The landscape design of the Red Star·Xintiandi Exhibition Area in Liuzhou is studied. The landscape design of the main space includes entrance( declaration),vestibule( etiquette),entrance hall( distinguished),rec...The landscape design of the Red Star·Xintiandi Exhibition Area in Liuzhou is studied. The landscape design of the main space includes entrance( declaration),vestibule( etiquette),entrance hall( distinguished),reception area( communication) and courtyard( artistic conception). The space design of plant landscape includes diversified plant configurations( multiple angels,multiple choices,and multiple levels) and artistic conception of plant space( colors,light and shadow,aroma and culture).展开更多
N6-methyladenosine(m^(6)A)plays crucial roles in development and cellular reprogramming.During embryonic development,pluripotency transitions from a naïve to a primed state,and modeling the reverse primed-to-na&#...N6-methyladenosine(m^(6)A)plays crucial roles in development and cellular reprogramming.During embryonic development,pluripotency transitions from a naïve to a primed state,and modeling the reverse primed-to-naïve transition(PNT)provides a valuable framework for investigating pluripotency regulation.Here,we show that inhibiting METTL3 significantly promotes PNT in an m^(6)A-dependent manner.Mechanistically,we found that suppressing METTL3 and YTHDF2 prolongs the lifetimes of pluripotency-associated mRNAs,such as Nanog and Sox2,during PNT.In addition,Gstp1 was identified as a downstream target of METTL3 inhibition and YTHDF2 knockout.Gstp1 overexpression enhances PNT,whereas its inhibition impedes the transition.Overall,our findings suggest that YTHDF2 facilitates the removal of pluripotency gene transcripts and Gstp1,thereby promoting PNT reprogramming through m^(6)A-mediated posttranscriptional control.展开更多
Considering the wide application of precast segmental bridge columns(PSBCs)in engineering practice,impact-resistant performance has gained significant attention.However,few studies have focused on PSBCs subjected to h...Considering the wide application of precast segmental bridge columns(PSBCs)in engineering practice,impact-resistant performance has gained significant attention.However,few studies have focused on PSBCs subjected to high-energy impacts caused by heavy truck collisions.Therefore,the behavior of PSBCs under a heavy truck impact was investigated in this study using high-fidelity finite element(FE)models.The detailed FE modeling methods of the PSBCs and heavy trucks were validated against experimental tests.The validated modeling methods were employed to simulate collisions between PSBCs and heavy trucks.The simulation results demonstrated that the engine and cargo caused two major peak impact forces during collision.Subsequently,the impact force,failure mode,displacement,and internal force of the PSBCs under heavy truck impacts were scrutinized.An extensive study was performed to assess the influence of the section size,truck weight,impact velocity,and number of precast segments on the impact responses.The truck weight was found to have a minor effect on the engine impact force.Damage was found to be localized at the bottom of the three segments,with the top remaining primarily undamaged.This parametric study demonstrated that larger cross-sections may be a preferred option to protect PSBCs against the impact of heavy trucks.展开更多
The synthesis of trifluoroethoxylated dihydropyrrolidones via rhodium-catalyzed oxidation and trifluoroethoxylation of pyrrolidones is presented in this paper. This process realized the trifluoroethoxylation ofnon-act...The synthesis of trifluoroethoxylated dihydropyrrolidones via rhodium-catalyzed oxidation and trifluoroethoxylation of pyrrolidones is presented in this paper. This process realized the trifluoroethoxylation ofnon-activated sp^(3) C–H by a domino approach for the first time, without requiring the preparation of substrates with halogens or guiding groups. The formed α,β-unsaturated-γ-butyrolactams can be furtherfunctionalized via the Michael addition reaction or realize the exchange of the trifluoroethoxy group tothe hexafluoroisopropoxy group. Such compounds exhibit anti-tumor activity in vitro and can be used ashit compounds for further research. This method provides an efficient domino approach for generatingvarious trifluoroethoxylated dihydropyrrolidones.展开更多
The COVID-19 pandemic has caused a global health crisis and significant social economic burden.While most individ-uals experience mild or non-specific symptoms,elderly individuals are at a higher risk of developing se...The COVID-19 pandemic has caused a global health crisis and significant social economic burden.While most individ-uals experience mild or non-specific symptoms,elderly individuals are at a higher risk of developing severe symptoms and life-threatening complications.Exploring the key factors associated with clinical severity highlights that key char-acteristics of aging,such as cellular senescence,immune dysregulation,metabolic alterations,and impaired regen-erative potential,contribute to disruption of tissue homeostasis of the lung and worse clinical outcome.Senolytic and senomorphic drugs,which are anti-aging treatments designed to eliminate senescent cells or decrease the asso-ciated phenotypes,have shown promise in alleviating age-related dysfunctions and offer a novel approach to treating diseases that share certain aspects of underlying mechanisms with aging,including COVID-19.This review summa-rizes the current understanding of aging in COVID-19 progression,and highlights recent findings on anti-aging drugs that could be repurposed for COVID-19 treatment to complement existing therapies.展开更多
文摘The landscape design of the Red Star·Xintiandi Exhibition Area in Liuzhou is studied. The landscape design of the main space includes entrance( declaration),vestibule( etiquette),entrance hall( distinguished),reception area( communication) and courtyard( artistic conception). The space design of plant landscape includes diversified plant configurations( multiple angels,multiple choices,and multiple levels) and artistic conception of plant space( colors,light and shadow,aroma and culture).
基金supported by the National Key R&D Program of China(2021YFA1102200,2024YFA1802300 and 2024YFA1107000)The National Natural Science Foundation of China(32225012)+4 种基金Major Project of Guangzhou National Laboratory(GZNL2023A02005)Guangdong Basic and Applied Basic Research Foundation(2025A1515012426,2023A1515010420)Science and Technology Projects in Guangzhou(2023A04J0724)Science and Technology Planning Project of Guangdong Province,China(2023B1212060050,2023B1212120009)Health@InnoHK Program launched by Innovation Technology Commission of the Hong Kong SAR,P.R.China.
文摘N6-methyladenosine(m^(6)A)plays crucial roles in development and cellular reprogramming.During embryonic development,pluripotency transitions from a naïve to a primed state,and modeling the reverse primed-to-naïve transition(PNT)provides a valuable framework for investigating pluripotency regulation.Here,we show that inhibiting METTL3 significantly promotes PNT in an m^(6)A-dependent manner.Mechanistically,we found that suppressing METTL3 and YTHDF2 prolongs the lifetimes of pluripotency-associated mRNAs,such as Nanog and Sox2,during PNT.In addition,Gstp1 was identified as a downstream target of METTL3 inhibition and YTHDF2 knockout.Gstp1 overexpression enhances PNT,whereas its inhibition impedes the transition.Overall,our findings suggest that YTHDF2 facilitates the removal of pluripotency gene transcripts and Gstp1,thereby promoting PNT reprogramming through m^(6)A-mediated posttranscriptional control.
基金The authors would like to acknowledge the financial support received from the National Natural Science Foundation of China(Grant Nos.52278188 and 51978258)Natural Science Foundation of the Jiangsu Province(No.BK20211196)+1 种基金Chongqing Natural Science Foundation(CSTB2022NSCQ-MSX0969)the SOAR fellowship from the University of Sydney.
文摘Considering the wide application of precast segmental bridge columns(PSBCs)in engineering practice,impact-resistant performance has gained significant attention.However,few studies have focused on PSBCs subjected to high-energy impacts caused by heavy truck collisions.Therefore,the behavior of PSBCs under a heavy truck impact was investigated in this study using high-fidelity finite element(FE)models.The detailed FE modeling methods of the PSBCs and heavy trucks were validated against experimental tests.The validated modeling methods were employed to simulate collisions between PSBCs and heavy trucks.The simulation results demonstrated that the engine and cargo caused two major peak impact forces during collision.Subsequently,the impact force,failure mode,displacement,and internal force of the PSBCs under heavy truck impacts were scrutinized.An extensive study was performed to assess the influence of the section size,truck weight,impact velocity,and number of precast segments on the impact responses.The truck weight was found to have a minor effect on the engine impact force.Damage was found to be localized at the bottom of the three segments,with the top remaining primarily undamaged.This parametric study demonstrated that larger cross-sections may be a preferred option to protect PSBCs against the impact of heavy trucks.
基金support from the National Science Foundation of China(No.21072131)Sichuan University-Lu Zhou Strategic Cooperation Projects(No.2017CDLZ-S34)。
文摘The synthesis of trifluoroethoxylated dihydropyrrolidones via rhodium-catalyzed oxidation and trifluoroethoxylation of pyrrolidones is presented in this paper. This process realized the trifluoroethoxylation ofnon-activated sp^(3) C–H by a domino approach for the first time, without requiring the preparation of substrates with halogens or guiding groups. The formed α,β-unsaturated-γ-butyrolactams can be furtherfunctionalized via the Michael addition reaction or realize the exchange of the trifluoroethoxy group tothe hexafluoroisopropoxy group. Such compounds exhibit anti-tumor activity in vitro and can be used ashit compounds for further research. This method provides an efficient domino approach for generatingvarious trifluoroethoxylated dihydropyrrolidones.
基金National Key R&D Program of China(2021YFE0112900)Austrian Science Fund(FWF)Herzfelder’sche Familienstiftung project P35268-B,BMBWF and WTZ-OEAD grant(CN 04/2021)+4 种基金Basic Research Project of Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences(GIBHBRP23-02)Youth Innovation Promotion Association,CAS,Science and Technology Planning Project of Guangdong Province,China(2023B1212060050,2023B1212120009)Science and Technology Projects in Guangzhou(2024A04J4199)Guangdong Basic and Applied Basic Research Foundation(2021A1515111044)National Science Foundation of China(32000414)。
文摘The COVID-19 pandemic has caused a global health crisis and significant social economic burden.While most individ-uals experience mild or non-specific symptoms,elderly individuals are at a higher risk of developing severe symptoms and life-threatening complications.Exploring the key factors associated with clinical severity highlights that key char-acteristics of aging,such as cellular senescence,immune dysregulation,metabolic alterations,and impaired regen-erative potential,contribute to disruption of tissue homeostasis of the lung and worse clinical outcome.Senolytic and senomorphic drugs,which are anti-aging treatments designed to eliminate senescent cells or decrease the asso-ciated phenotypes,have shown promise in alleviating age-related dysfunctions and offer a novel approach to treating diseases that share certain aspects of underlying mechanisms with aging,including COVID-19.This review summa-rizes the current understanding of aging in COVID-19 progression,and highlights recent findings on anti-aging drugs that could be repurposed for COVID-19 treatment to complement existing therapies.
