Energy has always been the most concerned topic in the world due to the large consumption. Various types of energy have been exploited and developed to enhance the output amount so that high requirements can be met. L...Energy has always been the most concerned topic in the world due to the large consumption. Various types of energy have been exploited and developed to enhance the output amount so that high requirements can be met. Like the hydro-energy, wind energy, and tidal energy, light energy as a renewable, clean, and widespread energy can be easily harvested. In microcosmic scale, some specific proteins and enzymes in green plants and bacteria play an important role in light harvest and energy conversion via photosynthesis. Inspired by the biomimetic sparks,these bioactive macromolecules and some artificially synthetic unites have been integrated together to improve the light-harvesting, and enhance their utilization efficiency. In this feature article, we primarily discuss that how to create the bio-inorganic hybrid energy converted system via biomimetic assembly strategy and artificially achieve the transformation from light into bioenergy, meanwhile highlight some promising works.展开更多
Ultrasound(US)activation of mechanophores in polymers that initiates cascade chemical reactions is a promising strategy for on-demand molecule release.However,the typical US frequency used for mechanochemistry is arou...Ultrasound(US)activation of mechanophores in polymers that initiates cascade chemical reactions is a promising strategy for on-demand molecule release.However,the typical US frequency used for mechanochemistry is around 20 kHz,producing inertial cavitation that exceeds the tolerance threshold of biological systems.Here,high-intensity focused US(HIFU)as a mechanical stimulus is introduced to drive the activation of disulfide mechanophores in hyperbranched star polymers(HBSPs)and microgels(MGLs).The mechanism of molecular release is attributed to the thiol-disulfide exchange reaction and subsequent intramolecular cyclization.We reveal that HBSPs and MGLs effectively transduce HIFU as mechanical input to chemical output,demonstrated by the quantification of the release of fluorescent umbelliferone(UMB).Moreover,an in vitro study of drug release is carried out using camptothecin as the model drug,which is covalently loaded in MGLs,demonstrating the potential of our system for controlled drug delivery to cancer cells.展开更多
What is the most favorite and original chemistry developed in your research group?The most favorite and original chemistry developed in my research group is about the reconstitution of motor proteins in artificially d...What is the most favorite and original chemistry developed in your research group?The most favorite and original chemistry developed in my research group is about the reconstitution of motor proteins in artificially designed and assembled units.It is based on the molecular assembly technique,but the method is different from the conventional approach.展开更多
The development of ultrasound-responsive microcapsule structures has resulted in several spatiotemporally controlled drug delivery systems for macromolecular cargoes,including proteins,nucleic acids,and even cells for...The development of ultrasound-responsive microcapsule structures has resulted in several spatiotemporally controlled drug delivery systems for macromolecular cargoes,including proteins,nucleic acids,and even cells for biomedical applications.However,utilizing microcapsules to transport small molecular cargoes remains a challenge,because the leakage of drugs before ultrasound irradiation might cause side effects such as the undesired toxicity and the decrease of effective drug concentration at the target site.Herein,we present a novel strategy to tackle these shortcomings by employing nanodrugs which refers to nanoparticles coated with small molecule drugs.We showed that the drug leakage was prevented when encapsulating the nanodrug in microcapsules.Moreover,the fabricated drug delivery system was responsive not only to unfocused high-intensity ultrasound but also to the clinically relevant high-intensity focused ultrasound.Finally,as a proof of concept,we showed that the antibacterial activity of the nanodrug@Microcapsules could be activated by applying ultrasound in situ.These results may provide new insights into the development of ultrasound triggered small molecule drug delivery assisted by metallic nanoparticles.展开更多
基金finically supported by the National Natural Science Foundation of China(Nos.21303219,21433010,21320102004,and 21273250)the National Basic Research Program of China(973 program,No.2013CB932802)
文摘Energy has always been the most concerned topic in the world due to the large consumption. Various types of energy have been exploited and developed to enhance the output amount so that high requirements can be met. Like the hydro-energy, wind energy, and tidal energy, light energy as a renewable, clean, and widespread energy can be easily harvested. In microcosmic scale, some specific proteins and enzymes in green plants and bacteria play an important role in light harvest and energy conversion via photosynthesis. Inspired by the biomimetic sparks,these bioactive macromolecules and some artificially synthetic unites have been integrated together to improve the light-harvesting, and enhance their utilization efficiency. In this feature article, we primarily discuss that how to create the bio-inorganic hybrid energy converted system via biomimetic assembly strategy and artificially achieve the transformation from light into bioenergy, meanwhile highlight some promising works.
基金supported by the German Research Foundation(grant nos.331065168,191948804,and 503981124)the National Natural Science Foundation of China(grant no.22277018)+2 种基金the Zhejiang Provincial Natural Science Foundation for Distinguished Young Scholars(grant no.LR23B030001)Wenzhou Institute,University of the Chinese Academy of Sciences(grant no.WIUCASQD2020015)M.X.acknowledges the financial support of the Alexander von Humboldt Foundation(grant no.3.5-CHN-1210658-HFST-P).
文摘Ultrasound(US)activation of mechanophores in polymers that initiates cascade chemical reactions is a promising strategy for on-demand molecule release.However,the typical US frequency used for mechanochemistry is around 20 kHz,producing inertial cavitation that exceeds the tolerance threshold of biological systems.Here,high-intensity focused US(HIFU)as a mechanical stimulus is introduced to drive the activation of disulfide mechanophores in hyperbranched star polymers(HBSPs)and microgels(MGLs).The mechanism of molecular release is attributed to the thiol-disulfide exchange reaction and subsequent intramolecular cyclization.We reveal that HBSPs and MGLs effectively transduce HIFU as mechanical input to chemical output,demonstrated by the quantification of the release of fluorescent umbelliferone(UMB).Moreover,an in vitro study of drug release is carried out using camptothecin as the model drug,which is covalently loaded in MGLs,demonstrating the potential of our system for controlled drug delivery to cancer cells.
基金The authors acknowledge the finan cial support from the National Natural Science Foundation of China(Nos.21433010,21872151 and 21320102004)。
文摘What is the most favorite and original chemistry developed in your research group?The most favorite and original chemistry developed in my research group is about the reconstitution of motor proteins in artificially designed and assembled units.It is based on the molecular assembly technique,but the method is different from the conventional approach.
基金the European Research Council through the Advanced Grant“Suprabiotics”(No.694610)J.L.F.was supported by a CSC scholarship.M.J.X.thanks the Alexander von Humboldt Foundation for a fellowship and financial support(No.3.5-CHN-1210658-HFST-P)L.F.Z.acknowledges financial support from Wenzhou Institute,University of Chinese Academy of Sciences(No.WIUCASQD2020015).
文摘The development of ultrasound-responsive microcapsule structures has resulted in several spatiotemporally controlled drug delivery systems for macromolecular cargoes,including proteins,nucleic acids,and even cells for biomedical applications.However,utilizing microcapsules to transport small molecular cargoes remains a challenge,because the leakage of drugs before ultrasound irradiation might cause side effects such as the undesired toxicity and the decrease of effective drug concentration at the target site.Herein,we present a novel strategy to tackle these shortcomings by employing nanodrugs which refers to nanoparticles coated with small molecule drugs.We showed that the drug leakage was prevented when encapsulating the nanodrug in microcapsules.Moreover,the fabricated drug delivery system was responsive not only to unfocused high-intensity ultrasound but also to the clinically relevant high-intensity focused ultrasound.Finally,as a proof of concept,we showed that the antibacterial activity of the nanodrug@Microcapsules could be activated by applying ultrasound in situ.These results may provide new insights into the development of ultrasound triggered small molecule drug delivery assisted by metallic nanoparticles.
