CO_(2)-enhanced oil recovery(CO_(2)-EOR)is an economically viable carbon capture,utilization,and storage(CCUS)technique that is widely practiced and greatly contributes to the achievement of carbon-neutral cities.Howe...CO_(2)-enhanced oil recovery(CO_(2)-EOR)is an economically viable carbon capture,utilization,and storage(CCUS)technique that is widely practiced and greatly contributes to the achievement of carbon-neutral cities.However,studies on CO_(2)-EOR source-sink matching involving different emission sources,different carbon capture rates,and stepwise CO_(2)pipeline construction are scarce.Considering four types of carbon sources,including coal-fired power,iron and steel,cement,and chemical plants,with different CO_(2)capture rates(85%,90%,95%,and 100%,respectively),and using a five-phased construction plan with a 25-year build-up period,we developed a method for quantifying carbon emissions from different sources,calculating the effective storage of carbon in CO_(2)-EOR and optimizing CO_(2)-EOR source-sink matching to reduce project costs.Using the Subei Basin in the Jiangsu Province,China,as a case study,we calculated the theoretical CO_(2)-EOR storage to be 1.7408×10^(8)t and the effective CO_(2)-EOR storage to be 0.435×10^(8)t.We analyzed the completion rate of transportation pipelines,the number of connected carbon sources,and the mass of CO_(2)stored,as well as the cost-effectiveness and sensitivity.Implementation of CO_(2)-EOR effectively reduced the total cost of source-sink matching in the five-stage 25-year construction approach.The reduction of CO_(2)capture rates had no effect on the value of oil repelling.The capture cost significantly affected the total cost of source-sink matching,and the impacts of the carbon sources on the total cost were in the order coal-fired power>iron and steel>cement>chemical plants.This study provides an innovative tool for evaluating the CO_(2)storage potential of CO_(2)-EOR and provides an important framework for implementing CO_(2)-EOR and planning CCUS projects in the Subei Basin and similar regions.展开更多
Molybdenum disulfide(MoS_(2)),a typical two-dimensional transition metallic layered material,attracts tremendous attentions in the electrochemical energy storage due to its excellent physicochemical properties.However...Molybdenum disulfide(MoS_(2)),a typical two-dimensional transition metallic layered material,attracts tremendous attentions in the electrochemical energy storage due to its excellent physicochemical properties.However,with the deepening of the research and exploration of the lithium storage mechanism of these advanced MoS_(2)-based anode materials,the complex reaction process influenced by internal and external factors hinders the exhaustive understanding of the lithium storage process.To design stable anode material with high performance,it is urgent to review the mechanisms of reported anode materials and summarize the related factors that influence the reaction processes.This review aims to dissect all possible side reactions during charging and discharging process,uncover internal and external factors inducing various anode reactions and finally put forward strategies of controlling high cycling capacity and super-stable lithium storage capability of MoS_(2).This review will be helpful to the design of MoS_(2)-based lithium-ion batteries(LIBs) with excellent cycle performance to enlarge the application fields of these advanced electrochemical energy storage devices.展开更多
Molybdenum disulfide (MoS_(2)) with low cost, high activity and high earth abundance has been found to be a promising catalyst for the hydrogen evolution reaction (HER), but its catalytic activity is considerably limi...Molybdenum disulfide (MoS_(2)) with low cost, high activity and high earth abundance has been found to be a promising catalyst for the hydrogen evolution reaction (HER), but its catalytic activity is considerably limited due to its inert basal planes. Here, through the combination of theory and experiment, we propose that doping Ni in MoS_(2) as catalyst can make it have excellent catalytic activity in different reaction systems. In the EY/TEOA system, the maximum hydrogen production rate of EY/Ni-Mo-S is 2.72 times higher than that of pure EY, which confirms the strong hydrogen evolution activity of Ni-Mo-S nanosheets as catalysts. In the lactic acid and Na_(2)S/Na_(2)SO_(3) systems, when Ni-Mo-S is used as co-catalyst to compound with ZnIn_(2)S_(4) (termed as Ni-Mo-S/ZnIn_(2)S_(4)), the maximum hydrogen evolution rates in the two systems are 5.28 and 2.33 times higher than those of pure ZnIn_(2)S_(4), respectively. The difference in HER enhancement is because different systems lead to different sources of protons, thus affecting hydrogen evolution activity. Theoretically, we further demonstrate that the Ni-Mo-S nanosheets have a narrower band gap than MoS_(2), which is conducive to the rapid transfer of charge carriers and thus result in multi-photocatalytic reaction systems with excellent activity. The proposed atomic doping strategy provides a simple and promising approach for the design of photocatalysts with high activity and stability in multi-reaction systems.展开更多
Targeted therapy has been widely demonstrated as an effective strategy to treat cancers,the leading cause of death in the world.This minireview summarizes the technical platforms and methodologies utilized to develop ...Targeted therapy has been widely demonstrated as an effective strategy to treat cancers,the leading cause of death in the world.This minireview summarizes the technical platforms and methodologies utilized to develop and engineer therapeutic monoclonal antibodies and antibody-drug conjugates.First,the USA FDA approved monoclonal antibody(mAb)-based targeted therapies are reviewed.Then the representative innovative chimeric,humanized and fully human anti-cancer antibodies and antibody-drug conjugates are described.Finally,the past and predictive market trend of therapeutic antibodies is discussed.展开更多
The dynamic mechanical properties of the Ti-6Al-4V(TC4)alloy prepared by laser additive manufacturing(LAM-TC4)under the high strain rate(HSR)are proposed.The dynamic compression experiments of LAM-TC4 are conducted wi...The dynamic mechanical properties of the Ti-6Al-4V(TC4)alloy prepared by laser additive manufacturing(LAM-TC4)under the high strain rate(HSR)are proposed.The dynamic compression experiments of LAM-TC4 are conducted with the split Hopkinson pressure bar(SHPB)equipment.The results show that as the strain rate increases,the widths of the adiabatic shear band(ASB),the micro-hardness,the degree of grain refinement near the ASB,and the dislocation density of grains grow gradually.Moreover,the increase of dislocation density of grains is the root factor in enhancing the yield strength of LAM-TC4.Meanwhile,the heat produced from the distortion and dislocations of grains promotes the heat softening effect favorable for the recrystallization of grains,resulting in the grain refinement of ASB.Furthermore,the contrastive analysis between LAM-TC4 and TC4 prepared by forging(F-TC4)indicates that under the HSR,the yield strength of LAM-TC4 is higher than that of F-TC4.展开更多
a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors are considered to play a crucial role in synaptic plasticity in the developing visual cortex. In this study, we established a rat model of binocular form ...a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors are considered to play a crucial role in synaptic plasticity in the developing visual cortex. In this study, we established a rat model of binocular form deprivation by suturing the rat binocular eyelids before eye-opening at postnatal day 14. During development, the decay time of excitatory postsynaptic currents mediated by a-amino-3- hydroxy-5-methyl-4-isoxazolepropionic acid receptors of normal rats became longer after eye- opening; however, the decay time did not change significantly in binocular form deprivation rats. The peak value in the normal group became gradually larger with age, but there was no significant change in the binocular form deprivation group. These findings indicate that binocular form deprivation influences the properties of excitatory postsynaptic currents mediated by a-amino-3- hydroxy-5-methyl-4-isoxazolepropionic acid receptors in the rat visual cortex around the end of the critical period, indicating that form stimulation is associated with the experience-dependent modification of neuronal synapses in the visual cortex.展开更多
The catalytic descriptor with operational feasibility is highly desired towards rational design of high-performance catalyst especially the electrode/electrolyte solution interface working under mild conditions.Herein...The catalytic descriptor with operational feasibility is highly desired towards rational design of high-performance catalyst especially the electrode/electrolyte solution interface working under mild conditions.Herein,we demonstrate that the descriptorΩparameterized by readily accessible intrinsic properties of metal center and coordination is highly operational and efficient in rational design of single-atom catalyst(SAC)for driving electrochemical nitrogen reduction(NRR).Using twodimensional metal(M)-B_(x)P_(y)S_(z)N_m@C_(2)N as prototype SAC models,we reveal that^(*)N_(2)+(H~++e~-)→^(*)N_(2)H acts predominantly as the potential-limiting step(PLS)of NRR on M-B_(2)P_(2)S_(2)@C_(2)N and M-B_(1)P_(1)S_(1)N_(3)@C_(2)N regardless of the distinction in coordination microenvironment.Among the 28 screened M active sites,withΩvalues close to the optimal 4,M-B_(2)P_(2)S_(2)@C_(2)N(M=V(Ω=3.53),Mo(Ω=5.12),and W(Ω=3.92))and M-B_(1)P_(1)S_(1)N_(3)@C_(2)N(M=V(Ω=3.00),Mo(Ω=4.34),and W(Ω=3.32))yield the lowered limiting potential(U_(L))as-0.45,-0.54.-0.36,-0.58,-0.25,and-0.24 V,respectively,thus making them the promising NRR catalysts.More importantly,these SACs are located around the top of volcano-shape plot of U_(L) versusΩ,re-validatingΩas an effective descriptor for accurately predicting the high-activity NRR SACs even with complex coordination.Our study unravels the relationship between active-site structure and NRR performance via the descriptorΩ,which can be applied to other important sustainable electrocatalytic reactions involving activation of small molecules viaσ-donation andπ^(*)-backdonation mechanism.展开更多
Background:Bireociclib(XZP-3287)is a novel selective cyclin-dependent kinase 4 and 6(CDK4/6)inhibitor,with a favorable safety profile demonstrated in preclinical and phase I studies.BRIGHT-1 aimed to further explore t...Background:Bireociclib(XZP-3287)is a novel selective cyclin-dependent kinase 4 and 6(CDK4/6)inhibitor,with a favorable safety profile demonstrated in preclinical and phase I studies.BRIGHT-1 aimed to further explore the efficacy and safety of bireociclib monotherapy in patients with locally advanced,recurrent or metastatic,hormone receptor-positive and human epidermal growth factor receptor 2-negative(HR+/HER2−)breast cancer who had progressed on or after prior chemotherapy and endocrine therapy in advanced settings,without previous exposure to CDK4/6 inhibitors.Methods:In this open-label phase II trial,eligible patients received bireociclib 480 mg twice daily(BID)until disease progression or intolerable toxicities.The primary endpoint was the confirmed objective response rate(ORR)assessed by an independent review committee(IRC).The secondary endpoints included progression-free survival(PFS),investigator-assessed ORR,disease control rate(DCR),clinical benefit rate(CBR),duration of response(DoR),overall survival(OS),safety and the pharmacokinetic properties of bireociclib.Results:A total of 131 patients were enrolled.At data cutoff(July 31,2023),the IRC-assessed ORR was 29.8%(95%confidence interval[CI],22.1%to 38.4%),with a DCR of 73.3%(95%CI,64.8%to 80.6%),CBR of 42.0%(95%CI,33.4%to 50.9%)and a median DoR of 15.2 months(95%CI,9.5 months to not reached).The median PFS was 11.0 months(95%CI,7.3 months to 12.9 months)assessed by the IRC,and the median OS was 29.0 months(95%CI,24.9 months to not reached).The most frequently reported treatment-emergent adverse events(TEAEs)of any grade were diarrhea(93.1%),neutrophil count decreased(87.0%),white blood cell decreased(86.3%),vomiting(78.6%),anemia(72.5%),and platelet count decreased(72.5%).The grade≥3 TEAEs occurred in 109(83.2%)patients.The most common grade≥3 TEAEs were neutrophil count decreased(43.5%),white blood cell decreased(32.8%),hypokalemia(20.6%),and diarrhea(19.1%).Conclusions:Bireociclib monotherapy at 480 mg BID exhibited promising and sustained clinical activity,with no unexpected and acceptable toxicity in patients with recurrent or metastatic HR+/HER2−breast cancer who had progressed on or after previous therapy.Trial registration:Clinicaltrials.gov ID,NCT04539496.展开更多
CONSPECTUS:The 2023 Nobel Prize in Chemistry has recognized the important discovery and development of QDs.Colloidal semiconductor nanocrystals(NCs),known as quantum dots(QDs),have attracted increased attention for a ...CONSPECTUS:The 2023 Nobel Prize in Chemistry has recognized the important discovery and development of QDs.Colloidal semiconductor nanocrystals(NCs),known as quantum dots(QDs),have attracted increased attention for a wide range of potential applications,such as displays,lighting,photovoltaics,and biological imaging,because of their high quality and size-dependent optical properties.To obtain high-quality semiconductor NCs with reduced surface defects and boosted photoluminescence emission,semiconductor shell-based surface engineering is a commonly used strategy.展开更多
The recovery of lithium from spent lithium iron manganese phosphate batteries is crucial for the efficient utilization of lithium resources and for alleviating supply constraints.This study proposes a selective lithiu...The recovery of lithium from spent lithium iron manganese phosphate batteries is crucial for the efficient utilization of lithium resources and for alleviating supply constraints.This study proposes a selective lithium recovery method using a Na_(2)S_(2)O_(8)leaching system for spent lithium iron manganese phosphate battery cathodes.Na_(2)S_(2)O_(8)was selected based on an analysis of the thermodynamic data of each component in the leaching system.Essential leaching parameters,including H_(2)SO_(4)dosage,Na_(2)S_(2)O_(8)dosage,leaching time,and leaching temperature were systematically investigated.The results showed that under the optimized experimental conditions,the lithium leaching rate reached 97.4%with a selectivity of 96.24%.The recovered Li_(2)CO_(3)product meets battery grade requirements.展开更多
A pioneering boat-based survey was conducted in 2019,to gather baseline information regarding the presence,composition,relative abundance,and spatial distribution of deep-diving and off-shore cetaceans in the northern...A pioneering boat-based survey was conducted in 2019,to gather baseline information regarding the presence,composition,relative abundance,and spatial distribution of deep-diving and off-shore cetaceans in the northern South China Sea(SCS).A total of 27 sightings comprising at least 8 cetacean species were recorded during the 13-day survey,including 5 deep-diving species(i.e.Risso’s dolphin[Grampus griseus],short-finned pilot whale[Globicephala macrorhynchus],sperm whale[Physeter macrocephalus],Cuvier’s beaked whale[Ziphius cavirostris],and an unidentified beaked whale[either the ginkgo-toothed beaked whale,Mesoplodon ginkgodens,or Deraniyagala’s beaked whale,Mesoplodon hotaula]),as well as 3 off-shore dolphins(i.e.pantropical spotted dolphin[Stenella attenuate],striped dolphin[Stenella coeruleoalba],and Fraser’s dolphin[Lagenodelphis hosei]).With the exception of pantropical spotted dolphins,all other species were sighted and recorded at sea in the northern SCS for the first time.The pantropical spotted dolphin was the most frequently sighted species,comprising 30%of the total sightings.Deep-diving cetaceans were mainly sighted in the northern Xisha Archipelago,whereas off-shore dolphins were distributed across the survey area.The pantropical spotted dolphin was observed in aggregations of more than 100 individuals and nearly all encountered species included calves;these findings suggested that the survey area functions as an important feeding and calving ground for various cetacean species.This pioneering survey provides fundamental information regarding cetacean fauna in the northern SCS and highlights the need to strengthen research and conservation efforts concerning these species.展开更多
In recent years,a wide variety of centralised and decentralised algorithms have been proposed for residential charging of electric vehicles(EVs).In this paper,we present a mathematical framework which casts the EV cha...In recent years,a wide variety of centralised and decentralised algorithms have been proposed for residential charging of electric vehicles(EVs).In this paper,we present a mathematical framework which casts the EV charging scenarios addressed by these algorithms as optimisation problems having either temporal or instantaneous optimisation objectives with respect to the different actors in the power system.Using this framework and a realistic distribution network simulation testbed,we provide a comparative evaluation of a range of different residential EV charging strategies,highlighting in each case positive and negative characteristics.展开更多
Heteroatom doping is a promising approach to enhance catalytic activity by modulating physical properties,electronic structure,and reaction pathway.Herein,we demonstrate that appropriate Ni-doping could trigger a pref...Heteroatom doping is a promising approach to enhance catalytic activity by modulating physical properties,electronic structure,and reaction pathway.Herein,we demonstrate that appropriate Ni-doping could trigger a preferential transition of the basal plane from 2H(trigonal prismatic)to 1T′(clustered Mo)by inducing lattice distortion and S vacancy(SV)and thus dramatically facilitate its catalytic hydrogen evolution activity.It is noteworthy that the unique catalysts did possess superior catalytic performance of hydrogen evolution reaction(HER).The rate of photocatalytic hydrogen evolution could reach 20.45 mmol·g^(−1)·h^(−1) and reduced only slightly in the long period of the photocatalytic process.First-principles calculations reveal that the distorted Ni-1T′-MoS_(2) with SV could generate favorable water adsorption energy(Ead(H_(2)O))and Gibbs free energy of hydrogen adsorption(∆GH).This work exhibits a facile and promising pathway for synergistically regulating physical properties,electronic structure,or wettability based on the doping strategy for designing HER electrocatalysts.展开更多
Beaked whales represent around 25%of known extant cetacean species,yet they are the least known of all marine mammals.Identification of many Mesoplodon species has relied on examination of a few stranded individuals.P...Beaked whales represent around 25%of known extant cetacean species,yet they are the least known of all marine mammals.Identification of many Mesoplodon species has relied on examination of a few stranded individuals.Particularly,the ginkgo-toothed beaked whale(Mesoplodon ginkgodens)and Deraniyagala’s beaked whale(Mesoplodon hotaula)are among the least-known of beaked whale species,without confirmed sightings of living individuals to date.We present a sighting of 3 free-ranging individuals of M.ginkgodens/hotaula whale from a dedicated marine mammal vessel survey carried out in the South China Sea in April and May 2019.Photographic data(301 photographs)from the sighting were compared to photos of fresh stranded ginkgo-toothed beaked whale and Deraniyagala’s beaked whale from both historical and unpublished records.We found that free-ranging M.ginkgodens and M.hotaula individuals can be easily distinguished from other Mesoplodon species due to differences in melon and gape shapes and coloration patterns.However,accurate at-sea differentiation of M.ginkgodens and M.hotaula may not be possible due to high similarity in both coloration and scarring patterns.In addition to our photo-identification data,we collected what we believe to be the first preliminary descriptions of surfacing behavior and diving patterns of one of these species.Finally,the presence of scars possibly caused by fishing gear or marine litter raises concerns about anthropogenic impacts and conservation of these poorly known species.展开更多
Indo-Pacific humpback dolphins(Sousa chinensis)inhabit shallow coastal waters of the Indo-Pacific region including southeast China,with at least 6 putative populations identified to date in Chinese waters.However,the ...Indo-Pacific humpback dolphins(Sousa chinensis)inhabit shallow coastal waters of the Indo-Pacific region including southeast China,with at least 6 putative populations identified to date in Chinese waters.However,the connectivity among these populations has not yet been fully investigated.In the present study,we compared and crossmatched photographic catalogs of individual dolphins collected to date in the Pearl River Delta region,Leizhou Bay,Sanniang Bay,and waters southwest of Hainan Island,a total of 3158 individuals,and found no re-sighting of individual dolphins among the 4 study areas.Furthermore,there was a notable difference in the pigmentation pattern displayed by individuals from these 4 regions.We suggest that this may be a phenotypical expression of fine-scale regional differentiation among humpback dolphin groups,possibly distinct populations.Given the considerable conservation management implications it may carry(e.g.definition of management units),further research is much needed.展开更多
Scientific information is vital to the conservation of cetaceans and the management of whale-watching activities.The southern coastal waters of Sri Lanka are near a narrow continental shelf and biologically abundant i...Scientific information is vital to the conservation of cetaceans and the management of whale-watching activities.The southern coastal waters of Sri Lanka are near a narrow continental shelf and biologically abundant in cetacean species.Although the occurrence of cetaceans has been investigated in certain waters of Sri Lanka,few surveys have been conducted along the southern coast.To fill this gap,we conducted boat-based surveys from January to May 2017 to investigate the occurrence,diversity,and behavior of cetaceans in the waters off Mirissa,covering a survey area of 788.9 km2.During 55 survey days,we recorded a total of 242 cetacean sightings and identified at least 9 species(3 mysticetes and 6 odontocetes).The blue whale was the most common mysticete species(167 of 174 mysticete encounters),followed by the Omura’s whale(4 of 174)and Bryde’s whale(3 of 174).The spinner dolphin was the most common odontocete species(28 of 68 odontocete encounters),followed by the sperm whale(18 of 68),common bottlenose dolphin(13 of 68),short-finned pilot whale(5 of 68),melon-headed whale(2 of 68),and killer whale.Blue whales and sperm whales exhibited a clear preference for outer shelf and high slope areas,and blue whales were observed feeding along these waters.The present study provides near-baseline information on cetacean occurrence and diversity in whale-watching waters off southern Sri Lanka,and highlights the urgent need for proper management strategies for whale-watching activities.展开更多
基金Natural Science Foundation of Jiangsu Province,Grant/Award Number:BK20231488National Natural Science Foundation of China,Grant/Award Numbers:52378083,52078481。
文摘CO_(2)-enhanced oil recovery(CO_(2)-EOR)is an economically viable carbon capture,utilization,and storage(CCUS)technique that is widely practiced and greatly contributes to the achievement of carbon-neutral cities.However,studies on CO_(2)-EOR source-sink matching involving different emission sources,different carbon capture rates,and stepwise CO_(2)pipeline construction are scarce.Considering four types of carbon sources,including coal-fired power,iron and steel,cement,and chemical plants,with different CO_(2)capture rates(85%,90%,95%,and 100%,respectively),and using a five-phased construction plan with a 25-year build-up period,we developed a method for quantifying carbon emissions from different sources,calculating the effective storage of carbon in CO_(2)-EOR and optimizing CO_(2)-EOR source-sink matching to reduce project costs.Using the Subei Basin in the Jiangsu Province,China,as a case study,we calculated the theoretical CO_(2)-EOR storage to be 1.7408×10^(8)t and the effective CO_(2)-EOR storage to be 0.435×10^(8)t.We analyzed the completion rate of transportation pipelines,the number of connected carbon sources,and the mass of CO_(2)stored,as well as the cost-effectiveness and sensitivity.Implementation of CO_(2)-EOR effectively reduced the total cost of source-sink matching in the five-stage 25-year construction approach.The reduction of CO_(2)capture rates had no effect on the value of oil repelling.The capture cost significantly affected the total cost of source-sink matching,and the impacts of the carbon sources on the total cost were in the order coal-fired power>iron and steel>cement>chemical plants.This study provides an innovative tool for evaluating the CO_(2)storage potential of CO_(2)-EOR and provides an important framework for implementing CO_(2)-EOR and planning CCUS projects in the Subei Basin and similar regions.
基金financially supported by the National Funds for Distinguished Young Scientists (No. 61825503)the National Natural Science Foundation of China (Nos. 51902101, 61775101,61804082)+3 种基金the Youth Natural Science Foundation of Hunan Province (No. 2019JJ50044)Natural Science Foundation of Jiangsu Province (No. BK20201381)Science Foundation of Nanjing University of Posts and Telecommunications (No. NY219144)China Postdoctoral Science Foundation (Nos. 2020TQ0202, 2021M692161)。
文摘Molybdenum disulfide(MoS_(2)),a typical two-dimensional transition metallic layered material,attracts tremendous attentions in the electrochemical energy storage due to its excellent physicochemical properties.However,with the deepening of the research and exploration of the lithium storage mechanism of these advanced MoS_(2)-based anode materials,the complex reaction process influenced by internal and external factors hinders the exhaustive understanding of the lithium storage process.To design stable anode material with high performance,it is urgent to review the mechanisms of reported anode materials and summarize the related factors that influence the reaction processes.This review aims to dissect all possible side reactions during charging and discharging process,uncover internal and external factors inducing various anode reactions and finally put forward strategies of controlling high cycling capacity and super-stable lithium storage capability of MoS_(2).This review will be helpful to the design of MoS_(2)-based lithium-ion batteries(LIBs) with excellent cycle performance to enlarge the application fields of these advanced electrochemical energy storage devices.
基金financial support from the National Natural Science Foundation of China (Nos. 11974188,11304159)the China Postdoctoral Science Foundation (Nos. 2021T140339,2018M632345)+2 种基金the Qing Lan Project of Jiangsu Provincethe Natural Science Foundation of Jiangsu Province (Nos. BK20201381,BK20161512)NUPTSF (No. NY218022)。
文摘Molybdenum disulfide (MoS_(2)) with low cost, high activity and high earth abundance has been found to be a promising catalyst for the hydrogen evolution reaction (HER), but its catalytic activity is considerably limited due to its inert basal planes. Here, through the combination of theory and experiment, we propose that doping Ni in MoS_(2) as catalyst can make it have excellent catalytic activity in different reaction systems. In the EY/TEOA system, the maximum hydrogen production rate of EY/Ni-Mo-S is 2.72 times higher than that of pure EY, which confirms the strong hydrogen evolution activity of Ni-Mo-S nanosheets as catalysts. In the lactic acid and Na_(2)S/Na_(2)SO_(3) systems, when Ni-Mo-S is used as co-catalyst to compound with ZnIn_(2)S_(4) (termed as Ni-Mo-S/ZnIn_(2)S_(4)), the maximum hydrogen evolution rates in the two systems are 5.28 and 2.33 times higher than those of pure ZnIn_(2)S_(4), respectively. The difference in HER enhancement is because different systems lead to different sources of protons, thus affecting hydrogen evolution activity. Theoretically, we further demonstrate that the Ni-Mo-S nanosheets have a narrower band gap than MoS_(2), which is conducive to the rapid transfer of charge carriers and thus result in multi-photocatalytic reaction systems with excellent activity. The proposed atomic doping strategy provides a simple and promising approach for the design of photocatalysts with high activity and stability in multi-reaction systems.
基金supported by National Institutes of Health R21CA226491-01A1 (X.M.L.),1R01CA238273-01A1 (X.M.L.) and 1R01CA242917-01A1(X.M.L.)
文摘Targeted therapy has been widely demonstrated as an effective strategy to treat cancers,the leading cause of death in the world.This minireview summarizes the technical platforms and methodologies utilized to develop and engineer therapeutic monoclonal antibodies and antibody-drug conjugates.First,the USA FDA approved monoclonal antibody(mAb)-based targeted therapies are reviewed.Then the representative innovative chimeric,humanized and fully human anti-cancer antibodies and antibody-drug conjugates are described.Finally,the past and predictive market trend of therapeutic antibodies is discussed.
基金Supported by the United National Science Funds and Civil Aviation Funds(U1633104)Tianjin Science Funds for the Special of Science&Technology(17JCTPJC51800)+3 种基金Open Funds of the State Key Lab of Digital Manufacturing Equipment&Technology(DMETKF2017018)the Scientific Research Project of Tianjin Educational Committee(2019KJ119)the Fundamental Research Funds for the Central Universities(3122017017)Research Starting Funds of Civil Aviation University of China(09QD05S)。
文摘The dynamic mechanical properties of the Ti-6Al-4V(TC4)alloy prepared by laser additive manufacturing(LAM-TC4)under the high strain rate(HSR)are proposed.The dynamic compression experiments of LAM-TC4 are conducted with the split Hopkinson pressure bar(SHPB)equipment.The results show that as the strain rate increases,the widths of the adiabatic shear band(ASB),the micro-hardness,the degree of grain refinement near the ASB,and the dislocation density of grains grow gradually.Moreover,the increase of dislocation density of grains is the root factor in enhancing the yield strength of LAM-TC4.Meanwhile,the heat produced from the distortion and dislocations of grains promotes the heat softening effect favorable for the recrystallization of grains,resulting in the grain refinement of ASB.Furthermore,the contrastive analysis between LAM-TC4 and TC4 prepared by forging(F-TC4)indicates that under the HSR,the yield strength of LAM-TC4 is higher than that of F-TC4.
基金the National Natural Science Foundation of China, No.30772350
文摘a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors are considered to play a crucial role in synaptic plasticity in the developing visual cortex. In this study, we established a rat model of binocular form deprivation by suturing the rat binocular eyelids before eye-opening at postnatal day 14. During development, the decay time of excitatory postsynaptic currents mediated by a-amino-3- hydroxy-5-methyl-4-isoxazolepropionic acid receptors of normal rats became longer after eye- opening; however, the decay time did not change significantly in binocular form deprivation rats. The peak value in the normal group became gradually larger with age, but there was no significant change in the binocular form deprivation group. These findings indicate that binocular form deprivation influences the properties of excitatory postsynaptic currents mediated by a-amino-3- hydroxy-5-methyl-4-isoxazolepropionic acid receptors in the rat visual cortex around the end of the critical period, indicating that form stimulation is associated with the experience-dependent modification of neuronal synapses in the visual cortex.
基金supported by the National Natural Science Foundation of China (21673137)。
文摘The catalytic descriptor with operational feasibility is highly desired towards rational design of high-performance catalyst especially the electrode/electrolyte solution interface working under mild conditions.Herein,we demonstrate that the descriptorΩparameterized by readily accessible intrinsic properties of metal center and coordination is highly operational and efficient in rational design of single-atom catalyst(SAC)for driving electrochemical nitrogen reduction(NRR).Using twodimensional metal(M)-B_(x)P_(y)S_(z)N_m@C_(2)N as prototype SAC models,we reveal that^(*)N_(2)+(H~++e~-)→^(*)N_(2)H acts predominantly as the potential-limiting step(PLS)of NRR on M-B_(2)P_(2)S_(2)@C_(2)N and M-B_(1)P_(1)S_(1)N_(3)@C_(2)N regardless of the distinction in coordination microenvironment.Among the 28 screened M active sites,withΩvalues close to the optimal 4,M-B_(2)P_(2)S_(2)@C_(2)N(M=V(Ω=3.53),Mo(Ω=5.12),and W(Ω=3.92))and M-B_(1)P_(1)S_(1)N_(3)@C_(2)N(M=V(Ω=3.00),Mo(Ω=4.34),and W(Ω=3.32))yield the lowered limiting potential(U_(L))as-0.45,-0.54.-0.36,-0.58,-0.25,and-0.24 V,respectively,thus making them the promising NRR catalysts.More importantly,these SACs are located around the top of volcano-shape plot of U_(L) versusΩ,re-validatingΩas an effective descriptor for accurately predicting the high-activity NRR SACs even with complex coordination.Our study unravels the relationship between active-site structure and NRR performance via the descriptorΩ,which can be applied to other important sustainable electrocatalytic reactions involving activation of small molecules viaσ-donation andπ^(*)-backdonation mechanism.
基金supported by the National Major Scientific and Technological Special Project for“Significant New Drugs Development”(No.2018ZX09711002-011-027)the Chinese Academy of Medical Sciences(CAMS)Inno-vation Fund for Medical Sciences(CIFMS,2021-I2M-1-014 and 2023-12M-2-004).
文摘Background:Bireociclib(XZP-3287)is a novel selective cyclin-dependent kinase 4 and 6(CDK4/6)inhibitor,with a favorable safety profile demonstrated in preclinical and phase I studies.BRIGHT-1 aimed to further explore the efficacy and safety of bireociclib monotherapy in patients with locally advanced,recurrent or metastatic,hormone receptor-positive and human epidermal growth factor receptor 2-negative(HR+/HER2−)breast cancer who had progressed on or after prior chemotherapy and endocrine therapy in advanced settings,without previous exposure to CDK4/6 inhibitors.Methods:In this open-label phase II trial,eligible patients received bireociclib 480 mg twice daily(BID)until disease progression or intolerable toxicities.The primary endpoint was the confirmed objective response rate(ORR)assessed by an independent review committee(IRC).The secondary endpoints included progression-free survival(PFS),investigator-assessed ORR,disease control rate(DCR),clinical benefit rate(CBR),duration of response(DoR),overall survival(OS),safety and the pharmacokinetic properties of bireociclib.Results:A total of 131 patients were enrolled.At data cutoff(July 31,2023),the IRC-assessed ORR was 29.8%(95%confidence interval[CI],22.1%to 38.4%),with a DCR of 73.3%(95%CI,64.8%to 80.6%),CBR of 42.0%(95%CI,33.4%to 50.9%)and a median DoR of 15.2 months(95%CI,9.5 months to not reached).The median PFS was 11.0 months(95%CI,7.3 months to 12.9 months)assessed by the IRC,and the median OS was 29.0 months(95%CI,24.9 months to not reached).The most frequently reported treatment-emergent adverse events(TEAEs)of any grade were diarrhea(93.1%),neutrophil count decreased(87.0%),white blood cell decreased(86.3%),vomiting(78.6%),anemia(72.5%),and platelet count decreased(72.5%).The grade≥3 TEAEs occurred in 109(83.2%)patients.The most common grade≥3 TEAEs were neutrophil count decreased(43.5%),white blood cell decreased(32.8%),hypokalemia(20.6%),and diarrhea(19.1%).Conclusions:Bireociclib monotherapy at 480 mg BID exhibited promising and sustained clinical activity,with no unexpected and acceptable toxicity in patients with recurrent or metastatic HR+/HER2−breast cancer who had progressed on or after previous therapy.Trial registration:Clinicaltrials.gov ID,NCT04539496.
基金supported by the National Natural Science Foundation of China(22401155)the Natural Science Foundation of Jiangsu Province(BK20240632)+2 种基金the Natural Science Research Start-up Foundation of Recruiting Talents of Nanjing University of Posts and Telecommunications(NY223126)Project of State Key Laboratory of Organic Electronics and Information Displays(GZR2024010028)Anhui Provincial Natural Science Foundation(2408085QE137).
文摘CONSPECTUS:The 2023 Nobel Prize in Chemistry has recognized the important discovery and development of QDs.Colloidal semiconductor nanocrystals(NCs),known as quantum dots(QDs),have attracted increased attention for a wide range of potential applications,such as displays,lighting,photovoltaics,and biological imaging,because of their high quality and size-dependent optical properties.To obtain high-quality semiconductor NCs with reduced surface defects and boosted photoluminescence emission,semiconductor shell-based surface engineering is a commonly used strategy.
基金supported by Science and Technology Key Project of Anhui Province(grant No.2022e03020004),China.
文摘The recovery of lithium from spent lithium iron manganese phosphate batteries is crucial for the efficient utilization of lithium resources and for alleviating supply constraints.This study proposes a selective lithium recovery method using a Na_(2)S_(2)O_(8)leaching system for spent lithium iron manganese phosphate battery cathodes.Na_(2)S_(2)O_(8)was selected based on an analysis of the thermodynamic data of each component in the leaching system.Essential leaching parameters,including H_(2)SO_(4)dosage,Na_(2)S_(2)O_(8)dosage,leaching time,and leaching temperature were systematically investigated.The results showed that under the optimized experimental conditions,the lithium leaching rate reached 97.4%with a selectivity of 96.24%.The recovered Li_(2)CO_(3)product meets battery grade requirements.
基金supported by the National Key Research and Development Program of China(Grant number 2016YFC0300803)the National Natural Science Foundation of China(41406182,41306169 and 41422604)+2 种基金the incubating program of Institute of Deep-sea Science and Engineering,Chinese Academy of Sciences(Y960041001)the biodiversity investigation,observation and assessment program(2019-2023)of Ministry of Ecology and Environment of ChinaOcean Park Conservation Foundation Hong Kong(AW02-1920).
文摘A pioneering boat-based survey was conducted in 2019,to gather baseline information regarding the presence,composition,relative abundance,and spatial distribution of deep-diving and off-shore cetaceans in the northern South China Sea(SCS).A total of 27 sightings comprising at least 8 cetacean species were recorded during the 13-day survey,including 5 deep-diving species(i.e.Risso’s dolphin[Grampus griseus],short-finned pilot whale[Globicephala macrorhynchus],sperm whale[Physeter macrocephalus],Cuvier’s beaked whale[Ziphius cavirostris],and an unidentified beaked whale[either the ginkgo-toothed beaked whale,Mesoplodon ginkgodens,or Deraniyagala’s beaked whale,Mesoplodon hotaula]),as well as 3 off-shore dolphins(i.e.pantropical spotted dolphin[Stenella attenuate],striped dolphin[Stenella coeruleoalba],and Fraser’s dolphin[Lagenodelphis hosei]).With the exception of pantropical spotted dolphins,all other species were sighted and recorded at sea in the northern SCS for the first time.The pantropical spotted dolphin was the most frequently sighted species,comprising 30%of the total sightings.Deep-diving cetaceans were mainly sighted in the northern Xisha Archipelago,whereas off-shore dolphins were distributed across the survey area.The pantropical spotted dolphin was observed in aggregations of more than 100 individuals and nearly all encountered species included calves;these findings suggested that the survey area functions as an important feeding and calving ground for various cetacean species.This pioneering survey provides fundamental information regarding cetacean fauna in the northern SCS and highlights the need to strengthen research and conservation efforts concerning these species.
基金The authors would like to thank the Irish Social Science Data Archive(ISSDA)for providing access to the CER Smart Metering Project data.The authors also gratefully acknowledge funding for this research provided by Science Foundation Ireland(Grant 11/PI/1177 and Grant 09/SRC/E1780).
文摘In recent years,a wide variety of centralised and decentralised algorithms have been proposed for residential charging of electric vehicles(EVs).In this paper,we present a mathematical framework which casts the EV charging scenarios addressed by these algorithms as optimisation problems having either temporal or instantaneous optimisation objectives with respect to the different actors in the power system.Using this framework and a realistic distribution network simulation testbed,we provide a comparative evaluation of a range of different residential EV charging strategies,highlighting in each case positive and negative characteristics.
基金supported by the National Funds for Distinguished Young Scientists(No.61825503)the National Natural Science Foundation of China(Nos.51902101,61775101,and 61804082)+2 种基金the Natural Science Foundation of Jiangsu Province(Nos.BK20201381 and BK20210577)the Science Foundation of Nanjing University of Posts and Telecommunications(No.NY219144)the National College Student Innovation and Entrepreneurship Training Program.
文摘Heteroatom doping is a promising approach to enhance catalytic activity by modulating physical properties,electronic structure,and reaction pathway.Herein,we demonstrate that appropriate Ni-doping could trigger a preferential transition of the basal plane from 2H(trigonal prismatic)to 1T′(clustered Mo)by inducing lattice distortion and S vacancy(SV)and thus dramatically facilitate its catalytic hydrogen evolution activity.It is noteworthy that the unique catalysts did possess superior catalytic performance of hydrogen evolution reaction(HER).The rate of photocatalytic hydrogen evolution could reach 20.45 mmol·g^(−1)·h^(−1) and reduced only slightly in the long period of the photocatalytic process.First-principles calculations reveal that the distorted Ni-1T′-MoS_(2) with SV could generate favorable water adsorption energy(Ead(H_(2)O))and Gibbs free energy of hydrogen adsorption(∆GH).This work exhibits a facile and promising pathway for synergistically regulating physical properties,electronic structure,or wettability based on the doping strategy for designing HER electrocatalysts.
基金supported by the National Key Research and Development Program of China(Grant number 2016YFC0300803)the National Natural Science Foundation of China(41406182,41306169 and 41422604)+1 种基金the biodiversity investigation,observation and assessment program(2019-2023)of Ministry of Ecology and Environment of ChinaOcean Park Conservation Foundation Hong Kong(MM02-1516,AW02-1920).
文摘Beaked whales represent around 25%of known extant cetacean species,yet they are the least known of all marine mammals.Identification of many Mesoplodon species has relied on examination of a few stranded individuals.Particularly,the ginkgo-toothed beaked whale(Mesoplodon ginkgodens)and Deraniyagala’s beaked whale(Mesoplodon hotaula)are among the least-known of beaked whale species,without confirmed sightings of living individuals to date.We present a sighting of 3 free-ranging individuals of M.ginkgodens/hotaula whale from a dedicated marine mammal vessel survey carried out in the South China Sea in April and May 2019.Photographic data(301 photographs)from the sighting were compared to photos of fresh stranded ginkgo-toothed beaked whale and Deraniyagala’s beaked whale from both historical and unpublished records.We found that free-ranging M.ginkgodens and M.hotaula individuals can be easily distinguished from other Mesoplodon species due to differences in melon and gape shapes and coloration patterns.However,accurate at-sea differentiation of M.ginkgodens and M.hotaula may not be possible due to high similarity in both coloration and scarring patterns.In addition to our photo-identification data,we collected what we believe to be the first preliminary descriptions of surfacing behavior and diving patterns of one of these species.Finally,the presence of scars possibly caused by fishing gear or marine litter raises concerns about anthropogenic impacts and conservation of these poorly known species.
基金This research was financially supported by the National Natural Science Foundation of China(41406182,41306169,and 41422604)the biodiversity investigation,observation,and assessment program(2019-2023)of Ministry of Ecology and Environment of China+2 种基金Research Grants Council(RGC)of Hong Kong(General Research Fund HKU 768913M)Marine Ecology Enhancement Fund(MEEF2017015,MEEF2017015A,MEEF2017015B,and MEEF2017015C)Ocean Park Conservation Foundation Hong Kong(MM01-1415,MM02-1516,AW02-1920,AW04_1617,MM01_1920).
文摘Indo-Pacific humpback dolphins(Sousa chinensis)inhabit shallow coastal waters of the Indo-Pacific region including southeast China,with at least 6 putative populations identified to date in Chinese waters.However,the connectivity among these populations has not yet been fully investigated.In the present study,we compared and crossmatched photographic catalogs of individual dolphins collected to date in the Pearl River Delta region,Leizhou Bay,Sanniang Bay,and waters southwest of Hainan Island,a total of 3158 individuals,and found no re-sighting of individual dolphins among the 4 study areas.Furthermore,there was a notable difference in the pigmentation pattern displayed by individuals from these 4 regions.We suggest that this may be a phenotypical expression of fine-scale regional differentiation among humpback dolphin groups,possibly distinct populations.Given the considerable conservation management implications it may carry(e.g.definition of management units),further research is much needed.
基金The data analysis and paper writing were financially supported by the“One Belt and One Road”Science and Technology Cooperation Special Program of the International Partnership Program of Chinese Academy of Sciences(Grant number 183446KYSB20200016)the Indian Ocean Ninety-East Ridge Ecosystem and Marine Environment Monitoring and Protection,Supported by the China Ocean Mineral Resources R&D Association(no.DY135-E2-4)。
文摘Scientific information is vital to the conservation of cetaceans and the management of whale-watching activities.The southern coastal waters of Sri Lanka are near a narrow continental shelf and biologically abundant in cetacean species.Although the occurrence of cetaceans has been investigated in certain waters of Sri Lanka,few surveys have been conducted along the southern coast.To fill this gap,we conducted boat-based surveys from January to May 2017 to investigate the occurrence,diversity,and behavior of cetaceans in the waters off Mirissa,covering a survey area of 788.9 km2.During 55 survey days,we recorded a total of 242 cetacean sightings and identified at least 9 species(3 mysticetes and 6 odontocetes).The blue whale was the most common mysticete species(167 of 174 mysticete encounters),followed by the Omura’s whale(4 of 174)and Bryde’s whale(3 of 174).The spinner dolphin was the most common odontocete species(28 of 68 odontocete encounters),followed by the sperm whale(18 of 68),common bottlenose dolphin(13 of 68),short-finned pilot whale(5 of 68),melon-headed whale(2 of 68),and killer whale.Blue whales and sperm whales exhibited a clear preference for outer shelf and high slope areas,and blue whales were observed feeding along these waters.The present study provides near-baseline information on cetacean occurrence and diversity in whale-watching waters off southern Sri Lanka,and highlights the urgent need for proper management strategies for whale-watching activities.
