High-bandwidth nano-positioning stages(NPSs)have boosted the advancement of modern ultra-precise,ultra-fast measurement and manufacturing technologies owing to their fast dynamic response,high stiffness and nanoscale ...High-bandwidth nano-positioning stages(NPSs)have boosted the advancement of modern ultra-precise,ultra-fast measurement and manufacturing technologies owing to their fast dynamic response,high stiffness and nanoscale resolution.However,the nonlinear actuation,lightly damped resonance and multi-axis cross-coupling effect bring significant challenges to the design,modeling and control of high-bandwidth NPSs.Consequently,numerous advanced works have been reported over the past decades to address these challenges.Here,this article provides a comprehensive review of high-bandwidth NPSs,which covers four representative aspects including mechanical design,system modeling,parameters optimization and high-bandwidth motion control.Besides,representative high-bandwidth NPSs applied to atomic force microscope and fast tool servo are highlighted.By providing an extensive overview of the design procedure for high-bandwidth NPSs,this review aims to offer a systemic solution for achieving operation with high speed,high accuracy and high resolution.Furthermore,remaining difficulties along with future developments in this fields are concluded and discussed.展开更多
Bioprinting has exhibited remarkable promises for the fabrication of functional skin substitutes.However,there are some significant challenges for the treatment of full-thickness skin defects in clinical practice.It i...Bioprinting has exhibited remarkable promises for the fabrication of functional skin substitutes.However,there are some significant challenges for the treatment of full-thickness skin defects in clinical practice.It is necessary to determine bioinks with suitable mechanical properties and desirable biocompatibilities.Additionally,the key for printing skin is to design the skin structure optimally,enabling the function of the skin.In this study,the full-thickness skin scaffolds were prepared with a gradient pore structure constructing the dense layer,epidermis,and dermis by different ratios of bioinks.We hypothesized that the dense layer protects the wound surface and maintains a moist environment on the wound surface.By developing a suitable hydrogel bioink formulation(sodium alginate/gelatin/collagen),to simulate the physiological structure of the skin via 3D printing,the proportion of hydrogels was optimized corresponding to each layer.These results reveal that the scaffold has interconnected macroscopic channels,and sodium alginate/gelatin/collagen scaffolds accelerated wound healing,reduced skin wound contraction,and re-epithelialization in vivo.It is expected to provide a rapid and economical production method of skin scaffolds for future clinical applications.展开更多
基金National Natural Science Foundation of China under Grants 52335010,U2013211 and 52305486。
文摘High-bandwidth nano-positioning stages(NPSs)have boosted the advancement of modern ultra-precise,ultra-fast measurement and manufacturing technologies owing to their fast dynamic response,high stiffness and nanoscale resolution.However,the nonlinear actuation,lightly damped resonance and multi-axis cross-coupling effect bring significant challenges to the design,modeling and control of high-bandwidth NPSs.Consequently,numerous advanced works have been reported over the past decades to address these challenges.Here,this article provides a comprehensive review of high-bandwidth NPSs,which covers four representative aspects including mechanical design,system modeling,parameters optimization and high-bandwidth motion control.Besides,representative high-bandwidth NPSs applied to atomic force microscope and fast tool servo are highlighted.By providing an extensive overview of the design procedure for high-bandwidth NPSs,this review aims to offer a systemic solution for achieving operation with high speed,high accuracy and high resolution.Furthermore,remaining difficulties along with future developments in this fields are concluded and discussed.
基金This work was supported by the National Key R&D Program of China(2018YFA0703100)Jiangsu Key Technology Research Development Program(BE2017664)+3 种基金Shanghai Jiao Tong University Biomedical Engineering Cross Research Foundation(YG2017QN15)the National Natural Science Foundation of China(No.82072217 and 81772135)Shanghai health committee(20184Y0053)Shanghai“Rising stars of medical talent”Youth development program,Shanghai Jiao Tong University K.C.Wong Medical Fellowship Fund.
文摘Bioprinting has exhibited remarkable promises for the fabrication of functional skin substitutes.However,there are some significant challenges for the treatment of full-thickness skin defects in clinical practice.It is necessary to determine bioinks with suitable mechanical properties and desirable biocompatibilities.Additionally,the key for printing skin is to design the skin structure optimally,enabling the function of the skin.In this study,the full-thickness skin scaffolds were prepared with a gradient pore structure constructing the dense layer,epidermis,and dermis by different ratios of bioinks.We hypothesized that the dense layer protects the wound surface and maintains a moist environment on the wound surface.By developing a suitable hydrogel bioink formulation(sodium alginate/gelatin/collagen),to simulate the physiological structure of the skin via 3D printing,the proportion of hydrogels was optimized corresponding to each layer.These results reveal that the scaffold has interconnected macroscopic channels,and sodium alginate/gelatin/collagen scaffolds accelerated wound healing,reduced skin wound contraction,and re-epithelialization in vivo.It is expected to provide a rapid and economical production method of skin scaffolds for future clinical applications.
