods Thirteen SNPs of crucial molecules in the cGAS-STING signalling pathway were genotyped in 262 AML patients using the Sequenom MassARRAY system.The associations of SNPs with susceptibility,and induction chemo-therapy response were analysed using the chi-square test or Fisher’s exact test and univariate binary logistic regres-sion,the connection of SNPs with prognosis of AML was analysed using the log-rank test,and Kaplan–Meier curves were applied for survival estimation.Results In our study,gene polymorphisms of cGAS-STING signalling pathway molecules could be vitally associated with AML.In the recessive model,the cGAS rs311678 gene polymorphism could be closely related to AML suscep-tibility(CC vs.TT+TC,odds ratio(OR)=0.480,95%confidence interval(CI)=0.260–0.889,p=0.020).Moreover,IKKA rs3808917 might be associated with the WBC count,cGAS rs311678 could be associated with the bone marrow(BM)blast percentage,and NF-κB rs1056890 under codominant and recessive models could be connected with the HGB level.Patients who were STING rs7380272 TT/CT carriers was likely to have higher insensitivity to induction chemo-therapy than CC carriers(TT+CT vs.CC,OR=2.917,95%CI=1.073–7.929,p=0.036).Survival analysis indicated that the IKKB rs3747811 TT genotype might be associated with decreased overall survival(OS)(p<0.05).Conclusions SNPs of molecules in the cGAS-STING signalling pathway could be significantly associated with AML.The cGAS rs311678 gene polymorphism could be associated with AML susceptibility,the STING rs7380272 variant might be related to induction chemotherapy response,and IKKB rs3747811 tended to be associated with AML overall survival.Moreover,IKKA rs3808917 could be associated with the WBC count,cGAS rs311678 could be associated with the BM blast percentage,and NF-κB rs1056890 might be related to the HGB level.展开更多
Correction:Holist Integ Oncol 3,15(2024)https://doi.org/10.1007/s44178-024-00079-8 Following publication of the original article[1],the authors reported errors in Table 2,which have been corrected from.
基金the National Natural Science Foundation of China(No.22201202)the Natural Science Foundation of Zhejiang Province(No.LZ23B020001)+1 种基金Zhejiang Provincial Ten Thousand Talent Program(2023R5244)Open Research Fund of School of Chemistry and Chemical Engineering,Henan Normal University(2020zD04)is gratefully acknowledged.
文摘In the past decades,diazaphospholene hydrides(DAP-H)have emerged as powerful catalysts for a variety of reductive transformations.However,the radical processes with DAPs as catalysts are extremely rare.Herein,a DAP-catalyzed radical process of aryl halides to accessγ-spirolactams through a XAT/1,5-HAT/radical addition/HAT process is presented.This reaction features metal-free conditions and broad functional group tolerance,leading toγ-spirolactams in good yields.
基金supported by grants from the Distinguished Taishan Scholars in Climbing Plan(tspd20210321)Taishan Scholars-Distinguished Experts(tstp20230653)+3 种基金the National Natural Science Foundation of China(8200016582370165)the Key Program of Natural Science Foundation of Shandong Province(ZR2021MH302)the Horizontal Subject of Shandong University(6010121004).
文摘Purpose The aim of this study was to explore the relationships between single-nucleotide polymorphisms(SNPs)of crucial molecules in the cGAS-STING signalling pathway and the susceptibility to,induction chemotherapy response of,and prognosis of acute myeloid leukaemia(AML)in Chinese patients.Methods Thirteen SNPs of crucial molecules in the cGAS-STING signalling pathway were genotyped in 262 AML patients using the Sequenom MassARRAY system.The associations of SNPs with susceptibility,and induction chemo-therapy response were analysed using the chi-square test or Fisher’s exact test and univariate binary logistic regres-sion,the connection of SNPs with prognosis of AML was analysed using the log-rank test,and Kaplan–Meier curves were applied for survival estimation.Results In our study,gene polymorphisms of cGAS-STING signalling pathway molecules could be vitally associated with AML.In the recessive model,the cGAS rs311678 gene polymorphism could be closely related to AML suscep-tibility(CC vs.TT+TC,odds ratio(OR)=0.480,95%confidence interval(CI)=0.260–0.889,p=0.020).Moreover,IKKA rs3808917 might be associated with the WBC count,cGAS rs311678 could be associated with the bone marrow(BM)blast percentage,and NF-κB rs1056890 under codominant and recessive models could be connected with the HGB level.Patients who were STING rs7380272 TT/CT carriers was likely to have higher insensitivity to induction chemo-therapy than CC carriers(TT+CT vs.CC,OR=2.917,95%CI=1.073–7.929,p=0.036).Survival analysis indicated that the IKKB rs3747811 TT genotype might be associated with decreased overall survival(OS)(p<0.05).Conclusions SNPs of molecules in the cGAS-STING signalling pathway could be significantly associated with AML.The cGAS rs311678 gene polymorphism could be associated with AML susceptibility,the STING rs7380272 variant might be related to induction chemotherapy response,and IKKB rs3747811 tended to be associated with AML overall survival.Moreover,IKKA rs3808917 could be associated with the WBC count,cGAS rs311678 could be associated with the BM blast percentage,and NF-κB rs1056890 might be related to the HGB level.
文摘Correction:Holist Integ Oncol 3,15(2024)https://doi.org/10.1007/s44178-024-00079-8 Following publication of the original article[1],the authors reported errors in Table 2,which have been corrected from.
