Metamaterials have revolutionized wave control;in the last two decades,they evolved from passive devices via programmable devices to sensor-endowed self-adaptive devices realizing a user-specified functionality.Althou...Metamaterials have revolutionized wave control;in the last two decades,they evolved from passive devices via programmable devices to sensor-endowed self-adaptive devices realizing a user-specified functionality.Although deep-learning techniques play an increasingly important role in metamaterial inverse design,measurement post-processing and end-to-end optimization,their role is ultimately still limited to approximating specific mathematical relations;the metamaterial is still limited to serving as proxy of a human operator,realizing a predefined functionality.Here,we propose and experimentally prototype a paradigm shift toward a metamaterial agent(coined metaAgent)endowed with reasoning and cognitive capabilities enabling the autonomous planning and successful execution of diverse long-horizon tasks,including electromagnetic(EM)field manipulations and interactions with robots and humans.Leveraging recently released foundation models,metaAgent reasons in high-level natural language,acting upon diverse prompts from an evolving complex environment.Specifically,metaAgent's cerebrum performs high-level task planning in natural language via a multi-agent discussion mechanism,where agents are domain experts in sensing,planning,grounding,and coding.In response to live environmental feedback within a real-world setting emulating an ambient-assisted living context(including human requests in natural language),our metaAgent prototype self-organizes a hierarchy of EM manipulation tasks in conjunction with commanding a robot.metaAgent masters foundational EM manipulation skills related to wireless communications and sensing,and it memorizes and learns from past experience based on human feedback.展开更多
The excessive reactive oxygen species(ROS)is a hallmark associated with the initiation and progression of inflammatory bowel disease(IBD),which execrably form a vicious cycle of ROS and inflammation to continually pro...The excessive reactive oxygen species(ROS)is a hallmark associated with the initiation and progression of inflammatory bowel disease(IBD),which execrably form a vicious cycle of ROS and inflammation to continually promote disease progression.Here,the gold nanoparticles-embedded ceria nanoparticles(Au/CeO_(2))with enhanced antioxidant activities are designed to block this cycle reaction for treating IBD by scavenging overproduced ROS.The Au/CeO_(2) with core-shell and porous structure exhibits significantly higher enzymatic catalytic activities compared with commercial ceria nanoparticles,likely due to the effective exposure of catalytic sites,higher content of Ce(III)and oxygen vacancy,and accelerated reduction from Ce(IV)to Ce(III).Being coated with negatively-charged hyaluronic acid,the Au/CeO_(2)@HA facilitates accumulation in inflamed colon tissues via oral administration,reduces pro-inflammatory cytokines,and effectively alleviates colon injury in colitis mice.Overall,the Au/CeO_(2)@HA with good biocompatibility is a promising nano-therapeutic for treating IBD.展开更多
Objective:To analyze the association between iterative decomposition of water and fat with echo asymmetry and least-squares estimation quantification sequence(IDEAL-IQ)magnetic resonance imaging(MRI)of bone marrow fat...Objective:To analyze the association between iterative decomposition of water and fat with echo asymmetry and least-squares estimation quantification sequence(IDEAL-IQ)magnetic resonance imaging(MRI)of bone marrow fat fraction and bone marrow reserve function during concurrent chemoradiotherapy for cervical cancer.Methods:The study retrospectively analyzed twenty-six patients with stage IB1 to IVA cervical cancer treated between February 2020 and November 2020.All patients received concurrent chemoradiotherapy that included platinum alone or combined paclitaxel and platinum.Pelvic IDEAL-IQ MRI(plain and enhanced)was performed before and after treatment.Regions of interest,including the fifth lumbar vertebra,sacrum,ilium,ischium,and femoral neck,were manually delineated,and the bone marrow fat fraction was measured.Peripheral blood cell counts were recorded during treatment,and the relationship between the fat fraction values and changes in the blood cell counts was explored.Results:IDEAL-IQ MRI bone marrow fat fraction was associated with platelet nadir and platelet decline during treatment.The average pelvic bone marrow fat fraction before chemoradiotherapy was moderately negatively correlated with platelet count nadir during concurrent chemoradiotherapy(r=-0.450,P?0.021).The change in average pelvic bone marrow fat fraction through chemoradiotherapy was moderately positively correlated with the degree of thrombocytopenia(r=0.399,P=0.044).Conclusion:Bone marrow fat content quantified by IDEAL-IQ was associated with platelet count nadir and the degree of thrombocytopenia in patients with cervical cancer undergoing concurrent chemoradiotherapy.展开更多
基金supported by the National Key Research and Development Program of China under Grant Nos.2023YFB3811502,2021YFA1401002TJC acknowledges the support from the National Natural Science Foundation of China under Grant No.62288101.
文摘Metamaterials have revolutionized wave control;in the last two decades,they evolved from passive devices via programmable devices to sensor-endowed self-adaptive devices realizing a user-specified functionality.Although deep-learning techniques play an increasingly important role in metamaterial inverse design,measurement post-processing and end-to-end optimization,their role is ultimately still limited to approximating specific mathematical relations;the metamaterial is still limited to serving as proxy of a human operator,realizing a predefined functionality.Here,we propose and experimentally prototype a paradigm shift toward a metamaterial agent(coined metaAgent)endowed with reasoning and cognitive capabilities enabling the autonomous planning and successful execution of diverse long-horizon tasks,including electromagnetic(EM)field manipulations and interactions with robots and humans.Leveraging recently released foundation models,metaAgent reasons in high-level natural language,acting upon diverse prompts from an evolving complex environment.Specifically,metaAgent's cerebrum performs high-level task planning in natural language via a multi-agent discussion mechanism,where agents are domain experts in sensing,planning,grounding,and coding.In response to live environmental feedback within a real-world setting emulating an ambient-assisted living context(including human requests in natural language),our metaAgent prototype self-organizes a hierarchy of EM manipulation tasks in conjunction with commanding a robot.metaAgent masters foundational EM manipulation skills related to wireless communications and sensing,and it memorizes and learns from past experience based on human feedback.
基金This work was supported by the National Natural Science Foundation of China(82072068,82072167,81873931,and 81974382)the Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College of HUST,the Academic Doctor Supporting Program of Tongji Medical College,HUST,the Knowledge Innovation Special Project for Fundamental Research of Wuhan(2022020801010461)+1 种基金the Union Hospital Foundation for Young Scientist(2021xhqh01)the Open Foundation of Hubei Key Laboratory of Regenerative Medicine and Multi-disciplinary Translational Research(2022zsyx001).
文摘The excessive reactive oxygen species(ROS)is a hallmark associated with the initiation and progression of inflammatory bowel disease(IBD),which execrably form a vicious cycle of ROS and inflammation to continually promote disease progression.Here,the gold nanoparticles-embedded ceria nanoparticles(Au/CeO_(2))with enhanced antioxidant activities are designed to block this cycle reaction for treating IBD by scavenging overproduced ROS.The Au/CeO_(2) with core-shell and porous structure exhibits significantly higher enzymatic catalytic activities compared with commercial ceria nanoparticles,likely due to the effective exposure of catalytic sites,higher content of Ce(III)and oxygen vacancy,and accelerated reduction from Ce(IV)to Ce(III).Being coated with negatively-charged hyaluronic acid,the Au/CeO_(2)@HA facilitates accumulation in inflamed colon tissues via oral administration,reduces pro-inflammatory cytokines,and effectively alleviates colon injury in colitis mice.Overall,the Au/CeO_(2)@HA with good biocompatibility is a promising nano-therapeutic for treating IBD.
基金financially supported by Affiliated Cancer Hospital&Institute of Guangzhou Medical University Clinical Research 5555 Program,China[IIT-2020-002(FL5)]Guangzhou Regional Clinical Characteristic Technology Project,China(2023C-TS06).
文摘Objective:To analyze the association between iterative decomposition of water and fat with echo asymmetry and least-squares estimation quantification sequence(IDEAL-IQ)magnetic resonance imaging(MRI)of bone marrow fat fraction and bone marrow reserve function during concurrent chemoradiotherapy for cervical cancer.Methods:The study retrospectively analyzed twenty-six patients with stage IB1 to IVA cervical cancer treated between February 2020 and November 2020.All patients received concurrent chemoradiotherapy that included platinum alone or combined paclitaxel and platinum.Pelvic IDEAL-IQ MRI(plain and enhanced)was performed before and after treatment.Regions of interest,including the fifth lumbar vertebra,sacrum,ilium,ischium,and femoral neck,were manually delineated,and the bone marrow fat fraction was measured.Peripheral blood cell counts were recorded during treatment,and the relationship between the fat fraction values and changes in the blood cell counts was explored.Results:IDEAL-IQ MRI bone marrow fat fraction was associated with platelet nadir and platelet decline during treatment.The average pelvic bone marrow fat fraction before chemoradiotherapy was moderately negatively correlated with platelet count nadir during concurrent chemoradiotherapy(r=-0.450,P?0.021).The change in average pelvic bone marrow fat fraction through chemoradiotherapy was moderately positively correlated with the degree of thrombocytopenia(r=0.399,P=0.044).Conclusion:Bone marrow fat content quantified by IDEAL-IQ was associated with platelet count nadir and the degree of thrombocytopenia in patients with cervical cancer undergoing concurrent chemoradiotherapy.
