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A novel TLR7 agonist exhibits antiviral activity against pseudorabies virus
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作者 Yue Song Heng wang +9 位作者 mingyang wang Yumin wang Xiuxiang Lu Wenjie Fan Chen Yao Pengxiang Liu Yanjie Ma Shengli Ming Mengdi wang Lijun Shi 《Journal of Integrative Agriculture》 2026年第2期803-813,共11页
Innate immunity is the primary defense against viral infections,with Toll-like receptors(TLRs) playing a crucial role in this process.This study aims to highlight the effectiveness of a pyrrolo[3,2-d]pyrimidine deriva... Innate immunity is the primary defense against viral infections,with Toll-like receptors(TLRs) playing a crucial role in this process.This study aims to highlight the effectiveness of a pyrrolo[3,2-d]pyrimidine derivative(named TLR713),a potential TLR7 agonist,in inhibiting pseudorabies virus(PRV) replication both in vitro and in vivo.Tests on PK-15 cells demonstrated that TLR713 had no significant impact on cell viability,cell cycle progression,or apoptosis at concentrations of 0–3 μmol L^(–1).TLR713 could promote the phosphorylation of IκBα,p38,and JNK through TLR7,and increase the expression of inflammatory cytokines.In vitro,when cells were treated with TLR713,PRV proliferation was inhibited via TLR7 pathway.Analysis of the viral life cycle indicated that TLR713 could inhibit the replication of PRV,but not affect viral attachment,entry,assembly,or release.In vivo,TLR713 showed no side effects on mice at a concentration of 25 mg kg^(–1).It improved the survival rate of PRV-infected mice,reduced tissue viral load,and alleviated the inflammatory response.In summary,this study highlights the potential of TLR713 as a novel TLR7 agonist capable of inhibiting PRV replication and may offer new opportunities for developing antiviral therapies. 展开更多
关键词 Toll-like receptors TLR7 agonist innate immunity antiviral effect
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Experimental and numerical simulation of the attenuation effect of blast shock waves in tunnels at different altitudes 被引量:3
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作者 Changjiang Liu Hujun Li +3 位作者 Zhen wang Yong He Guokai Zhang mingyang wang 《Defence Technology(防务技术)》 2025年第1期120-141,共22页
Traffic engineering such as tunnels in various altitudinal gradient zone are at risk of accidental explosion,which can damage personnel and equipment.Accurate prediction of the distribution pattern of explosive loads ... Traffic engineering such as tunnels in various altitudinal gradient zone are at risk of accidental explosion,which can damage personnel and equipment.Accurate prediction of the distribution pattern of explosive loads and shock wave propagation process in semi-enclosed structures at various altitude environment is key research focus in the fields of explosion shock and fluid dynamics.The effect of altitude on the propagation of shock waves in tunnels was investigated by conducting explosion test and numerical simulation.Based on the experimental and numerical simulation results,a prediction model for the attenuation of the peak overpressure of tunnel shock waves at different altitudes was established.The results showed that the peak overpressure decreased at the same measurement points in the tunnel entrance under the high altitude condition.In contrast,an increase in altitude accelerated the propagation speed of the shock wave in the tunnel.The average error between the peak shock wave overpressure obtained using the overpressure prediction formula and the measured test data was less than15%,the average error between the propagation velocity of shock waves predicted values and the test data is less than 10%.The method can effectively predict the overpressure attenuation of blast wave in tunnel at various altitudes. 展开更多
关键词 Shock wave propagation TUNNEL Altitude effect Peak overpressure Shock waves velocity Engineering safety
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BlastGraphNet:An Intelligent Computational Method for the Precise and Rapid Prediction of Blast Loads on Complex 3D Buildings Using Graph Neural Networks 被引量:1
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作者 Zhiqiao wang Jiangzhou Peng +6 位作者 Jie Hu Mingchuan wang Xiaoli Rong Leixiang Bian mingyang wang Yong He Weitao Wu 《Engineering》 2025年第6期205-224,共20页
Accurate and efficient prediction of the distribution of surface loads on buildings subjected to explosive effects is crucial for rapidly calculating structural dynamic responses,establishing effective protective meas... Accurate and efficient prediction of the distribution of surface loads on buildings subjected to explosive effects is crucial for rapidly calculating structural dynamic responses,establishing effective protective measures,and designing civil defense engineering solutions.Current state-of-the-art methods face several issues:Experimental research is difficult and costly to implement,theoretical research is limited to simple geometries and lacks precision,and direct simulations require substantial computational resources.To address these challenges,this paper presents a data-driven method for predicting blast loads on building surfaces.This approach increases both the accuracy and computational efficiency of load predictions when the geometry of the building changes while the explosive yield remains constant,significantly improving its applicability in complex scenarios.This study introduces an innovative encoder-decoder graph neural network model named BlastGraphNet,which uses a message-passing mechanism to predict the overpressure and impulse load distributions on buildings with conventional and complex geometries during explosive events.The model also facilitates related downstream applications,such as damage mode identification and rapid assessment of virtual city explosions.The calculation results indicate that the prediction error of the model for conventional building tests is less than 2%,and its inference speed is 3-4 orders of magnitude faster than that of state-of-the-art numerical methods.In extreme test cases involving buildings with complex geometries and building clusters,the method achieved high accuracy and excellent generalizability.The strong adaptability and generalizability of BlastGraphNet confirm that this novel method enables precise real-time prediction of blast loads and provides a new paradigm for damage assessment in protective engineering. 展开更多
关键词 Blast load prediction Graph neural networks Data-driven learning Real-time prediction Protective engineering
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Coupling effect of size and strain rate on uniaxial compressive properties of coral reef limestone 被引量:1
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作者 Hongya Li Linjian Ma +3 位作者 mingyang wang Jiawen Wu Jiajun Deng Zeng Li 《International Journal of Mining Science and Technology》 2025年第11期1905-1919,共15页
As the main geomaterials for coral reefs oil or gas extraction and underground infrastructure construction,coral reef limestone demonstrates significantly distinct mechanical responses compared to terrigenous rocks.To... As the main geomaterials for coral reefs oil or gas extraction and underground infrastructure construction,coral reef limestone demonstrates significantly distinct mechanical responses compared to terrigenous rocks.To investigate the mechanical behaviour of coral reef limestone under the coupling impact of size and strain rate,the uniaxial compression tests were conducted on reef limestone samples with length-to-diameter(L/D)ratio ranging from 0.5 to 2.0 at strain rate ranging from 10^(−5)·s^(−1)to 10^(−2)·s^(−1).It is revealed that the uniaxial compressive strength(UCS)and residual compressive strength(RCS)of coral reef limestone exhibits a decreasing trend with L/D ratio increasing.The dynamic increase factor(DIF)of UCS is linearly correlated with the logarithm of strain rate,while increasing the L/D ratio further enhances the DIF.The elastic modulus increases with strain rate or L/D ratio increasing,whereas the Poisson’s ratio approximates to a constant value of 0.24.The failure strain increases with strain rate increasing or L/D ratio decreasing,while the increase in L/D ratio will inhibit the enhancing effect of the strain rate.The high porosity and low mineral strength are the primary factors contributing to a high RCS of 16.7%–64.9%of UCS,a lower brittleness index and multiple irregular fracture planes.The failure pattern of coral reef limestone transits from the shear-dominated to the splitting-dominated failure with strain rate increasing or L/D ratio decreasing,which is mainly governed by the constrained zones induced by end friction and the strain rate-dependent crack propagation.Moreover,a predictive formula incorporating coupling effect of size and strain rate for the UCS of reef limestone was established and verified to effectively capture the trend of UCS. 展开更多
关键词 Coral reef limestone Strain rate SIZE Failure mode Coupling effect
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Review on internal flow mechanism and control methods of axial flow compressor at low Reynolds number 被引量:1
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作者 Xuyang REN Xingen LU +6 位作者 mingyang wang Ge HAN Chengwu YANG Xu DONG Lipan YAO Yanfeng ZHANG Shengfeng ZHAO 《Chinese Journal of Aeronautics》 2025年第5期7-27,共21页
With the continuous increase of aeroengine flight ceiling(>20 km),the thin atmosphere at high altitudes and the size effect all cause the compressor component inlet Reynolds number to decrease rapidly to a critical... With the continuous increase of aeroengine flight ceiling(>20 km),the thin atmosphere at high altitudes and the size effect all cause the compressor component inlet Reynolds number to decrease rapidly to a critical value(approximately 2.0×10^(5)),and the significant transition process on the blade/endwall surface leads to the sharp degradation of compressor performance,which seriously affects the engine fuel consumption and working stability at high altitudes.In this paper,the research progress on the internal flow mechanism and flow control methods of axial compressors at low Reynolds numbers is reviewed from the aspects of quantification and prediction of performance variation,flow loss mechanism related to separation and transition,efficient transition control and flow field organization.The development trend of the low-Reynolds-number effect of axial flow compressors is noted,and the difficulties and application prospects of aerodynamic design and efficient flow control methods for compressors under low Reynolds numbers at high altitudes are discussed. 展开更多
关键词 LowReynolds number Axial compressor Flow mechanism Flow control methods AEROENGINE
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Energy-efficient and reliable urban rail transit:A new framework incorporating underground energy storage systems
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作者 Boyu Qin Jialing Liu +4 位作者 Hongzhen wang Zhaojian wang Ziming Xiong mingyang wang Qihu Qian 《iEnergy》 2025年第2期86-97,共12页
Within the transition process of urban rail transit systems,the challenges of high energy consumption,increasing carbon emissions,limited economic viability,and intricate risks emerge as significant hurdles.This paper... Within the transition process of urban rail transit systems,the challenges of high energy consumption,increasing carbon emissions,limited economic viability,and intricate risks emerge as significant hurdles.This paper proposes a novel energy utilization framework for the urban rail transit system that incorporates underground energy storage systems characterized by high resilience and low carbon.First,existing methods employed in urban rail transit are comprehensively reviewed.Then,a novel framework and strategic significance of the urban rail transit system incorporating underground energy storage systems are introduced.This integration effectively utilizes and manages diverse renewable energy sources and the available space resources.The viability is demonstrated through a case study by combining Nanjing metro.Finally,suggestions for research in pivotal areas are summarized. 展开更多
关键词 Urban rail transit underground space energy storage system renewable energy low carbon resilience enhancement
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Numerical analysis of a vented methane/air explosion in a large-scale chamber
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作者 Huadao Xing Guangan Xu +4 位作者 Yanyu Qiu Song Sun Bin Li mingyang wang Lifeng Xie 《Defence Technology(防务技术)》 2025年第10期207-219,共13页
The internal and external flow fields during vented explosions of methane were characterized through numerical simulation,and the capability of numerical simulation thereof was validated by previous experimental data ... The internal and external flow fields during vented explosions of methane were characterized through numerical simulation,and the capability of numerical simulation thereof was validated by previous experimental data at three ignition positions.The venting mechanism was revealed by the simulated concentration distribution,temperature profile,and airflow velocity.The results show rear ignition results in the external methane mass distribution taking the form of"mushroom"and columnar flames in the external space,which can be expressed as a third-order polynomial relationship with distance;central ignition forms a relationship of the form y=AxB.Front ignition causes the temperature to show a tendency to repeated oscillations(rising,falling,and rising).Central ignition generates the maximum vented airflow velocity(V_(max)=320 m/s)upon vent opening.The results indicate that it is acceptable to apply numerical simulation of methane explosions in practice. 展开更多
关键词 METHANE Vented explosion Numerical simulation Ignition position Field behavior
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Experimental investigation on the anti-detonation performance of composite structure containing foam geopolymer backfill material
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作者 Hang Zhou Hujun Li +6 位作者 Zhen wang Dongming Yan Wenxin wang Guokai Zhang Zirui Cheng Song Sun mingyang wang 《Defence Technology(防务技术)》 2025年第1期304-318,共15页
The compression and energy absorption properties of foam geopolymers increase stress wave attenuation under explosion impacts,reducing the vibration effect on the structure.Explosion tests were conducted using several... The compression and energy absorption properties of foam geopolymers increase stress wave attenuation under explosion impacts,reducing the vibration effect on the structure.Explosion tests were conducted using several composite structure models,including a concrete lining structure(CLS)without foam geopolymer and six foam geopolymer composite structures(FGCS)with different backfill parameters,to study the dynamic response and wave dissipation mechanisms of FGCS under explosive loading.Pressure,strain,and vibration responses at different locations were synchronously tested.The damage modes and dynamic responses of different models were compared,and how wave elimination and energy absorption efficiencies were affected by foam geopolymer backfill parameters was analyzed.The results showed that the foam geopolymer absorbed and dissipated the impact energy through continuous compressive deformation under high strain rates and dynamic loading,reducing the strain in the liner structure by 52%and increasing the pressure attenuation rate by 28%.Additionally,the foam geopolymer backfill reduced structural vibration and liner deformation,with the FGCS structure showing 35%less displacement and 70%less acceleration compared to the CLS.The FGCS model with thicker,less dense foam geopolymer backfill,having more pores and higher porosity,demonstrated better compression and energy absorption under dynamic impact,increasing stress wave attenuation efficiency.By analyzing the stress wave propagation and the compression characteristics of the porous medium,it was concluded that the stress transfer ratio of FGCS-ρ-579 was 77%lower than that of CLS,and the transmitted wave energy was 90%lower.The results of this study provide a scientific basis for optimizing underground composite structure interlayer parameters. 展开更多
关键词 Explosion load Composite structure Geopolymer foam Energy absorption
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Dynamic strength of rocks and physical nature of rock strength 被引量:8
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作者 Qihu Qian Chengzhi Qi mingyang wang 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE 2009年第1期1-10,共10页
Time-dependence of rock deformation and fracturing is often ignored.However,the consideration of the time-dependence is essential to the study of the deformation and fracturing processes of materials,especially for th... Time-dependence of rock deformation and fracturing is often ignored.However,the consideration of the time-dependence is essential to the study of the deformation and fracturing processes of materials,especially for those subject to strong dynamic loadings.In this paper,we investigate the deformation and fracturing of rocks,its physical origin at the microscopic scale,as well as the mechanisms of the time-dependence of rock strength.Using the thermo-activated and macro-viscous mechanisms,we explained the sensitivity of rock strength to strain rate.These mechanisms dominate the rock strength in different ranges of strain rates.It is also shown that a strain-rate dependent Mohr-Coulomb-type constitutive relationship can be used to describe the influence of strain rate on dynamic rock fragmentation.A relationship between the particle sizes of fractured rocks and the strain rate is also proposed.Several time-dependent fracture criteria are discussed,and their intrinsic relations are discussed.Finally,the application of dynamic strength theories is discussed. 展开更多
关键词 rock dynamics deformation and fracturing TIME-DEPENDENCE dynamic strength criteria of fracturing
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Effect of diagenetic variation on the static and dynamic mechanical behavior of coral reef limestone 被引量:4
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作者 Linjian Ma Jiajun Deng +3 位作者 mingyang wang Jianping wang Bin Fang Jiawen Wu 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2024年第7期893-908,共16页
Coral reef limestone at different depositional depths and facies differ remarkably on the textural and mineralogical characteristics,owing to the complex sedimentary diagenesis.To explore the effects of pore structure... Coral reef limestone at different depositional depths and facies differ remarkably on the textural and mineralogical characteristics,owing to the complex sedimentary diagenesis.To explore the effects of pore structure and mineral composition associated with diagenetic variation on the mechanical behavior of reef limestone,a series of quasi-static and dynamic compression tests along with microscopic examinations were performed on the reef limestone at shallow and deep burial depths.It is revealed that the shallow reef limestone(SRL)is classified as a porous aragonite-type carbonate rock with high porosity(55.3±3.2)%and pore connectivity.In comparison,the deep reef limestone(DRL)is mainly composed of dense calcite-type calcium carbonate with low porosity(4.9±1.6)%and pore connectivity.The DRL strengthened and stiffened by the tight grain framework consistently displays much higher values of the dynamic compressive strength,elastic modulus,brittleness index,and specific energy absorption than those of the SRL.The gap between two types of limestone further increases with an increase in strain rate.It appears that the failure pattern of SRL is dominated by the inherent defects like weak bonding interfaces and growth lines,revealed by the intricate fracturing network and mixed failure.Likewise,although the preexisting megapores in DRL may affect the crack propagation on pore tips to a certain distance,it hardly alters the axial splitting failure of DRL under impacts.The stress wave propagation and attenuation in SRL is primarily controlled by the reflection and diffusion caused by plenty mesopores,as well as an energy dissipation in layer-wise pore collapse and adjacent grain crushing,while the stress wave in DRL is highly hinged on the insulation and diffraction induced by the isolated megapores.This process is accompanied by the energy dissipation behavior of inelastic deformation resulted from the pore-emanated microcracking. 展开更多
关键词 Reef limestone Dynamic behavior Mineral composition Pore structure Wave propagation Energy dissipation
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Investigation of Anticorrosive Performance of Oil-infused Slippery and Superhydrophobic Brass Surfaces by Laser Texturing 被引量:3
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作者 Li Zhang Chong Zhang +2 位作者 Jingrong Tang Bo Hao mingyang wang 《Journal of Bionic Engineering》 SCIE EI CSCD 2021年第5期1157-1167,共11页
Brass is widely used in machinery,electronic appliances and emerging industries.The corrosion resistance of laser-induced superhydrophobic surface of brass needs to be improved.In recent years,bionic surface with slip... Brass is widely used in machinery,electronic appliances and emerging industries.The corrosion resistance of laser-induced superhydrophobic surface of brass needs to be improved.In recent years,bionic surface with slippery coating has attracted much attention because of its excellent corrosion inhibition performance.Here,we first prepared the superhydrophobic surface of brass by nanosecond laser ablation combined with fluoroalkyl silane modification,and then injected silicone oil into the prepared superhydrophobic matrix to obtain a slippery coating surface.PDP and EIS tests in 3.5 wt.%NaCl solution showed that the corrosion resistance of the slippery surface was better than that of the superhydrophobic surface.This study can play a certain role in promoting the development of metal anticorrosive coating and is of great significance in the preparation of slippery surface by laser induction,and provides a convenient and eff ective means for metal anticorrosion in the industrial field. 展开更多
关键词 Nanosecond laser SUPERHYDROPHOBIC Slippery surface Corrosion resistance
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Effects of surface roughness on the aerodynamic performance of a high subsonic compressor airfoil at low Reynolds number 被引量:2
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作者 mingyang wang Chengwu YANG +3 位作者 Ziliang LI Shengfeng ZHAO Yanfeng ZHANG Xin’gen LU 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2021年第3期71-81,共11页
The aerodynamic performance of compressor airfoil is significantly affected by the surface roughness at low Reynolds number(Re).In the present study,numerical simulations have been conducted to investigate the impact ... The aerodynamic performance of compressor airfoil is significantly affected by the surface roughness at low Reynolds number(Re).In the present study,numerical simulations have been conducted to investigate the impact of surface roughness on the profile loss of a high subsonic compressor airfoil at Re=1.5×10^(5).Four roughness locations,covering 10%,30%,50%and 100%of the suction surface from the leading edge and seven roughness magnitudes(Ra)ranging from 52 to525 lm were selected.Results showed that the surface roughness mainly determined the loss generation process by influencing the structure of the Laminar Separation Bubble(LSB)and the turbulence level near the wall.For all the roughness locations,the variation trend for the profile loss with the roughness magnitude was similar.In the transitionally rough region,the negative displacement effect of the LSB was suppressed with the increase of roughness magnitude,leading to a maximum decrease of 14.6%,16.04%,16.45%and 10.20%in the profile loss at Ra=157 lm for the four roughness locations,respectively.However,with a further increase of the roughness magnitude in the fully rough region,the stronger turbulent dissipation enhanced the growth rate of the turbulent boundary layer and increased the profile loss instead.By comparison,the leading edge roughness played a dominant role in the boundary layer development and performance variation.To take fully advantage of the surface roughness reducing profile loss at low Re,the effects of roughness on suppressing LSB and inducing strong turbulent dissipation should be balanced effectively. 展开更多
关键词 Aerodynamic performance Compressor airfoil Low Reynolds number Separation bubble Surface roughness Viscous dissipation
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Vortex dynamics and entropy generation in separated transitional flow over a compressor blade at various incidence angles 被引量:2
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作者 mingyang wang Ziliang LI +4 位作者 Ge HAN Chengwu YANG Shengfeng ZHAO Yanfeng ZHANG Xin’gen LU 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2022年第3期42-52,共11页
The transition process within a Laminar Separation Bubble(LSB)that formed on a compressor blade surface was investigated using Large Eddy Simulations(LESs)at a Reynolds number of 1.5×10^(5) and incidence angles o... The transition process within a Laminar Separation Bubble(LSB)that formed on a compressor blade surface was investigated using Large Eddy Simulations(LESs)at a Reynolds number of 1.5×10^(5) and incidence angles of 0°,+3°,and+5°.The vortex dynamics in the separated shear layers were compared at various incidence angles and its effects on the loss generation were clarified through entropy analysis.Results showed that transition onset,which was accurately identified by the Linear Stability Theory(LST),was significantly promoted at the increased incidence angle.As such,the development of LSB was suppressed and the relative role of viscous instability played in the transition process was weakened.At the incidence angle of 0°,two-dimensional spanwise vortices detached from the blade surface and roiled up periodically,which were further stretched and eventually evolved into large-scale hairpin vortices.As time passed,the fully developed hairpin vortices broke down into small-scale eddies.Meanwhile,the flow near the wall reversely ejected into the outer separated shear layers and a sweeping process happened subsequently,forcing the separated shear layers to reattach and accelerating the generation of turbulent fluctuations.By comparison,the strength of vortex rolling-up was weakened at higher incidence angles,and the vortex pairing and breakdown of large-scale vortices were less pronounced.Therefore,the level of turbulent fluctuations that generated in the separated shear layers was reduced.Detailed entropy analysis showed that the turbulent dissipation effect related to the Reynolds shear stresses determined the largest amount of positive entropy generation,which declined to a lower level as the incidence angle increased from 0°to+5°.Correspondingly,the profile loss was reduced by 50.4%. 展开更多
关键词 Aerodynamic performance Compressor airfoil ENTROPY Incidence angle Separation bubble Vortex dynamics
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Establishment of an Objective Standard for the Definition of Binary Tropical Cyclones in the Western North Pacific 被引量:3
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作者 Fumin REN Yanjun XIE +2 位作者 Biwen YIN mingyang wang Guoping LI 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2020年第11期1211-1221,共11页
To develop an objective standard for defining binary tropical cyclones(BTCs)in the western North Pacific(WNP),two best-track datasets,from the China Meteorological Administration and the Joint Typhoon Warning Center,w... To develop an objective standard for defining binary tropical cyclones(BTCs)in the western North Pacific(WNP),two best-track datasets,from the China Meteorological Administration and the Joint Typhoon Warning Center,were adopted for statistical analyses on two important characteristics of BTCs-two TCs approaching each other,and counterclockwise spinning.Based on the high consistency between the two datasets,we established an objective standard,which includes a main standard for defining BTCs and a secondary standard for identifying typical/atypical BTCs.The main standard includes two requirements:two coexisting TCs are a pair of BTCs if(i)the separation distance is≤1800 km,and(ii)this separation maintains for at least 12 h.Meanwhile,the secondary standard defines a typical BTC as one for which there is at least one observation when the two TCs approach each other and spin counterclockwise simultaneously.Under the standard,the ratio of typical BTCs increases as the BTC duration increases or the minimum distance between the two TCs decreases.Then,using the JTWC dataset,it was found that there are 505 pairs of BTCs during the period 1951−2014,including 328 typical BTCs and 177 atypical BTCs,accounting for 65.0%and 35.0%of the total,respectively.In addition,a study of two extreme phenomena-the maximum approaching speed and the maximum counterclockwise angular velocity in typical BTCs-shows that the configuration of the circulation conditions and the distribution of the BTCs favor the formation of these extreme phenomena. 展开更多
关键词 objective standard binary tropical cyclones Western North Pacific
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Explosion resistance performance of reinforced concrete box girder coated with polyurea:Model test and numerical simulation 被引量:2
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作者 Guangpan Zhou Rong wang +2 位作者 mingyang wang Jianguo Ding Yuye Zhang 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第3期1-18,共18页
To study the anti-explosion protection effect of polyurea coating on reinforced concrete box girder,two segmental girder specimens were made at a scale of 1:3,numbered as G(without polyurea coating)and PCG(with polyur... To study the anti-explosion protection effect of polyurea coating on reinforced concrete box girder,two segmental girder specimens were made at a scale of 1:3,numbered as G(without polyurea coating)and PCG(with polyurea coating).The failure characteristics and dynamic responses of the specimens were compared through conducting explosion tests.The reliability of the numerical simulation using LS-DYNA software was verified by the test results.The effects of different scaled distances,reinforcement ratios,concrete strengths,coating thicknesses and ranges of polyurea were studied.The results show that the polyurea coating can effectively enhance the anti-explosion performance of the girder.The top plate of middle chamber in specimen G forms an elliptical penetrating hole,while that in specimen PCG only shows a very slight local dent.The peak vertical displacement and residual displacement of PCG decrease by 74.8% and 73.7%,respectively,compared with those of specimen G.For the TNT explosion with small equivalent,the polyurea coating has a more significant protective effect on reducing the size of fracture.With the increase of TNT equivalent,the protective effect of polyurea on reducing girder displacement becomes more significant.The optimal reinforcement ratio,concrete strength,thickness and range of polyurea coating were also drawn. 展开更多
关键词 Explosive load Explosion resistance performance Model test POLYUREA Concrete box girder Numerical simulation
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Time-dependent dilatancy for brittle rocks 被引量:2
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作者 Jie Li mingyang wang +2 位作者 Kaiwen Xia Ning Zhang Houxu Huang 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2017年第6期1054-1070,共17页
This paper presents a theoretical study on time-dependent dilatancy behaviors for brittle rocks. The theory employs a well-accepted postulation that macroscopically observed dilatancy originates from the expansion of ... This paper presents a theoretical study on time-dependent dilatancy behaviors for brittle rocks. The theory employs a well-accepted postulation that macroscopically observed dilatancy originates from the expansion of microcracks. The mechanism and dynamic process that microcracks initiate from local stress concentration and grow due to localized tensile stress are analyzed. Then, by generalizing the results from the analysis of single cracks, a parameter and associated equations for its evolution are developed to describe the behaviors of the microcracks. In this circumstance, the relationship between microcracking and dilatancy can be established, and the theoretical equations for characterizing the process of rock dilatancy behaviors are derived. Triaxial compression and creep tests are conducted to validate the developed theory. With properly chosen model parameters, the theory yields a satisfactory accuracy in comparison with the experimental results. 展开更多
关键词 Time-dependent dilatancy Microcracking Subcritical crack growth Rock deformation and failure
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Effect of substrate orientations on the electrochemical and localized corrosion behavior of a quad-layer Al alloy composite 被引量:2
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作者 mingyang wang Yuanyuan Ji +5 位作者 Da-Hai Xia Dejing Zhou Yesen Zhu Zhiming Gao Zhenbo Qin Wenbin Hu 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2024年第9期57-68,共12页
Electrochemical and localized corrosion behavior of a 4045/7072/3003 M/4045 Al alloy composite in 3.5 wt.%NaCl solution was investigated from cross-sectional and plane directions by electrochemical impedance spectrosc... Electrochemical and localized corrosion behavior of a 4045/7072/3003 M/4045 Al alloy composite in 3.5 wt.%NaCl solution was investigated from cross-sectional and plane directions by electrochemical impedance spectroscopy,polarization curves,and high-resolution microscopic examination.Plane directions showed higher corrosion resistance than the cross-sectional surface,with almost all localized corrosion initiated from Si-containing inclusions.The cross-section showed a complex galvanic effect among the four layers,the galvanic coupling between 4045/7072 accelerated the dissolution of 7072 because 7072 served as the anode,however,the galvanic coupling between 3003 M/4045 protected 4045 from corrosion,indicating that 3003 M served as the anode. 展开更多
关键词 Al alloy composite sheet Localized corrosion Electrochemical behavior
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Wuling powder alleviates depressive-like behavior by attenuating endoplasmic reticulum stress in the mouse hippocampus 被引量:2
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作者 Lu Feng Wei Huang +7 位作者 Ji Zheng Dongmei Li mingyang wang Junya Liu Shujie Fan Chao Ji Nan Yang Yanyong Liu 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2024年第9期783-794,共12页
The response to endoplasmic reticulum(ER)stress has been noted in both human depression cases and depression models in rodents.Wuling powder,derived from the mycelium of the esteemed fungus Xylaria Nigripes(Kl.)Sacc,h... The response to endoplasmic reticulum(ER)stress has been noted in both human depression cases and depression models in rodents.Wuling powder,derived from the mycelium of the esteemed fungus Xylaria Nigripes(Kl.)Sacc,has demonstrated efficacy in alleviating depressive symptoms.The purpose of this research was to explore the antidepressant properties of Wuling powder and its basic molecular effects,particularly regarding alterations in ER stress.A model of social defeat stress was created by introducing a mouse to the cage of an unfamiliar,hostile mouse for intervals of 5–10 min daily over a span of 10 d.Subsequently,the mice received oral doses of Wuling powder for 2 weeks.The social approach-avoidance assay was employed to evaluate signs of depression-like behaviors.Moreover,protein and gene expressions linked to ER stress triggered by social defeat were analyzed through Western blotting analysis and quantitative real-time PCR.The behavioral tests indicated that Wuling powder ameliorated behaviors associated with depression due to social defeat stress.Treatment with Wuling powder markedly reduced the increased levels of the 78-k Da glucose-regulated protein and protein disulfide isomerase caused by social defeat stress.It also diminished the expression of inositol-requiring enzyme 1α(IRE1α)and spliced X box-binding protein-1(s XBP1)at the protein and m RNA levels.Furthermore,Wuling treatment notably decreased the levels of phosphorylated eukaryotic initiation factor 2 alpha kinase(P-e IF2α),activating transcription factor 4(ATF4)and C/EBP homologous protein(CHOP),simultaneously enhancing the ratio of B-cell lymphoma 2(Bcl-2)to Bcl-2-associated X protein(Bax).These results suggested that Wuling powder could alleviate ER stress and inhibit cell apoptosis in the hippocampus by inhibiting protein translation and synthesis,thereby attenuating depressive-like behavior. 展开更多
关键词 DEPRESSION Wuling powder Endoplasmic reticulum stress Unfolded protein response
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Dynamically triggered seismicity on a tectonic scale:A review 被引量:2
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作者 Chengzhi Qi mingyang wang +2 位作者 Gevorg Kocharyan Artem Kunitskikh Zefan wang 《Deep Underground Science and Engineering》 2024年第1期1-24,共24页
Earthquakes triggered by dynamic disturbances have been confirmed by numerous observations and experiments.In the past several decades,earthquake triggering has attracted increasing attention of scholars in relation t... Earthquakes triggered by dynamic disturbances have been confirmed by numerous observations and experiments.In the past several decades,earthquake triggering has attracted increasing attention of scholars in relation to exploring the mechanism of earthquake triggering,earthquake prediction,and the desire to use the mechanism of earthquake triggering to reduce,prevent,or trigger earthquakes.Natural earthquakes and large‐scale explosions are the most common sources of dynamic disturbances that trigger earthquakes.In the past several decades,some models have been developed,including static,dynamic,quasi‐static,and other models.Some reviews have been published,but explosiontriggered seismicity was not included.In recent years,some new results on earthquake triggering have emerged.Therefore,this paper presents a new review to reflect the new results and include the content of explosion‐triggered earthquakes for the reference of scholars in this area.Instead of a complete review of the relevant literature,this paper primarily focuses on the main aspects of dynamic earthquake triggering on a tectonic scale and makes some suggestions on issues that need to be resolved in this area in the future. 展开更多
关键词 dynamic disturbances dynamic models problems for future research quasi‐static models static models triggered seismicity
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Scale-space effect and scale hybridization in image intelligent recognition of geological discontinuities on rock slopes 被引量:1
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作者 mingyang wang Enzhi wang +1 位作者 Xiaoli Liu Congcong wang 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第4期1315-1336,共22页
Geological discontinuity(GD)plays a pivotal role in determining the catastrophic mechanical failure of jointed rock masses.Accurate and efficient acquisition of GD networks is essential for characterizing and understa... Geological discontinuity(GD)plays a pivotal role in determining the catastrophic mechanical failure of jointed rock masses.Accurate and efficient acquisition of GD networks is essential for characterizing and understanding the progressive damage mechanisms of slopes based on monitoring image data.Inspired by recent advances in computer vision,deep learning(DL)models have been widely utilized for image-based fracture identification.The multi-scale characteristics,image resolution and annotation quality of images will cause a scale-space effect(SSE)that makes features indistinguishable from noise,directly affecting the accuracy.However,this effect has not received adequate attention.Herein,we try to address this gap by collecting slope images at various proportional scales and constructing multi-scale datasets using image processing techniques.Next,we quantify the intensity of feature signals using metrics such as peak signal-to-noise ratio(PSNR)and structural similarity(SSIM).Combining these metrics with the scale-space theory,we investigate the influence of the SSE on the differentiation of multi-scale features and the accuracy of recognition.It is found that augmenting the image's detail capacity does not always yield benefits for vision-based recognition models.In light of these observations,we propose a scale hybridization approach based on the diffusion mechanism of scale-space representation.The results show that scale hybridization strengthens the tolerance of multi-scale feature recognition under complex environmental noise interference and significantly enhances the recognition accuracy of GD.It also facilitates the objective understanding,description and analysis of the rock behavior and stability of slopes from the perspective of image data. 展开更多
关键词 Image processing Geological discontinuities Deep learning MULTI-SCALE Scale-space theory Scale hybridization
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