A novel Pt/Cu-zeolite A/graphene based electrocatalyst was successfully prepared by chemical reduction method for methanol electrooxidation. Graphite oxide and Cu functionalized zeolite A were simultaneously reduced b...A novel Pt/Cu-zeolite A/graphene based electrocatalyst was successfully prepared by chemical reduction method for methanol electrooxidation. Graphite oxide and Cu functionalized zeolite A were simultaneously reduced by NaBH4 to prepare Cu-zeolite A/graphene support which was used to deposit Pt nanoparticles. The nanostructure and composition of as-prepared Pt/Cu-zeolite A/sraphene composites were characterized by X-ray diffrac- tometer, X-ray fluorescence, Fourier transform infrared spectrometer and scanning electron microscopy. The electrocatalytic properties of Pt/Cu-zeolite A/sraphene modified electrode for methanol oxidation were investigated by cyclic voltammetry and chronoamperometry in 0.10 mol/L H2SO4＋0.50 mol/L CH3OH solution. Compared with Pt/zeolite A/graphene electrode and Pt/graphene electrode, Pt/Cu-zeolite A/graphene based electrode exhibited obviously enhanced current and higher electrocatalytic activity for methanol electrooxidation. The increased electrocatalytic activity was attributed to the presence of zeolite A and reduced graphene oxide based dual template, which significantly increased the effective electrode surface and facilitated the diffusion of analytes into the electroactive catalyst.展开更多
Myocardial infarction(MI),commonly known as a heart attack,remains a leading cause of death worldwide.Standard treatments,such as coronary stent placement or coronary artery bypass graft surgery,aim to restore blood f...Myocardial infarction(MI),commonly known as a heart attack,remains a leading cause of death worldwide.Standard treatments,such as coronary stent placement or coronary artery bypass graft surgery,aim to restore blood flow to ischemic myocardial tissue.However,a significant complication of these procedures is ischemia/reperfusion(I/R)injury,which occurs when blood flow is restored,triggering oxidative stress,inflammation,and calcium overload that can further damage the heart.To limit the I/R injury following the coronary recanalization of an MI heart,we designed stromal-platelet membrane-inspired nanoparticles(SPINs)that consist of a poly(lactic-co-glycolic acid)(PLGA)core,decorated by a dual membrane coating:a platelet membrane for precise adhesion to the damaged endothelium area and a stromal cell membrane to enhance receptor-ligand interactions and immune-evasiveness.This unique dual-membrane configuration synergistically reduces fibrosis and inflammation while promoting angiomyogenesis.This combination integrates the vascular injury targeting and immune-evasive properties of the nanoparticle,making this dual-membrane design a promising add-on intervention to augment post-percutaneous coronary intervention recovery,enhancing outcomes and offering potential improved cardiac repair.展开更多
文摘A novel Pt/Cu-zeolite A/graphene based electrocatalyst was successfully prepared by chemical reduction method for methanol electrooxidation. Graphite oxide and Cu functionalized zeolite A were simultaneously reduced by NaBH4 to prepare Cu-zeolite A/graphene support which was used to deposit Pt nanoparticles. The nanostructure and composition of as-prepared Pt/Cu-zeolite A/sraphene composites were characterized by X-ray diffrac- tometer, X-ray fluorescence, Fourier transform infrared spectrometer and scanning electron microscopy. The electrocatalytic properties of Pt/Cu-zeolite A/sraphene modified electrode for methanol oxidation were investigated by cyclic voltammetry and chronoamperometry in 0.10 mol/L H2SO4＋0.50 mol/L CH3OH solution. Compared with Pt/zeolite A/graphene electrode and Pt/graphene electrode, Pt/Cu-zeolite A/graphene based electrode exhibited obviously enhanced current and higher electrocatalytic activity for methanol electrooxidation. The increased electrocatalytic activity was attributed to the presence of zeolite A and reduced graphene oxide based dual template, which significantly increased the effective electrode surface and facilitated the diffusion of analytes into the electroactive catalyst.
基金supported by grants from the National Institute of Health(1R01HL175373-01 to K.H.)the American Heart Association(21CDA855570 to K.H.)(24CDA1277521 to D.Z).
文摘Myocardial infarction(MI),commonly known as a heart attack,remains a leading cause of death worldwide.Standard treatments,such as coronary stent placement or coronary artery bypass graft surgery,aim to restore blood flow to ischemic myocardial tissue.However,a significant complication of these procedures is ischemia/reperfusion(I/R)injury,which occurs when blood flow is restored,triggering oxidative stress,inflammation,and calcium overload that can further damage the heart.To limit the I/R injury following the coronary recanalization of an MI heart,we designed stromal-platelet membrane-inspired nanoparticles(SPINs)that consist of a poly(lactic-co-glycolic acid)(PLGA)core,decorated by a dual membrane coating:a platelet membrane for precise adhesion to the damaged endothelium area and a stromal cell membrane to enhance receptor-ligand interactions and immune-evasiveness.This unique dual-membrane configuration synergistically reduces fibrosis and inflammation while promoting angiomyogenesis.This combination integrates the vascular injury targeting and immune-evasive properties of the nanoparticle,making this dual-membrane design a promising add-on intervention to augment post-percutaneous coronary intervention recovery,enhancing outcomes and offering potential improved cardiac repair.
